Voyager, LEOcloud to Advance Space-Based Edge Computing TechnologyUnlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.Photo: Summerland Museum & Archives Society A reunion of local War Brides gathered in Marjorie Lane's garden. 27th April 1987 Identified: Front: Stevie Ross, Mary Coates, Amy Lamb, Kathy Davidson, Olive Danyluk, Kay Agur; 2nd: Marjorie Lane, Jo Callan, Hilda Hornseth, Mima Laidlaw; 3rd Gwen Seifert, Elizabeth Watt, Enid Dorn, Nora Aten; Back: Grace Quanstrom, Rose Bruce, Olive King, Doris Hancock, Hilda Pickerkel, Diana Rippley, Ida Grahn. Continuing in the theme of Remembrance and to share parts of their new "Summerland Serves" exhibit, the Summerland Museum and Archives Society took a look back at love during the world wars. "These photos remind us that the world wars affected all facets of society, in many different and often unexpected ways. They are also a testament to the fact that even in the darkest of circumstances, love can triumph," the museum said in their post. One photo featured shows a 1987 reunion of Summerland's war brides. "The term “war bride” refers to the young women, mostly from Britain, who married Canadian servicemen during the World Wars," the museum added. "The official Government of Canada History of the First World War reports that an estimated 54,000 relatives accompanied the returning troops following demobilization." According to the museum's collection of Immigration Branch statistics, roughly 65,000 soldiers’ dependents, consisting of 44,000 brides and 21,000 children, were brought to Canada after the Second World War. Summerland itself became home to 43 of these war brides. "The Canadian Army took a dim view of these romantic encounters, with Commanding Officers being instructed to refuse consent for marriage outright if they were 'not satisfied that a reasonable basis for a happy marriage existed.'" A local war bride, Doiran Blagborne Thomson, shared that her wedding had to be postponed since the permission needed from her fiancé’s Commanding Officer didn't come through in time. She told the museum "I had to be investigated!" Even with barriers and deterrence, thousands of marriages took place. "As the number of war brides grew, the Canadian Government established the Canadian Wives’ Bureau, whose job it was to assist the wives of Canadian servicemen and their children," the museum said. "Many of the war brides were sent to their new homeland on empty returning troop ships, disembarking at Pier 21 in Halifax, and from there taking special war bride trains bound for various points across Canada." "One can only imagine how different life in the Okanagan must have been for these newlyweds, and what courage these young women had, to leave behind family and friends to establish a new life in a foreign country." Summerland's war brides got together socially during the 1980s and 1990s, bonded by their shared experience. To check out testimonies from two of Summerland's war brides, Enid Dorn and Doiran Blagborne Thomson, head to the website here. The museum's new military exhibit "Summerland Serves" opened on Friday. The Summerland Museum & Archives Society shares photos and information from their archives every week for Throwback Thursday on their social media, which can be found online here. Photo: Summerland Museum & Archives Society Olive Danyluk and her husband Mike on their wedding day in England during the war. Olive was a war bride.
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Title: Exploring the Luxurious Bath Culture at Northeast China, where the Lobby is Overflowing with Suitcases
Furthermore, the recent regulatory reforms in sectors such as technology and education have instilled a sense of reassurance among investors. These reforms, while initially met with apprehension, have been perceived as a necessary step towards creating a more transparent and regulated market environment. As a result, investors are increasingly confident in the long-term prospects of Chinese concept stocks.
As the investigation into the murder unfolded, a disturbing discovery was made - the suspect had been in contact with a group of like-minded individuals who shared his extreme views. Together, they had drafted a manifesto outlining their radical beliefs and calling for violent action against perceived enemies of their cause.Trump's casting call as he builds out his administration: TV experience preferred
Title: A 90's Guy from Shenyang Resigns for Love and Sells Ice Cream in WuhanNoneWhat sets Greenwood apart from other young talents is his maturity and composure in front of goal. He possesses a sharp footballing intelligence that enables him to anticipate the movements of the opposition defense and make the right decisions at the crucial moments. His ability to create scoring opportunities for himself and his teammates is a testament to his skill and vision on the field.
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However, amidst the flurry of excitement surrounding the soaring stock prices, it is crucial to address an important aspect that often goes overlooked - the issue of copyright and original work declaration. In the world of financial journalism and market analysis, the importance of crediting original sources and respecting intellectual property rights cannot be overstated.
As the 89-year-old woman and her granddaughter embrace each other, surrounded by the lush beauty of the forest that once seemed so perilous, they are reminded that nature's bounty can provide sustenance, solace, and strength in the most challenging of circumstances. In their shared triumph over adversity, they embody the timeless lesson that love, resilience, and the healing power of the natural world can overcome even the most daunting of challenges.Four new military helicopters purchased for Air Corps in deal worth almost €100mThe iconic Birkin bag, debuted by French fashion house Hermès in 1984, has long been a symbol of luxury and exclusivity. Named after actress and singer Jane Birkin , the bag is handcrafted and produced in limited numbers, due to its high price tag. Depending on its model and condition, a genuine Birkin bag can sell anywhere from $18,000 to $225,000 on resale platforms such as Wrist Aficionado, cementing its status as a coveted fashion accessory for the wealthy elite. However, a new twist has emerged in the world of luxury fashion, as a convincing dupe of the Birkin bag has gone viral. Available on W almart .com for under $100, the lookalike leather bag has garnered significant attention, particularly among fashion enthusiasts who admire the style of the Birkin but cannot or choose not to afford the authentic version. Despite the sharp contrast in price, the dupe is said to resemble the luxurious original, providing a much more budget-friendly option for those desiring the high-end aesthetic. The viral success of this affordable alternative has ignited an ongoing debate online, as shoppers flock to Walmart to secure their own version of the bag. Unfortunately, due to high demand, the lookalike bags are currently sold out, but eager buyers can check back on the retailer’s website in hopes of new stock being added. The incident highlights the growing trend of "dupe" culture in the fashion industry, where consumers are increasingly seeking affordable alternatives to high-end, designer items. As fashion enthusiasts continue to debate the merits of designer dupes versus original pieces, it is clear that the market for affordable alternatives to high-end luxury items is rapidly expanding. Whether the viral Birkin bag dupe will remain a fleeting trend or become a permanent fixture in the world of fashion remains to be seen.In conclusion, Zhang Anda's triumph in the Snooker Scottish Open is a testament to his skill, composure, and determination in the face of adversity. His performance in the match was nothing short of exemplary, embodying the spirit of competition and sportsmanship that defines the game of snooker. As he progresses to the last 32, Zhang Anda has cemented his status as a formidable contender and a player to watch in the world of professional snooker.