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2025-01-26
Plans Required to Cover Treatment for SOD1-ALS ARLINGTON, Va. , Dec. 11, 2024 /PRNewswire/ -- The Centers for Medicare & Medicaid Services (CMS) has announced a first-of-its-kind directive requiring Medicare Advantage plans to approve coverage for Qalsody, a treatment for people living with genetic SOD1-ALS. This decision reflects the ALS Association's commitment to ensuring that people living with ALS have access to promising ALS treatments without delay. "This is a victory for the entire ALS community," said Calaneet Balas, president and CEO of the ALS Association. "It's critical that FDA-approved treatments are made accessible rather than being labeled as 'experimental.' We are grateful to everyone in our community who helped make this day happen." Balas added: "We hope this sends a message to the entire rare disease community and pharmaceutical industry that new treatments can be developed and made accessible to those who will benefit from them. We need to ensure more ALS treatments are developed and approved that will help everyone living with ALS." The ALS Association played a key role in the historic CMS directive by participating and advocating for the research, approval, and accessibility of Qalsody for people living with ALS. In 2004, the ALS Association was the first to fund research into ALS-specific antisense oligonucleotide (ASO) technology, investing over $1.3 million in groundbreaking studies that laid the foundation for the development of Qalsody. This early commitment supported preclinical studies, safety trials, and the first-in-human phase 1 trial, which established SOD1 as a viable therapeutic target. In 2023, Qalsody became the first gene-based therapy approved for ALS , thanks in part to the ALS Association's efforts, including a united push from the ALS community for FDA accelerated approval. This new CMS directive provides precedent for state regulators to issue similar actions for other private insurers. According to the Valor study published in 2022 , Qalsody, which was developed specifically to target the RNA produced by mutated SOD1 genes, has demonstrated significant promise in clinical trials and real-world studies. In the phase 3 VALOR trial, Qalsody reduced levels of mutated SOD1 proteins in cerebral spinal fluid by 35% within eight weeks and decreased bloodstream levels of neurofilament light chain (NfL)—a key biomarker of neurodegeneration—by 50% within 12-16 weeks. These biological changes translated into measurable clinical benefits, including slower disease progression, improved respiratory function, and enhanced quality of life after 52 weeks of treatment. Real-world data has since validated these findings, with some patients stabilizing or even experiencing improvements in motor function and quality of life. When insurance companies began denying access to Qalsody, labeling it as "experimental," the ALS Association took decisive action, working directly with CMS to launch an investigation into these unjust denials. By presenting evidence of widespread insurance rejections and demonstrating the critical need for immediate intervention. In addition to working with CMS, the ALS Association actively engaged policymakers, held strategic meetings with state and federal legislators, and served as a staunch advocate for patients, ensuring their voices were heard and their rights to life-changing treatment were upheld. The ALS Association urges anyone previously denied Qalsody by their Medicare Advantage plan to contact their ALS specialist immediately to begin the process of securing access to this critical treatment. For more information on the CMS directive visit als.org About the ALS Association The ALS Association is the largest ALS organization in the world. The ALS Association funds global research collaborations, assists people with ALS and their families through its nationwide network of care and certified clinical care centers, and advocates for better public policies for people with ALS. The ALS Association is working to make ALS a livable disease while urgently searching for new treatments and a cure. For more information about the ALS Association, visit our website at www.als.org . About ALS Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects nerve cells in the brain and spinal cord. Over the course of the disease, people lose the ability to move, to speak, and eventually, to breathe. The disease is always fatal, usually within five years of diagnosis. Few treatment options exist, resulting in a high unmet need for new therapies to address functional deficits and disease progression. View original content to download multimedia: https://www.prnewswire.com/news-releases/groundbreaking-directive-ensures-als-patients-on-medicare-advantage-gain-access-to-qalsody-302329525.html SOURCE The ALS Associationjackpot cash casino slots

