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Korea Institute of Civil Engineering and Building Technology developed a smart monitoring system that applies digital sensing technology to maintain and manage small- and medium-sized aging bridges. In general, maintenance monitoring technology is applied to long-span bridges such as cable-stayed bridges and suspension bridges. This monitoring system consumes a lot of resources for design and installation, and the system configuration itself is complex, so there are limits to its application for maintenance of small- and medium-sized bridges. Currently, the most actively used bridge monitoring system is operated based on measurement and sensing. Due to the nature of the signal, the analog method is vulnerable to electrical noise, so there is a high possibility of data quality deterioration, and there are limitations in effectively processing various types of signals collected from sensors. Additionally, because analog sensors require 1:1 wiring between the sensor and the receiver, the configuration complexity and installation cost increase dramatically as the system grows. The digital sensing technique adopted by KICT to overcome the limitations and problems of analog sensors has a low possibility of data quality deterioration due to noise. It also has excellent data transmission speed and processing ability, making up for the shortcomings of analog sensing. In addition, by using the BUS communication serial connection method, multiple sensor data can be integrated and transmitted through a single wire. This method is widely used in various applications due to its simplicity and economic efficiency. Furthermore, it has the advantage of complementing and replacing analog sensing in terms of simplification of system configuration. In the case of Vietnam, which co-participated in the study, various transportation infrastructure, including bridges, are being built along with economic growth, but effective maintenance techniques are more required. Although overseas manpower and technology are being introduced to perform facility maintenance, only a few applications are being made to long-span bridges and due to a limited maintenance budget and lack of technology and professional manpower. Safety monitoring for general of small- and medium-sized bridges has not been implemented, so it is necessary to introduce efficient monitoring techniques suited to local conditions. The research team led by Dr. Dong-woo, Seo, at the Department of Structural Engineering Research of KICT, developed a monitoring system that can be efficiently applied to small- and medium-sized aging bridges through digital sensing techniques, and verified the performance of the system by demonstrating it on site with a research team at UTC in Vietnam. The measurement performance and local applicability of the based smart monitoring system were confirmed. In particular, the smart monitoring technique developed by KICT can accurately calculate the vertical displacement of the target bridge with simple sensor placement and coordinate input. This is provided to the user in real time through a GUI ( ), and simple operations are required to operate the system and produce results. As a result of local verification in Vietnam, the bridge vertical displacement and actual measured deflection results showed an accuracy of more than 95%. Dr. Seo said, "The biggest advantage of the developed digital smart monitoring technique is user-friendliness. Easy to use and economical monitoring technique through a simple system installment method using digital sensors and a GUI-based data analysis system."
Police hunt for UnitedHealthcare CEO's masked killer after 'brazen, targeted' attack on NYC street NEW YORK (AP) — UnitedHealthcare’s CEO has been shot and killed in what police say is a “brazen, targeted attack” outside a Manhattan hotel where the health insurer was holding its investor conference. The shooting rattled the city and set off a massive dragnet hours before the annual Rockefeller Center Christmas tree lighting. Police say 50-year-old Brian Thompson was shot around 6:45 a.m. Wednesday as he walked alone to the New York Hilton Midtown from a nearby hotel. New York City Police Commissioner Jessica Tisch says the shooter appeared to be “lying in wait for several minutes” before approaching Thompson from behind and opening fire. Police have not yet established a motive. UnitedHealthcare CEO kept a low public profile. Then he was shot to death in New York NEW YORK (AP) — Brian Thompson led one of the biggest health insurers in the US but was unknown to millions of people his decisions affected. The fatal shooting of UnitedHealthcare's chief executive on a midtown Manhattan sidewalk Wednesday became a mystery that riveted the nation. Police say it was a targeted killing. Thompson was 50. He had worked at the company for 20 years and had run health care giant UnitedHealth Group Inc.'s insurance business since 2021. It provides health coverage for more than 49 million Americans and brought in $281 billion in revenue last year. Thompson's $10.2 million annual compensation made him one of the company’s highest-paid executives. Supreme Court seems likely to uphold Tennessee's ban on medical treatments for transgender minors WASHINGTON (AP) — Hearing a high-profile culture-war clash, the Supreme Court on Wednesday seemed likely to uphold Tennessee’s ban on gender-affirming care for minors. The justices’ decision, not expected for several months, could affect similar laws enacted by another 25 states and a range of other efforts to regulate the lives of transgender people, including which sports competitions they can join and which bathrooms they can use. The case is being weighed by a conservative-dominated court after a presidential election in which Donald Trump and his allies promised to roll back protections for transgender people. The Biden administration’s top Supreme Court lawyer warned a decision favorable to Tennessee also could be used to justify nationwide restrictions on transgender healthcare for minors. Hegseth fights to save Pentagon nomination as sources say Trump considers DeSantis WASHINGTON (AP) — Pete Hegseth, Donald Trump’s Pentagon pick, is fighting to hold on to his Cabinet nomination amid growing questions about his personal conduct as the president-elect’s team considers alternatives, including