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Google and the US government faced off in a federal court on Monday, as each side delivered closing arguments in a case revolving around the technology giant's alleged unfair domination of online advertising. The trial in a Virginia federal court is Google's second US antitrust case now under way as the US government tries to rein in the power of big tech. In a separate trial, a Washington judge ruled that Google's search business is an illegal monopoly, and the US Justice Department is asking that Google sell its Chrome browser business to resolve the case. The latest case, also brought by the Justice Department, focuses on ad technology for the open web -- the complex system determining which online ads people see when they surf the internet. The vast majority of websites use a trio of Google ad software products that together, leave no way for publishers to escape Google's advertising technology, the plaintiffs allege. Publishers -- including News Corp and Gannett publishing -- complain that they are locked into Google's advertising technology in order to run ads on their websites. "Google is once, twice, three times a monopolist," DOJ lawyer Aaron Teitelbaum told the court in closing arguments. Presiding judge Leonie Brinkema has said that she would deliver her opinion swiftly, as early as next month. Whatever Brinkema's judgment, the outcome will almost certainly be appealed, prolonging a process that could go all the way to the US Supreme Court. The government alleges that Google controls the auction-style system that advertisers use to purchase advertising space online. The US lawyers argue that this approach allows Google to charge higher prices to advertisers while sending less revenue to publishers such as news websites, many of which are struggling to stay in business. The US argues that Google used its financial power to acquire potential rivals and corner the ad tech market, leaving advertisers and publishers with no choice but to use its technology. The government wants Google to divest parts of its ad tech business. Google dismissed the allegations as an attempt by the government to pick "winners and losers" in a diverse market. The company argues that the display ads at issue are just a small share of today's ad tech business. Google says the plaintiffs' definition of the market ignores ads that are also placed in search results, apps and social media platforms and where, taken as a whole, Google does not dominate. "The law simply does not support what the plaintiffs are arguing in this case," said Google's lawyer Karen Dunn. She warned that if Google were to lose the case, the winners would be rival tech giants such as Microsoft, Meta or Amazon, whose market share in online advertising is ascendant as Google's share is falling. The DOJ countered that it simply "does not matter" that Google is competing in the broader market for online ads. "That is a different question" than the market for ads on websites that is the target of the case, said Teitelbaum. Google also points to US legal precedent, saying arguments similar to the government's have been refuted in previous antitrust cases. Dunn also warned that forcing Google to work with rivals in its ad products would amount to government central planning that the court should reject. If the judge finds Google to be at fault, a new phase of the trial would decide how the company should comply with that conclusion. And all that could be moot if the incoming Trump administration decides to drop the case. The president-elect has been a critic of Google's, but he warned earlier this month that breaking it up could be "a very dangerous thing." arp/dwReport: Chargers expect WR Ladd McConkey, LB Khalil Mack to play vs. Ravensjili okbet

Senate passes defense bill that will raise troop pay and aims to counter China's powerIt’s just like Lane Hutson and Cole Caufield, really. We were all looking forward to seeing them arrive in Montreal... The excitement is there when we talk about the Canadiens’ prospects, because since his selection at No. 5 in the draft, positive comments have been coming from everywhere when he’s in the news. Tony DeAngelo on his SKA teammate Ivan Demidov: “He’s a world class talent.” – /r/Habs (@HabsOnReddit) During his appearance on the podcast, DeAngelo also stated that he sees Demidov becoming a 30-goal-per-season top-6 winger... In the worst-case scenario. If – – Demidov progresses as DeAngelo predicts, the Canadiens will have one of the best players in the National League on their hands. But that’s what makes the defender’s comments so interesting: he’s around Demidov every day or so, and he’s in the best possible situation to see him progress... And you can’t discount the fact that DeAngelo knows the National League. Obviously, as much as everyone wants DeAngelo to be right, chances are it won’t work out too. And I’m not saying that to denigrate Ivan Demidov’s talent: it can happen to any talented prospect who makes the jump to the NHL. There have been examples in the past, and it’s not to be dismissed. – Interesting. Defender Chris Jandric has been absolutely dominant in the ECHL since getting loaned by the Rocket. 11 points in 9 games, and he looks like Lane Hutson out there, skating circles around everyone. Second in the ECHL for points per game by a defender with at least 9 games played.... – Andrew Zadarnowski (@AZadarski) – Artem Zub is out with a long-term injury. Report: Sens aggressively pursuing defensemen after Zub injury – theScore NHL (@theScoreNHL) – The three NHL stars of the week. Zach Werenski has earned his place on the – RDS (@RDSca)Another stowaway caught on Delta flight raises major concerns about airport safety