Sacramento State knocks off Air Force 63-61First Horizon Names New Head of Investor RelationsBEIRUT — Israel's military launched airstrikes across Lebanon on Monday, unleashing explosions throughout the country and killing at least 31 while Israeli leaders appeared to be closing in on a negotiated ceasefire with the Hezbollah militant group. Israeli strikes hit commercial and residential buildings in Beirut as well as in the port city of Tyre. Military officials claimed they targeted areas known as Hezbollah strongholds. They issued evacuation orders for Beirut's southern suburbs, and strikes landed across the city, including meters from a Lebanese police base and the city's largest public park. The barrage came as officials indicated they were nearing agreement on a ceasefire, while Israeli Prime Minister Benjamin Netanyahu's Security Cabinet prepared to discuss an offer on the table. Bulldozers remove the rubble of a destroyed building Monday that was hit in an Israeli airstrike in Dahiyeh, in the southern suburb of Beirut, Lebanon. Foreign ministers from the world’s leading industrialized nations also expressed cautious optimism Monday about possible progress on a ceasefire. “Knock on wood,” Italian Foreign Minister Antonio Tajani said as he opened the Group of Seven meeting outside Rome. “We are perhaps close to a ceasefire in Lebanon," he said. "Let's hope it's true and that there's no backing down at the last-minute.” A ceasefire in Gaza and Lebanon was foremost on the agenda of the G7 meeting in Fiuggi, outside Rome, that gathered ministers from Canada, France, Germany, Italy, Japan, the United Kingdom and the United States, in the last G7 encounter of the Biden administration. For the first time, the G7 ministers were joined by their counterparts from Saudi Arabia, Egypt, Jordan, the United Arab Emirates and Qatar, as well as the Secretary General of the Arab League. Thick smoke, flames and debris erupt Monday from an Israeli airstrike that targeted a building in Tayouneh, Beirut, Lebanon. Meanwhile, massive explosions lit up Lebanon's skies with flashes of orange, sending towering plumes of smoke into the air as Israeli airstrikes pounded Beirut's southern suburbs Monday. The blasts damaged buildings and left shattered glass and debris scattered across nearby streets. Some of the strikes landed close to central Beirut and near Christian neighborhoods and other targets where Israel issued evacuation warnings, including in Tyre and Nabatiyeh province. Israeli airstrikes also hit the northeast Baalbek-Hermel region without warning. Lebanon's Health Ministry said Monday that 26 people were killed in southern Lebanon, four in the eastern Baalbek-Hermel province and one in Choueifat, a neighborhood in Beirut's southern suburbs that was not subjected to evacuation warnings on Monday. The deaths brought the total toll to 3,768 killed in Lebanon throughout 13 months of war between Israel and Hezbollah and nearly two months since Israel launched its ground invasion. Many of those killed since the start of the war between Israel and Hezbollah have been civilians, and health officials said some of the recovered bodies were so severely damaged that DNA testing would be required to confirm their identities. Israel claims to have killed more than 2,000 Hezbollah members. Lebanon's Health Ministry says the war has displaced 1.2 million people. Destroyed buildings stand Monday in the area of a village in southern Lebanon as seen from northern Israel. Israeli ground forces invaded southern Lebanon in early October, meeting heavy resistance in a narrow strip of land along the border. The military previously exchanged attacks across the border with Hezbollah, an Iran-backed militant group that began firing rockets into Israel the day after the war in Gaza began last year. Lebanese politicians have decried the ongoing airstrikes and said they are impeding ceasefire negotiations. The country's deputy parliament speaker accused Israel of ramping up its bombardment to pressure Lebanon to make concessions in indirect ceasefire negotiations with Hezbollah. Elias Bousaab, an ally of the militant group, said Monday that the pressure has increased because "we are close to the hour that is decisive regarding reaching a ceasefire." Israeli officials voiced similar optimism Monday about prospects for a ceasefire. Mike Herzog, the country's ambassador to Washington, earlier in the day told Israeli Army Radio that several points had yet to be finalized. Though any deal would require agreement from the government, Herzog said Israel and Hezbollah were "close to a deal." "It can happen within days," he said. Israeli officials have said the sides are close to an agreement that would include withdrawal of Israeli forces from southern Lebanon and a pullback of Hezbollah fighters from the Israeli border. But several sticking points remain. A member of the Israeli security forces inspects an impact site Sunday after a rocket fired from Lebanon hit an area in Rinatya, outskirts of Tel Aviv, Israel. After previous hopes for a ceasefire were dashed, U.S. officials cautioned that negotiations were not yet complete and noted that there could be last-minute