Manchester City, Arsenal, and now Tottenham. The list of top Premier League teams beaten at Bournemouth this season is growing. Dean Huijsen took advantage of Tottenham’s weakness at set pieces to head home a 17th-minute winner in Bournemouth’s 1-0 victory on Thursday. Bournemouth climbed into ninth — a point and a place above Tottenham in the standings — and underlined its penchant for surprising high-profile visitors to Vitality Stadium. Man City’s remarkable four-game losing run in the Premier League started with a 2-1 defeat at Bournemouth, while fellow title contender Arsenal’s first loss of the season also came at the Vitality, 2-0 on Oct. 19. This was Spurs' sixth defeat of the campaign. They now have as many wins as losses, highlighting the inconsistency blighting their season, and their seven away results so far make remarkable reading: aside from a 3-0 win at Manchester United and a 4-0 thrashing of Man City, Tottenham has lost four and drawn the other at relegation candidate Leicester. An inability to defend set plays continues to hurt Ange Postecoglou’s side. A week after Roma scored twice from them in a 2-2 draw in the Europa League, Huijsen roamed free in the area at a corner and headed home unmarked. Postecoglou said in May said he “wasn’t interested” about his side’s fallibility while defending set pieces, and said after losing 1-0 to Arsenal in September — after a goal from Gabriel at a corner — that “it’s my burden to carry and I’m happy to do that.” “We started well and conceded a really poor goal," Postecoglou said after the Bournemouth game. “It’s a difficult place to come when giving the opposition the opportunity to play in the manner they want.” IWOBI DOUBLE Alex Iwobi scored goals early and late in the game to lead Fulham to a 3-1 win over Brighton. The Nigeria winger intercepted a stray pass out from the back by Brighton goalkeeper Bart Verbruggen and slotted into an unguarded net for the opener in the fourth minute and curled home Fulham’s clinching goal in the 87th. Carlos Baleba equalized for Brighton in the 56th before Brighton midfielder Matt O’Riley – a former Fulham academy player – deflected the ball into his own net from a corner to put the home side back in front. Fulham climbed to sixth in the standings, a point and a place behind Brighton. AP soccer: https://apnews.com/hub/soccer
Bill Brennan and Adam Kinzinger join The Lead
FLORHAM PARK, N.J. (AP) — New York Jets running back Breece Hall could play Sunday at Jacksonville after missing a game with a knee injury. Hall has been dealing with a hyperextension and injured MCL in his left knee that sidelined him last Sunday at Miami. But he was a full participant at practice Friday after sitting out Wednesday and Thursday. Hall was officially listed as questionable on the team's final injury report. “He looks good right now,” interim coach Jeff Ulbrich said. “So it’s promising.” Hall leads the Jets with 692 yards rushing and four touchdown runs, and he also has 401 yards receiving and two scores on 46 catches. A pair of rookies helped New York offset Hall's absence last weekend, with Braelon Allen rushing for 43 yards on 11 carries, and Isaiah Davis getting 40 yards on 10 attempts and scoring his first rushing touchdown. “We’re hopeful and we’ll see how it goes,” Ulbrich said of Hall. The Jets will get star cornerback Sauce Gardner back after he missed a game with a hamstring injury, but New York's secondary appears likely to be without cornerback D.J. Reed because of a groin injury. Reed was listed as doubtful after he didn't practice Thursday or Friday. “It’s been something that’s kind of lingered here and there,” Ulbrich said. “It’s gotten aggravated and then it went away, and then it got aggravated again. So, it’s just dealing with that.” Backup Brandin Echols is out with a shoulder injury, so veteran Isaiah Oliver or rookie Qwan'tez Stiggers could get the start opposite Gardner if Reed can't play. Kendall Sheffield also could be elevated from the practice squad for the second game in a row. Ulbrich said kick returner Kene Nwangwu will be placed on injured reserve after breaking a hand last weekend at Miami. The injury came a week after he was selected the AFC special teams player of the week in his Jets debut, during which he returned a kickoff 99 yards for a touchdown and forced a fumble in a loss to Seattle. “To put him out there with a broken hand, just thought it’d be counterproductive for him and for us as