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Do it Best Successfully Completes Purchase of True ValueSir Keir Starmer said he would be looking towards a “better, brighter future for every person” in a Christmas message following a turbulent year for the UK. The Prime Minister said the season was a time to remember the importance of “being there for one another”, including in “the more difficult times”. He also expressed hope for “peace, particularly in the Middle East as the birthplace of the Christmas story” amid spiralling conflict across the region. The message comes after a challenging first five months in office for the Labour Government and against the backdrop of a flatlining economy and rising inflation. Sir Keir said: “This Christmas, people will be travelling up and down the country. Heading home, visiting relatives and loved ones to celebrate together the hope and joy of this special season. “It’s a time to remind ourselves what’s really important. Family. Friendship. And fellowship between all people. “Being there for one another – in these celebrations, as well as the more difficult times.” To our military and veterans, the whole nation thanks you for the sacrifices you make to keep us safe. My government will serve you as you have served your country. I wish you and your families a very happy Christmas and a peaceful New Year. pic.twitter.com/LphMZog6np — Keir Starmer (@Keir_Starmer) December 22, 2024 The Prime Minister sought to strike an optimistic note following another year of political upheaval for Britain, which saw Labour win a landslide victory after a surprise election called by Rishi Sunak in the summer. After taking office in July, the new Government made a series of unpopular decisions as ministers confronted the realities of creaking public services and strained national finances. As well as dealing with the economic inheritance, Sir Keir said he needed to fix a “broken society” which manifested itself in summer riots across the country after the Southport knife attack. Sir Keir said: “This Christmas, I will be hoping for peace, particularly in the Middle East as the birthplace of the Christmas story. “I’ll be looking towards a better, brighter future for every person and celebrating the joy and wonder that Christmas brings. “So, from my family to yours, I hope you have a very merry Christmas.” The message comes after revised official figures released on Monday indicated that UK gross domestic product (GDP) showed no growth between July and September. Downing Street defended the Government’s record so far when asked about the data, telling reporters: “We had to take those tough decisions to lay the foundations of growth such that we can then deliver the higher living standards over this Parliament that people want to see.” The Prime Minister also used his message to thank those spending Christmas serving others, including in the NHS and emergency services, the armed forces, churches and charities. “I know that this is not an easy time for everyone, and my thoughts are with all those who are lonely this Christmas. “Having a tough time, missing a loved one. You are not alone,” he said. Meanwhile, Kemi Badenoch said Christmas was a time to reflect on “all that’s happened in the year” and “support all of those people who need our assistance”. “I want to take this opportunity to say thank you to everyone, not just in the Conservative Party or in my constituency, but across the country,” the Tory leader said. “For all that you have been doing in your communities, supporting each other and helping to keep all our towns, villages and places going. “I think that Christmas is a time for us to reflect on all that’s happened in the year. “Sometimes we have amazing years. “Sometimes, like when I lost my dad, we have difficult years and we’re commiserating, but we do it together. “But it’s a time for us to support all of those people who need our assistance, who need our help, who need our support.” She added: “And I’m looking forward to 2025. “I wish you all the very best for the New Year and all of the exciting things to come.” Liberal Democrat leader Sir Ed Davey said: “This year, I’ve had the chance to spend time with some amazing young carers. “Incredible young people who will spend this Christmas doing what they do all year round; looking after loved ones who are ill or disabled. “Carers embody the Christmas spirit of love, selflessness and generosity. “So I hope we can all take some time to think of them, and keep them in our hearts. “And wish them – and everyone – a Christmas full of peace, joy and love.”