hitches that either delay or destroy an agreement. "Nothing is done until everything is done," White House national security spokesman John Kirby said Monday. The proposal under discussion to end the fighting calls for an initial two-month ceasefire during which Israeli forces would withdraw from Lebanon and Hezbollah would end its armed presence along the southern border south of the Litani River. The withdrawals would be accompanied by an influx of thousands more Lebanese army troops, who have been largely sidelined in the war, to patrol the border area along with an existing U.N. peacekeeping force. Western diplomats and Israeli officials said Israel demands the right to strike in Lebanon if it believes Hezbollah is violating the terms. The Lebanese government says such an arrangement would authorize violations of the country's sovereignty. On paper, being more sustainable and eco-friendly while shopping sounds great—so why don't more people do it? There is growing consumer consciousness about the environmental impact of where people choose to shop and the sustainability of the products they buy. According to McKinsey, over 60% of individuals surveyed in 2020 said they would be willing to pay more for a product that is packaged in an eco-friendly way. Since 2019, products marketed as being environmentally sustainable have seen a 28% growth in revenue compared to 20% for products with no such marketing, a 2023 McKinsey and NielsenIQ report found. Much of this is thanks to the preferences and attitudes of Gen Z, who, on average, care more than their older counterparts about being informed shoppers. The younger generation also has more social justice and environmental awareness altogether. Shoppers are willing to spend around 9.7% more on a product they know is sourced or manufactured sustainably, with 46% saying they would do so explicitly because they want to reduce their environmental footprint, according to a 2024 PwC report. Sustainable practices consumers look for from companies include production methods, packaging, and water conservation. But despite the growing consciousness around being more environmentally responsible, consumer actions don't always align with their values. In psychology, this is defined as the "say-do gap": the phenomenon wherein people openly express concern and intention around an issue, but fail to take tangible action to make a change. According to the Harvard Business Review in 2019, most consumers (65%) say they want to buy from brands that promote sustainability, but only 1 in 4 follow through. So why don't people actually shop sustainably, despite how much they express a preference for eco-friendly products—and how can we close the gap? The RealReal examined reports from the Harvard Business Review and other sources to explore why some shoppers want to buy sustainably but struggle to follow through. This lack of action isn't due to a lack of caring—in many cases, it's hard to know how to be a sustainable consumer and other factors are often outside of shoppers' control. But the more people shop sustainably, the easier and more accessible that market will be for everyone—making it much easier for folks to buy aligned with their values. There are many obstacles preventing shoppers from upholding eco-friendly habits as much as they may want to—but not all of these barriers are necessarily real, or accurately understood. Shopping sustainably simply isn't convenient or accessible for many. Those who live in apartment buildings are 50% less likely to recycle , according to Ipsos. Reasons for this can vary from lack of space to buildings being excluded altogether because of recycling contamination issues. Many believe that sustainable products are too expensive or of a lower quality. The former is often true, which does create a hurdle for many: The manufacturing processes and materials for sustainable products are pricey. For instance, organic cotton requires an intensive production process free of certain chemicals or pesticides; by definition, true eco-friendly products can't be mass-produced, further upping their price tag. Using recycled materials for packaging, or obtaining an eco certification, can also be expensive. However, although the narrative of eco-friendly products being more expensive is true, there is often more of an effort to use better quality materials that last longer than their noneco-friendly counterparts. This could end up saving consumers money in the long run: By paying more upfront, they can get more wear out of sustainable fashion, for instance. There is also undeniable political rhetoric surrounding eco-friendly products—however, despite many Conservative politicians decrying sustainable products, members of all generations are increasingly choosing to prioritize shopping sustainably regardless of their political affiliation, according to research from NYU Stern Center for Sustainable Business . This finding shows a trend toward seeing sustainability as a nonpartisan subject everyone can benefit from, no matter where they