Florida Gov. Ron DeSantis. But Hegseth says, “We’re not backing down one bit." The Trump transition team is concerned about Hegseth’s path to Senate confirmation and is actively looking at potential replacements, according to a person familiar with the matter. Hegseth is under pressure as senators weigh a series of allegations that have surfaced against him. Beyond DeSantis, there have been discussions about shifting Michael Waltz, who was named by Trump as his national security adviser, to the Defense Department Israeli strikes on a Gaza tent camp kill at least 21 people, hospital says KHAN YOUNIS, Gaza Strip (AP) — A Palestinian health official said Wednesday that at least 21 people were killed in Israeli strikes on a camp housing displaced people in Gaza. The Israeli military said it struck senior Hamas militants. The strikes hit in the Muwasi area, a sprawling coastal camp housing hundreds of thousands of displaced people. It came after Israeli forces struck targets in other areas of Gaza. According to Palestinian medics, strikes in central Gaza killed eight people, including four children. The war in Gaza is nearly 14 months old and showing no end in sight, despite international efforts to revive negotiations toward a ceasefire. South Korean President Yoon's martial law declaration raises questions over his political future SEOUL, South Korea (AP) — President Yoon Suk Yeol’s stunning martial law declaration lasted just hours, but experts say it raised serious questions about his ability to govern for the remaining 2 1/2 years of his term. The opposition-controlled parliament overturned the edict, and his rivals on Wednesday took steps to impeach him. Yoon's move baffled many experts. One analyst called his action “political suicide.” Yoon’s political fate may depend on whether a large number of people in coming days take to the streets to push for his ouster. Yoon hasn't commented on the impeachment bid. But the political instability he unleashed could make it more difficult for his government to nurse a decaying economy. Police say searchers don’t expect to find woman in Pennsylvania sinkhole alive UNITY TOWNSHIP, Pa. (AP) — The search for a woman who is believed to have fallen into a sinkhole in western Pennsylvania has become a recovery effort after two treacherous days of digging through mud and rock produced no signs of life. Pennsylvania State Police spokesperson Trooper Steve Limani said during a news conference Wednesday that authorities no longer believe they will find 64-year-old Elizabeth Pollard alive, but that the search for her remains continues. Limani says crews have seen "no signs of any form of life or anything.” Pollard was last seen alive Monday evening when she went out looking for her cat in the village of Marguerite, about 40 miles east of Pittsburgh. Two children wounded and gunman dead after shooting at Northern California school PALERMO, Calif. (AP) — Sheriff’s officials say two children have been wounded in a shooting at a small religious school in Northern California and the gunman is dead. A Butte County Sheriff’s Office spokesperson says Wednesday the wounded students were taken to hospitals in unknown condition after the shooting at Feather River School of Seventh-Day Adventists in Palermo, north of Sacramento. The spokesperson says the suspect died after apparently shooting himself. A motive is unknown. French lawmakers vote to oust prime minister in the first successful no-confidence vote since 1962 PARIS (AP) — France’s far-right and left-wing lawmakers have joined together to vote on a no-confidence motion prompted by budget disputes that forces Prime Minister Michel Barnier and his Cabinet to resign. The National Assembly approved the motion by 331 votes. A minimum of 288 were needed. President Emmanuel Macron insisted he will serve the rest of his term until 2027. However, he will need to appoint a new prime minister for the second time after July’s legislative elections led to a deeply divided parliament. Macron will address the French on Thursday evening, his office said, without providing details. Barnier is expected to formally resign by then. White House says at least 8 US telecom firms, dozens of nations impacted by China hacking campaign WASHINGTON (AP) — A top White House official says at least eight U.S. telecom firms and dozens of nations have been impacted by a Chinese hacking campaign. Deputy national security adviser Anne Neuberger offered the new details Wednesday about the breadth of the sprawling Chinese hacking campaign that gave officials in Beijing access to private texts and phone conversations of an unknown number of Americans. Neuberger divulged the scope of the hack a day after the FBI and the Cybersecurity and Infrastructure Security Agency issued guidance intended to help root out the hackers and prevent similar cyberespionage in the future. White House officials cautioned that a number of telecommunication firms and countries impacted could still grow.A provincial mining industry leader says B.C. could end up profiting from trade tensions between China and the United States over critical minerals. Michael Goehring, president and chief executive officer of the Mining Association of British Columbia, said Wednesday, (Dec. 4), that China's decision to ban exports of certain critical minerals and rare earths to the United States demonstrates why it is "vital" for Canada and the U.S. to reduce their dependence on authoritarian regimes for critical mineral supplies and mineral processing. "British Columbians can play a key role in providing the critical minerals the U.S. and our other allies need in the years to come," Goehring said. "B.C. has, or produces, 16 of the 50 minerals the United States has identified as being critical to the nation’s economic and national security. In fact, seven per cent of B.C.’s exports to the US in 2022 were critical minerals and metals, including aluminum, germanium, gallium, indium, lead and zinc." China announced Tuesday, (Dec. 3), that it would immediately ban sales of gallium and germanium among other minerals to the United States following the U.S.'s decision to limit Chinese access to American-made digital technology. China is world's leading supplier of many minerals used in technologies deemed critical in fields like transportation, communication and alternative energy, all of which have a military