Thousands of elderly drivers have been caught breaking a crucial Highway Code rule. One motorist - aged 98 - was among three drivers in their 90s who received licence endorsements for phone-related offences, according to data obtained from the DVLA. An FOI (Freedom of Information Act) request has laid the number of drivers, motorists and road users in the UK who have been rumbled using a mobile phone while driving. If caught, drivers face a minimum £200 fine and six penalty points on their licence. Mark Tongue, Joint CEO and Co-Founder of Select Car Leasing, said: "Age is no barrier to being hit with a fine and points on your licence for being distracted by a mobile phone and all motorists, no matter how experienced they are, need to be aware of the dangers. READ MORE HMRC handing parents who earn under £100,000 free £3,600 in 'five minutes' "It's eye-opening to see such an elderly driver being collared by police after reaching for their phone, but perhaps not surprising given how technology has creeped into all aspects of our lives, no matter how old we might be. After all, age doesn't always equate to wisdom!” Mr Tongue added: "It's encouraging to see a projected dip in mobile phone-related driver prosecutions this year, but it's clear the message still needs ramming home about just how dangerous reaching for your device can be." Drivers in their 70s received 875 endorsements, while those in their 80s accounted for 84 cases but 4,475 endorsements were given to drivers aged 61-70, so born before 1963. Anyone caught using their handheld device while driving could face a fine of up to £1,000 as well as 6 points on their licence or a full driving ban. Edmund King AA president said: "The AA has long campaigned to make handheld mobile phone use while driving as socially unacceptable as drink driving and we warmly welcome the new law. This is a much-needed toughening of the rules to help make our roads safer. "Those who believe they can still play with their phone because it’s in a cradle must think again – they leave themselves open to prosecution for either careless or dangerous driving. The best thing to do is to convert your glovebox into a phone box. We all need to keep our hands on the wheel and our eyes on the road."
More than 20 states and cities designate December as Osteopathic Medicine MonthLara Trump announced on social media Saturday that she’s taking her name out of consideration for Florida’s soon-to-be vacant Senate seat. It’s a smart move by the president-elect’s daughter-in-law—since she probably wasn’t going to get the seat anyway. “After an incredible amount of thought, contemplation, and encouragement from so many, I have decided to remove my name from consideration for the United States Senate,” Trump wrote in a post on X, formerly Twitter. x After an incredible amount of thought, contemplation, and encouragement from so many, I have decided to remove my name from consideration for the United States Senate. I could not have been more honored to serve as RNC co-chair during the most high-stakes election of our... https://t.co/ARdvTQki9N — Lara Trump (@LaraLeaTrump) December 21, 2024 One of Florida’s Senate seats will be up for grabs soon because Donald Trump tapped Sen. Marco Rubio to be the next secretary of state. Rubio’s replacement will be selected by Florida Gov. Ron DeSantis, who has a hot-and-cold professional relationship with the incoming president. Whoever DeSantis appoints for the role will fill the seat until 2026 . Then there will be a special election to decide who will serve the last two years of Rubio’s term. Lara, who is married to Trump’s son, Eric, announced earlier this month that she would step down as co-chair of the Republican National Committee, which signaled to some that she was being considered for the Senate role. The nepo hire also received several early endorsements from other Republicans including Elon Musk’s mother , who said that Lara would be a great addition to the political theatre commonly known as Capitol Hill. But it doesn’t seem that DeSantis was inclined to give Lara a slot in the Senate. In November, he said that he would appoint Rubio’s replacement in early 2025 and promised to do “extensive vetting and candidate interviews” before settling