With technical prowess and considerable style, Marta danced around two sliding defenders, outwitted a goalkeeper and calmly scored as another player rushed forward in desperation to stop her. It was more Marta Magic. That goal last weekend helped propel the Orlando Pride into Saturday's National Women's Soccer League championship game against the Washington Spirit. Barbra Banda also scored in the Pride's 3-2 semifinal victory over the Kansas City Current . While Banda has had an incredible first season with the Pride, captain Marta has been the talisman that has helped lead the team in its remarkable turnaround this year. The last time the Pride were in the NWSL playoffs was in 2017 — Marta's first year with the club. But this season they nearly went undefeated, going 23 games without a loss to start the season before losing 2-0 to the Portland Thorns with just two regular-season games left. “I think because of the way that we did it, during this season, from beginning to now, it’s something very special that I’ve never had before with any other club that I’ve played for," Marta said. "Plus year by year, we see in America, strong competition. This is the best league in the world. And you never know what’s going to happen, and it’s hard to keep winning the games, being in the first place almost like the whole season. That’s why it’s really different and so special.” Marta’s goal was the latest gasp-inducing moment in a stellar career filled with them. Known by just her first name, the 38-year-old is a six-time FIFA world player of the year. "Let's see if tomorrow I can do something similar — or even better," Marta said on Friday. Her teammate Kylie Strom chimed in: “That was the greatest goal I've ever witnessed, hands down." Appropriate. Earlier this year, FIFA announced that the best goal in women's soccer each year would earn the Marta Award. In a lighthearted moment the day before the title match, Marta was asked if she thought it was possible she might give the award to herself. “You guys need to decide, because who votes for the best goal in the year? It’s you. It’s the people in the public. So it should be really interesting, like Marta’s Award goes to Marta!” she said with a laugh. Marta has played in six World Cups for Brazil and played this summer in her sixth Olympics, winning a silver medal after falling in the final to the United States . She previously said this would be her final year with the national team. But since then Brazil was named the host of the 2027 Women's World Cup. "I had a conversation with my coach, the national team coach, and I was really clear about playing in 2027. I told him it’s not my goal anymore,” she said. “But I’m always available to help the national team. And if they think I still can do something during this preparation for the World Cup, yeah, I would be happy to help them." Marta's club career started in Brazil when she was just 16. She has also played in Sweden and in the U.S. professional women's leagues that came before the NWSL. With nine regular-season goals, Marta has had one of her best seasons since she joined the Pride. “I can never pick a side, I never pick favorites — but I love to see this for Marta," U.S. coach Emma Hayes said. “Marta is someone we all like, admire and are grateful for. And that goal was just like prime Marta at her best. And so grateful for and thankful for her that she got the opportunity with another game with her team.” The Pride went 18-2-6 this season, clinching the NWSL Shield for the first trophy in club history. Orlando also set a record with 60 regular-season points to finish atop the standings. “We are sitting top of the table, but I think there still are a lot of doubters. I think there’s people out there who say, maybe this was a one-off season,” Strom said. “But we’re here to prove them all wrong. So I think we do carry a bit of that underdog mentality still with us.” The second-seeded Spirit advanced to the title match at Kansas City's CPKC Stadium last weekend on a penalty shootout after a 1-1 draw against defending champions Gotham FC. The Spirit's roster includes Trinity Rodman, a standout forward who formed the so-called “Triple Espresso” trio with Mallory Swanson and Sophia Smith for the United States at the Olympics. AP soccer: https://apnews.com/hub/soccerOfficial Govt & Legal Notices For Dec 18 2024

Quick Links Gulfstream has become the pinnacle of American executive aircraft manufacturing Bombardier has established a reputation for innovation and reliability So what has made these two companies so uniquely successful? Not long after jet-powered aircraft entered the skies in the second half of the twentieth century, manufacturers were hard at work developing executive aircraft that could efficiently whisk the rich and famous across the globe, without having to interact with commercial airline passengers anywhere along the way. private jets offered a level of convenience that most could never even imagine, as they allow one to walk directly onto their own aircraft without ever clearing security after arriving just seconds before takeoff and touch down in a new city as quickly as the plane can get you there . Private jets would become the ultimate status symbol as the 1960s and 70s came around, and they have made appearances in dozens of movies over the years when the ownership of such an aircraft is immediately meant to denote one's wealth and importance. With such a wealthy clientele and such a hefty demand for these kinds of executive aircraft, no shortage of aircraft manufacturers immediately sought to claim their piece of the profits that could be earned from building private jets . Get all the latest aviation news