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2025-01-25
Where connections brew: New heritage gallery celebrates Singapore’s coffee shop cultureNinety percent of cancer deaths are due to the spread of cancer, not complications from the original tumor. Thus, for over 50 years now, scientists have been on a quest to identify which malignant mutations within the tumor allow rogue cells to break away from the primary tumor and travel through the bloodstream and lymphatic system to metastasize throughout the body. But new research suggests an alternative mechanism has been overlooked—elusive mutations driving metastasis may not be developing within the twisted DNA of tumors themselves, but within the patient's regular, inherited DNA. The findings, published in Cell , provide the first evidence of genetic predisposition to breast cancer metastasis, with far-reaching clinical implications—including a potential therapy that could prevent it. "Metastasis we believe is, at least in part, a hereditary disorder," says Sohail Tavazoie, the Leon Hess Professor at Rockefeller. "We have been so focused on the cancer cells , the 'seeds," that we've ignored the germline—'the soil." It's now clear that focusing on the soil is critical." Root of the problem Although scientists have rigorously investigated metastasis for decades, extensive genomic sequencing of metastatic tumors have come up empty. Patient tumors are full of mutated genes, but none have been shown to specifically drive metastasis. "So, we hypothesized instead that maybe the host's own genetics, not the tumor, is providing those mutations," Tavazoie says. In fact, Tavazoie and colleagues had previously demonstrated that various germline alleles of APOE can enhance or suppress melanoma metastasis. To find out whether breast cancer metastasis operates in a similar manner, the Tavazoie lab dove into human genetics with large patient cohorts from multiple countries. A common variant of the PCSK9 gene immediately caught their attention. Present in the germlines of 70 percent of white women, this gene variant was associated with reduced breast cancer survival. And when the team engineered mice with the relevant variant form of human PCSK9, the rate of metastasis increased. Colleagues at Lund University in Sweden further validated these results with an analysis of a large Scandinavian cohort of early-stage breast cancer patients. Their findings were stark: patients with the PCSK9 variant faced a 22 percent risk of metastasis within 15 years, compared to a 2 percent risk among those without it. "Our results emphasize the importance of international collaboration, which by definition involves researchers and patient cohorts from multiple countries," says Wenbin Mei, a graduate fellow in Tavazoie's lab and lead author on the paper. "Further, this demonstrates just how powerful human genetics has become. With new technologies that combine computational analysis with experimental models, we're in a great era to answer difficult questions." Digging deeper The study also sheds light on how the PCSK9 variant drives metastasis. By degrading the LRP1 receptor on cancer cells, the variant appears to unleash a cascade of gene activation ideal for metastatic initiation. Interestingly, the lab's prior work on melanoma found that the APOE alleles that promote or suppress metastasis also act on LRP1. "It's remarkable that, in two different cancers, the mechanism of metastasis converges on this one receptor," Tavazoie says. Future work from the lab will focus on LRP1's suspiciously consistent role in metastasis. Despite the evidence now linking the PCSK9 variant to metastatic disease, Tavazoie clarifies that patients with this variant should not be alarmed. The data suggests that patients with the variant have a 22 percent risk of metastasis, as compared to a 2 percent risk without the variant. "The majority of patients with early-stage breast cancers harboring either variant will still never develop metastasis," he says. But he now is optimistic about the possibility of reducing metastatic disease among the less fortunate 22 percent. The present study includes preliminary work suggesting that PCSK9 can be suppressed with an antibody that blocks the activity of PCSK9 that is already approved for high cholesterol. "This is a safe and well-tolerated drug," Tavazoie says, while cautioning that clinical trials will be necessary to demonstrate its efficacy in cancer. "Our hope is that high-risk patients with this variant could one day be treated proactively, reducing their chances of metastasis by targeting the specific signals that elicit this outcome." More information: Wenbin Mei et al, A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor, Cell (2024). DOI: 10.1016/j.cell.2024.11.009Beyoncé has decided to play into Netflix’s previous technology issues during a promotional video for her NFL Christmas Gameday halftime show . The “Texas Hold ‘Em” singer will be performing at the halftime show during the Christmas Day NFL game between the Baltimore Ravens and the Houston Texans at NRG Stadium, in the Grammy winner’s hometown. To advertise the performance, Beyoncé shared a promotional video on both X (formerly