on a pick. The GOP governor has not talked publicly about who he is considering, but several people are reportedly in the mix , including Florida Attorney General Ashley Moody, Lt. Gov. Jeanette Núñez, and former Florida House Speaker Jose Oliva. In other words, despite his many personal flaws , DeSantis seems to want someone with at least an ounce of government experience for the role. That would exclude Lara, who launched a new activewear line in November and is hilariously trying to be a singer . Even Trump, who installed Lara as head of the Republican National Committee, seemed doubtful his daughter-in-law would get picked for the Senate seat. When asked last Monday whether DeSantis would appoint her, Trump suggested that he wasn’t expecting any favors from his onetime political nemesis, whom Trump once called “ Meatball Ron ” and “ Ron DeSanctimonious .” “I don’t. I probably don’t, but I don’t know,” Trump said when asked if thought DeSantis would tap Lara for the role. “Ron is doing a good job. It is his choice, nothing to do with me.” But don’t get too excited yet, as this won’t be the last we hear of Lara. “I do have a big announcement that I’m excited to share in January, so, stay tuned,” she wrote. “I remain incredibly passionate about public service and look forward to serving our country again sometime in the future. In the meantime, I wish Governor DeSantis the best of luck with this appointment.” Lara isn’t alone among daughters-in-law recently snubbed for government roles that their fathers-in-law wanted them to have. At least this nepo hire has her music career to fall back on. x RNC Chair Lara Trump releases her new music video. pic.twitter.com/iRplU6VIDy — Ron Filipkowski (@RonFilipkowski) September 2, 2024 If you value having free and reliable access to the information and resources we provide, we’re asking for your help today. Will you make a donation of $5, $25, or whatever you can afford to help us reach our year-end goal?
Ohtani wins third AP Male Athlete of the Year awardWASHINGTON (AP) — Lawmakers, meet your latest lobbyists: online influencers from TikTok. The platform is once again bringing influencers to Washington, this time to lobby members of Congress to reject a fast-moving bill that would force TikTok's Beijing-based parent company to sell or be banned in the United States. On Tuesday, some influencers began a two-day advocacy event in support of TikTok, which arranged their trip ahead of a House floor vote on the legislation on Wednesday. But unlike a similar lobbying event the company put together last March when talks of a TikTok ban reached a fever pitch, this year’s effort appeared more rushed as the company scrambles to counter the legislation, which advanced rapidly on Capitol Hill. Summer Lucille, a TikTok content creator with 1.4 million followers who is visiting Washington this week, said if TikTok is banned, she “don’t know what it will do” to her business, a plus-sized boutique in Charlotte, North Carolina. “It will be devastating,” Lucille said in an interview arranged by the platform. In an unusual showing of bipartisanship, a House panel unanimously approved the measure last week. President Joe Biden has said he will sign the legislation if lawmakers pass it. But it’s unclear what will happen in the Senate, where several bills aimed at banning TikTok have stalled. The legislation faces other roadblocks. Former president and current presidential candidate Donald Trump, who holds sway over both House and Senate Republicans, has voiced opposition to the bill, saying it would empower Meta-owned Facebook, which he continues to lambast over his 2020 election loss. The bill also faces pushback from some progressive lawmakers in the House as well as civil liberties groups who argue it infringes on the First Amendment. TikTok could be banned if ByteDance, the parent company, doesn’t sell its stakes in the platform and other applications it owns within six months of the bill’s enactment. The fight over the platform takes place as U.S.