Lions rush for 3 scores and use stingy defense to beat Colts 24-6 for 9th straight winMOUNTAIN VIEW, Calif., Dec. 03, 2024 (GLOBE NEWSWIRE) -- NeuroPace, Inc. (Nasdaq: NPCE), a commercial-stage medical device company focused on transforming the lives of people living with epilepsy, today announced completion of enrollment and implant procedures in its feasibility investigational device exemption (IDE) study of the RNS® System for the treatment of Lennox-Gastaut Syndrome (LGS), a devastating form of childhood-onset epilepsy characterized by cognitive dysfunction and frequent generalized onset seizures that often lead to injury. The IDE study uses the RNS System, which has demonstrated safety and effectiveness of brain-responsive stimulation for treating medically intractable focal onset seizures in people 18 and older, to evaluate whether brain-responsive neurostimulation can also be used to treat LGS. NeuroPace received a $9.3 million National Institutes of Health (NIH) grant through the Brain Research through Advancing Innovative Neurotechnologies® (BRAIN) Initiative to evaluate its responsive neuromodulation technology in those who suffer from LGS. The IDE study funded by the grant was conducted at six sites and enrolled a total of 20 patients 12 years of age and older with LGS and drug-resistant generalized onset seizures. The study will evaluate the safety and effectiveness of the RNS System in treating seizures associated with LGS. “We are pleased to announce the advancement of our LGS IDE study and look forward to the data and learnings it provides. The results from this study could support further research of RNS therapy to improve the treatment of people with LGS. We appreciate the dedicated efforts of the investigators, research teams, participants and their families,” said Martha Morrell, MD, Chief Medical Officer of NeuroPace. “After completing the one-year open label period, participants will transition to the long-term follow-up period, which will continue over the next 18 months.” "LGS is a devastating, childhood-onset seizure disorder that leads to lifelong disability. 85% of those with LGS continue to have seizures into adulthood despite aggressive treatment, 98% suffer from intellectual disability, and they are 12 times more likely to die prematurely than others their age," said Tracy Dixon-Salazar, PhD, Executive Director of the LGS Foundation and mother of an adult living with LGS. "LGS families desperately need innovative treatment options to manage their seizures, and we are excited about this new study." Disclaimer: Research reported in this press release was supported by the National Institutes of Health’s Brain Research Through Advancing Innovative Neurotechnologies (BRAIN) Initiative under award number UH3NS109557. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. About the RNS® System The RNS® System, a paradigm-shifting treatment for drug-resistant focal epilepsy, is the only brain-responsive neuromodulation system approved by the FDA. The closed-loop technology delivers personalized, data-driven treatment targeted to the seizure source by continuously monitoring brain activity, recognizing a patient’s unique seizure pattern, and responding in real-time with imperceptible stimulation to prevent seizures. By recording ongoing EEG data, the RNS System provides physicians with a unique “window to the brain,” enabling them to remotely monitor their patients, gain insights based on brain activity, and use that information to optimize patient care. Long-term clinical studies demonstrate that the RNS System provides significant reduction in seizure frequency and enduring improvements in quality of life and cognition with no stimulation-related side effects. The RNS System is available at most comprehensive epilepsy centers in the United States and is widely covered by insurance. It is currently approved in the United States as an adjunctive therapy for patients 18 years of age and older with drug-resistant focal epilepsy. See full indication for use and important safety information at www.neuropace.com/safety/ . About NeuroPace, Inc. Based in Mountain View, Calif., NeuroPace is a commercial-stage medical device company focused on transforming the lives of people living with epilepsy by reducing or eliminating the occurrence of debilitating seizures. Its novel and differentiated RNS System is the first and only commercially available, brain-responsive platform that delivers personalized, real-time treatment at the seizure source. This platform can drive a better standard of care for patients suffering from drug-resistant epilepsy and has the potential to offer a more personalized solution and improved outcomes to the large population of patients suffering from other brain disorders. Forward Looking Statements This press release may contain forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. These statements may be identified by words such as “aims,” “anticipates,” “believes,” “could,” “estimates,” “expects,” “forecasts,” “goal,” “intends,” “may,” “plans,” “possible,” “potential,” “seeks,” “will” and variations of these words or similar expressions that are intended to identify forward-looking statements, although not all forward-looking statements contain these words. Actual results or events could differ materially from the plans, intentions and expectations disclosed in these forward-looking statements as a result of various factors, including: risks related to regulatory compliance and expectations for regulatory approvals to expand the market for NeuroPace’s RNS System and other important factors. These and other risks and uncertainties include those described more fully in the section titled “Risk Factors” and “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and elsewhere in NeuroPace’s public filings with the U.S. Securities and Exchange Commission (SEC), including its Quarterly Report on Form 10-Q for the quarter ended September 30, 2024, filed with the SEC on November 12 , 2024, as well as any other reports that it may file with the SEC in the future. Forward-looking statements contained in this announcement are based on information available to NeuroPace as of the date hereof. NeuroPace undertakes no obligation to update such information except as required under applicable law. These forward-looking statements should not be relied upon as representing NeuroPace’s views as of any date subsequent to the date of this press release and should not be relied upon as a prediction of future events. In light of the foregoing, investors are urged not to rely on any forward-looking statement in reaching any conclusion or making any investment decision about any securities of NeuroPace. Investor Contact: Jeremy Feffer Managing Director LifeSci Advisors jfeffer@lifesciadvisors.com
SEOUL, South Korea — South Korean President Yoon Suk Yeol said he will lift his martial law decree, giving in to the parliament’s opposition, just hours after his dramatic move imposing it Tuesday. Yoon said in a televised address early Wednesday that he will “accept the National Assembly’s demand and lift the martial law through a cabinet meeting,” which he said he had called but its members hadn’t yet arrived. He will immediately lift the martial law when they convene, he said. Yoon, 63, stunned the nation, lawmakers and investors earlier by declaring martial law in a high-stakes move he claimed would prevent the opposition from trying to paralyze his administration amid a political rift that is set to deepen markedly. The South Korean leader’s political future will be put to test after his daring move, which caught even his fellow party members and foreign allies like the U.S. by surprise. “I request the National Assembly to immediately stop the reckless acts of paralyzing the functions of the state through repeated impeachments, legislative manipulation, and budget manipulation,” Yoon said in his earlier televised address. After Yoon announced he would lift the decree, South Korea’s Joint Chiefs of Staff said its troops that had been mobilized for the martial law declaration have returned to their original posts as of 4:22 a.m., Yonhap reported. No unusual activities have been spotted from North Korea, it added. The move was viewed by analysts as a risky political play that was likely to backfire rather than an attempt to return to military-led regimes of the past. With his own government and party kept in the dark alongside the U.S. and other friendly nations, Yoon created a chaotic moment that left him isolated and even further from controlling the political agenda going forward. Early Wednesday morning, 190 lawmakers in the 300-seat parliament unanimously voted to demand the lifting of martial law. The president had said his move was intended to protect freedom and constitutional order, that it wouldn’t have an impact on South Korea’s foreign policy, and that it would help eradicate the influence of North Korean supporters. A proclamation released after the address banned all political activities and strikes and said media would be subject to control of the Martial Law Command. Korean assets were battered during New York trading. The won suffered its sharpest drop since the global financial crisis to hit 1444.65 its lowest in over two years, before paring losses. Samsung Electronics’ London-listed shares fell as much as 7.2% then regained some ground. The finance minister and central bank chief met and promised to provide unlimited liquidity to markets if needed. The Bank of Korea will meet early Wednesday, just a week after a surprise rate cut partly triggered by heightened uncertainty generated by U.S. President-elect Donald Trump’s election victory. Adding