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When Inter Miami were dumped out of Major League Soccer's playoffs in the first round, their former Spain international full-back Jordi Alba questioned the fairness of the post-season format. Miami had topped the Eastern Conference and the overall regular season standings with a record points tally a performance which earned them the 'Supporters' Shield'. But there would be no title battle against the best in the West for Lionel Messi and Company after they contrived to lose two matches in their best-of-three series against an Atlanta United team which finished ninth in the East and 20th in the overall standings. "I think this format is a bit unfair. It has been done for many years but I think it should be the champion of one conference against the champion of the other, to make it as fair as possible," Alba said. Alba's comments prompted much debate among MLS fans and plenty of accusations of sour grapes but they did serve to highlight that this year's playoffs, if not MLS's playoffs in general, would certainly not be a battle of the best versus best. Defending champions Columbus Crew, who finished second in the Supporters' Shield race, were also eliminated in the first round, adding to the sense that the knockout phase of the season is very much a competition of its own. So on Saturday, after the international break disrupted the flow of the post-season, the Conference semi-finals, will see a "Hudson River Derby" between two New York teams who couldn't finish in the top 10 in the regular season. New York City, Manchester City's sister club, have home-field advantage after finishing in 13th spot while the New York Red Bulls travel from New Jersey, having ended up in 16th place. The 'home field' isn't actually NYCFC's usual home of Yankee Stadium, which is being used for a college football game, but Citi Field, home of New York's other baseball club, the Mets. - LAFC face rivals - Later on Saturday, in the Western Conference, 2022 MLS Cup winners and last year's beaten finalists, Los Angeles FC, are at home to the Seattle Sounders. That fixture feels much more like the kind of playoff game that was expected -- LAFC finished top of the West while Seattle were fourth. LAFC faces the Sounders for the fourth time in an elimination match over the last 13 months, having defeated Seattle in the 2023 Western Conference semifinals, the 2024 Leagues Cup quarterfinal and the 2024 US Open Cup semifinal. Each of those matches was hosted by Seattle. LAFC, with former France stars in goalkeeper Hugo Lloris and striker Olivier Giroud, enter the encounter unbeaten in their last 10 meetings with the Sounders, with their last loss to Seattle coming in a 2-0 defeat in 2021. On Sunday, surprise package Atlanta, with their 40-year-old goalkeeper Brad Guzan having impressed so many with his heroics against Miami, will return to Florida to take on Orlando City, who finished fourth in the East. Atlanta won at Orlando on the last day of the regular campaign, a victory that allowed them to sneak into the wildcard round but which also completed a home and away double for the Georgia side. "Obviously, in Major League Soccer, anything can happen," said Orlando coach Oscar Pareja. "Our responsibility is to play one game at a time. This one, we're going to be ready for sure," he added. The weekend rounds off with Los Angeles Galaxy hosting Minnesota United who, under former Manchester United assistant coach Eric Ramsay, came through a best-of-three series against higher-ranked Real Salt Lake. The Galaxy start as favourites but, as this season has shown in abundance, that counts for little. "We know they are a top team at this level with top individual players who are very difficult to beat at home but...I feel that if we are a good version of what we have been over the last 10-12 games... I certainly won't be painting it as a one sided game," said Ramsay. sev/js
