首页 > 

90jili tongits go

2025-01-16
A mum has lashed out at teachers who made her autistic son wear a comic Christmas tie at school. Year 9 pupil Lenny Walton goes to the Royal Harbour Academy in Ramsgate. On Tuesday, the 13-year-old arrived at school without his tie - contrary to the school’s uniform policy, and was given the comic tie to wear instead. His mum, Natasha Parry, said: “It was the first time he forgot his tie in two years at the school. “I was taking my mum to hospital that morning and couldn’t go back for it. “I told him to apologise to the teachers and explain. Instead two teachers from student services gave him a Christmas tie to wear - laughing as they did so. “They said if he didn’t wear it, he would get a detention.” Ms Parry continued: “When he got home from school that day I could see straight away something was wrong. “At first I couldn’t get it out of him, but then he blurted it out. “Because of the tie he had felt humiliated and he had been bullied all day. He was so upset. He said he never wanted to go back.” So far Lenny has not returned to class. Ms Parry said she had tried phoning the school every day since, to explain the effect the incident had had on her son, but she did not get a reply until 4.10pm today (Friday). By that time, Ms Parry had posted about the incident on Facebook, asking: “Am I overreacting? Or is this genuinely not OK? “I just want to know if this is appropriate behaviour on the school’s part or if I’m being unreasonable to expect more understanding.” Her post quickly garnered more than 300 responses, all condemning the school’s behaviour. Typical comments were: “Adults bullying an already vulnerable child is not ok!” “Causing a child to be the laughing stock of the school is bullying!” “No, I’d be absolutely livid. Surely this is worse than no tie at all!” “Shame on the school!” Another said: “They publicly humiliated him. Autism or not, no child should have to go through this.” “That’s setting him up to be picked on!” “Regardless of any conditions etc this is sickening. To humiliate anyone let alone a child is cruel.” Ms Parry said: “When I got the phone call, it wasn’t an apology. “It was to ask me to take the Facebook post down. “They said they had a good relationship with Lenny but felt the post might spoil that. I don’t know if that was some kind of veiled threat.” Ms Parry described her son as already a nervous child with a lot of social anxiety. The incident had just made matters worse. She is hoping to get Lenny back to school on Monday. The Royal Harbour Academy has been approached for a comment.COPENHAGEN, Denmark--(BUSINESS WIRE)--Dec 8, 2024-- Genmab A/S (Nasdaq: GMAB): Genmab A/S (Nasdaq: GMAB) today announced results from the Phase 1b/2 EPCORE ® CLL-1 clinical trial evaluating epcoritamab (Abstract #883), a T-cell engaging bispecific antibody administered subcutaneously, demonstrated an overall response rate (ORR) of 61 percent and a complete response (CR) rate of 39 percent in difficult-to-treat adult patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) treated with epcoritamab monotherapy. These results, from the monotherapy expansion (EXP) cohort (n=23) of the trial, along with the first safety data from the optimization (OPT) cohort, were presented at the 66 th Annual Meeting and Exposition of the American Society of Hematology (ASH), during the ASH Annual Meeting Press Program. The data will be presented during an oral session on December 9, 2024. In the EXP cohort, the median time to response was two (2.0) months and the median time to CR was 5.6 months. Among all patients in the cohort, median progression-free survival (PFS) was 12.8 months and median overall survival (OS) was not reached (median follow-up was 22.8 months). An estimated 65 percent of patients were alive at 15 months. Among 12 responders evaluable for minimal residual disease (MRD) by next-generation sequencing in peripheral blood, nine patients (75 percent) had undetectable MRD. The most frequent non-hematologic treatment-emergent adverse events (TEAEs) in the EXP cohort were cytokine release syndrome (CRS; 96 percent), diarrhea (48 percent), peripheral edema (48 percent), fatigue (43 percent), and injection-site reaction (43 percent). Cytopenias were common (anemia, 65 percent; thrombocytopenia, 65 percent; neutropenia, 48 percent); however, most patients had baseline anemia and thrombocytopenia, suggesting that these events were largely disease-related. Three cases of immune effector cell-associated neurotoxicity syndrome (ICANS) were reported (one Grade 1; two Grade 2), and there was one clinical tumor lysis syndrome (CTLS) case (Grade 2). These cases did not lead to treatment discontinuation. Four fatal TEAEs occurred - two cases of pneumonia, one case of sepsis and one case of squamous cell carcinoma of the skin. The EXP cohort followed a 2-step step-up dose regimen, and CRS was manageable and primarily low grade (9 percent Grade 1, 70 percent Grade 2, 17 percent Grade 3). In the first data from the separate OPT cohort, which followed a 3-step step-up dose regimen, CRS severity was substantially reduced with only low-grade events (71 percent Grade 1, 12 percent Grade 2). In both cohorts, CRS events primarily occurred following the first full dose, and none led to treatment discontinuation. No ICANS or CTLS cases were reported in the OPT cohort. “These EPCORE CLL-1 data are encouraging, especially as the majority of patients were heavily pre-treated with at least four lines of therapy,” said Alexey Danilov, MD, PhD, Marianne and Gerhard Pinkus, Professor and Director of Early Clinical Therapeutics and Associate Director of the Toni Stephenson Lymphoma Center, Department of Hematology and Hematopoietic Cell Transplantation, City of Hope. “Despite progress in treating chronic lymphocytic leukemia, there remains a tremendous need for additional therapeutic options for high-risk patients whose disease has progressed following standard chemoimmunotherapy and targeted therapies.” Additional data from the EXP cohort showed high response rates in patients with high-risk factors treated with epcoritamab, including TP53 aberrations, IGHV-unmutated disease and double-exposed disease – prognostic markers that are associated with disease progression and decreased survival. i,ii,iii In patients with TP53 aberrations (n=15), the ORR was 67 percent with a CR of 33 percent. Among patients with IGHV-unmutated disease (n=16), the ORR was 63 percent, and the CR was 44 percent. In double-refractory patients, the ORR was 53 percent, and the CR was 37 percent. All patients in the trial had prior chemoimmunotherapy, and most patients had previously received targeted therapies such as BTK and BCL2 inhibitors (double-exposed) and had high-risk disease characteristics. “Chronic lymphocytic leukemia is incurable, and patients often need a variety of treatments throughout their lifetime, especially if their disease has high-risk prognostic factors, has relapsed or has become refractory to the current standard-of-care, including