to the sense of chaos, the nation’s largest union federation called a general strike in defiance of Yoon’s order. The shock announcement to impose martial law for the first time since the democratization of South Korea in 1987 caught even Yoon’s own party off guard. Han Dong-hoon, leader of Yoon’s People Power Party, condemned the move and vowed to stop it, in a sign of the president’s increasing isolation and his lack of consultation. The move also surprised the White House, prompting Deputy Secretary of State Kurt Campbell to say that the Biden administration was watching the developments with “grave concern.” Yoon’s abrupt decision came after months of wrangling and deadlock in parliament between the president’s minority government and the main opposition Democratic Party, but with little expectation that the president would take such a drastic step. The opposition has been trying to force its budget proposal through parliament and has submitted an impeachment motion against the chief prosecutor after months of also trying to get Yoon’s wife prosecuted. Adding to the fractious political rift, the DP’s leader has faced multiple court cases and was convicted last month of election-law violations, barring him from running for president if it is finalized. Amid the political standoff, Yoon had vetoed a string of bills passed by parliament and at times angering his own party. His latest act ramped up tensions considerably domestically, while also creating high uncertainty abroad for the outlook of one of the world’s key suppliers of semiconductors and a stalwart U.S. ally in an increasingly complex security environment in Asia. Even though the martial law order lasted less than a day, the political instability it will generate is set to last two or three years, according to Lee Won-Jae, a sociology professor at at Kaist Graduate School of Culture Technology in Daejeon. “Martial law has lost its effect, so from this moment on, all state institutions exercising physical force, including the military and police of the Republic of Korea, are obligated not to follow unlawful or unfair instructions,” Han, the leader of Yoon’s party, said in a Facebook post. Yoon’s moves came at a time of high uncertainty for the nation as its trade-dependent economy faces potential tariffs from Trump’s incoming U.S. administration. Bloomberg Economics estimates that full imposition of tariffs on China, South Korea and other U.S. trading partners could reduce Seoul’s exports to the U.S. by as much as 55%. Meanwhile, North Korea continues to present a security concern as it deepens its ties with Russia, having sent thousands of troops there to help in Moscow’s war against Ukraine. Russia’s defense minister visited Pyongyang last week in the latest sign of talks between the two countries. Russia may help provide North Korea key technology for its weapons programs including its intercontinental ballistic missiles. “We shouldn’t be fooled — this has nothing at all to do with North Korea and all to do with domestic politics,” said Defense Priorities Fellow Daniel DePetris. China suggested its citizens residing in South Korea keep calm and try to avoid going outdoors for anything non-essential, the country’s embassy said in a post on social media Tuesday night. The embassy also asked Chinese citizens to comply with official orders from the Korean government and “use caution” over sharing political opinions. “The domestic uncertainty adds to the external pressures in recent weeks as the market is starting to price in the rise of higher U.S. tariffs under the new Trump administration,” said Aroop Chatterjee, a strategist at Wells Fargo. “Korea is an open economy sensitive to shifts in global export demand and spillovers from a weaker China.” While it remains to be seen if the short-lived declaration of martial law will have a lasting impact on markets and the economy, Yoon’s high-stakes move is certain to knock confidence in his leadership and his reliability as a bullwark of democracy in a nation with many authoritarian neighbors. “U.S. officials look to South Korea now as a beacon of democracy so for a president to pull a fast one like this is certainly shocking and unprecedented,” said DePetris. Bank of Korea’s monetary board, which unexpectedly cut the key rate last week, will also hold an extraordinary meeting Wednesday morning to discuss steps to shield the economy and markets. “From a near-term policy standpoint, apart from the market disruptions, uncertainty could also arise in the event of cabinet changes,” Goldman Sachs Group Inc. analysts Goohoon Kwon and Kamakshya Trivedi wrote in a note Tuesday. (With assistance from Maria Elena Vizcaino.) ©2024 Bloomberg L.P. Visit bloomberg.com. Distributed by Tribune Content Agency, LLC.15 Picks up to 60% Off from the Victoria's Secret Semi-Annual Sale — Today Only!