and security dimension. Chinese efforts to use its dominance in these materials as leverage have not gone unnoticed, as several western jurisdictions have sought out alternative suppliers, including Canada. "In fact, Canada and the U.S. initiated the Joint Action Plan on Critical Minerals Collaboration in 2020 under President Trump to reduce our vulnerability," Goehring said." China’s export ban highlights the need to accelerate our efforts through the Joint Action Plan to grow a resilient North American critical mineral supply chain and advance our mutual economic, defense and security objectives." Whether Goehring's appeal will resonate among decision-makers on either side of the U.S-Canada border is a different question given the prospect of trade tensions with Trump returning to the White House next month. With 17 new critical mineral projects under development, Britisch Columbia can make what Goehring called "a meaningful contribution to North America’s future" while creating jobs for workers, stability for resource communities and shared prosperity throughout B.C. "But these benefits can only be realized if we modernize and expedite the mine permitting and approval process," he said. "(We) are in a race and we need to act quickly. Ongoing permitting delays and uncertainty needlessly drive away investment and lead to deferred or unrealized economic benefits. We need mine permitting to be a competitive advantage for our province."None
NoneAs the college football regular season winds down, the intrigue in some of the Week 13 matchups turns way up. WATCH: Stream most of this week’s top college football games live for FREE with Fubo (free trial) or with DirecTV Stream (free trial). In the Big Ten, undefeated Indiana tries to keep rolling toward a berth in the Big Ten championship game when the fifth-ranked Hoosiers visit No. 2 Ohio State. The one-loss Buckeyes are 11-point favorites. Meanwhile, No. 4 Penn State, which also remains alive in the chase to face top-ranked Oregon in the conference title game, faces a potentially tough road game against the Minnesota Golden Gophers. The Nittany Lions are favored by 11.5 points. In the Pac-12, Oregon State will look to end its losing streak when the Beavers play host to Washington State . The Beavers have lost five in a row and are 11.5-point underdogs, but can they put a complete game together against the Cougars? Check out this week’s college football odds and score predictions for all the Big Ten and Pac-12 games from the CFB coverage team at The Oregonian/OregonLive. Purdue (1-9, 0-7) at Michigan State (4-6, 2-5) Game details: 5 p.m. PT Friday at Spartan Stadium in East Lansing, Michigan TV channel and live stream: Fox and Fox Sports Live Latest line: Michigan State by 13.5 Over/under: 47.5 Predictions Ryan Clarke: Michigan State 31, Purdue 17 James Crepea: Michigan State 28, Purdue 14 Nick Daschel: Michigan State 31, Purdue 27 Aaron Fentress: Michigan State 31, Purdue 20 Joe Freeman: Michigan State 30, Purdue 15 Sean Meagher: Michigan State 34, Purdue 17 Joel Odom: Michigan State 31, Purdue 10 Bill Oram: Michigan State 28, Purdue 13 Washington State (8-2) at Oregon State (4-6) Game details: 4 p.m. PT Saturday at Reser Stadium in Corvallis TV channel and live stream: The CW Latest line: Washington State by 11.5 Over/under: 57.5 Predictions Ryan Clarke: Washington State 30, Oregon State 7 James Crepea: Washington State 35, Oregon State 14 Nick Daschel: Washington State 38, Oregon State 17 Aaron Fentress: Washington State 27, Oregon State 17 Joe Freeman: Washington State 32, Oregon State 17 Sean Meagher: Washington State 42, Oregon State 21 Joel Odom: Washington State 38, Oregon State 14 Bill Oram: Washington State 38, Oregon State 23 No. 5 Indiana (10-0, 7-0) at No. 2 Ohio State (9-1, 6-1) Game details: 9 a.m. PT Saturday at Ohio Stadium in Columbus TV channel and live stream: Fox and Fox Sports Live Latest line: Ohio State by 11 Over/under: 52.5 Predictions Ryan Clarke: Ohio State 37, Indiana 34 James Crepea: Ohio State 42, Indiana 35 Nick Daschel: Ohio State 31, Indiana 29 Aaron Fentress: Ohio State 38, Indiana 25 Joe Freeman: Ohio State 28, Indiana 27 Sean Meagher: Indiana 38, Ohio State 35 Joel Odom: Ohio State 31, Indiana 21 Bill Oram: Ohio State 26, Indiana 24 No. 25 Illinois (7-3, 4-3) at Rutgers (6-4, 3-4) Game details: 9 a.m. PT Saturday at SHI Stadium in Piscataway, New Jersey TV channel and live stream: Peacock Latest line: Rutgers by 1 Over/under: 47.5 Predictions Ryan Clarke: Illinois 22, Rutgers 14 James Crepea: Illinois 28, Rutgers 14 Nick Daschel: Illinois 24, Rutgers 20 Aaron Fentress: Illinois 23, Rutgers 20 Joe Freeman: Rutgers 24, Illinois 23 Sean Meagher: Illinois 28, Rutgers 24 Joel Odom: Illinois 27, Rutgers 17 Bill Oram: Illinois 28, Rutgers 14 Iowa (6-4, 4-3) at Maryland (4-6, 1-6) Game details: 9 a.m. PT Saturday at SECU Stadium in College Park, Maryland TV channel and live stream: Big Ten Network and Fox Sports Live Latest line: Iowa by 3.5 Over/under: 43.5 Predictions Ryan Clarke: Iowa 28, Maryland 20 James Crepea: Iowa 28, Maryland 21 Nick Daschel: Iowa 20, Maryland 14 Aaron Fentress: Iowa 33, Maryland 18 Joe Freeman: Iowa 27, Maryland 20 Sean Meagher: Iowa 21, Maryland 17 Joel Odom: Iowa 34, Maryland 13 Bill Oram: Maryland 35, Iowa 21 No. 4 Penn State (9-1, 6-1) at Minnesota (6-4, 4-3) Game details: 12:30 p.m. PT Saturday at Huntington Bank Stadium in Minneapolis TV channel and live stream: CBS and cbssports.com Latest line: Penn State by 11.5 Over/under: 44.5 Predictions Ryan Clarke: Minnesota 27, Penn State 24 James Crepea: Penn State 35, Minnesota 21 Nick Daschel: Penn State 24, Minnesota 23 Aaron Fentress: Penn State 31, Minnesota 17 Joe Freeman: Penn State 31, Minnesota 21 Sean Meagher: Penn State 30, Minnesota 24 Joel Odom: Penn State 28, Minnesota 16 Bill Oram: Minnesota 28, Penn State 18 Wisconsin (5-5, 3-4) at Nebraska (5-5, 2-5) Game details: 12:30 p.m. PT Saturday at Memorial Stadium in Lincoln, Nebraska TV channel and live stream: Big Ten Network and Fox Sports Live Latest line: Nebraska by 1 Over/under: 41.5 Predictions Ryan Clarke: Nebraska 24, Wisconsin 7 James Crepea: Nebraska 24, Wisconsin 17 Nick Daschel: Nebraska 20, Wisconsin 14 Aaron Fentress: Wisconsin 24, Nebraska 23 Joe Freeman: Wisconsin 23, Nebraska 20 Sean Meagher: Wisconsin 28, Nebraska 27 Joel Odom: Wisconsin 20, Nebraska 17 Bill Oram: Nebraska 21, Wisconsin 