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Commerce Bank cut its stake in shares of ResMed Inc. ( NYSE:RMD – Free Report ) by 3.5% during the 3rd quarter, according to its most recent 13F filing with the Securities and Exchange Commission. The firm owned 6,375 shares of the medical equipment provider’s stock after selling 234 shares during the quarter. Commerce Bank’s holdings in ResMed were worth $1,556,000 as of its most recent SEC filing. A number of other institutional investors have also recently made changes to their positions in the stock. OFI Invest Asset Management bought a new stake in ResMed in the second quarter valued at approximately $32,000. Ashton Thomas Securities LLC acquired a new stake in shares of ResMed during the third quarter worth $34,000. Versant Capital Management Inc raised its stake in ResMed by 196.7% during the second quarter. Versant Capital Management Inc now owns 181 shares of the medical equipment provider’s stock worth $35,000 after buying an additional 120 shares during the last quarter. Financial Connections Group Inc. acquired a new position in ResMed in the second quarter valued at $37,000. Finally, Blue Trust Inc. boosted its position in ResMed by 182.7% during the second quarter. Blue Trust Inc. now owns 212 shares of the medical equipment provider’s stock valued at $42,000 after acquiring an additional 137 shares during the last quarter. Institutional investors own 54.98% of the company’s stock. Insider Activity In other ResMed news, insider Kaushik Ghoshal sold 5,000 shares of the company’s stock in a transaction on Thursday, September 12th. The stock was sold at an average price of $252.56, for a total value of $1,262,800.00. Following the completion of the transaction, the insider now owns 21,788 shares in the company, valued at $5,502,777.28. This represents a 18.67 % decrease in their position. The sale was disclosed in a document filed with the Securities & Exchange Commission, which is available through the SEC website . Also, CFO Brett Sandercock sold 1,000 shares of the firm’s stock in a transaction on Monday, September 9th. The shares were sold at an average price of $246.42, for a total value of $246,420.00. Following the sale, the chief financial officer now directly owns 96,812 shares of the company’s stock, valued at approximately $23,856,413.04. This represents a 1.02 % decrease in their ownership of the stock. The disclosure for this sale can be found here . Insiders sold a total of 62,174 shares of company stock valued at $14,882,278 over the last three months. Corporate insiders own 0.71% of the company’s stock. Analyst Upgrades and Downgrades Check Out Our Latest Analysis on ResMed ResMed Price Performance Shares of NYSE:RMD opened at $243.78 on Friday. The company has a current ratio of 2.92, a quick ratio of 1.91 and a debt-to-equity ratio of 0.13. The stock has a market cap of $35.79 billion, a PE ratio of 32.29, a price-to-earnings-growth ratio of 1.77 and a beta of 0.69. The stock’s fifty day simple moving average is $241.86 and its two-hundred day simple moving average is $224.47. ResMed Inc. has a 1-year low of $151.95 and a 1-year high of $260.49. ResMed ( NYSE:RMD – Get Free Report ) last released its quarterly earnings results on Thursday, October 24th. The medical equipment provider reported $2.20 earnings per share for the quarter, beating analysts’ consensus estimates of $2.03 by $0.17. ResMed had a net margin of 23.15% and a return on equity of 25.53%. The company had revenue of $1.22 billion for the quarter, compared to analyst estimates of $1.19 billion. During the same period last year, the firm earned $1.64 earnings per share. The firm’s revenue was up 11.1% on a year-over-year basis. As a group, analysts forecast that ResMed Inc. will post 9.28 EPS for the current fiscal year. ResMed Dividend Announcement The firm also recently announced a quarterly dividend, which will be paid on Thursday, December 12th. Stockholders of record on Thursday, November 7th will be paid a $0.53 dividend. The ex-dividend date is Thursday, November 7th. This represents a $2.12 dividend on an annualized basis and a dividend yield of 0.87%. ResMed’s payout ratio is presently 28.08%. ResMed Company Profile ( Free Report ) ResMed Inc develops, manufactures, distributes, and markets medical devices and cloud-based software applications for the healthcare markets. The company operates in two segments, Sleep and Respiratory Care, and Software as a Service. It offers various products and solutions for a range of respiratory disorders, including ApneaLink Air, a portable diagnostic device that measures oximetry, respiratory effort, pulse, nasal flow, and snoring; and NightOwl, a portable, cloud-connected, and disposable diagnostic device that measures AHI based on derived peripheral arterial tone, actigraphy, and oximetry over several nights. Recommended Stories Want to see what other hedge funds are holding RMD? Visit HoldingsChannel.com to get the latest 13F filings and insider trades for ResMed Inc. ( NYSE:RMD – Free Report ). Receive News & Ratings for ResMed Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for ResMed and related companies with MarketBeat.com's FREE daily email newsletter .Speaker schedules opposition motions after Tories opt against own non-confidence vote