lie on the political spectrum. Some might think eco-friendly clothing, in particular, is not fashion-forward; after all, many of the top clothing retailers in the world partake in fast fashion. However, brands are increasingly being recognized as 'cool' and 'trendy' for supporting environmentally ethical practices, particularly as younger generations prioritize sustainability, as noted before. Many increasingly popular online stores are taking advantage of this paradigm shift by offering secondhand shopping options that are not only fashionable, but also more affordable, like ThredUp or Poshmark. Additionally, many legacy large-name brands are hopping on the sustainability movement and are gaining appreciation from loyal customers. Amazon's Climate Pledge Friendly program partners with third-party certification bodies to make it easier for shoppers to identify eco-friendly products as they browse the website. H&M's newly launched H&M Rewear program debuts a resale platform that allows the resale of all clothing brands—not just their own. Similarly, Patagonia's Worn Wear program allows shoppers to trade in and buy used gear and clothing. The federal government is also working to close this gap. The Environmental Protection Agency's Safer Choice program is attempting to make sustainable shopping easier for consumers and companies alike. It includes a directory of certified products, a list of safer chemicals to look out for on labels, a "Safer Choice" label that products can earn to denote they are eco-friendly, and resources for manufacturers looking to adopt more sustainable practices. Most of all, though, the biggest way shoppers can shift toward sustainable shopping is through their behaviors and attitudes amongst their peers and communities. Studies show that humans largely care what others think of their actions; the more shoppers make environmentally conscious shopping the norm, the more others will follow suit. From an economic perspective, the more consumers shop eco-friendly, the more affordable and accessible these products will become, too: Sustainable products are currently more expensive because they are not in high demand. Once demand rises, production rates and prices can lower, making these products more accessible for all. Story editing by Carren Jao. Additional editing by Kelly Glass. Copy editing by Kristen Wegrzyn. This story originally appeared on The RealReal and was produced and distributed in partnership with Stacker Studio. Get local news delivered to your inbox!

Democrat Derek Tran defeats GOP Rep. Michelle Steel in Southern California swing House districtNew research has revealed that the majority of teachers are hesitant or uninterested in utilising artificial intelligence (AI) for student learning and assessment. A study conducted by BCS, The Chartered Institute for IT, involving over 5,000 teachers discovered that 64% are not professionally using AI tools such as ChatGPT, with 19% expressing no interest in future use. The survey also highlighted a lack of clarity regarding school policies on AI, with 41% of respondents stating their school lacks an agreed approach to AI, and 17% unsure if any policy exists. The study, which encompassed 2,000 secondary schools in England, found that despite the widespread availability of AI tools, 84% of those surveyed have not altered their methods of assessing student work, and only 41% regularly check homework or coursework for content plagiarised from the web via AI tools. In its report, BCS advocates for the inclusion of AI understanding as a significant component of teacher training, in addition to broader digital literacy. The IT organisation suggests that schools should establish and publish AI policies on their websites, but emphasises the need for clear guidance from the Department for Education, qualifications regulator Ofqual, and other bodies. Julia Adamson, BCS's Managing Director for Education and Public Benefit, highlighted the promise of AI in education: "Teachers see the opportunity AI presents to transform their work and the lives of their students, from saving time on lesson plans, to personalising learning for each young person." She emphasised, however, the need for adequate training: "But they need better training and guidance to grow in confidence with AI, to make sure it is used fairly and that it doesn’t cause greater disadvantage in the education system." Sarah Hannafin, NAHT Policy Head, acknowledged the potential of AI but urged cautious implementation: "While it is clear that AI has huge potential benefits for schools and children’s learning, it is important that these are harnessed in the right way." She added that, despite the potential, professionals require support: "It is understandable that school leaders and teachers need training and guidance in order to feel confident using AI. It is also true that no AI tool is infallible or can replace the judgement and knowledge of a human expert. There are also lots of safeguarding and ethical considerations around use of this technology."