14 Northwestern (4-6, 2-5) at Michigan (5-5, 3-4) Game details: 12:30 p.m. PT Saturday at Michigan Stadium in Ann Arbor TV channel and live stream: FS1 and Fox Sports Live Latest line: Michigan by 10.5 Over/under: 36.5 Predictions Ryan Clarke: Michigan 31, Northwestern 10 James Crepea: Michigan 17, Northwestern 10 Nick Daschel: Northwestern 21, Michigan 20 Aaron Fentress: Michigan 29, Northwestern 10 Joe Freeman: Michigan 24, Northwestern 10 Sean Meagher: Michigan 21, Northwestern 14 Joel Odom: Michigan 16, Northwestern 13 Bill Oram: Michigan 33, Northwestern 17 USC (5-5, 3-5) at UCLA (4-6, 3-5) Game details: 7:30 p.m. PT Saturday at the Rose Bowl in Pasadena, California TV channel and live stream: NBC and Peacock Latest line: USC by 5 Over/under: 51.5 Predictions Ryan Clarke: UCLA 38, USC 31 James Crepea: USC 35, UCLA 28 Nick Daschel: UCLA 28, USC 27 Aaron Fentress: USC 31, UCLA 26 Joe Freeman: USC 30, UCLA 24 Sean Meagher: UCLA 33, USC 28 Joel Odom: USC 36, UCLA 30 Bill Oram: UCLA 49, USC 47Drone operators worry that anxiety over mystery sightings will lead to new restrictions
ATLANTA , Dec. 23, 2024 /PRNewswire/ -- KORE Group Holdings, Inc. (NYSE: KORE) ("KORE" or the "Company"), the global pure-play Internet of Things ("IoT") hyperscaler and provider of IoT Connectivity, Solutions, and Analytics, today announced it has received notification (the "Acceptance Letter") from the New York Stock Exchange (the "NYSE") that the NYSE has accepted the Company's previously-submitted plan (the "Plan") to regain compliance with the NYSE's continued listing standards set forth in Section 802.01B of the NYSE Listed Company Manual relating to minimum market capitalization and stockholders' equity. In the Acceptance Letter, the NYSE granted the Company an 18-month period from September 12, 2024 (the "Plan Period") to regain compliance with the continued listing standards. As part of the Plan, the Company is required to provide the NYSE quarterly updates regarding its progress towards the goals and initiatives in the Plan. In the Plan, Kore included details regarding previously reported operational restructuring activities, as well as an outlook on the Company's business. The Company expects its common stock will continue to be listed on the NYSE during the Plan Period, subject to the Company adherence to the Plan and compliance with other applicable NYSE continued listing standards. The Company's receipt of such notification from the NYSE does not affect the Company's business, operations or reporting requirements with the U.S. Securities and Exchange Commission. Cautionary Note on Forward-Looking Statements This press release includes certain statements that are not historical facts but are forward-looking statements for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995. Forward-looking statements generally are accompanied by words such as "believe," "guidance," "project," "may," "will," "estimate," "continue," "anticipate," "intend," "expect," "should," "would," "plan," "predict," "potential," "seem," "seek," "future," "outlook," and similar expressions that predict or indicate future events or trends or that are not statements of historical matters. These forward-looking statements include, but are not limited to, statements regarding expected progress with the Company's compliance plan submitted to the NYSE, expected compliance with continued listing standards of the NYSE and expected continued listing of the Company's common stock on the NYSE. These statements are based on various assumptions and on the current expectations of KORE's management. These forward-looking statements are provided for illustrative purposes only and are not intended to serve as and must not be relied on by any investor or other person as, a guarantee, an assurance, a prediction or a definitive statement of fact or probability. Actual events and circumstances are difficult or impossible to predict and will differ from assumptions. Many actual events and circumstances are beyond the control of KORE. These forward-looking statements are subject to a number of risks and uncertainties, including general economic, financial, legal, political and business conditions and changes in domestic and foreign markets; the potential effects of COVID-19; risks related to the rollout of KORE's business and the timing of expected business milestones; risks relating to the integration of KORE's acquired companies, including the acquisition of Twilio's IoT business, changes in the assumptions underlying KORE's expectations regarding its future business; our ability to negotiate and sign a definitive contract with a customer in our sales funnel; our ability to realize some or all of estimates relating to customer contracts as revenue, including any contractual options available to customers or contractual periods that are subject to termination for convenience provisions; the effects of competition on KORE's future business; and the outcome of judicial proceedings to which KORE is, or may become a party. If the risks materialize or assumptions prove incorrect, actual results could differ materially from the results implied by these forward-looking statements. There may be additional risks that KORE presently does not know or that KORE currently believes are immaterial that could also cause actual results to differ materially from those contained in the forward-looking statements. In addition, forward-looking statements reflect KORE's expectations, plans or forecasts of future events and views as of the date of this press release. KORE anticipates that subsequent events and developments will cause these assessments to change. However, while KORE may elect to update these forward-looking statements at some point in the future, KORE specifically disclaims any obligation to do so. These forward-looking statements should not be relied upon as representing KORE's assessments as of any date subsequent to the date of this press release. Accordingly, undue reliance should not be placed upon the forward-looking statements. KORE Investor Contact: Vik Vijayvergiya Vice President, IR, Corporate Development and Strategy vvijayvergiya@korewireless.com (770) 280-0324 View original content to download multimedia: https://www.prnewswire.com/news-releases/kore-announces-nyse-acceptance-of-plan-to-regain-listing-compliance-302338621.html SOURCE KORE Group Holdings, Inc.