targeted therapies,” said Dr. Judith Klimovsky, Executive Vice President & Chief Development Officer, Genmab. “These early data show the potential therapeutic applicability of epcoritamab in relapsed or refractory chronic lymphocytic leukemia, and further reinforce the potential of epcoritamab as a core therapy for the treatment of B-cell malignancies.” Use of epcoritamab in CLL is not approved in the U.S. or in the EU or in any other territory. The safety and efficacy of epcoritamab for use in CLL have not been established. About Chronic Lymphocytic Leukemia (CLL) Chronic lymphocytic leukemia (CLL) is the most prevalent type of leukemia, affecting over 200,000 people in the United States alone. iv Chronic lymphocytic leukemia can be classified as either slow growing (indolent) or fast growing (aggressive). v CLL is incurable, and many patients will likely relapse and progress on frontline therapies. vi Most patients will experience consecutive episodes of disease progression and will require several lines of treatment in their lifetime. vii,viii About the EPCORE ® CLL-1 Trial EPCORE ® CLL-1 is a Phase 1b/2, open-label, multi-center trial to evaluate the safety and preliminary efficacy of epcoritamab as a monotherapy and in combination with standard of care agents in patients with difficult-to-treat relapsed/refractory (R/R) chronic lymphocytic leukemia (CLL), R/R small lymphocytic lymphoma (SLL) and Richter's Syndrome (RS). The trial consists of two parts: a dose-escalation phase (Phase 1b) and an expansion phase (Phase 2). Patients with RS are only included in the expansion phase. The primary objective of Phase 1b is to determine the recommended Phase 2 dose and the maximum tolerated dose as well as establish the safety profile of epcoritamab monotherapy and epcoritamab plus venetoclax in participants with R/R CLL. The purpose of Phase 2 is to assess and evaluate the preliminary efficacy, safety and tolerability profiles of epcoritamab monotherapy and epcoritamab plus venetoclax for patients with R/R CLL and SLL. Additionally, epcoritamab monotherapy and combination therapy will be evaluated in patients with RS to assess their efficacy, safety and tolerability profiles. More information on this trial can be found at https://www.clinicaltrials.gov/ (NCT: 04623541). About Epcoritamab Epcoritamab is an IgG1-bispecific antibody created using Genmab's proprietary DuoBody ® technology and administered subcutaneously. Genmab's DuoBody-CD3 technology is designed to direct cytotoxic T cells selectively to elicit an immune response toward target cell types. Epcoritamab is designed to simultaneously bind to CD3 on T cells and CD20 on B cells and induces T-cell-mediated killing of CD20+ cells. ix Epcoritamab (approved under the brand name EPKINLY ® in the U.S. and Japan, and TEPKINLY ® in the EU) has received regulatory approval in certain lymphoma indications in several territories. Epcoritamab is being co-developed by Genmab and AbbVie as part of the companies' oncology collaboration. The companies will share commercial responsibilities in the U.S. and Japan, with AbbVie responsible for further global commercialization. Both companies will pursue additional international regulatory approvals for the investigational R/R FL indication and additional approvals for the R/R DLBCL indication. Genmab and AbbVie continue to evaluate the use of epcoritamab as a monotherapy, and in combination, across lines of therapy in a range of hematologic malignancies. This includes five ongoing Phase 3, open-label, randomized trials including a trial evaluating epcoritamab as a monotherapy in patients with R/R DLBCL compared to investigator's choice chemotherapy ( NCT04628494 ), a trial evaluating epcoritamab in combination with R-CHOP in adult patients with newly diagnosed DLBCL ( NCT05578976 ), a trial evaluating epcoritamab in combination with rituximab and lenalidomide (R 2 ) in patients with R/R FL ( NCT05409066 ), a trial evaluating epcoritamab in combination with rituximab and lenalidomide (R 2 ) compared to chemoimmunotherapy in patients with previously untreated FL ( NCT06191744 ), and a trial evaluating epcoritamab in combination with lenalidomide compared to chemotherapy infusion in patients with R/R DLBCL ( NCT06508658 ). The safety and efficacy of epcoritamab has not been established for these investigational uses. Please visit www.clinicaltrials.gov for more information. EPKINLY ® (epcoritamab-bysp) U.S. INDICATIONS & IMPORTANT SAFETY INFORMATION What is EPKINLY? EPKINLY is a prescription medicine used to treat adults with certain types of diffuse large B-cell lymphoma (DLBCL), high-grade B-cell lymphoma, or follicular lymphoma (FL) that has come back or that did not respond to previous treatment after receiving 2 or more treatments. EPKINLY is approved based on patient response data. Studies are ongoing to confirm the clinical benefit of EPKINLY. It is not known if EPKINLY is safe and effective in children. Important Warnings—EPKINLY can cause serious side effects, including: People with DLBCL or high-grade B-cell lymphoma should be hospitalized for 24 hours after receiving their first full dose of EPKINLY on day 15 of cycle 1 due to the risk of CRS and neurologic problems. Tell your healthcare provider or get medical help right away if you develop a fever of 100.4°F (38°C) or higher; dizziness or lightheadedness; trouble breathing; chills; fast heartbeat; feeling anxious; headache; confusion; shaking (tremors); problems with balance and movement, such as trouble walking; trouble speaking or writing; confusion and disorientation; drowsiness, tiredness or lack of energy; muscle weakness; seizures; or memory loss. These may be symptoms of CRS or neurologic problems. If you have any symptoms that impair consciousness, do not drive or use heavy machinery or do other dangerous activities until your symptoms go away. EPKINLY can cause other serious side effects, including: Your healthcare provider will monitor you for symptoms of CRS, neurologic problems, infections, and low blood cell counts during treatment with EPKINLY. Your healthcare provider may temporarily stop or completely stop treatment with EPKINLY if you develop certain side effects. Before you receive EPKINLY, tell your healthcare provider about all your medical conditions, including if you have an infection, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. If you receive EPKINLY while pregnant, it may harm your unborn baby. If you are a female who can become pregnant, your healthcare provider should do a pregnancy test before you start treatment with EPKINLY and you should use effective birth control (contraception) during treatment and for 4 months after your last dose of EPKINLY. Tell your healthcare provider if you become pregnant or think that you may be pregnant during treatment with EPKINLY. Do not breastfeed during treatment with EPKINLY and for 4 months after your last dose of EPKINLY. In DLBCL or high-grade B-cell lymphoma, the most common side effects of EPKINLY include CRS, tiredness, muscle