a team, so it unfortunately cuts the season short and what a bright light he was,” Ulbrich said. “What an amazing future I think he has in this league. With saying that, he’s already been a really good player for quite a while, so (it's) unfortunate, but he’ll be back.” Offensive lineman Xavier Newman (groin) is doubtful, while right guard Alijah Vera-Tucker (ankle) and RT Morgan Moses (wrist) are questionable. AP NFL: https://apnews.com/hub/NFLAs the leaves fall, the heat goes on, the temperatures drop and the sweaters and jackets are pulled from storage, it’s also a great time to think about making a pot of soup. Soup is one of the best comfort foods, perfect for those New England fall and winter days. Whether you fancy clam or corn chowder, a roasted butternut squash soup, a classic Italian sausage orzo or something unique like lasagna soup, there’s a special place in everyone’s heart for that big pot on the stove. We have found five recipes that are sure to make your mouth water. No matter what soup preference you may have, you’ll find something to cook for the whole family. This recipe is by Allrecipes.com . Ingredients 2 tablespoons butter 1 small onion, chopped 1 stalk celery, chopped 1 medium carrot, chopped 2 medium potatoes, cubed 1 medium butternut squash – peeled, seeded, and cubed 1 (32 fluid ounce) container chicken stock salt and freshly ground black pepper to taste Directions Gather all ingredients. Melt butter in a large pot over medium heat, and cook onion, celery, carrot, potatoes, and squash until lightly browned, about 5 minutes. Pour in enough chicken stock to cover vegetables. Bring to a boil over medium-high heat. Reduce heat to low, cover pot, and simmer until all vegetables are tender, about 40 minutes. Transfer soup to a blender and process until smooth. Return to the pot and mix in any remaining stock to reach desired consistency. Season with salt and pepper. This recipe is by Allrecipes.com . Ingredients 2 cups cubed potatoes 1 cup diced carrots 1 cup diced celery 1 cup minced onion 3 (6.5 ounce) cans minced clams, drained with juice reservedwater to cover 3⁄4 cup butter 3⁄4 cup all-purpose flour 1 quart half-and-half cream 2 tablespoons red wine vinegar 1 1⁄2 teaspoons salt ground black pepper to taste Directions Place potatoes, carrots, celery, and onion into a large skillet; pour in clam juice and add enough water to cover. Cook and stir over medium-low heat until vegetables are tender. Meanwhile, melt butter in a large, heavy saucepan over medium heat. Whisk in flour until smooth. Whisk in cream and stir constantly until thick and smooth. Stir in vegetable mixture with any juices until just heated through. Stir in clams just before serving. If they cook too much they get tough. When clams are heated through, stir in vinegar and season with salt and pepper. This recipe is by Allrecipes.com . Ingredients Noodles: 8 ounces dry lasagna noodles 1 tablespoon olive oil 2 tablespoons butter Soup Base: 2 tablespoons olive oil 1 pound lean ground beef 6 ounces bulk Italian sausage, or 1 Italian sausage links, casing removed 1 cup diced yellow onion 3 cloves garlic, minced 2 tablespoons tomato paste 1/4 teaspoon crushed red pepper flakes (optional) 1/4 teaspoon dried oregano 1/2 teaspoon freshly ground black pepper 1 1⁄2 teaspoons kosher salt, or to taste 1 (24 ounce) jar prepared marinara sauce, or 3 cups homemade marinara sauce 4 cups chicken broth 2 1⁄2 cups water 2 tablespoons chopped fresh Italian parsley Cheese Mixture: 12 ounces ricotta cheese 3 ounces mozzarella cheese, shredded 1/2 cup finely grated Parmigiano-Reggiano cheese Garnish: 1/2 cup torn fresh basil and Italian parsley leaves (optional) Directions Fill a large pot with lightly salted water and bring to a rolling boil. Stir in lasagna noodles and return to a boil. Cook pasta uncovered, stirring occasionally, until just flexible, 4 to 5 minutes. Transfer noodles into cold water until cooled; drain very well. Preheat the oven to 475 degrees F (245 degrees C). Line a baking sheet with parchment paper, and grease parchment with 1 tablespoon olive oil. Cut noodles in half lengthwise. Arrange noodles in evenly overlapping rows on the prepared baking sheet. Brush with melted butter, and use fingers to rub some butter between the noodles. Bake noodles in the preheated oven until they are golden, blistered, and are beginning to brown with crispy outside edges. Let cool; cut into bite-sized pieces. Meanwhile, add 2 