OSAKA, Japan & CAMBRIDGE, Mass.--(BUSINESS WIRE)--Dec 12, 2024-- Takeda ( TSE:4502/NYSE:TAK ) will host an investor R&D Day today beginning at 8:30 a.m. JST in Tokyo. The meeting will focus on programs in the company’s late-stage pipeline, the transformative value they could deliver to patients, and the market opportunities they represent. “We are focused on advancing our innovative pipeline and accelerating late-stage programs to deliver sustainable revenue growth to 2030 and beyond, building upon the strong momentum of our Growth and Launch Products,” said Christophe Weber, Takeda chief executive officer. “The first three Phase 3 programs will read out in 2025, initiating a cadence of potential filings across multiple indications over the next several years.” Eight Regulatory Filings in FY2025 – FY2029 The late-stage pipeline includes oveporexton (TAK-861), zasocitinib (TAK-279), rusfertide (TAK-121), mezagitamab (TAK-079), fazirsiran (TAK-999) and elritercept (TAK-226). Combined these programs have potential peak revenue 1 of $10B - $20B. Data from three Phase 3 programs is expected to read out in 2025: Filings for these three indications are expected in fiscal years 2025 and 2026. Five additional indication filings for late-stage programs are on pace for fiscal years 2027 through 2029: “Takeda has established an exciting, late-stage pipeline of transformative therapies that we believe will deliver value to our company and, most importantly, to the patients we serve around the world,” said Andy Plump, president of R&D at Takeda. “As we continue scaling our capabilities and maximizing R&D investment to deliver the late-stage pipeline, we are also progressing an exciting early-stage pipeline, supporting a cutting-edge research organization, and focusing on creative business development across our therapeutic areas to sustain Takeda’s future and continue to meet significant unmet patient needs.” 2024 R&D Day Agenda The meeting includes the following presentations and speakers: A Global, Innovation-Driven Biopharmaceutical Company Christophe Weber, President & CEO R&D Strategy and Pipeline Highlights Andy Plump, President, Research and Development Neuroscience: Deep-Dive on Orexin Franchise Sarah Sheikh, Head of Neuroscience Therapeutic Area Unit and Head of Global Development Ramona Sequeira, President of Global Portfolio Division Gastrointestinal and Inflammation: Deep-Dive on Zasocitinib, Rusfertide, Mezagitamab, Fazirsiran Chinwe Ukomadu, Head of Gastrointestinal and Inflammation Therapeutic Area Unit Ramona Sequeira, President of Global Portfolio Division Oncology: Deep-Dive on Elritercept – Newly Announced Business Development Deal Teresa Bitetti, President Global Oncology Business Unit P.K. Morrow, Head of Oncology Therapeutic Area Unit Webcast Details A live webcast of the meeting begins at 8:30 a.m. JST December 13 (6:30 p.m. EST December 12). Presentations are available on the Investor Relations section of Takeda’s website where a video replay will be available following the meeting. About Takeda Takeda is focused on creating better health for people and a brighter future for the world. We aim to discover and deliver life-transforming treatments in our core therapeutic and business areas, including gastrointestinal and inflammation, rare diseases, plasma-derived therapies, oncology, neuroscience and vaccines. Together with our partners, we aim to improve the patient experience and advance a new frontier of treatment options through our dynamic and diverse pipeline. As a leading values-based, R&D-driven biopharmaceutical company headquartered in Japan, we are guided by our commitment to patients, our people and the planet. Our employees in approximately 80 countries and regions are driven by our purpose and are grounded in the values that have defined us for more than two centuries. For more information, visit www.takeda.com . Important Notice For the purposes of this notice, “press release” means this document, any oral presentation, any question and answer session and any written or oral material discussed or distributed by Takeda Pharmaceutical Company Limited (“Takeda”) regarding this release. This press release (including any oral briefing and any question-and-answer in connection with it) is not intended to, and does not constitute, represent or form part of any offer, invitation or solicitation of any offer to purchase, otherwise acquire, subscribe for, exchange, sell or otherwise dispose of, any securities or the solicitation of any vote or approval in any jurisdiction. No shares or other securities are being offered to the public by means of this press release. No offering of securities shall be made in the United States except pursuant to registration under the U.S. Securities Act of 1933, as amended, or an exemption therefrom. This press release is being given (together with any further information which may be provided to the recipient) on the condition that it is for use by the recipient for information purposes only (and not for the evaluation of any investment, acquisition, disposal or any other transaction). Any failure to comply with these restrictions may constitute a violation of applicable securities laws. The companies in which Takeda directly and indirectly owns investments are separate entities. In this press release, “Takeda” is sometimes used for convenience where references are made to Takeda and its subsidiaries in general. Likewise, the words “we”, “us” and “our” are also used to refer to subsidiaries in general or to those who work for them. These expressions are also used where no useful purpose is served by identifying the particular company or companies. Forward-Looking Statements This press release and any materials distributed in connection with this press release may contain forward-looking statements, beliefs or opinions regarding Takeda’s future business, future position and results of operations, including estimates, forecasts, targets and plans for Takeda. Without limitation, forward-looking statements often include words such as “targets”, “plans”, “believes”, “hopes”, “continues”, “expects”, “aims”, “intends”, “ensures”, “will”, “may”, “should”, “would”, “could”, “anticipates”, “estimates”, “projects” or similar expressions or the negative thereof. These forward-looking statements are based on assumptions about many important factors, including the following, which could cause actual results to differ materially from those expressed or implied by the forward-looking statements: the economic circumstances surrounding Takeda’s global business, including general economic conditions in Japan and the United States; competitive pressures and developments; changes to applicable laws and regulations, including global health care reforms; challenges inherent in new product development, including uncertainty of clinical success and decisions of regulatory authorities and the timing thereof; uncertainty of commercial success for new and existing products; manufacturing difficulties or delays; fluctuations in