Twitter) and in an Instagram post. The video shows the “Halo” singer sitting on a football field as she strums the banjo. However, as she pulls down her sunglasses the screen immediately starts buffering, paying homage to previous issues the streaming service had when airing the Mike Tyson vs Jake Paul fight back in November. After buffering the video ends with the singer winking as the Netflix logo appears alongside the Ravens and Texans logos. “I’m sending you big joy and love on this Cowboy Christmas Eve,” Beyoncé captioned her Instagram post. “I’ll see y’all tomorrow, in my city HTX.” Netflix even joined in on the joke as they commented underneath her X post, “now hold on...” They also changed their X bio to “roasted by beyoncé 12.24.24.” The Texans vs Ravens game will start at 4:30 p.m. ET. This will mark the first time Beyoncé will be performing any songs from her Cowboy Carter album live since it was released in March. The games are part of the three-season deal Netflix signed for $75 million for exclusive Christmas Day game rights. They will also be airing at least one NFL game on Christmas Day in 2025 and 2026 as part of the deal. Throughout the Tyson and Paul fight many people turned to X to complain about how they had seen more buffering symbols on their screens than the fight itself. “I’d love to watch this live but I’ve seen the buffering logo more than any of the fights,” one tweet read. Fans were concerned about how Netflix was going to be able to handle their first year of broadcasting NFL games given their struggles airing the fight. Howard Stern specifically spoke about the buffering issues on his Sirius XM radio show. “I don’t know how this stuff works, but you gotta make sure it works,” Stern said. “You f*** up people’s football, there is hell to pay. You better not.” Shortly after the fight, Netflix’s Chief Technology Officer Elizabeth Stone addressed the complaints , reportedly telling employees: “This unprecedented scale created many technical challenges, which the launch team tackled brilliantly by prioritizing stability of the stream for the majority of viewers.” “I’m sure many of you have seen the chatter in the press and on social media about the quality issues.” “We don’t want to dismiss the poor experience of some members and know we have room for improvement, but still consider this event a huge success,” the CTO concluded, noting that over 60 million viewers streamed the match. In addition to the Ravens vs Texans game, Netflix will also be airing another game at 1 p.m. ET where the Kansas City Chiefs will take on the Pittsburgh Steelers at Acrisure Stadium in Pittsburgh.how to withdraw in phlboss using gcash

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QAMISHLI, Syria (AP) — Kurdish-led fighters in Syria, known as the Syrian Democratic Forces, said Tuesday they have launched a counter-offensive against the Turkish-backed Syrian National Army to take back areas near Syria’s northern border with Turkey . The Kurdish-led SDF is Washington’s critical ally in Syria, targeting sleeper cells of the extremist Islamic State group scattered across the country's east. Since the fall of the totalitarian rule of Bashar Assad earlier this month, clashes have intensified between the U.S.-backed group and the SNA, which captured the key city of Manbij and the areas surrounding it. The intense weekslong clashes come at a time when Syria, battered by over a decade of war and economic misery, negotiates its political future following half a century under the Assad dynasty’s rule. Ruken Jamal, spokesperson of the Women’s Protection Unit, or YPJ, which is under the SDF, told The Associated Press that its fighters are just over 11 kilometers (7 miles) away from the center of Manbij in their ongoing counter-offensive. She accused Ankara of trying to weaken the group’s influence in negotiations over Syria’s political future through the SNA, “Syria is now in a new phase, and discussions are underway about the future of the country,” Jamal said. “Turkey is trying, through its attacks, to distract us with battles and exclude us from the negotiations in Damascus.” A Britain-based opposition war monitor, the Syrian Observatory for Human Rights, says that since the SNA’s offensive in northern Syria against the Kurds started earlier this month, dozens from both sides have been killed. U.S. Defense Secretary Lloyd Austin spoke on Tuesday with Turkish Minister of National Defense Yaşar Güler, according to Pentagon press secretary Maj. Gen. Pat Ryder. Ryder said they discussed the ongoing situation in Syria, and Austin emphasized that close and continuous coordination is crucial to a successful effort to counter IS in the country. They also discussed the importance of setting the conditions to enable a more secure and stable Syria. Ankara sees the SDF as an affiliate of its sworn enemy, the Kurdistan Workers’ Party, or PKK, which it classifies as a terrorist organization. Turkish-backed armed groups alongside Turkish jets for years have attacked positions where the SDF are largely present across northern Syria, in a bid to create a buffer zone free from the group along the large shared border. While the SNA was involved in the lightning