A team of Children's Medical Research Institute (CMRI) scientists has identified a new method for producing a therapeutic product that has the potential to improve the treatment of cancer. The work by Associate Professor Leszek Lisowski and his Translational Vectorology Research Unit is published in the journal Molecular Therapy . Chimeric antigen receptor (CAR) T cells, also known as CAR T therapies, are a relatively new form of treatment showing very exciting results for several types of cancer. While initially validated for the treatment of B cell malignancies, especially acute lymphoblastic leukemia (ALL), the technology has also shown promise for other cancer types, including solid tumors. In most cases, CAR T cells are made by modifying the patients' own T cells so they produce a specifically designed chimeric antigen receptor , enabling them to seek and kill cancer cells. To convert T cells into CAR T cells, the patients' cells are modified using a viral vector encoding the CAR component. Currently, there are six US Food and Drug Administration-approved CAR T products, all of which use viral vectors as a delivery system. To improve CAR T products, researchers are investigating how the viral vectors affect CAR T cells, especially their specificity and long-term efficacy. In recent years, advances in CAR T technology have included the use of new viral vectors to deliver the functional CAR to patients' T cells to generate therapeutic CAR T products. Based on their inherent safety, AAV vectors, which are most commonly used to deliver therapeutic genes directly to patients and are currently the technology behind eight marketed gene therapy products, are the next frontier in CAR T products. In this study, Associate Professor Lisowski and his team, including author Adrian Westhaus, developed a new method to bioengineer novel bespoke AAV variants that enable more efficient targeting of patients' T cells, positioning them as the next generation of AAV vectors for CAR T product development. In a proof-of-concept study, the CMRI team has discovered two novel AAV capsids, known as AAV-T1 and AAV-T2, which can produce therapeutic CAR T cells using a five-fold lower dose of the vector. This significantly lower vector dose not only could lead to a lower cost of future CAR T products, but, more importantly, the team was also able to show that the therapeutic CAR T cells developed using these new AAVs killed cancer cells with higher efficiency, thus potentially also increasing the therapeutic potency of the new therapies. "To achieve this goal, we studied how AAV vectors influence the rate of gene editing and have used that knowledge to develop a novel AAV selection method, which allows us to rapidly bioengineer novel AAVs for gene editing applications, which is the strategy used to permanently modify T cells to make CAR T cells," A/Prof Lisowski said. "Following the selection process, we performed functional validations of the selected viral vectors. The two top performing candidates (AAV-T1 and AAV-T2) generated CAR T cells more efficiently and produced CAR Ts that were more functionally active than AAV6, which is the AAV currently used for CAR T development." More information: Adrian Westhaus et al, Tailoring capsid directed evolution technology for improved AAV-mediated CAR-T generation, Molecular Therapy (2024). DOI: 10.1016/j.ymthe.2024.12.012Trudeau told Trump Americans would also suffer if tariffs are imposed, a Canadian minister says
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Want government money for a heat pump? Time might be running out toggle caption ANDREW CABALLERO-REYNOLDS/AFP via Getty Images/AFP Heat pumps are electric appliances that can both heat and cool your home. Scientists see them as a climate solution because heat pumps reduce planet-heating emissions. They cut pollution from burning gas for heating, and reduce the use of gas infrastructure that leaks planet-heating methane gas. And heat pumps are highly efficient, which means less electricity is needed to use them than traditional heating systems like fossil fuel furnaces and boilers. Researchers at the Department of Energy's National Renewable Energy Laboratory calculate that 62% to 95% of households would save money by switching to a heat pump. " It's an enormous