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COLLEGE PARK, Md. (AP) — Tafara Gapare scored 19 points, freshman Derik Queen had 15 points and eight rebounds and Maryland beat Bucknell 91-67 on Wednesday night. Maryland opened the game on a 15-2 run, extended it to 25-7 with 10:38 left and led 51-28 at the break. The Terrapins led by at least 16 points the entire second half, which included runs of 12-0 and 9-0. Gapare scored the 10 straight points during the second-half run. Gapare threw down a highlight dunk while being fouled with 2:08 remaining to give Maryland an 89-62 lead. He was called for a technical foul after stepping over Patrick O’Brien, who was attempting to take a charge. Jayden Williams made the two free throws for Bucknell and Gapare missed his free-throw attempt that would have tied his career high of 20 points. Maryland (6-1) has won 20 consecutive home games against unranked nonconference foes with its last loss coming on Dec. 1, 2021, against Virginia Tech in the ACC/Big Ten Challenge. Julian Reese added 14 points and Selton Miguel scored 13 for Maryland. Gapare, a Georgia Tech transfer, reached double-figure scoring as a Terp for the first time. The Terrapins shot 50% from the field with three 3-pointers apiece by Gapare and Miguel. Ruot Bijiek led Bucknell (4-4) with 20 points and Josh Bascoe added 10. The Bison turned it over 20 times leading to 22 Maryland points. Maryland stays at home to play Alcorn State on Sunday. Bucknell returns home to play Siena on Saturday. ___ Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college basketball: https://apnews.com/hub/ap-top-25-college-basketball-poll and https://apnews.com/hub/college-basketballCLEVELAND (AP) — Shane Bieber's comeback with Cleveland has double meaning. And deeper meaning. The former Cy Young winner re-signed with the Guardians on Wednesday, a reunion that seemed unlikely when he became a free agent following last season. However, the 29-year-old Bieber decided to stick with the AL Central champions after making just two starts in 2024 before undergoing Tommy John surgery. There were other offers. None of them matched what he already had in Cleveland. “It's the relationships,” Bieber said on a Zoom call. "The development staff. The coaching staff. My teammates. Having continuity and familiarity in those realms I feel like can prove beneficial not only to me but my family and everybody really involved. "That was big for me to feel confident in my rehab where I’m at right now. Nobody knows me as well as Cleveland does and vice versa, so I’m happy to be continuing with them." Bieber agreed last week to a one-year, $14 million contract . The deal includes a $16 million player option for 2026. Not long ago, it seemed as if Bieber, who is 62-32 with a 3.22 ERA in 132 starts over seven seasons for Cleveland, was determined to continue his career elsewhere. He had turned down previous long-term offers in the past from the Guardians, and it was expected he would sign with another contender, likely on the West Coast. But the California native has a special connection with the Guardians, who selected him in the fourth round of the 2016 draft. And while a setback, the injury and surgery helped Bieber realize that he was already in the perfect place. “I had plenty of great meetings and beneficial and progressive meetings with other ball clubs,” he said. "Everybody handled everything first class all the way, and I’ve got great things to say about plenty of other organizations. “Ultimately, Cleveland made the call and I was happy to receive it and come to terms and so I’m happy with where I’m at. My family’s ecstatic. It was very clearly the right decision for not only myself, my family, and we’re excited to continue it.” Bieber, who won the AL Cy Young in the pandemic-shortened 2020 season, threw only 12 innings last season before lingering issues with his elbow forced him to have surgery. He is expected to join Cleveland's rotation at some point in 2025. He's throwing three days a week at 90 feet and encouraged by his progress. As for when he'll take the mound in a game, that's currently unknown. “I’m pushing, pushing, pushing.” he said. “I feel great. I haven’t skipped a beat. When I ask for a (return) date, they don’t even give me a date. So there’s a long way to go.” A two-time All-Star, Bieber burst onto the national stage in 2019 