and bone pain, injection site reactions, fever, stomach-area (abdominal) pain, nausea, and diarrhea. The most common severe abnormal laboratory test results include decreased white blood cells, decreased red blood cells, and decreased platelets. In follicular lymphoma the most common side effects of EPKINLY include injection site reactions, CRS, COVID-19, tiredness, upper respiratory tract infections, muscle and bone pain, rash, diarrhea, fever, cough, and headache. The most common severe abnormal laboratory test results include decreased white blood cells and decreased red blood cells. These are not all of the possible side effects of EPKINLY. Call your doctor for medical advice about side effects. You are encouraged to report side effects to the FDA at (800) FDA-1088 or www.fda.gov/medwatch or to Genmab US, Inc. at 1-855-4GENMAB (1-855-443-6622). Please see Full Prescribing Information and Medication Guide , including Important Warnings. Globally, prescribing information varies; refer to the individual country product label for complete information. About Genmab Genmab is an international biotechnology company with a core purpose of guiding its unstoppable team to strive toward improving the lives of patients with innovative and differentiated antibody therapeutics. For 25 years, its passionate, innovative and collaborative team has invented next-generation antibody technology platforms and leveraged translational, quantitative and data sciences, resulting in a proprietary pipeline including bispecific T-cell engagers, antibody-drug conjugates, next-generation immune checkpoint modulators and effector function-enhanced antibodies. By 2030, Genmab’s vision is to transform the lives of people with cancer and other serious diseases with knock-your-socks-off (KYSO ® ) antibody medicines. Established in 1999, Genmab is headquartered in Copenhagen, Denmark, with international presence across North America, Europe and Asia Pacific. For more information, please visit Genmab.com and follow us on LinkedIn and X . This Media Release contains forward looking statements. The words “believe,” “expect,” “anticipate,” “intend” and “plan” and similar expressions identify forward looking statements. Actual results or performance may differ materially from any future results or performance expressed or implied by such statements. The important factors that could cause our actual results or performance to differ materially include, among others, risks associated with preclinical and clinical development of products, uncertainties related to the outcome and conduct of clinical trials including unforeseen safety issues, uncertainties related to product manufacturing, the lack of market acceptance of our products, our inability to manage growth, the competitive environment in relation to our business area and markets, our inability to attract and retain suitably qualified personnel, the unenforceability or lack of protection of our patents and proprietary rights, our relationships with affiliated entities, changes and developments in technology which may render our products or technologies obsolete, and other factors. For a further discussion of these risks, please refer to the risk management sections in Genmab’s most recent financial reports, which are available on www.genmab.com and the risk factors included in Genmab’s most recent Annual Report on Form 20-F and other filings with the U.S. Securities and Exchange Commission (SEC), which are available at www.sec.gov . Genmab does not undertake any obligation to update or revise forward looking statements in this Media Release nor to confirm such statements to reflect subsequent events or circumstances after the date made or in relation to actual results, unless required by law. Genmab A/S and/or its subsidiaries own the following trademarks: Genmab ®; the Y-shaped Genmab logo ®; Genmab in combination with the Y-shaped Genmab logo ®; HuMax ®; DuoBody ®; HexaBody ®; DuoHexaBody ®, HexElect ® and KYSOTM. EPCORE ®, EPKINLY ®, TEPKINLY ® and their designs are trademarks of AbbVie Biotechnology Ltd. i Campo, et al. TP53 Aberrations in Chronic Lymphocytic Leukemia: An Overview of the Clinical Implications of Improved Diagnostics. Haematologica . 2018 Nov 15;103(12):1956–1968. https://haematologica.org/article/view/8691 . ii Galieni, et al. Unmutated IGHV at Diagnosis in Patients With Early Stage CLL Independently Predicts for Shorter Follow-Up Time to First Treatment (TTFT). Leukemia Research. 2024. https://doi.org/10.1016/j.leukres.2024.107541 . iii Zuber, et al. Efficacy and Effectiveness Outcomes of Treatments for Double-Exposed Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma Patients: A Systematic Literature Review. Cancer Medicine . 2024. https://doi.org/10.1002/cam4.70258 . iv Fedele, et al. Chronic Lymphocytic Leukemia: Time to Care for the Survivors. Journal of Clinical Oncology . 2024. https://ascopubs.org/doi/10.1200/JCO.23.02738 . v Penn Medicine. Chronic Lymphocytic Leukemia (CLL). Accessed November 2024. https://www.pennmedicine.org/cancer/types-of-cancer/leukemia/types-of-leukemia/chronic-lymphocytic-leukemia . vi Odetola, et al. Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL). Curr Hematol Malig Rep . 2023 Jun 6:1–14. doi: 10.1007/s11899-023-00700-z vii Moreno, Carol. Standard Treatment Approaches for Relapsed/Refractory Chronic Lymphocytic Leukemia After Frontline Chemoimmunotherapy. Hematology Am Soc Hematol Educ Program . 2020 Dec 4;2020(1):33-40. doi: 10.1182/hematology.2020000086. viii Leukemia & Lymphoma Society. Relapsed and Refractory CLL. Accessed November 2024. https://www.lls.org/leukemia/chronic-lymphocytic-leukemia/treatment/relapsed-and-refractory . ix Engelberts PJ, et al. DuoBody-CD3xCD20 Induces Potent T-Cell-Mediated Killing of Malignant B Cells in Preclinical Models and Provides Opportunities for Subcutaneous Dosing. EBioMedicine . 2020;52:102625. doi: 10.1016/j.ebiom.2019.102625. View source version on businesswire.com : https://www.businesswire.com/news/home/20241208951291/en/ CONTACT: David Freundel, Senior Director, Global R&D & Portfolio Communications T: +1 609 430 2481; E:dafr@genmab.com Andrew Carlsen, Vice President, Head of Investor Relations T: +45 3377 9558; E:acn@genmab.com KEYWORD: DENMARK EUROPE INDUSTRY KEYWORD: RESEARCH FDA CLINICAL TRIALS BIOTECHNOLOGY HEALTH PHARMACEUTICAL OTHER SCIENCE SCIENCE ONCOLOGY SOURCE: Genmab A/S Copyright Business Wire 2024. PUB: 12/08/2024 11:00 AM/DISC: 12/08/2024 11:02 AM http://www.businesswire.com/news/home/20241208951291/en90jili tongits go

Invest Smarter with the Piotroski Score: A Game-Changer on InvestingProNASSAU, Bahamas (AP) — Alyssa Ustby and Lexi Donarski scored 14 points apiece, and Ustby added 14 rebounds to lead No. 16 North Carolina to a 53-36 victory over Villanova in a semifinal game at the Women's Battle 4 Atlantis on Sunday. The Tar Heels (5-1) play Indiana in the championship game on Monday. The Hoosiers upset No. 18 Baylor 73-65 in Sunday's first semifinal. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.