from Simple Flying! Two manufacturers have emerged as industry leaders: Canadian Bombardier and American Gulfstream While dozens of manufacturers exist within the market today that build private jets, two North American manufacturers have increasingly risen to the top of the industry. For starters, there is Gulfstream, a producer of large corporate aircraft that have increasingly become a major status symbol in American society. Recognizable by its large, round windows and sleek fuselages, a Gulfstream aircraft is easy to identify on the tarmac, and the General Dynamics Corporation, which is the manufacturer's parent company , has certainly reaped the benefits of these jets' commercial success. Qatar Executive will soon outfit its Gulfstream G650s with upgraded WiFi options Bombardier, a Canadian manufacturer, is the second of these major North American heavy private jet manufacturers and has multiple different aircraft series, including its flagship Global Express family. Unlike Gulfstream, which pretty much exclusively builds private jets, Bombardier has a handful of other business ventures that complement its executive aircraft offerings. For starters, the Canadian manufacturer has been behind multiple successful commercial aircraft programs, including the development of what would eventually become the Airbus A220 after a purchase from the European planemaker. The company also has multiple other manufacturing units, including those that operate in the defense space and even some that build locomotives. Your changes have been saved Email is sent Email has already been sent Across the board, there are some key differences between these two manufacturers, which have emerged as industry leaders, and their principal competitors. Let's take a deeper look at the stories of both of these companies and examine their success to understand why they have risen to the top of the industry. Gulfstream has become the pinnacle of American executive aircraft manufacturing Let's begin by looking deeper at Gulfstream Aerospace, which has established itself as a leading producer of next-generation business jets that ensure passenger comfort and a luxury experience remains at the forefront of the company's design focus. The company was born as a subdivision of Grumman Aircraft Engineering and has slowly developed its trademark commitment to quality through decades of growth. Gulfstream's commercial lineup currently includes several aircraft that have been distinguished for offering customers exceptional performance, incorporating next-generation features, and having top-of-the-line luxury cabins. The aircraft in the company's lineup are as follows: G280 G400 G500/G600 G650/G650ER G700 G800 The G650 and G700 were groundbreaking when they entered the market for offering ultra-long-range capabilities and cruising at exceptionally high speeds, with the G650 offering a higher service ceiling than any business aircraft that came before it, able to cruise as high as 51,000 feet. The G800, which is the latest Gulfstream model to enter the market , offers the longest range of the company's jets, making it optimal for customers looking to fly across the globe with as few stops as possible. The Gulfstream G700 recently set 65 city-pair speed records Gulfstream has also made an effort to set the industry's standard when it comes to technological innovation on the flight deck, making these jets easier to fly than many competing products. For starters, Gulfstream aircraft now come with the company's PlaneView Avionics Suite, which offers next-generation navigation systems and large screens, according to Honeywell Aerospace . The company further redefined the nature of flight deck design by introducing Enhanced Vision Systems (EVS) to improve flight safety under low-visibility conditions, allowing the aircraft to operate in almost any weather. Gulfstream was the first business jet manufacturer to incorporate these EVS systems as standard on all of its aircraft. Gulfstream remains a forward-looking company, and, under General Dynamics' management, the manufacturer has emerged as a pioneer in supersonic business travel, with the company developing technologies to minimize the impact of sonic booms. While the economics of supersonic passenger aviation may prevent the introduction of faster-than-sound commercial aircraft for decades, private jet customers have the means and the desire for speed and convenience that could support supersonic aircraft. The manufacturer has always pointed to its extensive customer support network and system of global service centers as another reason why customers continue to trust and purchase aircraft from Gulfstream . With a flagship facility in Georgia, the company offers a broad array of support services to customers, including maintenance, revenue, and overhaul (MRO). Bombardier has established a reputation for innovation and reliability Bombardier, a manufacturer based in Montreal, Quebec, has become known for its ability to produce innovative business jets that offer customers comfort, efficiency, and reliability. The company was the most commercially successful private jet manufacturer of 2023, with over 130 aircraft delivered to customers across the globe. The company has two different principal private jet series, each of which brings a lot to the table with impressive design and performance capabilities. Details about the manufacturer's two principal executive aircraft families can be observed in the table below: Aircraft series: Models: Global Express Global 5000 Global 6000 Global 5500 Global 6500 Global 7500/8000 Challenger Challenger 300 Challenger 600 Challenger 800/850 These aircraft models have been distinguished for their