insurgency — led by the Islamic group Hayat Tahrir al-Sham — that toppled Assad, it has continued its push against the SDF, seen as Syria’s second key actor for its political future. On Monday, the SDF spokesperson Farhad Shami said its forces pushed back the Turkish-backed rebels from areas near the Tishrin Dam on the Euphrates River, a key source of hydroelectric power. He said the SDF also destroyed a tank belonging to the rebels southeast of Manbij. The British-based war monitor said on Tuesday that the Kurdish-led group, following overnight fighting, has reclaimed four villages in the areas near the strategic dam. Turkish jets also pounded the strategic border town of Kobani in recent days. During Syria’s uprising-turned-conflict, the Kurds carved out an enclave of autonomous rule across northeastern Syria, never fully allying entirely with Assad in Damascus nor the rebels trying to overthrow him. Even with the Assad family out of the picture, it appears that Ankara’s position won’t change, with Turkish Foreign Minister Hakan Fidan’s landmark visit to Syria maintaining a strong position on the Kurdish-led group in his meeting with HTS's de facto leader Ahmad al-Sharaa . “It has turned the region into a cauldron of terror with PKK members and far-left groups who have come from Turkey, Iraq, Iran and Europe," Fidan said in a news conference after the meeting. “The international community is turning a blind eye to this lawlessness because of the wardenship it provides (against IS).” With the ongoing fighting, SDF Commander Mazloum Abdi has expressed concern about a strong IS resurgence due to the power vacuum in Syria and the ongoing fighting, which has left the Kurdish-led group unable to carry out its attacks and raids on the extremists’ scattered sleeper cells. Tens of thousands of children, family members, and supporters of IS militants are still held in large detention centers in northeastern Syria, in areas under SDF control. Chehayeb reported from Beirut.Cheers and beers for Ruud van Nistelrooy as Leicester reign starts with winTORONTO -- TORONTO (AP) — President-elect Donald Trump was joking when he suggested Canada become the 51st U.S. state during a dinner with Prime Minister Justin Trudeau, a Canadian minister who attended their recent dinner said Tuesday. Fox News reported that Trump made the comment in response to Trudeau raising concerns that Trump's threatened tariffs on Canada would damage Canada's economy. Public Safety Minister Dominic LeBlanc, who attended the Friday dinner at Trump's Mar-a-Lago club, said Trump's comments were in jest. “The president was telling jokes. The president was teasing us. It was, of course, on that issue, in no way a serious comment,” LeBlanc told reporters in Ottawa. LeBlanc described it as a three-hour social evening at the president’s residence in Florida on a long weekend of American Thanksgiving. “The conversation was going to be light-hearted,” he said. He called the relations warm and cordial and said the fact that “the president is able to joke like that for us” indicates good relations. On Tuesday, Trump appeared to continue with the joke, posting on his Truth Social platform an AI-generated image of himself standing on a mountain with a Canadian flag next to him with the caption “Oh Canada!" Some Canadians had fun with it. “If I were President Trump, I’d think twice before invading Canada. The last time the U.S. tried something like that— back in the War of 1812 —it didn’t exactly end well. Canada even burned down the White House,” former Quebec Premier Jean Charest joked on X. Earlier last week, the Republican president-elect threatened to impose a 25% tax on all products entering the U.S. from Canada and Mexico unless they stem the flow of migrants and drugs. Trudeau requested the meeting in a bid to avoid the tariffs by convincing Trump that the northern border is nothing like the U.S. southern border with Mexico . Trudeau held a rare meeting with opposition leaders on Tuesday about U.S-Canada relations and later said that opposition Conservative leader Pierre Poilievre shouldn’t amplify the erroneous narratives that Americans are saying about the border. “Less than one percent of migrants coming into the United States irregularly come from Canada and 0.2 percent of the fentanyl coming into the United States comes from Canada,” Trudeau said in Parliament. Canadian officials have said there are plans to put more helicopters, drones and law enforcement officers at the border. At the dinner, Kristen Hillman, Canada's ambassador to the U.S., said America’s trade deficit with Canada was also raised. Hillman said the U.S. had a $75 billion trade deficit with Canada last year but noted a third of what Canada sells into the U.S. is energy exports and prices have been high. “Trade balances are something that he focuses on so it’s important to engage in that conversation but to put it into context,” Hillman told The Associated Press. “We are one-tenth the size of the United States so a balanced trade deal would mean per capita we are buying 10 times more from the U.S. than they are buying from us. If that’s his metric we will certainly engage on that.” Hillman said Canada sold $170 billion