EAGAN, Minn. (AP) — The Minnesota Vikings waived cornerback Akayleb Evans on Saturday in another setback for their beleaguered 2022 draft class. Evans started 15 games last season, but he had been relegated to a special teams role this year after the Vikings added veteran cornerbacks Stephon Gilmore and Shaquill Griffin. Evans was a fourth-round pick out of Missouri, one of three defensive backs among Minnesota's first five selections in 2022. Lewis Cine (first round) was waived and Andrew Booth (second round) was traded earlier this year. One of their second-round picks, guard Ed Ingram, lost his starting spot last week. Evans was let go to clear a roster spot for tight end Nick Muse, who was activated from injured reserve to play on Sunday at Chicago. The Vikings ruled tight end Josh Oliver out of the game with a sprained ankle. AP NFL: https://apnews.com/hub/NFL

The Manufacturers Life Insurance Company Purchases 7,783 Shares of Vertiv Holdings Co (NYSE:VRT)

All products and services featured are independently chosen by editors. However, Billboard may receive a commission on orders placed through its retail links, and the retailer may receive certain auditable data for accounting purposes. Can you hear it? Sleigh bells ringing in the distance, the snow is starting to fall and Christmas movies are rolling out: Love them or hate them, the holidays are here. See latest videos, charts and news See latest videos, charts and news A season of joy and happiness sweeps over the globe once a year, but no matter how you might feel about the holidays, there’s always something to be grateful for and giving gifts is a show of appreciation to the people you love most. Even for the early-bird shoppers, finding the right gift can be a challenge, and that’s where we come in. Billboard’s e-comm team tests out hundreds of items to give our keep our readers in the know about everything we’re loving — from the trendiest looks to the coolest gadgets. To get the holiday vibes going, Billboard has returned with the Shop 100 . Our annual shop list compiles the best in electronics, beauty, fashion and other giftable goodies. For music lovers, certified audiophiles and anyone looking for a comprehensive gift guide to make holiday shopping run a little smoother, the Shop 100 is here to help. What made our list this year? From portable Bluetooth speakers and earbuds to the hottest gaming consoles, the best over-ear headphones on the market (tested by Billboard’s e-comm editor). You’ll also find a range of holiday gift offerings including jewelry, toys, books, beauty essentials and celebrity-owned gifts options from Beyoncé, Selena Gomez, Rihanna, Dolly Parton, Snoop Dogg and other stars. Ready to dive into the Shop 100? Keep reading to check out our best gift picks of the year. Part frame, part speaker. Samsung Music Frame is one-of-a-kind speaker, surprisingly suitable for large and small spaces. What’s so great about the Frame? It’s worthy of hype – from sound quality to size. Plus, you can swap out the photos, mount it on a wall like a real frame or place it on a surface. Shop Samsung’s limited-edition Wicked Samsung Frame here . Cheaper in price, but not in quality. Meta Quest 3S has all the necessary bells and whistles for a quality VR experience with some necessary updates – namely in the headset’s weight and overall fit. Bose Ultra Open Earbuds fit on the lower helix of the ear instead of sitting directly inside, which gives you a uniquely immersive listening experience. They’re super comfortable (BLACKPINK’s LISA loves how they fit), lightweight and available in black, white, moonstone blue, sandstone, white smoke, chilled lilac and other colors. This Nike men’s puffer stands up to the cold while keeping you perfectly warm. Made with Nike’s PrimaLoft Thermoplume insulation and water-repellent ripstop fabric, Nike Sportswear’s men’s puffer is available black, iron gray, green, yellow, light blue and royal blue (sizes ranging from XS to 4XL tall). Between designs and function, Sonos Ace hits the right marks with 30 hours of battery, Active Noise Cancellation, spatial audio, Dolby Atmos, active head tracking and the list goes on. Sonos Ace headphones are available on black and white. Apple packed a lot of power in this 5x5x2-inch device. The all-new M4 chips transforms Mac Mini into a unstoppable processor that’s great for editing, music production and other creative tasks. 2024 saw the return of more than a few classics. Among them? The Beats Pill. The portable speaker made a comeback with a stronger battery and better sound quality. Enhanced in power and sound quality, Apple’s AirPods 4 features the powerful H2 chip, with personalized Spatial Audio and dynamic head tracking. AirPods 4 with Active Noise Cancellation takes the technology a step further featuring adaptive audio, transparency mode to hear the world around you and Conversation Awareness, which lowers the volume when you’re speaking to someone. TV in the palm of your hands. The new Google TV Steamer lets you stream Netflix, Hulu, Disney+, YouTube and other streaming platforms in 4K HDR. Equipped with Dolby Vision, the streaming device is 22 percent faster than its predecessor. The holidays means it’s time to party! This JBL speaker will last you well beyond the festive season and into the new year. JBL’s Party 100 features hi-powered sound, a 12-hour battery and LED lighting that syncs to the music. It’s also splashproof and dustproof. Cher: The Memoir is the first in a two-part biography series from the music legend. Travel back to the 1984 through Prince and Purple Rain . The book features rare photos and memorabilia of the Purple One in all his glory. Rock out with this wireless guitar controller from PDP Riffmaster. The controller is compatible with Xbox Series X|S, Xbox One, Windows 10/11 PC, Rock Band 4 , Fortnite Festival and Audio Jack . Shoot for the stars, land on the moon. Lego and Pharrell Williams teamed up for Over the Moon, an motivational builder’s set that reminds you to aim high. Drop the beat! A cute set is for kiddie DJs in training. The Let the Beet Drop set features a light-up DJ Bunny, carrot and beet seesaw with 10 sound effects, a blueberry slider, melon spinner and melon turntable complete with scratching sounds. Samsung’s Galaxy Tab