revolutionary capabilities. The Global 7500 and Global 8000 are the fastest civil aircraft built since the supersonic Concorde, and both variants broke the sound barrier during flight testing, according to Airline Economics . In addition to this impressive operating speed, these aircraft offer the industry's longest range and have changed the nature of long-haul executive travel by connecting cities that previously would have been unreachable by nonstop flights. Nearly $10,000 per hour – a statement of prestige and a gateway to ultimate freedom in the skies. The Challenger series has broken fewer barriers. However, it has been extensively successful for different reasons. The Challenger series offers impressive reliability and cost-efficiency, allowing the aircraft to appeal to a different range of business travelers, including those who may not have been able to afford the company's top-of-the-line models. Bombardier, much like its American counterpart, has been quick to integrate next-generation technologies into its private jet design, allowing enhancements in performance and passenger comfort. The company has also built some of the most sustainable business jets to ever enter the skies, by making extensive use of efficient high-bypass turbofan engines and lightweight aircraft materials. Through these design choices, the company can offer customers lower fuel consumption (which significantly lowers costs and improves operating economics) while also lowering emissions, to align with environmental objectives set by many aviation regulatory agencies. Much like Gulfstream, Bombardier also offers a large network of customer support centers, including its latest facility which recently opened in Abu Dhabi, according to Aerospace Technology . The company aims to offer customers the most dynamic support network and maintains a commitment to customer satisfaction, which has been a key piece of the company's marketing tactics and helps set the company apart from its competitors. So what has made these two companies so uniquely successful? We have already discussed the many reasons why Bombardier and Gulfstream have been able to find sustained success in manufacturing business aircraft, but one critical reason why these aircraft often outperform competitors has yet to be discussed. Both manufacturers have established a respected and well-defined brand image, helping them maintain a reputation among their key customers. Ultimately, there are not many people worldwide interested in purchasing private jets, making reputation crucial for these companies. While technological innovations, reliability, and customer support are significant factors in the success of both Bombardier and Gulfstream, these manufacturers also excel at convincing buyers that their products are superior to those of their competitors. Lastly, and most importantly, they emphasize their impeccable brand image and the unrivaled prestige that comes with owning their jets.Amgen raises quarterly dividend by 5.8% to $2.38/share

In context: Fujikura Ltd., founded by Zenpachi Fujikura in 1885, continues to thrive, fueled by the rapid growth of AI products and research initiatives. Originally focused on producing silk and cotton-insulated wires, the company has evolved to specialize in advanced cable systems for the modern tech industry. After barely weathering the pandemic in 2020, Fujikura is now enjoying a period of unprecedented growth in the Japanese stock market, driven by demand in AI and data center operations. The Tokyo-based company specializes in manufacturing electrical equipment, including power and telecommunication systems, optical fiber devices, and more. According to a recent Bloomberg report, Fujikura has become the best-performing stock on the Nikkei 225 Stock Average, with its share price surging over 400 percent in 2024. The company is also set to join the widely followed MSCI global stock market index. One of Fujikura's most in-demand products is its ultra-thin fiber optic cables, which boast some of the smallest diameters in the industry. These cables can be deployed in tight spaces without requiring additional tunneling, according to CFO Kazuhito Iijima. Notably, Apple is one of Fujikura's largest customers. Iijima noted that demand for data center products began surging significantly around 2022, leaving company executives puzzled at first. Now, it's clear that AI is the primary driver behind the booming business. Fujikura is projected to achieve ¥104 billion ($674 million) in operating income during the current fiscal year, marking a 17 percent year-over-year increase. A substantial 70 percent of Fujikura's revenue comes from outside Japan, with 38 percent originating from the United States. In 2020, the company faced its first loss in a decade, attributed to the Covid-19 pandemic and escalating trade tensions between the US and China. The return of the Trump administration could reignite these challenges, but Fujikura has been preparing for such scenarios. To mitigate risks, Iijima confirmed that the company has established a US-based production facility dedicated to manufacturing high-density optical fiber cables. The plant is designed to comply with the Build America Buy America Act , ensuring resilience "even if new issues arise that are disadvantageous to imported materials," Iijima stated. Looking ahead, Fujikura is preparing for emerging opportunities as global data center capacity is projected to grow by 33 percent annually through 2030, according to McKinsey & Company. The company is also exploring future markets, with nuclear fusion reactors – a potential clean energy breakthrough – seen as a promising avenue that will likely require extensive cabling solutions.