worth of energy products last year to the U.S. About 60% of U.S. crude oil imports are from Canada, and 85% of U.S. electricity imports as well. Canada is also the largest foreign supplier of steel, aluminum and uranium to the U.S. and has 34 critical minerals and metals that the Pentagon is eager for and investing for national security. About 77% of Canada’s exports go to the U.S. Trudeau's government successfully employed a “Team Canada” approach during Trump’s first term in office when the free trade deal between Canada, the U.S. and Mexico was renegotiated. But Trudeau’s minority government is in a much weaker position politically now and faces an election within a year. Poilievre, Canada's opposition leader, said the tariffs would harm Americans. “The president-elect was elected on a promise to make America richer. These tariffs would make America poorer,” Poilievre said after meeting with Trudeau. Poilievre said the U.S. would be wise to do more free trade with its best friend and closest ally. Canada is the top export destination for 36 U.S. states. Nearly 3.6 billion Canadian dollars ($2.7 billion) worth of goods and services cross the border each day. Trudeau returned home after the dinner at Mar-a-Lago club in Florida without assurances Trump would back away from threatened tariffs on all products from the major American trading partner. Trump called the talks “productive” but signaled no retreat from a pledge that Canada says unfairly lumps it in with Mexico over the flow of drugs and migrants into the United States. The flows of migrants and seizures of drugs are vastly different. U.S. customs agents seized 43 pounds of fentanyl at the Canadian border during the last fiscal year, compared with 21,100 pounds at the Mexican border. Most of the fentanyl reaching the U.S. — where it causes about 70,000 overdose deaths annually — is made by Mexican drug cartels using precursor chemicals smuggled from Asia. On immigration, the U.S. Border Patrol reported 1.53 million encounters with irregular migrants at the southwest border with Mexico between October 2023 and September 2024. That compares to 23,721 encounters at the Canadian border during that time.

A short Christmas benediction from the past that has aged quite well

The Matulich family delivered the news in a heartfelt note on their website. “It is with a mix of deep gratitude and heartfelt emotion that we share some bittersweet news: after 45 incredible years, Steamer’s The Grillhouse will be closing its doors. This decision was not made lightly, and while it marks the end of an era, we want to take this moment to celebrate everything Steamer’s has meant to our family and to this wonderful community.” The Los Gatos restaurant, which has been the town’s premier seafood destination and a downtown mainstay, will shut down after dinner service on Christmas Eve. Siblings Paul, Mark and Linda Matulich opened the restaurant on Aug, 17, 1979, and Steamer’s has remained under that family’s ownership and direction since then. The restaurant moved to its current University Avenue location in 1999. As longtime seafood experts, the Matulich family has steered the menu’s evolution over the years, supplementing the classic entrees of Seafood Linguine, Steamed Clams and Atlantic Lobster with dishes such as Asian BBQ Glazed Salmon and Roasted Mussels with a Thai Curry-Lime Butter. But never count out the classics. “I put two kids through college on that linguine,” a chuckling Paul told the Mercury News on the occasion of the restaurant’s 40th anniversary. Related Articles Besides thanking customers, the family gave a social media shout-out to their loyal employees, some of whom have worked at Steamer’s for many years. “As we enter our final month, we are asking the Los Gatos community to show our amazing team some extra love and appreciation.” From now until the closing date, Steamer’s will maintain its Wednesday-Sunday hours of lunch from 11:30 a.m. to 2 p.m. and dinner starting at 4:30 p.m. The last reservation accepted is at 8 p.m. “As we prepare to say goodbye, we invite you to join us in these final weeks to celebrate the legacy of Steamer’s,” the family wrote. “Together, let’s raise a toast to the memories, the milestones, and the incredible journey we’ve shared.” Details: 31 University Ave., Los Gatos;

PORT-AU-PRINCE, Haiti (AP) — Haiti’s online media association said two reporters were killed and several others were wounded in a gang attack on Tuesday on the reopening of Port-au-Prince’s biggest public hospital. Street gangs have taken over an estimated 85% of Haiti’s capital, Port-au-Prince, and they forced the closure of the General Hospital early this year. Authorities had pledged to reopen the facility Tuesday but as journalists gathered to cover the event, suspected gang members opened fire in a vicious Christmas Eve attack. Robest Dimanche, a spokesman for the Online Media Collective, identified the dead journalists as Markenzy Nathoux and Jimmy Jean. Dimanche said an unspecified number of reporters had also been wounded in the attack, which he blamed on the Viv Ansanm coalition of gangs. Haiti’s interim president, Leslie Voltaire, said in an address to the nation that journalists and