A9 offers 4GB RAM, 64GB of memory, 128GB of storage and an 11-inch display screen to stream, play music and take video calls during (and after) the holidays. Let’s get loud! Bose SoundLink has a good amount of sound power and 30 hours of playtime. Available in black and blue, the SoundLink features Bluetooth 5.0, an IP67 water-resistant rating and it measures 4.73 x 10.42-inches. The Hatch 2 helps you sleep deeper and longer with multiple sleep sounds — white noise, pink noise, brown noise and more. Easily one of the best collection from Rare Beauty, Find Comfort is a refreshing array of fragrances, body wash and lotions to add more comfort to your self-care routine. Gloss Bomb is an icon, so why not stock up? Fenty Beauty’s holiday gift set comes with 10 luscious, Gloss Bomb lip glosses including Fu$$y, Hot Cherry, Diamond Milk, Cake Shake, Trophy Wife along with new shades: Purple Pepp’r, Smoke’d Quartz, Idoll’ize You and Roast ‘Em. Dyson Airwrap with a festive makeover. Dyson’s an all-in-one styling wand is designed for various hair types. One of New Balance’s bestsellers makes a stylish holiday gift. For comfort and style, slip into the New Balance 330. Luxury in a bottle. Beyonce’s Cécred haircare line delivers a salon-like experience at home, and yes, the products actually work (I highly recommend the clarifying shampoo and hydrating conditioner). Victor & Rolloff’s Flowerbomb blends ruby orchid with Red Roxy Vanilla Bean and vine peach accord. YSL’s MYSLF is a woodsy scent with bergamot and fresh orange blossom. A three-in-one hair curler with a swappable barrel with nine adjustable heat settings, what’s not to love? Pattern Beauty’s innovative hair tool lets steam do the talking. The hair steamer can be used to detangle to hydrate, stretching and deep condition your hair. “See you in space, cowboy.” Logic collaborated with Crunchyroll on an anime-inspired capsule collection that includes this Cowboy Beebop Varsity Jacket. Timberland celebrated the 30th anniversary of the Notorious B.I.G.’s Ready to D.I.E. album with a special installment of the classic, 6-inch boot available in black and wheat. “Love is like a butterfly.” Dolly Parton’s Kendra Scott collaboration is inspired by her 1974 hit. The Gold Air Heart necklace represents Parton’s love for music. Nameplate necklaces are out, initial necklaces are in. Abbott Lyons Bubble Initial Necklace comes in gold or silver and chain sizes ranging from 14 to 24-inches long. Ring in the holidays with a lovely gift set from Gorjana. The three-piece set comes in silver or 18k gold plated settings. A little shimmer never hurts! Pandora’s sparkling Tennis Bracelet is adorned with cubic zirconia stones with a gold plated, rose plated or sterling silver bracelet. Mejuri’s Heirloom ring was made to be passed down — and it happens to be one of of Taylor Swift’s favorite rings . The ring is available in garnet, blue topaz, London blue topaz and honey quartz stones. Oura Ring is the tech version of jewelry. The smart ring tracks your sleep, stress, heart rate and more. Adidas Solar powered headphones offer to up to 80 extra hours of playtime and and made from recycled materials. Cushion on the pavement. Nike’s Motiva sneaker is made for walking in ultimate comfort with next-level cushioning and enough grooves to help you step into a new era. Meta’s Ray Ban Smart Glasses seem like something you might see in a spy movie but modernized for present day. You can record, takes calls and check Instagram and Facebook with these glasses. Feel the chill. Alo Yoga’s Sherpa Hat is a cozy gift for the fashionably fierce. There’s a reason why Carhartt’s cuffed beanie has been around for almost 40 years. Apart from being affordable and extremely warm (not too thick, not too thin), you can get them in a bunch of different colors besides black, brown, grey and white. Dangerously comfortable and perfect for gifting. The Bean Boots from L.L. Bean’s Noah Kahan collection are almost out of stock in men’s sizes, so don’t wait to snag these (also available in women’s sizes ). Say hello to style and sophistication. The Coach Leah Loafer is a great addition to any closet. Nothing says cozy footwear like an ubersoft, crochet Ugg slipper (available in cream, black and charcoal). Rihanna’s Savage x Fenty released a festive, paisley Onsies for the whole family. Carhartt isn’t just for craftsmen, ranchers, and mechanics. It’s also a growing brand in streetwear fashion. Made from thick ringspun cotton duck, The Carhartt Detroit Jacket is a sleek and stylish piece of outerwear that’s durable and warm for the fall and winter months. It honestly feels like you’re wrapped in a cozy blanket. The jacket comes in two colors, Carhartt brown and black, as well as in a wide range of different sizes. – Rudie Obias Zara’s faux leather Bomber Jacket offers a slouchy, oversized fit that you can style up or down. Up, up and away! The Bigger Carry-On is touted as one of the best bags for travel (it’s pilot and flight attendant-approved). Away’s Carry-On collection of durable suitcases are available in different sizes and several colors including black, brown, navy, orange, red and olive green. The perfect travel buddy. Rare Beauty’s Puffer Travel Tote became my favorite travel bag this year — it’s super trendy with plenty of space to pack your wallet, tech gadgets, clothes and other essential — and easy to clean. Make it a Coach Christmas! The Brooklyn Shoulder Bag 28 comes in five colors including maple, black, stone, dark ruby and dark cedar. A camera bags, but make it fashion. From Swift to Hilary Duff and Megan Fox, lots of celebrities have sported camera bags. This Tory Burch bag is a smaller, crossbody purse that’s perfect for a night on the town. Whether you’re streaming a music festival, live concert, sporting event, movie or your favorite TV series, Sonos Arc changes the way you experience entertainment. The soundbar works especially well in smaller rooms and is designed for TVs of 50-inches or more (or slightly less, in my case). The Arc features 11 drivers, Dolby Atmos, Apple TruePlay, voice control and other capabilities. A slew of new, PS5 consoles hit the market this year including the PS5 Pro, one of the latest consoles joining the Sony’s lineup alongside the PS5 Slim and 30th anniversary