The level cap in Fortnite has been removed for Chapter 6 Season 1, and one player already sits at Level 1,014. Fortnite Chapter 6 Season 1 started all players on even footing, but some users wasted no time rushing to hit the max level of 1,000. Within days, players regretted the impatience, after finding themselves unable to progress through the OG Battle Pass because they’d already hit the level cap . It was unclear if or how Epic Games would address such a rare occurrence, but a quick solution has already gone live. One Fortnite player blazes past Level 1,000 after Epic removes level cap As spotted by ItsADAMO (via ShiinaBR), Epic Games has eliminated the seasonal level cap for Chapter 6 Season 1. Fortnite players can now level up beyond 1,000 and still unlock Battle Pass rewards . The proof is in the Level Leaderboards tracked by Fortnite.gg . At the time of writing, the leaderboards show that one dedicated player has already reached Level 1,014. Interestingly, a few other users sit just below them at Level 1,000. EPIC REMOVED THE LEVEL CAP FROM FORTNITE 🔥 Players can now level up forever – The current #1 unemployment final boss already has Level 1,014 💀 (Noticed by @ItsADAMO_ & @Many0354 ) pic.twitter.com/XCJcQAhAaS Whether or not Level 1,000-plus players can continue leveling up without limits until Season 2 remains to be seen. However, XP grinders will likely have a better understanding of this uncharted territory in the days and weeks ahead, even though each level still requires 80,000 XP. This level cap change counts as one of many leveling-related adjustments Fortnite has received since Chapter 6 Season 1 kicked off on December 1. The chapter launched with a new unified XP system that nerfed XP gains across several game modes. Following backlash from the community, Epic Games buffed the XP caps in Creative, LEGO, Fortnite OG, and Reload. Related: Even more balance adjustments may sit on the horizon, especially since Fortnite will soon play host to brand-new modes like Brick Life and Ballistic, the latter being a first-person 5v5 experience.Percentages: FG .547, FT .725. 3-Point Goals: 12-22, .545 (Hunter 7-10, Rogers 3-6, Carter 1-2, Haggerty 1-4). Team Rebounds: 2. Team Turnovers: 1. Blocked Shots: 2 (Cisse 2). Turnovers: 12 (Dainja 3, Haggerty 3, Hunter 2, Jourdain 2, Okojie, Rogers). Steals: 2 (Haggerty, Hunter). Technical Fouls: Dainja, 2:29 first. Percentages: FG .492, FT .792. 3-Point Goals: 14-30, .467 (Karaban 4-8, Ball 3-6, Stewart 2-3, Mahaney 2-4, McNeeley 2-4, Diarra 1-4, Ross 0-1). Team Rebounds: 2. Team Turnovers: 1. Blocked Shots: 3 (Reed 3). Turnovers: 9 (Diarra 3, Johnson 2, Reed 2, Karaban, Mahaney). Steals: 3 (Diarra, Johnson, McNeeley). Technical Fouls: Huskies, 15:50 first; Johnson, 2:29 first; coach Dan Hurley, 00:39 first. .President Emmanuel Macron is to name a new prime minister on Friday, aides said, after days of deadlock over finding a candidate to replace Michel Barnier whose ousting by parliament pushed France into a fresh crisis. Barnier was toppled in a historic no-confidence vote on December 4 and there had been expectations Macron would announce his successor in an address to the nation even a day later. But in a sign of the stalemate in French politics after inconclusive legislative elections this summer, he did not name his successor then and has now missed a 48-hour deadline he gave at a meeting meeting of party leaders on Tuesday. On Thursday, Macron left France on a day-long trip to key EU and NATO ally Poland but shortened the visit in an apparent bid to finalise the appointment. "The statement naming the prime minister will be published tomorrow (Friday) morning," said an aide to to the president, asking not to be named, late Thursday just after Macron touched down from the trip to Poland. "He is finishing his consultations," the aide added, without giving further details. Whoever is named will be the sixth prime minister of Macron's mandate after the toppling of Barnier, who lasted only three months, and faces an immediate challenge in thrashing out a budget to pass parliament. Each premier under Macron has served successively less time in office and there is no guarantee for the new premier that they will not follow this pattern. Macron remains confronted with the complex political equation that emerged from the snap parliamentary polls -- how to secure a government against a no-confidence vote in a bitterly divided lower house where no party or alliance has a majority. All the candidates widely floated so far have encountered objections from at least one side of the political spectrum. "They are stuck," said a person close to Macron, asking not to be named and lamenting that "each name gets blocked." "No one is in agreement around the president," added the source, expressing hope Macron will surprise everyone with an unexpected choice. More from this section Macron's rumoured top pick, veteran centrist Francois Bayrou, raises hackles on the left -- wary of continuing the president's policies -- and on the right, where he is disliked by influential former president Nicolas Sarkozy. Beyond Bayrou, prime ministerial contenders include former Socialist prime minister Bernard Cazeneuve, current Defence Minister Sebastien Lecornu, a Macron loyalist, and former foreign minister Jean-Yves Le Drian. Another name being discussed in the media is Roland Lescure, a former industry minister, but the nomination of the former Socialist risks inflaming the right. These "are names that have been around for years and haven't seduced the French. It's the past. I want us to look to the future," Greens leader Marine Tondelier said. "The French public want a bit of enthusiasm, momentum, fresh wind, something new," she told France 2 television. Polls indicate the public is fed up with the crisis. Just over two-thirds