interest and currency exchange rates; claims or concerns regarding the safety or efficacy of marketed products or product candidates; the impact of health crises, like the novel coronavirus pandemic, on Takeda and its customers and suppliers, including foreign governments in countries in which Takeda operates, or on other facets of its business; the timing and impact of post-merger integration efforts with acquired companies; the ability to divest assets that are not core to Takeda’s operations and the timing of any such divestment(s); and other factors identified in Takeda’s most recent Annual Report on Form 20-F and Takeda’s other reports filed with the U.S. Securities and Exchange Commission, available on Takeda’s website at: https://www.takeda.com/investors/sec-filings-and-security-reports/ or at www.sec.gov . Takeda does not undertake to update any of the forward-looking statements contained in this press release or any other forward-looking statements it may make, except as required by law or stock exchange rule. Past performance is not an indicator of future results and the results or statements of Takeda in this press release may not be indicative of, and are not an estimate, forecast, guarantee or projection of Takeda’s future results. Peak Sales and PTRS Estimates References in this press release to peak revenue potential ranges are estimates that have not been adjusted for probability of technical and regulatory success (PTRS) and should not be considered a forecast or target. These peak revenue potential ranges represent Takeda’s assessments of various possible future commercial scenarios that may or may not occur. References in this press release to PTRS are to internal estimates of Takeda regarding the likelihood of obtaining regulatory approval for a particular product in a particular indication. These estimates reflect the subjective judgment of responsible Takeda personnel and have been approved by Takeda’s Portfolio Review Committee for use in internal planning. Medical Information This press release contains information about products that may not be available in all countries, or may be available under different trademarks, for different indications, in different dosages, or in different strengths. Nothing contained herein should be considered a solicitation, promotion or advertisement for any prescription drugs including the ones under development. Elritercept license agreement Elritercept is included for reference only. Takeda entered into an exclusive license agreement with Keros for global rights, in all territories outside of mainland China, Hong Kong and Macau, to Elritercept. The closing of the transaction is subject to receipt of regulatory approval(s), expected in the first calendar quarter of 2025. Takeda does not currently have rights to Elritercept. ___________________________ 1 References in this presentation to peak revenue potential are estimates that have not been adjusted for probability of technical and regulatory success (PTRS) and should not be considered a forecast or target. These peak revenue ranges represent Takeda’s assessments of various possible future commercial scenarios that may or may not occur. View source version on businesswire.com : https://www.businesswire.com/news/home/20241211148492/en/ CONTACT: Investor Relations Christopher O’Reilly Christopher.oreilly@takeda.com +81 (0) 90-6481-3412 Takeda Media Relations media_relations@takeda.com KEYWORD: MASSACHUSETTS UNITED STATES JAPAN NORTH AMERICA ASIA PACIFIC INDUSTRY KEYWORD: ONCOLOGY HEALTH NEUROLOGY CLINICAL TRIALS PHARMACEUTICAL BIOTECHNOLOGY SOURCE: Takeda Pharmaceutical Company Limited Copyright Business Wire 2024. PUB: 12/12/2024 05:30 PM/DISC: 12/12/2024 05:30 PM http://www.businesswire.com/news/home/20241211148492/en
Will Indiana beat Ohio State? Can Oregon State upset Washington State? Our Week 13 CFB picks
Giants' 10th straight loss showed once again that they need a young QBPresident Bola Tinubu has emphasized the need to tackle the root causes of corruption in Nigeria, advocating for systemic solutions that address the socio-economic factors driving the menace. Don't miss out! Join Legit.ng's Sports News channel on WhatsApp now! During his first presidential media chat, Tinubu underscored the importance of improving living conditions, ensuring access to social amenities, and providing fair wages to reduce corruption in all its forms. He believes that creating an environment where citizens have access to basic necessities and opportunities will significantly reduce the temptation to engage in corrupt activities. Tinubu identified a lack of social amenities and inadequate funding for education as key factors that push people toward corrupt practices. He highlighted the importance of ensuring that workers receive a living wage, citing his increase in the minimum wage as a step in the right direction. The President stressed that his administration is focused on making tough but necessary decisions to stabilize the economy , including tackling corruption at its roots. He also reiterated his belief in the power of free market forces to address economic challenges, emphasizing that price control is not the solution to soaring prices of goods and services. Read also Tax reform bills: Tinubu declares readiness to make concessions According to the president, one of the Economic and Financial Crimes Commission's (EFCC) responsibilities was to block all loopholes in government ministries, agencies, and parastatals. The president reiterated that corruption can not be eradicated but can be brought to the lowest level. See the video of the media chat here: PAY ATTENTION: Follow us on Instagram - get the most important news directly in your favourite app! Source: Legit.ng
Metro moversTrump brushes off Ontario threat to pull U.S. energy plug as booze ban pondered
Players must be assigned female at birth or have transitioned to female before going through male puberty to compete in LPGA tournaments or the eight USGA championships for females under new gender policies published Wednesday. The policies, which begin in 2025, follow more than a year of study involving medicine, science, sport physiology and gender policy law. The updated policies would rule out eligibility for Hailey Davidson, who missed qualifying for the U.S. Women's Open this year by one shot and came up short in LPGA Q-school. Davidson, who turned 32 on Tuesday, began hormone treatments when she was in her early 20s in 2015 and in 2021 underwent gender-affirming surgery, which was required under the LPGA's previous gender policy. She had won this year on a Florida mini-tour called NXXT Golf until the circuit announced in March that players had to be assigned female at birth. People are also reading... “Can't say I didn't see this coming,” Davidson wrote Wednesday on an Instagram story. “Banned from the Epson and the LPGA. All the silence and people wanting to stay ‘neutral’ thanks for absolutely nothing. This happened because of all your silence.” LPGA commissioner Mollie Marcoux Samaan, who