police were among the victims of the attack. He did not specify how many casualties there were, or give a breakdown for the dead or wounded. “I send my sympathies to the people who were victims, the national police and the journalists,” Voltaire said, pledging “this crime is not going to go unpunished.” A video posted online by the reporters trapped inside the hospital showed what appeared to be two lifeless bodies of men on stretchers, their clothes bloodied. One of the men had a lanyard with a press credential around his neck. Radio Télé Métronome initially reported that seven journalists and two police officers were wounded. Police and officials did not immediately respond to calls for information on the attack. Street gangs have taken over an estimated 85% of Haiti’s capital, Port-au-Prince. They forced the closure of the General Hospital early this year during violence that also targeted the main international airport and Haiti’s two largest prisons. Authorities had pledged to reopen the facility Tuesday but as journalists gathered to cover the event, suspected gang members opened fire. Video posted online earlier showed reporters inside the building and at least three lying on the floor, apparently wounded. That video could also not be immediately verified. Johnson “Izo” André, considered Haiti’s most powerful gang leader and part of a gang known as Viv Ansanm, which that has taken control of much of Port-au-Prince , posted a video on social media claiming responsibility for the attack. The video said the gang coalition had not authorized the hospital’s reopening. Haiti has seen journalists targeted before. In 2023, two local journalists were killed in the space of a couple of weeks — radio reporter Dumesky Kersaint was fatally shot in mid-April that year, while journalist Ricot Jean was found dead later that month. In July, former Prime Minister Garry Conille visited the Hospital of the State University of Haiti, more widely known as the General Hospital, after authorities regained control of it from gangs. The hospital had been left ravaged and strewn with debris. Walls and nearby buildings were riddled with bullet holes, signaling fights between police and gangs. The hospital is across the street from the national palace, the scene of several battles in recent months. Gang attacks have pushed Haiti’s health system to the brink of collapse with looting, setting fires, and destroying medical institutions and pharmacies in the capital. The violence has created a surge in patients and a shortage of resources to treat them. Haiti’s health care system faces additional challenges during the rainy season, which is likely to increase the risk of water-borne diseases. Poor conditions in camps and makeshift settlements have heightened the risk of diseases like cholera, with over 84,000 suspected cases in the country, according to UNICEF. ___ Follow AP’s coverage of Latin America and the Caribbean at https://apnews.com/hub/latin-america Evens Sanon, The Associated PressChad Chronister, Donald Trump’s pick to run the DEA, withdraws name from considerationHaiti gang attack on journalists covering a hospital reopening leaves 2 dead, several wounded

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Trump raced to pick many Cabinet posts. He took more time to settle on a treasury secretary WASHINGTON (AP) — President-elect Donald Trump launched a blitz of picks for his Cabinet, but he took his time settling on billionaire investor Scott Bessent as his choice for treasury secretary. The Republican not only wanted someone who jibes with him, but an official who can execute his economic vision and look straight out of central casting while doing so. With his Yale University education and pedigree trading for Soros Fund Management before establishing his own funds, Bessent will be tasked with a delicate balancing act. Trump expects him to help reset the global trade order, enable trillions of dollars in tax cuts, ensure inflation stays in check, manage a ballooning national debt and still keep the financial markets confident. Voters rejected historic election reforms across the US, despite more than $100M push JEFFERSON CITY, Mo. (AP) — Election reform advocates had hoped for a big year at the ballot box. That's because a historic number of states were considering initiatives for ranked choice voting or to end partisan primaries. Instead, voters dealt them big losses in the November elections. Voters in Arizona, Colorado, Idaho, Missouri, Montana, Nevada, Oregon and South Dakota all rejected proposed changes to their voting systems. In Alaska, a proposal to repeal ranked choice voting appears to have narrowly fallen short. The losses in many states came even though election reform supporters raised more than $100 million, easily outpacing opponents. Supporters say they aren't giving up but plan to retool their efforts. The week that upped the stakes of the Ukraine war KYIV, Ukraine (AP) — This past week has seen the most significant escalation in hostilities Ukraine has witnessed since Russia's full-scale invasion and marks a new chapter in the nearly three-year war. It began with U.S. President Joe Biden reversing a longstanding policy by granting