tablespoons olive oil to a soup pot, and place over high heat. Add beef and sausage. Use a spatula to break up the meat into small pieces; cook without stirring until liquid evaporates and meat begins to sizzle in its own fat, then continue to cook and stir until meat begins to brown, about 7 minutes. Add onions, garlic, tomato paste, red pepper flakes, dried oregano, black pepper, and kosher salt. Cook and stir until onions begin to turn translucent, 3 to 4 minutes. Stir in chicken broth, tomato sauce, and water. Bring to a simmer, reduce heat to medium low, and simmer for 45 minutes. Stir ricotta cheese, mozzarella cheese, and Parmesan cheese together in a bowl; set aside. Increase the heat under soup to medium high; stir in noodle pieces. Cook, stirring, until pasta is tender, about 10 minutes. Reduce heat to low, and stir in the 2 tablespoons Italian parsley. Serve in bowls with a scoop of cheese mixture, and sprinkle with freshly torn basil and Italian parsley if desired. This recipe is by juliasalbum.com . Ingredients 15 oz spicy Italian sausage crumbled 1 teaspoon Italian seasoning or Herbs from Provence fresh thyme to taste red pepper flakes to taste 1 cup orzo uncooked 8 oz portobello mushrooms (2 big mushroom caps chopped) 4 cloves garlic minced 5 cups chicken stock 5 oz fresh spinach 1⁄2 cup heavy cream Directions Add crumbled Italian sausage, Italian seasoning, a generous amount of fresh thyme (no sprigs, just leaves), and red pepper flakes to a large saucepan. Cook. on medium heat, regularly stirring to break the sausage. Once the sausage released juices and is half cooked, add 1 cup of uncooked orzo, chopped portobello, and minced garlic, and cook, constantly stirring, for about 3 minutes on medium heat until portobello mushrooms soften but are not cooked through. Add 5 cups of chicken stock, stir everything well, cover with the lid, bring to a boil, and cook for about 5 or 10 minutes until the orzo is cooked. Add spinach to the soup, cover with the lid and let it wilt on low heat, occasionally stirring. Once the spinach has wilted, remove the soup from the heat and add heavy cream. Stir everything and season with salt and pepper. Add more red pepper flakes, if you like. Top with fresh thyme. This recipe is by Allrecipes.com . Ingredients 6 tablespoons unsalted butter 1 1⁄2 cups chopped onions 1 1⁄2 cups chopped celery 4 cups water 8 potatoes, peeled and cubed 15 slices American cheese – broken into pieces 4 tablespoons all-purpose flour 2 1⁄3 cups milk 2 tablespoons chopped fresh parsley Directions Melt the butter in a large pot over medium heat. Saute the onions and celery in the butter for 5 to 10 minutes, or until tender. Stir in the water and potatoes, bring to a boil and then simmer until the potatoes are tender. Add the cheese and stir until melted. In a separate small bowl, combine the flour and the milk and stir well until the flour is mostly dissolved. Pour this into the soup slowly, stirring constantly, until soup has thickened, about 5 minutes. Garnish with the parsley. 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Her visit to Syria to meet with then-President Bashar Assad around the time of Trump’s first inauguration during the country’s bloody civil war stunned the Washington national security establishment.SOUTHERN PINES, N.C. , Nov. 21, 2024 /PRNewswire/ -- Newly released provisional data from the CDC this week shows that drug overdose deaths in the United States are declining, giving hope that there is some improvement in what still remains a nationwide epidemic. The decline- roughly 14% over the previous 12 month period - can likely be attributed to a number of factors such as addiction prevention education, drug disposal solutions, like DisposeRx, and the now widely available overdose-reversing drug, naloxone. In addition to the many illicit drugs on the market, approximately 300,000 opioid prescriptions are dispensed daily in the United States , making the pharmacist a key resource in education and prevention. By focusing on preventing the access to and misuse of leftover medications, DisposeRx congratulates pharmacists for playing a pivotal role in starting to change patient behavior. Since 2017, over 50 million DisposeRx packets have been distributed nationwide along with important prevention education for patients at the time they are picking up a prescription. In 2021, Mitch Barnett , lead author in "Barriers and motivational factors for engaging in novel