of respondents to one Elabe poll published on Wednesday said they want politicians to reach a deal not to overthrow a new government. But confidence is limited, with around the same number saying they did not believe the political class could reach agreement. In a separate IFOP poll, far-right National Rally (RN) figurehead Marine Le Pen was credited with 35 percent support in the first round of a future presidential election -- well ahead of any likely opponent. She has said she is "not unhappy" that her far-right party was left out of the horse-trading around the government, appearing for now to benefit from the chaos rather than suffer blame for bringing last week's no-confidence vote over the line. In a critical looming moment, Le Pen on March 31, 2025 faces the verdict in an embezzlement trial on charges she denies. If convicted, she could lose the chance of standing in the 2027 elections and with it her best chance yet of winning the Elysee. burs-tgb-sjw/rlp

Gaurav Chaudhary Expands Dickey's Barbecue Pit in Arizona with Vision and Dedication

THOUSAND OAKS, Calif. , Dec. 10, 2024 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced that its Board of Directors declared a $2.38 per share dividend for the first quarter of 2025. The dividend will be paid on March 7, 2025 , to all stockholders of record as of the close of business on February 14, 2025 . About Amgen Amgen discovers, develops, manufactures and delivers innovative medicines to help millions of patients in their fight against some of the world's toughest diseases. More than 40 years ago, Amgen helped to establish the biotechnology industry and remains on the cutting-edge of innovation, using technology and human genetic data to push beyond what's known today. Amgen is advancing a broad and deep pipeline that builds on its existing portfolio of medicines to treat cancer, heart disease, osteoporosis, inflammatory diseases and rare diseases. In 2024, Amgen was named one of the "World's Most Innovative Companies" by Fast Company and one of "America's Best Large Employers" by Forbes, among other external recognitions . Amgen is one of the 30 companies that comprise the Dow Jones Industrial Average ® , and it is also part of the Nasdaq-100 Index ® , which includes the largest and most innovative non-financial companies listed on the Nasdaq Stock Market based on market capitalization. For more information, visit Amgen.com and follow Amgen on X , LinkedIn , Instagram , TikTok , YouTube and Threads . Forward-Looking Statements This news release contains forward-looking statements that are based on the current expectations and beliefs of Amgen. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including any statements on the outcome, benefits and synergies of collaborations, or potential collaborations, with any other company (including BeiGene, Ltd. or Kyowa Kirin Co., Ltd.), the performance of Otezla® (apremilast) (including anticipated Otezla sales growth and the timing of non-GAAP EPS accretion), our acquisitions of Teneobio, Inc., ChemoCentryx, Inc., or Horizon Therapeutics plc (including the prospective performance and outlook of Horizon's business, performance and opportunities, any potential strategic benefits, synergies or opportunities expected as a result of such acquisition, and any projected impacts from the Horizon acquisition on our acquisition-related expenses going forward), as well as estimates of revenues, operating margins, capital expenditures, cash, other financial metrics, expected legal, arbitration, political, regulatory or clinical results or practices, customer and prescriber patterns or practices, reimbursement activities and outcomes, effects of pandemics or other widespread health problems on our business, outcomes, progress, and other such estimates and results. Forward-looking statements involve significant risks and uncertainties, including those discussed below and more fully described in the Securities and Exchange Commission reports filed by Amgen, including our most recent annual report on Form 10-K and any subsequent periodic reports on Form 10-Q and current reports on Form 8-K. Unless otherwise noted, Amgen is providing this information as of the date of this news release and does not undertake any obligation to update any forward-looking statements contained in this document as a result of new information, future events or otherwise. No forward-looking statement can be guaranteed and actual results may differ materially from those we project. Our results may be affected by our ability to successfully market both new and existing products domestically and internationally, clinical and regulatory developments involving current and future products, sales growth of recently launched products, competition from other products including biosimilars, difficulties or delays in manufacturing our products and global economic conditions. In addition, sales of our products are affected by pricing pressure, political and public scrutiny and reimbursement policies imposed by third-party payers, including governments, private insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments and domestic and international trends toward managed care and healthcare cost containment. Furthermore, our research, testing, pricing, marketing and other operations are subject to extensive regulation by domestic and foreign government regulatory authorities. We or others could identify safety, side effects or manufacturing problems with our products, including our devices, after they are on the market. Our business may be impacted by government investigations, litigation and product liability claims. In addition, our business may be impacted by the adoption of new tax legislation or exposure to additional tax liabilities. If we fail to meet the compliance obligations in the