amount of savings," says Ari Matusiak, CEO of the nonprofit, Rewiring America. "That's just a fact of the technology being superior." Sponsor Message The Biden administration's 2022 climate legislation introduced new federal tax incentives of up to $2,000 for heat pump equipment and installation costs. Many states as well as cities and utilities offer additional financial incentives. So what money is available right now for a prospective heat pump buyer? And how might a second Trump administration and a Republican-controlled Congress impact this money? Here are the answers to your heat pump and money questions. Before we get to money, remind me, how do heat pumps work? Heat pumps are "basically this magical two-in-one device," Matusiak says. For cooling, heat pumps work like air conditioners. They run on electricity and use refrigerants. For heating, heat pumps also use refrigerants. The refrigerants absorb bits of heat from outdoor air and bring them inside to warm up a home. Some types of heat pumps are specifically designed for extra cold climates, and heat pump sales are booming in countries like Norway, Finland and Sweden. What kind of money can I currently get from the federal government... Julia Simon
Baltimore Ravens head coach John Harbaugh offered a fairly vague answer Monday while discussing why Diontae Johnson didn't see the field against the Philadelphia Eagles during Sunday's 24-19 loss. "At this time, I'm going to have to wait just to clarify it," he told reporters . "There's some moving parts there that we're going to have to figure out and explore and just see where we're at. I know that's not the answer you want, but that's the best I can do in fairness to everybody right now." The Ravens traded a fifth-round pick to the Carolina Panthers for Johnson and a sixth-round selection on Oct. 29, but in four games with the Ravens, he's managed just one catch for six yards. He's so far down the pecking order that he didn't even see action on Sunday after starter Rashod Bateman left the game in the third quarter with a knee injury. In the past three games, he's played a grand total of 17 snaps and has been targeted just three times with no catches, leaving his future in Baltimore up in the air as the team heads into its bye. "We'll just work it out [and] see where we're at over the next few days this week," Harbaugh said when asked if Johnson would remain with the Ravens. The Ravens have a number of mouths to feed, with quarterback Lamar Jackson and Derrick Henry proving a major threat in the run game and Zay Flowers, Bateman, Mark Andrews and Isaiah Likely headlining the passing game. Johnson has clearly not been able to break through, even ceding snaps to the inconsistent Nelson Agholor, and Harbaugh's comments on Monday made it seem as though a release could be an option, potentially one even requested by Johnson behind closed doors. Despite that fact, Lamar Jackson has said he wants the veteran receiver to stick around. "We want him out there," Jackson said. "He's a great receiver. We didn't get him from the Panthers for nothing." Maybe not, but it doesn't feel like Johnson has a future in Baltimore.Srinagar, Dec 25: A Kashmiri doctor has spearheaded the discovery of a groundbreaking potential cure for lung fibrosis, paving the way for aspiring scientists not only in Kashmir but across the world. In an exclusive conversation with Greater Kashmir , Dr Muzamil Majid Khan shared his inspiring journey and insights from the small village in Baramulla to the renowned research hubs of Heidelberg into the drug that could transform the lives of millions worldwide. A widely available cough suppressant, dextromethorphan, may hold the key to treating lung fibrosis, a serious condition that currently has no cure. The discovery, part of a study published in the December 2024 issue of Science Translational Medicine, represents a major step forward in combating the disease, which affects over 7.61 lakh people in Europe alone, according to the World Health Organisation (WHO). Dr Khan, a Kashmiri scientist currently based at EMBL Heidelberg in Germany is the first author of the paper. Lung fibrosis is caused by excessive scarring in the lungs due to an accumulation of collagen, leading to tissue stiffness, breathing difficulties, and, in severe cases, organ failure. The risk factors include environmental irritants like asbestos, chemotherapy side effects, or autoimmune conditions. Dr Khan and his colleagues aimed to identify effective treatments for the condition