Kyiv permission to deploy American longer-range missiles inside Russian territory and ended with Moscow striking Ukraine with a new experimental ballistic weapon that has alarmed the international community and heightened fears of further escalation. Israeli strikes without warning in central Beirut kill at least 15 as diplomats push for cease-fire BEIRUT, Lebanon (AP) — Lebanese officials say Israeli airstrikes have killed at least 15 people and injured dozens in central Beirut as the once-rare strikes in the heart of Lebanon’s capital continue without Israeli warning. Diplomats are scrambling to broker a cease-fire but describe the disputed issues that remain. The current proposal calls for a two-month cease-fire during which Israeli forces would withdraw from Lebanon and Hezbollah would end its armed presence along the southern border south of the Litani River. Lebanon’s Health Ministry says Israeli bombardment has killed more than 3,500 people in Lebanon in the months of fighting that have turned into all-out war. Storm dumps record rain in Northern California, while US Northeast deals with winter storms HEALDSBURG, Calif. (AP) — A major storm continues to drop heavy snow and record rain in California, causing small landslides and flooding some streets. Meanwhile on the opposite coast blizzard or winter storm warnings were in effect Saturday for areas spanning from the Northeast to central Appalachia. The storm on the West Coast arrived in the Pacific Northwest earlier this week, killing two people and knocking out power to hundreds of thousands, before moving through Northern California. Forecasters predicted that both coasts would begin to see a reprieve from the storms as the system in the northeast moves into eastern Canada and the one in the West heads south. Even with access to blockbuster obesity drugs, some people don't lose weight Most people taking popular drugs like Ozempic and Wegovy to lose weight have shed significant pounds. But obesity experts say that roughly 20% of patients — as many as 1 in 5 — may not see robust results with the new medications. The response to the drugs varies from person to person and can depend on genetics, hormones and differences in how the brain regulates energy. Undiagnosed medical conditions and some drugs can prevent weight loss. Experts say it can take experimentation to help so-called nonresponders find results. Fighting between armed sectarian groups in restive northwestern Pakistan kills at least 37 people PESHAWAR, Pakistan (AP) — A senior Pakistani police officer says fighting between armed sectarian groups in the country's restive northwest has killed at least 37 people. The overnight violence was the latest to rock Kurram, a district in Khyber Pakhtunkhwa province, and comes days after a deadly gun ambush killed 42 people. The officer said Saturday that armed men torched shops, houses and government property overnight. Gunfire is ongoing between rival tribes. Although Sunnis and Shiites generally live together peacefully in Pakistan, tensions remain in some areas, especially Kurram. These Peruvian women left the Amazon, but their homeland still inspires their songs and crafts LIMA, Peru (AP) — Many Shipibo-Konibo craftswomen migrated from their Indigenous communities in the Amazon to Peru's capital, Lima, in the past few decades. Their ancestors' legacy remains present through their songs and techniques, and some of them have managed to make a living out of their crafts. Textiles, jewelry and paintings convey the culture, worldview and beliefs from the lands where they were born. Doctor at the heart of Turkey's newborn baby deaths case says he was a 'trusted' physician ISTANBUL (AP) — The Turkish doctor at the center of an alleged fraud scheme that led to the deaths of 10 babies says he was a “trusted” physician. Dr. Firat Sari is one of 47 people on trial accused of transferring newborn babies to neonatal units of private hospitals, where they were allegedly kept for prolonged and sometimes unnecessary treatments in order to receive social security payments. Sari said patients were referred to him because people trusted him and he did not bribe anyone involved with Turkey’s emergency medical phone line. Sari, said to be the plot’s ringleader, faces up to 583 years in prison. Hydrate. Make lists. Leave yourself time. And other tips for reducing holiday travel stress Travel, especially during the holiday season, can be stressful. But following some tips from the pros as you prepare for a trip can make for a smoother, less anxious experience. One expert traveler suggests making a list a week before you go of things you need to do and pack. Cross off each item as you complete it during the week. Another tip: Carry your comfort zone with you. That could mean noise-cancelling headphones, playlists meant to soothe airport travelers, entertainment and snacks from home. Carry a change of clothes and a phone charger in case of delays. Stay hydrated. Leave extra time. And know your airline's rules. Downloading the airline's app can help with that.Stewartville football captures second consecutive Class 3A state title in dominating fashion


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