NoneOur community members are treated to special offers, promotions and adverts from us and our partners. You can check out at any time. More info Caolan Boyd-Munce admits his late strike against Rangers was a satisfying one for him personally after a challenging few months. St Mirren clinched the three points late-on in Paisley on Boxing Day thanks to a perfect goal from Boyd-Munce which saw the Buddies win 2-1. And while it was sweet for Buddies fans after a 13-year wait to see a league win on home soil over the Glasgow giants, it was extra special for the Northern Irish matchwinner. With the recent birth of baby son Roux, the 24-year-old admits that it has been a challenging few months for him and partner Joanne. “It meant a lot,” he said. “I had my little baby born in September and it felt a little bit like when the world gets on top of you. Even though it’s not; it’s not big issues but it does. It feels like it, especially with a little one coming. “You have always got that little bit of pressure and you don’t know when the next good moment is going to come. Renfrewshire Live, the new free app dedicated to bringing you around the clock breaking news, is now available to download. Powered by the Paisley Daily Express, Renfrewshire Live is your go-to source for news, features and sport with live coverage provided direct to the app, seven days a week. The dedicated team of experienced journalists, responsible for the publication of the award-winning Express, will focus on breaking news, day and night, across Renfrewshire’s towns and villages. There is also a dedicated St Mirren section that will follow every kick of the ball with the Buddies. Available on both Android and Apple. D ownload here: smarturl.it/RenfrewLiveSocial “It’s a strange feeling, you’re dreaming about it and everything. So, when that went in, the relief kind of just left me a little bit. It was class. All he [baby Roux] does is smile, to be fair. He’s probably crying because he’s seen it go in. That’s when it changes!” Victory over Rangers means it's three wins on the bounce for Saints who are sitting nicely within the Premiership's top six ahead of Sunday's visit of Dundee. They are six points clear of Hibernian in seventh place, who notched up a huge win over their city rivals Hearts, and are also seven points off faltering Aberdeen in third place. And Boyd-Munce says the late goals plundered in recent games with St Johnstone, Ross County and Gers is a show of character from his team-mates – even when the chips are down. Boyd-Munce said: “It’s character, isn’t it? Even last year, to be fair, I think the Aberdeen game last year summed it up when Toyosi [Olusanya] scored the last-minute winner. “It’s one thing we’ve always got. I don’t think anyone’s ever really questioned that, whether they’ve come out and questioned other things. But especially when it’s people like Oisin [Smyth] who hasn’t played much. “He waited for his chance, two games in a row he’s scored. A winner against Ross County as well. I think it shows that everyone has to be ready, everyone has been ready and, yeah, it’s testament to character. Boyd-Munce added of the build up to his goal: “As soon as he [Evan Mooney] set it to me, I was like: ‘I can’t miss this’. “I do it all week in training, then get to the game and never get the chance to shoot. So, I was like, ‘do you know what, today, I’m just making the box’. “As soon as I hit it I knew. You knew about it as soon as the ball went in, you heard the noise. I don’t know if it was just because it was Christmas or what! But you felt it.” Don't miss the latest Renfrewshire headlines – sign up to our free daily newsletter here
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Instead of just being proud of working for MNCs, Indians are now daring to create their own multinational companies, he reiterated. New Delhi: Indians are increasingly daring to create their own multinational companies, in a defining change that will fuel next stage of economic growth, asserted Union Minister Hardeep Singh Puri on Sunday. The Union Minister also emphasized that India needs to further nurture talent in deeptech domains to hasten the reversal of 'brain drain'. "We have always had good talent, but have also lamented that our youngsters leave India to pursue work and studies abroad," he wrote in a post on X, sharing an article he authored for a financial daily titled 'India, take a deeptech breath.' "The trend is now noticeably reversing - a significant victory in its own right. Indians are coming back or even deciding to stay put when offered enticing opportunities abroad so that they can build in India, for the world," he added. Puri noted that India's startup success is the cumulative effect of such individual decisions, the full magnitude of which will be realised by the coming generations. For many decades, Puri argued, while Indian engineers and scientists were recognized for their talent and dedication in global technology companies and universities, they couldn't dare to incubate their tech startups in India. This, according to him, were due to onerous patents framework, lack of funding, crumbling infrastructure and lack of government support. "As a result of the dedicated focus of PM Narendra Modi in making India a hub for innovation, even the most cutting edge, deep tech and frontier tech start ups, lead by Indian students with PhDs from major global universities are now taking root in India," Puri explained in his post. Instead of just being proud of working for MNCs, Indians are now daring to create their own multinational companies, he reiterated. The National Deeptech Startup Policy outlines a roadmap to spur innovation in critical domains like semiconductors, AI, and space tech. AI is so widespread in India's software services now. Puri pointed out that it is no coincidence, that India now has the third-largest start-up ecosystem in the world. Stay informed on all the latest news , real-time breaking news updates, and follow all the important headlines in india news and world News on Zee News.‘It brings back memories of Aberfan’: coal tip collapse in storms sparks revolt in Welsh valley