consoles . The bestselling Xbox Carbon Black holds up nicely with 1TB of storage, 4K gaming with 120 FPS. The legacy lives on. The Chronicles of DOOM: Unraveling Rap’s Masked Iconoclast paints a moving portrait of the mysterious rapper starting from his childhood to his passing in 2020. E.V.E is spilling t-e-a in her bestselling memoir Whose That Girl? From growing up in Philadelphia to rap stardom, marriage and motherhood, the “Illest Pitbull in a Skirt” continues to evolve. Snoop Dogg’s Skechers collab has expanded from sneaker to slides and comfy clogs. The Arch Fit Footsteps clog features charms with Snoop’s face. Adidas OG Sambas look even better in the viral Earth Stone colorway. A beautiful translation of Ithell Colquhoun’s artistry, Dr. Marten’s 1460 boot utilized the late British painter’s decalcomania technique to create this design. You’ll be seeing things more clearly with Samsung’s Crystal UDH TV. Bring the arcade home. This top-selling arcade cabinet comes preloaded with NBA Jam , NBA Jam Tournament Edition and NBA Hangtime . Apple’s iPad Mini has a turbo A17 Pro chip with an 8.3-inch Liquid Retina display. If you’re looking for a gift for someone who lives in an apartment, then the Solo Stove Mesa is an ideal pick to create a bit of ambiance in a limited outdoor space. It’s a small fire pit that sits safely on top of a table with its included ring stand in a patio or balcony, while the Solo Stove Mesa is smokeless with the company’s iconic “Signature 360-degree Airflow” system to keep fires contained and burning throughout an evening outside. It comes in nine colors, such as stainless steel, water, ash, mulberry, deep olive and more. — Rudie Obias Google Pixel 9 has a 24-hour battery, a 6.3-inch display screen, 128GB of storage, and Google’s most powerful camera to date. A powerful Bluetooth speaker for the size and price. The Wylen II features 17+ hours of listening time (it takes 2.5 hours to fully charge). It’s IP67 dust and waterproof means that it can be safely submerged in up to 3 feet of water for up to 30 minutes (available in black and cream). Victrola’s Fully Automatic Turntable is equipped with Bluetooth and AudioTechnica cartridge for top-tier audio. A comfortable chair is pivotal to any gaming setup. Available in black, blue, pink, red and white, the N-Gen Video Gaming chair features a footrest, headrest and lumbar pillow. Lisa Marie Presley shares never-before-told stories in this moving memoir written before her death in 2023 and completed by her daughter Riley Keough. Jojo has persevered through child stardom to finding her own form of balance. The “Too Light Too Late” singer recounts the ups and down of fame in Over the Influence . Dolly Parton’s Good Lookin’ Cookin’ cookbook is a collection Southern staples including barbecue spare ribs, colorful coleslaw, mac and cheese and strawberry shortcake. T-Pain is spicing things up for his latest collaboration with Spicewalla. The Sauce is the brand’s first-ever hot sauce. From country music to haircare, fragrances and SirDavis Whisky, Beyoncé is covering all the bases. SirDavis is an 88 proof whiskey (not for the faint of heart) that stands out just as well as it blends in. Fans of Hell’s Kitchen and Love Island are familiar with HexClad’s viral cookware. The brand’s 10-inch pan is designed for frying, sautéing and searing. Kelly Rowland, Oprah Winfrey and Hailey Bieber are some of the stars that have used HexClad. A portable pot for meats, veggies, grains and enough one-pot meals to get you through winter? Sounds like a dream come true. It’s KitchenAid’s beloved stand mixer, but in a sleek Evergreen colorway with a gorgeous, wooden bowl. Jadakiss is in the coffee business. The New York rapper launched KISS Café with his father and son in 2022. Named after Jadakiss (Beijo means “kiss” in Portuguese), KISS Cafe carries dark, medium and light roasts and coffee mugs . A cheeseboard shaped like a turntable is a great gift idea for music fans. Get it while you still can. A “wicked” cup collaboration worth celebrating. Stanely’s Wicked -inspired Thirst Quencher includes pink and green sizes of the 40z and 30z tumblers. Stressed? Theragun Mini can fit in a small bag or purse for immediate back, neck and muscle relief (available in black, dessert rose, pink, green and blue). A cozy blanket needs to be on every holiday gift list. Elton John and Stalkin + Co. collaborated on this lovely collection of fragrant candles. Why wouldn’t the Queen of Christmas has her own Barbie doll (and holiday merch )? The Mariah doll is ready to deck the halls with boughs of holly. Sonic Edition releases rare photos of beloved artists including Oasis, Madonna, Prince, Tina Turner and other music icons. This black-and-white snapshot of Oasis’ Noel and Liam Gallagher at the Columbia Hotel a day after they were banned in 1994. Apple’s iPhone 10 is lighter and faster than the previous model and the screen is 30 percent larger. HP’s convertible Chromebook has a near-perfect customer rating. The Chromebook Plus feature a 14-inch display screen and powerful Intel Core processor. An easy way to keep your money secured. The card holder is great space-saver for attending concerts and music festivals. Digital pics are nice, but it’s good to have photos that you can hold in hand (or stick on the wall). Cannon’s Mini Photo printer makes that possible. Sony’s ZV-1F Vlog Camera is a user-friendly, starter camera for vlogging and content creation. Beats Studio Pro headphones lasts for up to 40 hours, but what I like most about them, besides the sound quality, is that they’re foldable and easily connect to iOS or Android. Wrong answers only! Mistaken Lyrics Coasters will make a fun gift option or stocking stuffer and a great conversation-starter. Gifties for Swifties! Taylor Swift Style takes fans on a journey through the pop star’s fashion evolution. A keepsake journal for music memories. The Concert Journal includes writing prompts for you to take note of things like ticket prices, venues, quotes from concerts and your favorite memories. Dave Matthews The Dreaming Tree red wine offers a smooth and tasty, blend of wines with notes of raspberry, caramel oak and mixed berry. Dolly Parton’s has wine too! Her chardonnay mixes white peach and lemon zest with a hint of