when he was named MVP of the midsummer event in Cleveland. He has the highest strikeout ratio per nine innings (10.2) and third-highest winning percentage (.660) in the franchise's 124-year history. Bieber is one of just three Cleveland pitchers to start five season openers, joining Stan Coveleski (1917-21) and Corey Kluber (2015-19). While Bieber had some elbow issues in the past, he didn't appear to be struggling before being shut down. He struck out 11 in six scoreless innings against Oakland on March 28, and followed that up with six more shutout innings at Seattle on April 2. Days later, and with his season officially over, Bieber became emotional during a news conference at Progressive Field. He knew that in the short-term his life would be different and baseball, as he had always known it, would be on the backburner. Bieber said it took a while before he “digested” his new reality. He coped by immersing himself in his recovery, and Bieber found joy in watching his teammates storm through an unexpected season to a division title. Although it may not have been the same because he wasn't contributing on the field the way he always had, the hardships may have given Bieber something he needed. “It’s provided a lot of perspective,” he said. “It was a hard season this year for me and my family, but it was a great one. We’re expecting a baby and it was a season full of growth and I’m very excited to continue that into 2025.” AP MLB: https://apnews.com/hub/MLBNEW YORK (AP) — U.S. stocks are rising toward records Tuesday after Donald Trump’s latest talk about tariffs created only some ripples on Wall Street, even if they could roil the global economy were they to take effect. The S&P 500 climbed 0.5% and was on track to top its all-time high set a couple weeks ago. The Dow Jones Industrial Average added 81 points, or 0.2%, to its own record set the day before, while the Nasdaq composite was 0.5% higher, with less than an hour remaining in trading. Stock markets abroad were down, but mostly only modestly, after President-elect Trump said he plans to impose sweeping new tariffs on Mexico, Canada and China as soon as he takes office. Stock indexes were down 0.1% in Shanghai and nearly flat in Hong Kong, while Canada's main index edged down by just 0.1%. Trump has often praised the use of tariffs , but investors are weighing whether his latest threat will actually become policy or is just an opening point for negotiations. For now, the market seems to be taking it more as the latter. Unless the United States can prepare alternatives for the autos, energy products and other goods that come from Mexico, Canada and China, such tariffs would raise the price of imported items all at once and make households poorer, according to Carl Weinberg and Rubeela Farooqi, economists at High Frequency Economics. They would also hurt profit margins for U.S. companies, while raising the threat of retaliatory tariffs by other countries. General Motors sank 8.2%, and Ford Motor fell 2.6% because both import automobiles from Mexico. Constellation Brands, which sells Modelo and other Mexican beer brands in the United States, dropped 3.9%. Beyond the pain such tariffs would cause U.S. households and businesses, they could also push the Federal Reserve to slow or even halt its cuts to interest rates. The Fed had just begun easing its main interest rate from a two-decade high a couple months ago to offer support to the job market . While lower interest rates can boost the overall economy and prices for investments, they can also offer more fuel for inflation. “Many” officials at the Fed's last meeting earlier this month said they should lower rates gradually, according to minutes of the meeting released Tuesday afternoon. Unlike tariffs in Trump's first term, his proposal from Monday night would affect products across the board. Trump’s tariff talk came almost immediately after U.S. stocks rose Monday amid excitement about his pick for Treasury secretary, Scott Bessent. The hope was the hedge-fund manager could steer Trump away from policies that balloon the U.S. government deficit, which is how much more it spends than it takes in through taxes and other revenue. The talk about tariffs overshadowed another set of mixed profit reports from U.S. retailers that answered few questions about how much more shoppers can keep spending. They’ll need