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British government officials have held two high-level, secret security meetings in the wake of mysterious drone activity over American air bases in England. That has led Borough President Vito Fossella to slam U.S. officials for their lack of transparency over drone activity in the United States. “What are we waiting for?” the borough president said in a prepared statement. The Times of London reported that two secret meetings of the Civil Contingencies Committee have been held by top U.K. officials after mystery drones buzzed American air bases in England. Concerns were heightened because the drones had technology so sophisticated that authorities have been unable to track them or identify those responsible, the Times said. Military officials have not ruled out the involvement of a hostile state but have expressed alarm that it has so far proved impossible to find the pilots responsible for controlling the drones. It was said that the drones were not programmed but were controlled in real time by live operators. Also known as COBRA or COBR, the meetings are convened to handle matters of national emergency or major disruption. Its purpose is to coordinate different departments and agencies in response to such emergencies. The meetings are held in the Cabinet Office Briefing Room in London and include top officials, including sometimes the British prime minister. “Our concern, from day one, has been the lack of transparency and clear understanding of these vast drone sightings,” Fossella said. “There were reports that even President Biden made attempts to determine what they were, and those attempts resulted in no credible information.” Said Fossella, “Each time our concerns are raised, we are told there is no public safety risk, even as our closest ally in Europe assesses the possibility that these drones may be operated by a foreign adversary.” He said, “If the United Kingdom can take this concern of public safety seriously, so can we. The federal government needs to do the right thing, sooner than later, and give the American public the answers they deserve.” The U.S. drone sightings were first reported in New Jersey five weeks ago and have spread to other parts of the country, including Staten Island and military bases across the U.S. Mystery drones have also been spotted over a U.S. military base in Germany. The Federal Aviation Administration has banned drones over certain areas of the country, including Staten Island, and has warned that deadly force could be used against operators who break the ban. Most Popular Stories by Tom WrobleskiAnge Postecoglou searching for answers over Tottenham’s injury crisis(The Center Square) – House Oversight Chair Rep. James Comer, R-Ky., has opened an investigation into the Federal Emergency Management Agency over reports that it discriminated against supporters of Donald Trump. Comer said whistleblower reports suggest anti-Trump discrimination is rampant and has been going on for years. “[O]n the condition of anonymity, a FEMA official stated that the practice avoiding ‘white or conservative-dominated’ areas is an ‘open secret at the agency that has been going on for years,’” Comer said in a letter to FEMA. The investigation comes after FEMA fired one of its hurricane response supervisors after news went viral that she told her workers to avoid “Trump houses.” However, that employee has publicly said she was only following orders and acting according to the culture at FEMA. Comer and more than two dozen Republican lawmakers sent a letter to FEMA Administrator Deanne Criswell demanding documentation, from internal policies to spending figures to incident reports. Lawmakers have pointed toward more anonymous sources backing up the fired employee’s claims. “Additionally, another whistleblower contacted the Committee during the hearing," the letter said. "This individual informed the Committee that a FEMA contractor warned a disabled veteran’s family in Georgia to remove Trump campaign materials from their home because FEMA supervisors viewed Trump supporters as domestic terrorists. At a hearing this week, U.S. Rep. Greg Steube, R-Fla., pointed to 35 of his constituents who shared similar stories with him. Lawmakers grilled Criswell over the discrimination reports at the hearing as well as FEMA’s recent focus on Diversity Equity and Inclusion efforts, something FEMA named as its number one goal in its latest strategic report. Lawmakers also raised concerns about the agency spending hundreds of millions of dollars on helping migrants. Defenders of FEMA have said the migrant funds do not take directly from disaster relief, while critics insist it shows missplaced priorities for the emergency relief agency. “In the fiscal year of 2023, FEMA spent nearly a billion dollars, $789 million, to shelter illegals in the United States,” Rep. Marjorie Taylor Green, R-Ga., said at the hearing, as The Center Square previously reported . “This past year it was $641 million, and this money is largely distributed through NGOs...and this was to house illegal aliens," she added. "Not Americans, who by the way all that money, that comes from Americans bank accounts when they write their checks to pay their taxes." At the hearing this week, Criswell also said she will request the Inspector General investigate the question of political discrimination at FEMA. She also said she does not think this fired employee is indicative of a broader problem in the agency but is looking into it. Criswell said FEMA workers went back to the homes that were skipped over by the fired employee and promised to ensure it doesn't happen again. “The Committee is in the process of investigating these claims,” the Oversight letter said. “If they are true, they would corroborate concerns that political discrimination extends beyond [the fired FEMA employee]. Furthermore, they suggest an apparent culture, whether sanctioned or not, within FEMA to politically discriminate against disaster survivors, specifically those who support President-elect Donald Trump.”