is resigning in January, said the new gender policy "is reflective of an extensive, science-based and inclusive approach." By making it to the second stage of Q-school, Davidson would have had very limited status on the Epson Tour, the pathway to the LPGA. The LPGA and USGA say their policies were geared toward being inclusive of gender identities and expression while striving for equity in competition. The LPGA said its working group of experts advised that the effects of male puberty allowed for competitive advantages in golf compared with players who had not gone through puberty. “Our policy is reflective of an extensive, science-based and inclusive approach,” said LPGA Commissioner Mollie Marcoux Samaan, who announced Monday that she is resigning in January. "The policy represents our continued commitment to ensuring that all feel welcome within our organization, while preserving the fairness and competitive equity of our elite competitions.” Mike Whan, the former LPGA commissioner and now CEO of the USGA, said it developed the updated policy independently and later discovered it was similar to those used by swimming, track and field, and other sports. United States Golf Association CEO Mike Whan said the new policy will prevent anyone from having "a competitive advantage based on their gender." “It starts with competitive fairness as the North star,” Whan said in a telephone interview. “We tried not to get into politics, or state by state or any of that stuff. We just simply said, ‘Where would somebody — at least medically today — where do we believe somebody would have a competitive advantage in the field?’ And we needed to draw a line. “We needed to be able to walk into any women's event and say with confidence that nobody here has a competitive advantage based on their gender. And this policy delivers that.” The “Competitive Fairness Gender Policy” for the USGA takes effect for the 2025 championship season that starts with the U.S. Women's Amateur Four-Ball on May 10-14. Qualifying began late this year, though there were no transgender players who took part. “Will that change in the years to come as medicine changes? Probably,” Whan said. “But I think today this stacks up.” The LPGA “Gender Policy for Competition Eligibility” would apply to the LPGA Tour, Epson Tour, Ladies European Tour and qualifying for the tours. Players assigned male at birth must prove they have not experienced any part of puberty beyond the first stage or after age 12, whichever comes first, and then meet limitation standards for testosterone levels. The LPGA begins its 75th season on Jan. 30 with the Tournament of Champions in Orlando, Florida. Sports Week in Photos: NBA Cup, NFL snow game and more Houston Rockets guard Jalen Green goes up for a dunk during the second half of an Emirates NBA cup basketball game against the Minnesota Timberwolves, Tuesday, Nov. 26, 2024, in Minneapolis. (AP Photo/Abbie Parr) Mari Fukada of Japan falls as she competes in the women's Snowboard Big Air qualifying round during the FIS Snowboard & Freeski World Cup 2024 at the Shougang Park in Beijing, Saturday, Nov. 30, 2024. (AP Photo/Andy Wong) LSU punter Peyton Todd (38) kneels in prayer before an NCAA college football game against Oklahoma in Baton Rouge, La., Saturday, Nov. 30, 2024. LSU won 37-17. (AP Photo/Gerald Herbert) South Africa's captain Temba Bavuma misses a catch during the fourth day of the first Test cricket match between South Africa and Sri Lanka, at Kingsmead stadium in Durban, South Africa, Saturday, Nov. 30, 2024. (AP Photo/Themba Hadebe) Philadelphia Eagles running back Saquon Barkley, left, is hit by Baltimore Ravens cornerback Marlon Humphrey, center, as Eagles wide receiver Parris Campbell (80) looks on during a touchdown run by Barkley in the second half of an NFL football game, Sunday, Dec. 1, 2024, in Baltimore. (AP Photo/Stephanie Scarbrough) Olympiacos' Francisco Ortega, right, challenges for the ball with FCSB's David Miculescu during the Europa League league phase soccer match between FCSB and Olympiacos at the National Arena stadium, in Bucharest, Romania, Thursday, Nov. 28, 2024. (AP Photo/Andreea Alexandru) Brazil's Botafogo soccer fans react during the Copa Libertadores title match against Atletico Mineiro in Argentina, during a watch party at Nilton Santos Stadium, in Rio de Janeiro, Saturday, Nov. 30, 2024. (AP Photo/Bruna Prado) Seattle Kraken fans react after a goal by center Matty Beniers against the San Jose Sharks was disallowed due to goaltender interference during the third period of an NHL hockey game Saturday, Nov. 30, 2024, in Seattle. The Sharks won 4-2. (AP Photo/Lindsey Wasson) New York Islanders left wing Anders Lee (27), center, fight for the puck with Boston Bruins defensemen Parker Wotherspoon (29), left, and Brandon Carlo (25), right during the second period of an NHL hockey game, Wednesday, Nov. 27, 2024, in Elmont, N.Y. (AP Photo/Julia Demaree Nikhinson) Jiyai Shin of Korea watches her shot on the 10th hole during the final round of the Australian Open golf championship at the Kingston Heath Golf Club in Melbourne, Australia, Sunday, Dec. 1, 2024. (AP Photo/Asanka Brendon Ratnayake) Mathilde Gremaud of Switzerland competes in the women's Freeski Big Air qualifying round during the FIS Snowboard & Freeski World Cup 2024 at the Shougang Park in Beijing, Friday, Nov. 29, 2024. (AP Photo/Andy Wong) Lara Gut-Behrami, of Switzerland, competes during a women's World Cup giant slalom skiing race, Saturday, Nov. 30, 2024, in Killington, Vt. (AP Photo/Robert F. Bukaty) New York Islanders goaltender Ilya Sorokin cools off during first period of an NHL hockey game against the Boston Bruins, Wednesday, Nov. 27, 2024, in Elmont, N.Y. (AP Photo/Julia Demaree Nikhinson) Brazil's Amanda Gutierres, second right, is congratulated by teammate Yasmin, right, after scoring her team's first goal during a soccer international between Brazil and Australia in Brisbane, Australia, Thursday, Nov. 28, 2024. (AP Photo/Pat Hoelscher) Las Vegas Raiders tight end Brock Bowers (89) tries to leap over Kansas City Chiefs cornerback Joshua Williams (2) during the first half of an NFL football game in Kansas City, Mo., Friday, Nov. 29, 2024. (AP Photo/Ed Zurga) Luiz Henrique of Brazil's Botafogo, right. is fouled by goalkeeper Everson of Brazil's Atletico Mineiro inside the penalty area during a Copa Libertadores final soccer match at Monumental stadium in Buenos Aires, Argentina, Saturday, Nov. 30, 2024. (AP Photo/Natacha Pisarenko) England's Alessia Russo, left, and United States' Naomi Girma challenge for the ball during the International friendly women soccer match between England and United States at Wembley stadium in London, Saturday, Nov. 30, 2024. (AP Photo/Kirsty Wigglesworth) Gold medalists Team Netherlands competes in the Team Sprint Women race of the ISU World Cup Speed Skating Beijing 2024 held at the National Speed Skating Oval in Beijing, Sunday, Dec. 1, 2024. (AP Photo/Ng Han Guan) Minnesota Vikings running back Aaron Jones (33) reaches for an