corporate integrity agreement between us and the U.S. government, we could become subject to significant sanctions. Further, while we routinely obtain patents for our products and technology, the protection offered by our patents and patent applications may be challenged, invalidated or circumvented by our competitors, or we may fail to prevail in present and future intellectual property litigation. We perform a substantial amount of our commercial manufacturing activities at a few key facilities, including in Puerto Rico , and also depend on third parties for a portion of our manufacturing activities, and limits on supply may constrain sales of certain of our current products and product candidate development. An outbreak of disease or similar public health threat, such as COVID-19, and the public and governmental effort to mitigate against the spread of such disease, could have a significant adverse effect on the supply of materials for our manufacturing activities, the distribution of our products, the commercialization of our product candidates, and our clinical trial operations, and any such events may have a material adverse effect on our product development, product sales, business and results of operations. We rely on collaborations with third parties for the development of some of our product candidates and for the commercialization and sales of some of our commercial products. In addition, we compete with other companies with respect to many of our marketed products as well as for the discovery and development of new products. Discovery or identification of new product candidates or development of new indications for existing products cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate or development of a new indication for an existing product will be successful and become a commercial product. Further, some raw materials, medical devices and component parts for our products are supplied by sole third-party suppliers. Certain of our distributors, customers and payers have substantial purchasing leverage in their dealings with us. The discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. Our efforts to collaborate with or acquire other companies, products or technology, and to integrate the operations of companies or to support the products or technology we have acquired, may not be successful. There can be no guarantee that we will be able to realize any of the strategic benefits, synergies or opportunities arising from the Horizon acquisition, and such benefits, synergies or opportunities may take longer to realize than expected. We may not be able to successfully integrate Horizon, and such integration may take longer, be more difficult or cost more than expected. 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Nagpur: Even after spending approximately Rs 1,500 crore to convert tar roads into cement concrete roads, Nagpur's motorists, particularly two-wheeler riders, face serious safety hazards due to poorly maintained interlocking blocks (I-blocks) alongside cement roads. Uneven surfaces and gaps, caused by improper installation and lack of upkeep, lead to accidents and public outrage. In July this year, Nagpur bench of Bombay high court comprising Justices Nitin Sambre and Abhay Mantri, expressed serious concerns over deteriorating condition of city roads. The court noted that even recently constructed cement roads were riddled with cracks and potholes. It attributed the issues to mismanagement and unplanned execution of road projects. Observing that incorrect alignment of cement roads was causing waterlogging and bumpy rides, the bench had ordered formation of an expert committee to comprehensively address problems. But situation on ground remains unchanged, with road-owning agencies disregarding HC directives. The road agencies may face potential contempt of court charges for their inaction and unsafe road conditions continue to endanger people's lives. Nagpur Municipal Corporation (NMC), along with other road-owning agencies like state Public Works Department (PWD) and National Highways Authority of India (NHAI), initially converted tar roads into cement roads to reduce long-term maintenance costs. Cement roads, projected to have a lifespan of over 50 years, were seen as a better alternative to tar roads, which require frequent renovations. However, partial concretisation of roads has created a new set of challenges. During a survey, TOI observed that road-owning agencies left portions of roads covered with I-blocks to allow for future utility installations, such as pipelines and cables. In several areas, these blocks have sunk below the level of cement roads or caused large gaps. At some locations, the gaps are wide enough to trap two-wheeler tyres, leading to accidents. Several stretches like in Ram Nagar, North Ambazari Road, VIP Road, Great Nag Road, and Inner Ring Road are among the worst affected where several riders have been injured. Uneven surfaces are further exacerbated by raised road heights, making navigation difficult. Waterlogging during rainy season often conceals these hazards, compounding the risk for motorists. Residents and urban planners have voiced their discontent, pointing to the lack of accountability and quality checks by NMC. "We have repeatedly complained about these gaps, but no action has been taken. These roads are a disaster waiting to happen," said Pravil Palkar, a resident of Narendra Nagar. Experts from Visvesvaraya National Institute of Technology (VNIT) have recommended implementing a ‘Pavement Management System' to road-owning agencies, including NMC, to address these issues effectively. This system, designed to ensure uniformity in road surfaces and better maintenance, could resolve the recurring problems of uneven I-blocks. "The system includes all the necessary clauses to handle