by repurposing existing drugs. “We wanted to discover novel drugs for lung fibrosis, knowing the challenges of developing new ones. Dextromethorphan stood out during our screening of FDA-approved drugs,” Dr Khan said. The research team employed cutting-edge techniques, including a “scar-in-a-jar” assay – an in vitro model that mimics the fibrotic scarring process. This high-throughput screening method allowed them to identify dextromethorphan as a drug that inhibits collagen trafficking in cells. Further studies using advanced technologies like proteomics, transcriptomics, and microscopy uncovered how the drug blocks the accumulation of collagen, reducing scarring in human lung fibroblasts, 3D-cultured lung tissues, and mouse models of lung fibrosis. Collaborating with the Translational Lung Research Center Heidelberg and Thoraxclinic, the team is now preparing for phase II clinical trials to evaluate dextromethorphan’s effects on human patients. Dr Khan’s path to this groundbreaking discovery is as remarkable as the study itself. Hailing from Hanjiwera Bala, a small village in Kashmir’s Baramulla district, his academic journey began in local schools before continuing in Srinagar. He attended Public High School, Gogji Bagh, and Jawahar Nagar Higher Secondary School before earning his Bachelors in Science at SP College, Srinagar. A turning point came when he secured a junior research position in the lab of the late Prof Obaid Siddiqi at NCBS, Bangalore. This opportunity set the foundation for his scientific career. Dr Khan pursued his PhD at the University of Heidelberg and now works as a staff scientist at EMBL Heidelberg, specialising in respiratory diseases and drug discovery. His achievement underscores the importance of hard work, determination, and community support. “It doesn’t matter which school or university you attend; what matters is your passion and persistence,” he advises young researchers from Kashmir. “Hard work never goes in vain, and the growing network of Kashmiri scientists around the world is here to guide and mentor those seeking support.”
By ROB GILLIES, Associated Press TORONTO (AP) — Prime Minister Justin Trudeau told Donald Trump that Americans would also suffer if the president-elect follows through on a plan to impose sweeping tariffs on Canadian products , a Canadian minister who attended their recent dinner said Monday. Trump threatened to impose tariffs on products from Canada and Mexico if they don’t stop what he called the flow of drugs and migrants across their borders with the United States. He said on social media last week that he would impose a 25% tax on all products entering the U.S. from Canada and Mexico as one of his first executive orders. Canadian Public Safety Minister Dominic LeBlanc, whose responsibilities include border security, attended a dinner with Trump and Trudeau at Trump’s Mar-a-Lago club on Friday. Trudeau requested the meeting in a bid to avoid the tariffs by convincing Trump that the northern border is nothing like the U.S. southern border with Mexico . “The prime minister of course spoke about the importance of protecting the Canadian economy and Canadian workers from tariffs, but we also discussed with our American friends the negative impact that those tariffs could have on their economy, on affordability in the United States as well,” LeBlanc said in Parliament. If Trump makes good on his threat to slap 25% tariffs on everything imported from Mexico and Canada, the price increases that could follow will collide with his campaign promise to give American families a break from inflation. Economists say companies would have little choice but to pass along the added costs, dramatically raising prices for food, clothing, automobiles, alcohol and other goods. The Produce Distributors Association, a Washington trade group, said last week that tariffs will raise prices for fresh fruit and vegetables and hurt U.S. farmers when the countries retaliate. Canada is already examining possible retaliatory tariffs on certain items from the U.S. should Trump follow through on the threat. After his dinner with Trump, Trudeau returned home without assurances the president-elect will back away from threatened tariffs on all products from the major American trading partner. Trump called the talks “productive” but signaled no retreat from a pledge that Canada says unfairly lumps it in with Mexico over the flow of drugs and migrants into the United States. “The idea that we came back empty handed is completely