-China relations have shifted to that of strategic rivalry, especially in areas such as advanced technologies and data security, seen as essential to each country’s economic prowess and national security. The shift, which started during the Trump years and has continued under Biden, has placed restrictions on export of advanced technologies and outflow of U.S. monies to China, as well as access to the U.S. market by certain Chinese businesses. The Biden administration also has cited human rights concerns in blacklisting a number of Chinese companies accused of assisting the state surveillance campaign against ethnic minorities. TikTok isn’t short on lobbyists. Its Beijing-based parent company ByteDance has a strong lobbying apparatus in Washington that includes dozens of lobbyists from well-known consulting and legal firms as well as influential insiders, such as former members of Congress and ex-aides to powerful lawmakers, according to the Foundation for Defense of Democracies. TikTok CEO Shou Zi Chew will also be in Washington this week and plans to meet with lawmakers, according to a company spokesperson who said Chew’s visit was previously scheduled. But influencers, who have big followings on social media and can share personal stories of how the platform boosted their businesses — or simply gave them a voice — are still perhaps one of the most powerful tools the company has in its arsenal. A TikTok spokesperson said dozens of influencers will attend the two-day event, including some who came last year. The spokesperson did not immediately respond to questions about how many new people would be attending this year’s lobbying blitz. The company is briefing them ahead of meetings with their representatives and media interviews. Lucille, who runs the boutique in North Carolina, says has seen a substantial surge in revenue because of her TikTok page. The 34-year-old began making TikTok content focusing on plus-sized fashion in March 2022, more than a decade after she started her business. She quickly amassed thousands of followers after posting a nine-second video about her boutique. Because of her popularity on the platform, her business has more online exposure and customers, some of whom have visited from as far as Europe. She says she also routinely hears from followers who are finding support through her content about fashion and confidence. JT Laybourne, an influencer who also came to Washington, said he joined TikTok in early 2019 after getting some negative comments on videos he posted on Instagram while singing in the car with his children. Laybourne, who lives in Salt Lake City, Utah, said he was attracted to the short-form video platform because it was easy to create videos that contained music. Like Lucille, he quickly gained traction on the app. He says he also received more support from TikTok users, who reacted positively to content he produced on love and positivity. Laybourne says the community he built on the platform rallied around his family when he had to undergo heart surgery in 2020. Following the surgery, he said he used the platform to help raise $1 million for the American Heart Association in less than two years. His family now run an apparel company that gets most of its traffic from TikTok. “I will fight tooth-and-nail for this app,” he said. But whether the opposition the company is mounting through lobbyists or influencers will be enough to derail the bill is yet to be seen. On Tuesday, House lawmakers received a briefing on national security concerns regarding TikTok from the FBI, Justice Department and intelligence officials. AP Journalist Didi Tang contributed to this report. This story was originally published on March 12, 2024. It was updated on December 23, 2024 to clarify a quote by TikTok content creator Summer Lucille.India’s Electronics Sector to Generate 12 million Jobs by 2027, Report Highlights
ASML (NASDAQ:ASML) Trading Down 0.3% – Here’s WhyPrimary Hyperoxaluria Therapeutics Market Size in the 7MM was ~USD 316 million in 2023, estimated DelveInsight 12-23-2024 11:20 PM CET | Health & Medicine Press release from: ABNewswire DelveInsight's "Primary Hyperoxaluria Market Insights, Epidemiology, and Market Forecast-2034 report offers an in-depth understanding of the Primary Hyperoxaluria, historical and forecasted epidemiology as well as the Primary Hyperoxaluria market trends in the United States, EU4 (Germany, Spain, Italy, France) the United Kingdom and Japan. Discover Key Insights into the Primary Hyperoxaluria Market with DelveInsight's In-Depth Report @ Primary Hyperoxaluria Market Size [ https://www.delveinsight.com/sample-request/primary-hyperoxaluria-market?