to stay resilient after helping the economy avoid a recession, despite the high interest rates instituted by the Fed to get inflation under control. Kohl’s tumbled 17.6% after its results for the latest quarter fell short of analysts’ expectations. CEO Tom Kingsbury said sales remain soft for apparel and footwear. A day earlier, Kingsbury said he plans to step down as CEO in January. Ashley Buchanan, CEO of Michaels and a retail veteran, will replace him. Best Buy fell 4.7% after likewise falling short of analysts’ expectations. Dick’s Sporting Goods topped forecasts for the latest quarter thanks to a strong back-to-school season, but its stock lost an early gain to fall 1.4%. A report on Tuesday from the Conference Board said confidence among U.S. consumers improved in November, but not by as much as economists expected. J.M. Smucker jumped 5.4% for one of the biggest gains in the S&P 500 after topping analysts' expectations for the latest quarter. CEO Mark Smucker credited strength for its Uncrustables, Meow Mix, Café Bustelo and Jif brands. Big Tech stocks also helped prop up U.S. indexes. Gains of 2.8% for Amazon and 2% for Microsoft were the two strongest forces lifting the S&P 500. In the bond market, Treasury yields rose following their big drop from a day before driven by relief following Trump’s pick for Treasury secretary. The yield on the 10-year Treasury climbed to 4.30% from 4.28% late Monday, but it’s still well below the 4.41% level where it ended last week. In the crypto market, bitcoin continued to pull back after topping $99,000 for the first time late last week. It's since dipped back toward $91,600, according to CoinDesk. It’s a sharp turnaround from the bonanza that initially took over the crypto market following Trump’s election. That boom had also appeared to have spilled into some corners of the stock market. Strategists at Barclays Capital pointed to stocks of unprofitable companies, along with other areas that can be caught up in bursts of optimism by smaller-pocketed “retail” investors. AP Business Writer Elaine Kurtenbach contributed. Copyright 2024 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission. Get the latest local business news delivered FREE to your inbox weekly.

Nebraska will be trying to preserve its perfect in-state record when it hosts South Dakota on Wednesday night in a nonconference game in Lincoln, Neb. The Cornhuskers (4-1) are 3-0 at home and also won Friday at then-No. 14 Creighton, beating their in-state rivals on the road for the second straight time. But the last time they did that, in 2022, they followed that win with a 16-point loss at Indiana to open Big Ten Conference play. "Believe me, we've addressed a lot of things," Nebraska coach Fred Hoiberg said. "A lot of people are saying some really positive things. You've got to find a way to put that behind you. I've liked how our team has responded and come back to work after that great win at Creighton." Brice Williams leads the Cornhuskers with 18.2 points per game and was one of five players in double figures against Creighton. Juwan Gary topped the list with 16. South Dakota (6-2) comes to town off a 112-50 home win Monday night over Randall, the third non-Division I school it has beat. The Coyotes' last game against a D1 opponent was Friday at Southern Indiana, resulting in a 92-83 loss. This will be South Dakota's second nonconference game against a Big Ten opponent, after a 96-77 loss at Iowa on Nov. 12. In December, the Coyotes also visit Santa Clara, hovering near the top 100 in KenPom adjusted efficiency, before jumping into Big Sky play. "The schedule is very good and that should help us," third-year South Dakota coach Eric Peterson said before the season. "We have some good nonconference games that should help prepare us for the end of the season." Nebraska has held four of its opponents to 67 or fewer points, with Saint Mary's the only one to top that number in the Cornhuskers' lone loss. Opponents are shooting 38.1 percent this season. South Dakota shot below 40 percent in its two previous games before shooting 62 percent against Randall. Isaac Bruns, who scored 20 to lead South Dakota in the Randall game, paces the Coyotes with 12.9 points per game. --Field Level MediaJuve deepen Man City crisis, Barcelona into Champions League knockouts

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