false,” LeBlanc said. “We had a very productive discussion with Mr. Trump and his future Cabinet secretaries. ... The commitment from Mr. Trump to continue to work with us was far from empty handed.” Joining Trump and Trudeau at dinner were Howard Lutnick, Trump’s nominee for commerce secretary, North Dakota Gov. Doug Burgum, Trump’s pick to lead the Interior Department, and Mike Waltz, Trump’s choice to be his national security adviser. Canada’s ambassador to the U.S., Kirsten Hillman, told The Associated Press on Sunday that “the message that our border is so vastly different than the Mexican border was really understood.” Hillman, who sat at an adjacent table to Trudeau and Trump, said Canada is not the problem when it comes to drugs and migrants. On Monday, Mexico’s president rejected those comments. “Mexico must be respected, especially by its trading partners,” President Claudia Sheinbaum said. She said Canada had its own problems with fentanyl consumption and “could only wish they had the cultural riches Mexico has.” Related Articles Flows of migrants and seizures of drugs at the two countries’ border are vastly different. U.S. customs agents seized 43 pounds of fentanyl at the Canadian border during the last fiscal year, compared with 21,100 pounds at the Mexican border. Most of the fentanyl reaching the U.S. — where it causes about 70,000 overdose deaths annually — is made by Mexican drug cartels using precursor chemicals smuggled from Asia. On immigration, the U.S. Border Patrol reported 1.53 million encounters with migrants at the southwest border with Mexico between October 2023 and September 2024. That compares to 23,721 encounters at the Canadian border during that time. Canada is the top export destination for 36 U.S. states. Nearly $3.6 billion Canadian (US$2.7 billion) worth of goods and services cross the border each day. About 60% of U.S. crude oil imports are from Canada, and 85% of U.S. electricity imports as well. Canada is also the largest foreign supplier of steel, aluminum and uranium to the U.S. and has 34 critical minerals and metals that the Pentagon is eager for and investing for national security.TROY, Ala. (AP) — Amir "Primo" Spears led UTSA with 29 points, including a three-point play with 25.8 seconds left, as the Roadrunners knocked off Merrimack 76-74 on Wednesday. Spears added five rebounds for the Roadrunners (2-3). Jonnivius Smith scored 11 points while shooting 5 of 7 from the field and added 20 rebounds. Marcus Millender went 3 of 9 from the field (2 for 6 from 3-point range) to finish with 10 points. Adam Clark led the way for the Warriors (1-6) with 28 points, six rebounds and four steals. Devon Savage added 15 points for Merrimack. Bryan Etumnu finished with 12 points, 11 rebounds and four blocks. The loss was the Warriors' sixth in a row. Damari Monsanto put up eight points in the first half for UTSA, who led 37-36 at halftime. Spears scored a team-high 24 points for UTSA in the second half. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .
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Adviser to the Minister of Foreign Affairs and Spokesperson for the Ministry of Foreign Affairs HE Dr Majed bin Mohammed al-Ansari participated Wednesday in a discussion session within the 10th MED Mediterranean Dialogues Conference. During his intervention in a session entitled, Reshaping global governance: starting with the Middle East and North Africa, Dr al-Ansari highlighted Qatar’s welcome of the ceasefire deal in Lebanon and its hopes that it will lead to a similar agreement to stop the ongoing war on the Gaza Strip and the Israeli attacks on the occupied West Bank. He added that the agreement is a success for international co-operation and gives hope for restoring confidence in the global system. He underscored Qatar’s mediation efforts as a strategic political option both regionally and globally, highlighting in this regard Doha’s November 2023 mediation efforts to hammer out a humanitarian truce in the Gaza Strip — an agreement that led to a temporary ceasefire in the enclave, the release of 240 Palestinian prisoners and 109 detainees in Gaza, and an increase in relief shipments. Dr al-Ansari stressed Qatar’s firm belief in the importance of joint co-operation and collective action with the countries of the region, the European Union and the UN to foster regional, international peace and stability. Related Story All set for the Tasweer Dialogues on August 19
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