incomplete pass ahead of Arizona Cardinals linebacker Mack Wilson Sr. (2) during the second half of an NFL football game Sunday, Dec. 1, 2024, in Minneapolis. (AP Photo/Abbie Parr) Buffalo Bills quarterback Josh Allen, foreground right, dives toward the end zone to score past San Francisco 49ers defensive end Robert Beal Jr. (51) and linebacker Dee Winters during the second half of an NFL football game in Orchard Park, N.Y., Sunday, Dec. 1, 2024. (AP Photo/Adrian Kraus) South Carolina guard Maddy McDaniel (1) drives to the basket against UCLA forward Janiah Barker (0) and center Lauren Betts (51) during the first half of an NCAA college basketball game, Sunday, Nov. 24, 2024, in Los Angeles. (AP Photo/Eric Thayer) Los Angeles Kings left wing Warren Foegele, left, trips San Jose Sharks center Macklin Celebrini, center, during the third period of an NHL hockey game Monday, Nov. 25, 2024, in San Jose, Calif. (AP Photo/Godofredo A. Vásquez) Melanie Meillard, center, of Switzerland, competes during the second run in a women's World Cup slalom skiing race, Sunday, Dec. 1, 2024, in Killington, Vt. (AP Photo/Robert F. 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Tech billionaire Elon Musk spent at least $270 million to help Donald Trump win the US presidency, according to new federal filings, making him the country's biggest political donor. SpaceX and Tesla CEO Musk, the world's richest person, was an ardent supporter of Trump's White House campaign -- funneling money into door knocking operations and speaking at his rallies. His financial backing, which has earned him a cost-cutting advisory role in Trump's incoming government, surpassed spending by any single political donor since at least 2010, according to data from nonprofit OpenSecrets. The Washington Post reported that Musk spent more this election cycle than Trump backer Tim Mellon, who gave nearly $200 million and was previously the Republican's top donor. Musk donated $238 million to America PAC, a political action committee that he founded to support Trump, filings late Thursday with the Federal Election Commission showed. An additional $20 million went to the RBG PAC, a group that used advertising to soften Trump's hardline reputation on the key voter issue of abortion. Musk has been an ever-present sidekick for Trump since his election victory in November, inviting him to watch a rocket launch in Texas by his SpaceX company. Trump has selected the South African-born tycoon and fellow ally Vivek Ramaswamy to head the so-called Department of Government Efficiency, through which the pair have promised to deliver billions of dollars of cuts in federal spending. However, with Musk's businesses all having varying degrees of interactions with US and foreign governments, his new position also raises concerns about conflict of interest. The president-elect has nominated several people close to Musk for roles in his administration, including investor David Sacks as the so-called AI and crypto czar. Meanwhile, billionaire astronaut Jared Isaacman, who has collaborated with Musk's SpaceX, was named the head of US space agency NASA. pgf-bjt/acbArticle content Odds are, you’ve seen — or maybe even worn — a pair of running shoes lately. Since launching 14 years ago, the Swiss brand has gone from being a favourite for runners in the know, to an option for anyone looking for innovation and performance from their active wear. and celebrity support has undoubtedly helped spur this popularity. We caught up with Dan Schade, general manager of On Americas, to learn more about the buzzy brand. On is a premium global sportswear brand. We create products that are rooted in innovation and performance and inspire people to move, including footwear, apparel and accessories. Founded in 2010 in Switzerland, On was created with the goal to revolutionize the sensation of running and bring something entirely new to runners around the world. Since then, we have expanded our innovations to include performance footwear, apparel and accessories for running, outdoor, training, all-day activities and tennis. Our target customer is anyone who enjoys movement. Whether you are a professional athlete, just kicking off your running journey, or making your mark on the tennis court, On is built on a shared love of movement. Each partnership and collaboration at On is about more than just a project. For On, it’s about connecting with like-minded individuals who inspire movement in every sense of the word and also have an authentic connection and love for our brand. Whether it’s Zendaya or Roger Federer, On is inspired by the people and brands who align with our values. Zendaya was an organic fan of On and we had seen her wearing our sneakers over the past few years. We were inspired by how she stays true to her beliefs by advocating for physical and mental well-being along with her passion for connecting with communities, both things that are very core to On’s DNA. So when we saw an opportunity to collaborate with her, we jumped on it. We are excited to see what the future holds. Our partners are also more than just ambassadors or spokespeople, they play a crucial and active role in brand decisions. With our partnership with Roger Federer, for example, he brought in his unique experience to help take tennis product development, marketing and fan experiences to new levels. The partnership was built on a mutual love for On’s products and shared passion for innovation and design. We also partner with athletes all over the world to ensure their input is incorporated into every aspect of our products, from the design to the technical specifications. In a way, we do not design product; we design how an athlete feels. Hellen Obiri, for instance, was an integral part of our newest Cloudboom Strike LS, the first shoe to feature our LightSpray technology. Hellen was the first woman to win the Boston Marathon back-to-back in nearly two decades, and she wore our shoe in the Paris Olympics, where she took home bronze. Our most notable launch of the year is , a high performance upper technology crafted by a revolutionary single-step manufacturing process. LightSpray ultralight uppers are sprayed — not built — by an automated robotic arm at our On Labs in Zurich. The process reduces CO2 emissions, paving the way for a circular future and faster, localized manufacturing. LightSpray is set to revolutionize performance uppers in the same way On CloudTec transformed midsoles, introducing a completely new design esthetic and feel. Not only that, but it has the potential to revolutionize all kinds of wearable products in the sportswear industry. The Cloudboom Strike LS is the first On shoe made with LightSprayT technology. The ultrathin LightSpray upper is precision-made for support, adaptable to the foot, seamless, and lace-free, resulting in an exceptionally lightweight, high-performance shoe weighing just 170g. To learn more about our story, products, technology and mission, visit
Keith Higgins Jr. scores 22 to lead Lehigh to 87-67 victory over Neumann