pineapple. Foster & Grant is a whiskey collab between Michale Bublé and distillers Paul Circa. The 84-proof, rye whiskey is distilled in Kentucky. A truly portable blender with USB charging and LED lighting. The Nutribullet Flip is powered by a 11.1V high-torque motor that lets you blend on the go. This blender can also be used as a tumbler cup (it keeps beverages cold for up to 24 hours). An interactive gift for rock fans featuring 64 guitars from rock history. Razer’s Ornata V3 X is described as a “lowkey” keyboard for a quiet and comfortable gaming session. For podcasting and recording, this bestselling Shure microphone comes equipped with voice isolation ideal for recording in not-so-quiet spaces. Not your average board game. Arcade1 Up Infinity Gaming Table features 50, digitized games including Monopoly 9, Battleship, Candyland, Checkers, Backgammon, Chutes and Ladders, Connect 4, Game of Life, Fling Hockey, Hungry, Hungry Hippos, Mahjong Deluxe, Mancala, Memory Matching Game and Mini Fini Football.None

Ustby, Donarski lead No. 16 North Carolina women over Villanova 53-36 in Battle 4 Atlantis semifinal

Cowboys G Zack Martin, CB Trevon Diggs out vs. Commanders

WASHINGTON (AP) — President Joe Biden said Sunday that the sudden collapse of the Syrian government under Bashar Assad is a “fundamental act of justice” after decades of repression, but it was “a moment of risk and uncertainty” for the Mideast. Read this article for free: Already have an account? As we navigate through unprecedented times, our journalists are working harder than ever to bring you the latest local updates to keep you safe and informed. Now, more than ever, we need your support. Starting at $14.99 plus taxes every four weeks you can access your Brandon Sun online and full access to all content as it appears on our website. or call circulation directly at (204) 727-0527. Your pledge helps to ensure we provide the news that matters most to your community! WASHINGTON (AP) — President Joe Biden said Sunday that the sudden collapse of the Syrian government under Bashar Assad is a “fundamental act of justice” after decades of repression, but it was “a moment of risk and uncertainty” for the Mideast. Read unlimited articles for free today: Already have an account? WASHINGTON (AP) — President Joe Biden said Sunday that the sudden collapse of the Syrian government under Bashar Assad is a “fundamental act of justice” after decades of repression, but it was “a moment of risk and uncertainty” for the Mideast. Biden spoke at the White House hours after after rebel groups completed a takeover of the country after more than a dozen years of violent civil war and decades of leadership by Assad and his family. The outgoing Biden administration and President-elect Donald Trump were working to make sense of new threats and opportunities across the Middle East. Biden credited action by the U.S. and its allies for weakening Syria’s backers — Russia, Iran and Hezbollah. He said “for the first time” that they could no longer defend Assad’s grip on power. “Our approach has shifted the balance of power in the Middle East,” Biden said, after a meeting with his national security team at the White House. Trump said Sunday that Assad had fled his country, which his family had ruled for decades, because close ally Vladimir Putin, the Russian president, “was not interested in protecting him any longer.” Those comments on Trump’s social media platform came a day after he used another post to decry the possibility of the U.S. intervening militarily in Syria to aid the rebels, declaring, “THIS IS NOT OUR FIGHT.” The Biden administration had no intention of intervening, according to Biden’s national security adviser. The U.S has about 900 troops in Syria, including forces working with Kurdish allies in the opposition-held northeast to prevent any resurgence of the Islamic State group. Biden said he intended those for troops to remain, adding that U.S. forces on Sunday conducted “dozens” of what he called “precision air strikes” on IS camps and operations in Syria. The Syrian opposition that brought down Assad is led by Hayat Tahrir al-Sham. The Biden administration has designated the group as a terrorist organization and says it has links to al-Qaida, although Hayat Tahrir al-Sham says it has since broken ties with al-Qaida. “We will remain vigilant,” Biden said. “Make no mistake, some of the rebel groups that took down Assad have their own grim record of terrorism and human rights abuses.” He added that the groups are “saying the right things now.” “But as they take on greater responsibility, we will assess not just their words, but their actions,” Biden said. Assad’s fall adds to an already tense situation throughout much of region on many fronts, including Israel’s war with Hamas in Gaza and its fragile cease-fire with Hezbollah in Lebanon. Trump, who takes office Jan. 20, 2025, made a connection between the upheaval in Syria and Russia’s war in Ukraine, noting that Assad’s allies in Moscow, as well as in Iran, the main sponsor of Hamas and Hezbollah, “are in a weakened state right now.” Vice President-elect JD Vance, a veteran of the U.S.-led war in Iraq, wrote on own social media Sunday to express skepticism about the insurgents. “Many of ‘the rebels’ are a literal offshoot of ISIS. One can hope they’ve moderated. Time will tell,” he said, using another acronym for IS. Trump has suggested that Assad’s ouster can advance the prospects for an end to fighting in Ukraine, which was invaded by Russia in February 2022. Trump wrote that Putin’s government “lost all interest in Syria because of Ukraine” and the Republican called for an immediate cease-fire, a day after meeting in Paris with the French and Ukrainian leaders. Daniel B. Shapiro, a deputy assistant secretary of defense for the Middle East, said the American military presence will continue in eastern Syria but was “solely to ensure the enduring defeat of ISIS and has nothing to do with other aspects of this conflict.” “We call on all parties in Syria to protect civilians, particularly those from Syria’s minority communities to respect international military norms and to work to achieve a resolution to include the political settlement,” Shapiro said. “Multiple actors in this conflict have a terrible track