such issues," said VNIT Professor and Head of the Department (Civil Engineering), Vishrut Landge. He criticised the lack of commitment from authorities, stating, "It is unfortunate that there is no willingness among officials to tackle the problem. The current state of cement roads is extremely disappointing and poses a significant risk of serious accidents." NMC chief engineer Leena Upadhaye had earlier said, "We are conducting a survey to identify accident-prone areas caused by uneven I-blocks. Necessary repairs will be carried out soon, and we will implement stricter quality checks." However, no substantial progress has been made on the ground, leaving citizens frustrated and vulnerable. Accident Hazards Uneven I-blocks alongside cement roads are a significant safety risk, especially for two-wheeler riders. Gaps between cement roads and I-blocks trap tyres, leading to accidents, particularly during rains when gaps are concealed. HC Observations Bombay high court's Nagpur bench expressed concerns over deteriorating cement roads. Highlighted poor alignment leading to waterlogging, cracks, and bumpy rides. Ordered the formation of an expert committee to address the issue, but no visible progress has been made. Recommendations VNIT experts suggest a ‘Pavement Management System' to ensure uniformity in road surfaces and address I-block issues. Nagpur: Even after spending approximately Rs 1,500 crore to convert tar roads into cement concrete roads, Nagpur's motorists, particularly two-wheeler riders, face serious safety hazards due to poorly maintained interlocking blocks (I-blocks) alongside cement roads. Uneven surfaces and gaps, caused by improper installation and lack of upkeep, lead to accidents and public outrage. In July this year, Nagpur bench of Bombay high court comprising Justices Nitin Sambre and Abhay Mantri, expressed serious concerns over deteriorating condition of city roads. The court noted that even recently constructed cement roads were riddled with cracks and potholes. It attributed the issues to mismanagement and unplanned execution of road projects. Observing that incorrect alignment of cement roads was causing waterlogging and bumpy rides, the bench had ordered formation of an expert committee to comprehensively address problems. But situation on ground remains unchanged, with road-owning agencies disregarding HC directives. The road agencies may face potential contempt of court charges for their inaction and unsafe road conditions continue to endanger people's lives. Nagpur Municipal Corporation (NMC), along with other road-owning agencies like state Public Works Department (PWD) and National Highways Authority of India (NHAI), initially converted tar roads into cement roads to reduce long-term maintenance costs. Cement roads, projected to have a lifespan of over 50 years, were seen as a better alternative to tar roads, which require frequent renovations. However, partial concretisation of roads has created a new set of challenges. During a survey, TOI observed that road-owning agencies left portions of roads covered with I-blocks to allow for future utility installations, such as pipelines and cables. In several areas, these blocks have sunk below the level of cement roads or caused large gaps. At some locations, the gaps are wide enough to trap two-wheeler tyres, leading to accidents. Several stretches like in Ram Nagar, North Ambazari Road, VIP Road, Great Nag Road, and Inner Ring Road are among the worst affected where several riders have been injured. Uneven surfaces are further exacerbated by raised road heights, making navigation difficult. Waterlogging during rainy season often conceals these hazards, compounding the risk for motorists. Residents and urban planners have voiced their discontent, pointing to the lack of accountability and quality checks by NMC. "We have repeatedly complained about these gaps, but no action has been taken. These roads are a disaster waiting to happen," said Pravil Palkar, a resident of Narendra Nagar. Experts from Visvesvaraya National Institute of Technology (VNIT) have recommended implementing a ‘Pavement Management System' to road-owning agencies, including NMC, to address these issues effectively. This system, designed to ensure uniformity in road surfaces and better maintenance, could resolve the recurring problems of uneven I-blocks. "The system includes all the necessary clauses to handle such issues," said VNIT Professor and Head of the Department (Civil Engineering), Vishrut Landge. He criticised the lack of commitment from authorities, stating, "It is unfortunate that there is no willingness among officials to tackle the problem. The current state of cement roads is extremely disappointing and poses a significant risk of serious accidents." NMC chief engineer Leena Upadhaye had earlier said, "We are conducting a survey to identify accident-prone areas caused by uneven I-blocks. Necessary repairs will be carried out soon, and we will implement stricter quality checks." However, no substantial progress has been made on the ground, leaving citizens frustrated and vulnerable. Accident Hazards Uneven I-blocks alongside cement roads are a significant safety risk, especially for two-wheeler riders. Gaps between cement roads and I-blocks trap tyres, leading to accidents, particularly during rains when gaps are concealed. HC Observations Bombay high court's Nagpur bench expressed concerns over deteriorating cement roads. Highlighted poor alignment leading to waterlogging, cracks, and bumpy rides. Ordered the formation of an expert committee to address the issue, but no visible progress has been made. Recommendations VNIT experts suggest a ‘Pavement Management System' to ensure uniformity in road surfaces and address I-block issues.

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