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr ] Key Takeaways from Primary Hyperoxaluria Market Report * In the assessment done by DelveInsight, the estimated total prevalent cases of Primary Hyperoxaluria in the 7MM were ~12 thousand in 2023. * The highest total diagnosed prevalent cases of Primary Hyperoxaluria were accounted by US in 2023 (~2 thousand), which are expected to show a rise in the future. * Among the European countries, the UK had the highest diagnosed prevalent cases of Primary Hyperoxaluria with ~220 cases, followed by Germany, which had prevalent population of ~188 in 2023. On the other hand, Spain had the lowest prevalent population (~100 cases). * Japan had the fewest total diagnosed prevalent cases of Primary Hyperoxaluria in 2023, accounting for approximately 2.5% of the cases in 7MM. * In 2023, in the US, the age-specific diagnosed prevalent cases of Primary Hyperoxaluria were highest for age group 0-4 (~780 cases), followed by 5-9 (~470 cases). The lowest number of cases was in the 15-19 years age group. * In 2023, in Japan, the type-specific diagnosed prevalent cases of Primary Hyperoxaluria were highest for Primary Hyperoxaluria Type 1 (~64 cases), followed by Primary Hyperoxaluria Type 2, Primary Hyperoxaluria Type 3 and unclassified. * The leading Primary Hyperoxaluria Companies such as Dicerna Pharmaceuticals, Inc., Allena Pharmaceuticals, Biocodex, Alnylam Pharmaceuticals, Biocodex, Dicerna Pharmaceuticals , and others * Promising Primary Hyperoxaluria Therapies such as Nedosiran (DCR-PHXC), ALLN-177, Stiripentol, Lumasiran, stiripentol (Diacomit), DCR-PHXC , and others Navigate the complexities of the Primary Hyperoxaluria Market: gain insights into drug trends, treatment scenarios, and epidemiological data through our insightful Primary Hyperoxaluria Market Forecast. Click here to get more insights @ Primary Hyperoxaluria Treatment Market [ https://www.delveinsight.com/sample-request/primary-hyperoxaluria-market?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr ] Primary Hyperoxaluria Epidemiology Segmentation in the 7MM * Prevalent Cases of Primary Hyperoxaluria in the 7MM * Diagnosed Prevalent Cases of Primary Hyperoxaluria in the 7MM * Gender-specific Cases of Diagnosed Prevalent Cases of Primary Hyperoxaluria in the 7MM * Age-specific Cases of Diagnosed Prevalent Cases of Primary Hyperoxaluria in the 7MM * Type-specific Cases of Diagnosed Prevalent Cases of Primary Hyperoxaluria in the 7MM Download the report to understand which factors are driving Primary Hyperoxaluria epidemiology trends @ Primary Hyperoxaluria Prevalence [ https://www.delveinsight.com/sample-request/primary-hyperoxaluria-market?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr ] Primary Hyperoxaluria Marketed Drugs * OXLUMO (Lumasiran/ALN-GO1): Alnylam Pharma Lumasiran (formerly ALN-GO1) developed by Alnylam Pharma, approved in Year 2020, is a subcutaneously administered, RNAi therapeutic targeting glycolate oxidase (GO). Lumasiran is designed to reduce hepatic levels of GO enzyme (encoded by HAO1), thereby depleting substrate necessary for oxalate production, which directly contributes to the pathophysiology of Primary Hyperoxaluria type 1. * RIVFLOZA (nedosiran/DCR-PHXC): Dicerna Pharmaceuticals, Inc. Dicerna Pharmaceutical's Nedosiran (formerly referred to as DCR-PHXC) is an advanced therapy utilized with the company's GalXC technology to treat patients with Primary Hyperoxaluria. It was approved in Year 2023. It inhibits the lactate dehydrogenase (LDH) enzyme in the final common step of this pathway and thereby attempts to prevent this overproduction of oxalate. This LDH enzyme inhibition occurs specifically in the liver due to the incorporation of GalNAc targeting ligands in nedosiran that bind specifically to the asialoglycoprotein receptors (ASGPR) on hepatic cell surfaces. Primary Hyperoxaluria Emerging Drugs * Stiripentol (Diacomit): Biocodex Stiripentol is an anticonvulsant drug used in treating epilepsy as an adjunct therapy along with Clobazam and Valproic acid. This drug is currently approved in the US, Canada, and European countries as oral tablets marketed as Diacomit. Unrelated to other anticonvulsants, stiripentol belongs to the group of aromatic allylic alcohols and may potentiate the effect of other antiepileptic drugs (AEDs) due to pharmacokinetic interactions. It elevates gamma-aminobutyric acid (GABA) levels, a major inhibitory neurotransmitter that regulates electrical activity in the central nervous system. Get In-Depth Knowledge on Primary Hyperoxaluria Market Trends and Forecasts with DelveInsight @ Primary Hyperoxaluria Treatment Market [ https://www.delveinsight.com/sample-request/primary-hyperoxaluria-market?