record to include Assad’s horrific crimes, Russia’s indiscriminate aerial bomb bombardment, Iranian-back militia involvement and the atrocities of ISIS,” he added. Shapiro, however, was careful not to directly say Assad had been deposed by the insurgents. “If confirmed, no one should shed any tears over the Assad regime,” he said. As they pushed toward the Syrian capital of Damascus, the opposition freed political detainees from government prisons. The family of missing U.S. journalist Austin Tice renewed calls to find him. “To everyone in Syria that hears this, please remind people that we’re waiting for Austin,” Tice’s mother, Debra, said in comments that hostage advocacy groups spread on social media. “We know that when he comes out, he’s going to be fairly dazed & he’s going to need lots of care & direction. Direct him to his family please!” Tice disappeared in 2012 outside Damascus, amid intensification of what became a civil war stretching more than a decade. We’ve remained committed to returning him to his family,” Biden said at the White House. “We believe he’s alive, we think we can get him back but we have no direct evidence to that yet. And Assad should be held accountable.” The president added: “We have to identify where he is.” ___ Associated Press writer Jon Gambrell in Manama, Bahrain, and AP White House Correspondent Zeke Miller contributed to this report. Advertisement Advertisement

Travis Kelce’s NFL playoff journey could coincide with Taylor Swift's major collaboration with Dolly PartonPresident-elect Donald Trump praised Pete Hegseth, his embattled nominee for Defense secretary, in a social media post Friday, but some of the president-elect's allies are doubtful Hegseth can make it through the confirmation process. Hegseth doesn't appear to have the votes in the Senate to get confirmed and his nomination is in trouble, according to two sources close to Trump. "I believe the votes are not there for Pete," said a Trump adviser who asked not to be identified. "They're not going to be there. I think Trump will let Pete fight and come to that conclusion on his own." The second source said Hegseth's nomination appears to be doomed unless Trump "goes into full push." More: Pete Hegseth controversy explained: What to know amid backlash to Trump's Defense pick Trump lauded Hegseth, a combat veteran and former Fox News host, on social media Friday, writing that he "is doing very well." "His support is strong and deep, much more so than the Fake News would have you believe," Trump added. Trump seems committed to Hegseth for now, said a third source close to the president-elect. "That is my current sense," said the source. Hegseth's nomination has been teetering, though, amid a series of revelations about his personal life. He was accused of sexual assault, which he denies and for which he has never faced charges. And a whistleblower report first detailed by The New Yorker alleged he was forced out of leadership roles with two nonprofit veterans groups - Concerned Vets for America and Vets for Freedom - for personal misconduct, mismanagement of funds and intoxication on the job. More: Pete Hegseth vows he won't drink 'a drop of alcohol' if confirmed as defense secretary There also have been reports about excessive drinking by Hegseth during his stint at Fox News. The New York Times published an email sent to Hegseth by his mother in which she wrote “I have no respect for any man that belittles, lies, cheats, sleeps around and uses women for his own power and ego. You are that man (and have been for years)." Penelope Hegseth went on television this week to defend him and said she regrets the email. "Pete Hegseth is going to get his hearing before the Senate Armed Services Committee, not a sham hearing before the American media. We believe that Pete Hegseth is the right guy to lead the Department of Defense," Vice President-elect JD Vance told reporters Friday in North Carolina. "That’s why President Trump nominated him. We’re not abandoning this nomination.” Mark Lucas, who succeeded Pete Hegseth as executive director of Concerned Vets for America, dismissed the concerns about him as political. He said he didn't have any issues with Hegseth and is volunteering to testify before a Senate panel to support his confirmation Lucas also criticized people attacking Hegseth for doing so behind the cloak of anonymity. More: Alcohol, antipathy cloud Pete Hegseth sex assault allegations with conflicting accounts "They're going to run the same playbook against Pete Hegseth that they did with Brett Kavanaugh ," he told USA TODAY, referring to the Supreme Court justice who was accused sexual assault as a teenager during his 2018 confirmation. "If people want to come forward, they can. They can say whatever they want under oath. But it's going to be investigated." Hegseth may not benefit from the same "choir boy" treatment as Kavanaugh, said Mike Davis, who piloted Kavanaugh's contentious hearings as a Senate Judiciary Committee chief counsel. "Hegseth admits he was certainly not a choir boy. The Kavanaugh claims were ridiculous. Everyone who knew him knew he was a virgin into his 20s − then suddenly he's a serial rapist in high school?" Davis told USA TODAY. "Everyone knows Hegseth was a playboy. That doesn't mean he was a rapist. And the accusations, while serious, may not withstand public scrutiny after her public testimony." Davis said his group, the Article III Project, is mobilizing a phone, email and social media blitz to support Kash Patel and Hegseth. Hegseth's struggles have Trump considering a backup. He has been weighing replacing Hegseth with Florida Gov. Ron DeSantis , who ran against him in the GOP presidential primary. DeSantis, a Navy veteran, will join Trump at the Army-Navy football game on Dec. 14, according to Fox News . Hegseth said during his visit to the Capitol this week to meet with senators that he spoke with Trump and the president-elect is standing behind him. "He said: 'Keep going, keep fighting. I’m behind you all the way,'" Hegseth said of his conversation with Trump. "Why would I back down? I’ve always been a fighter. I'm here for the war fighters."Vikings waive former starting cornerback Akayleb Evans in another blow to 2022 draft class

Previous: 90jili tongits
Next: 90jili tw