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr ] Primary Hyperoxaluria Market Outlook The global burden of Primary Hyperoxaluria has increased over the years. Among the seven major markets, the United States has reported having maximum diagnosed prevalent cases of Primary Hyperoxaluria. Though the prevalence of Primary Hyperoxaluria is high across the US, the condition is often misdiagnosed, ultimately leading to a lower treatable pool (when compared to the total prevalent population of the disease) that contributes to the market size of Primary Hyperoxaluria. Primary Hyperoxaluria Treatment Market The Primary Hyperoxaluria treatment usually started with citrates, vitamin B6, and hyperhydration. After that, iRNA therapies begin. Patients with advanced kidney failure go for kidney transplantation. Transplantation methods depend on the type of primary hyperoxaluria and the particular patient, but combined liver and kidney transplantation is the method of choice in patients with PH1, and isolated kidney transplantation is the preferred method with PH2. Gain a strategic edge in the Primary Hyperoxaluria Market: explore comprehensive drug insights, treatment updates, and epidemiological forecasts in our in-depth Primary Hyperoxaluria Market Forecast. Click here to lead in advancements @ Primary Hyperoxaluria Clinical Trials Assessment [ https://www.delveinsight.com/sample-request/primary-hyperoxaluria-market?utm_source=abnewswire&utm_medium=pressrelease&utm_campaign=ypr ] Scope of the Primary Hyperoxaluria Market Report * Study Period: 2020-2034 * Coverage: 7MM * Primary Hyperoxaluria Companies: Dicerna Pharmaceuticals, Inc., Allena Pharmaceuticals, Biocodex, Alnylam Pharmaceuticals, Biocodex, Dicerna Pharmaceuticals, and others * Primary Hyperoxaluria Therapies: Nedosiran (DCR-PHXC), ALLN-177, Stiripentol, Lumasiran, stiripentol (Diacomit), DCR-PHXC, and others * Primary Hyperoxaluria Therapeutic Assessment: Primary Hyperoxaluria current marketed and Primary Hyperoxaluria emerging therapies * Primary Hyperoxaluria Market Dynamics: Primary Hyperoxaluria market drivers and Primary Hyperoxaluria market barriers * Competitive Intelligence Analysis: SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies * Primary Hyperoxaluria Unmet Needs, KOL's views, Analyst's views, Primary Hyperoxaluria Market Access and Reimbursement Table of Contents 1. Primary Hyperoxaluria Market Report Introduction 2. Executive Summary for Primary Hyperoxaluria 3. SWOT analysis of Primary Hyperoxaluria 4. Primary Hyperoxaluria Patient Share (%) Overview at a Glance 5. Primary Hyperoxaluria Market Overview at a Glance 6. Primary Hyperoxaluria Disease Background and Overview 7. Primary Hyperoxaluria Epidemiology and Patient Population 8. Country-Specific Patient Population of Primary Hyperoxaluria 9. Primary Hyperoxaluria Current Treatment and Medical Practices 10. Primary Hyperoxaluria Unmet Needs 11. Primary Hyperoxaluria Emerging Therapies 12. Primary Hyperoxaluria Market Outlook 13. Country-Wise Primary Hyperoxaluria Market Analysis (2020-2034) 14. Primary Hyperoxaluria Market Access and Reimbursement of Therapies 15. Primary Hyperoxaluria Market Drivers 16. Primary Hyperoxaluria Market Barriers 17. Primary Hyperoxaluria Appendix 18. Primary Hyperoxaluria Report Methodology 19. DelveInsight Capabilities 20. Disclaimer 21. About DelveInsight About DelveInsight DelveInsight is a leading Healthcare Business Consultant, and Market Research firm focused exclusively on life sciences. It supports Pharma companies by providing comprehensive end-to-end solutions to improve their performance. It also offers Healthcare Consulting Services, which benefits in market analysis to accelerate the business growth and overcome challenges with a practical approach. Media Contact Company Name: DelveInsight Business Research LLP Contact Person: Yash Bhardwaj Email:Send Email [ https://www.abnewswire.com/email_contact_us.php?pr=primary-hyperoxaluria-therapeutics-market-size-in-the-7mm-was-usd-316-million-in-2023-estimated-delveinsight ] Phone: 9650213330 Address:304 S. Jones Blvd #2432 City: Las Vegas State: NV Country: United States Website: https://www.delveinsight.com/case-study/respiratory-domain-conference-coverage This release was published on openPR.