opioid and medication disposal-related services in community pharmacies" , explored the pharmacy pilot program in the state of Iowa , where pharmacists were incentivized to provide drug disposal education and tools with every opioid prescription. The results demonstrated that providing in-home disposal education at the pharmacy counter benefited the local communities, the patients, the environment, and provided a lot of personal satisfaction to the pharmacists themselves. "To prevent overdoses, ultimately with disposal kits, just get medications out of people's hands... so it doesn't get into somebody else's hands..." said a pharmacist participating in the study. "We go the extra mile for our patients so this program fits well" DisposeRx is proud to support pharmacy and all the efforts they've made over the last several years to provide a free solution to their patients. DisposeRx single use packets are available without a prescription at over 60,000 pharmacy locations nationwide. "It's not enough just to try and reduce the number of opioids prescribed and provide naloxone as an emergency option. People need education to understand how often their unused medications could end up in the wrong hands and how they can prevent that," said DisposeRx President and CEO, William Simpson . "The real work is in reducing the number of pills available to cause future addictions" The value of the pharmacist as a trusted member of the healthcare ecosystem and their easy and convenient access to patients on a regular basis make them the ideal educator to change patient behavior and create a sustainable decline in overdose deaths. For more information on DisposeRx and how they are supporting the Pharmacist in preventing injury from misused medications, please visit www.disposerx.com . About DisposeRx, Inc. DisposeRx, Inc. is located in Southern Pines, North Carolina and committed to solving the problem of prescription drug safety. We aim to achieve new standards in both the education and safety of medication management, by reducing the risks associated with diversion, overdoses, accidental poisonings and death. Our prevention initiatives are where mission and purpose come together making DisposeRx one of the nation's most essential social impact and patient safety companies. By addressing the problems of prescription medication and drug safety, our team is empowering communities to challenge the opioid crisis head-on. Our belief is that one company can profoundly affect family safety and where innovative solutions can make a real generational difference. SOURCE DisposeRx, Inc.What to know about Lori Chavez-DeRemer, Trump’s pick for labor secretaryA provides fresh look at who's coming up short on sleep
A man threw a liquid on former Delhi Chief Minister and Aam Aadmi Party (AAP) national convener Arvind Kejriwal during his padayatra in the Capital’s Greater Kailash Assembly constituency on Saturday. A war of words ensued between the ruling AAP and the BJP following the incident, with Delhi Urban Development Minister Saurabh Bharadwaj alleging that the attacker was a worker of the Opposition party who threw spirit on Mr. Kejriwal to “set him afire”. “The man was carrying spirit in one hand and a matchbox in the other. He threw spirit that fell on Kejriwal and me but he could not start the fire. Our alert volunteers and the public overpowered him,” he told reporters. Delhi BJP spokesperson Praveen Shankar Kapoor dismissed the accusation and asked why such incidents take place with the AAP chief “ahead of every Assembly election”. The police also rejected Mr. Bharadwaj’s claim, saying the liquid thrown on the former CM was water. DCP (South) Ankit Chauhan said the attacker was identified as Ashok Jha, who works as a bus marshal. A Delhi Transport Corporation official confirmed that Mr. Jha, a home guard, worked as a bus marshal at the Khanpur bus depot. “When Mr. Kejriwal was shaking hands with his supporters, Jha threw water at him, but he was immediately caught,” the DCP said. The officer said though AAP did not have permission to carry out the padayatra in the area, they had deployed security personnel in both uniform and plain clothes for crowd control. The police were yet to register an FIR till the time of going to press. Another police officer said they would take a call on the registration of an FIR following Mr. Jha’s interrogation. Meanwhile, Delhi Chief Minister Atishi condemned the incident. In a post on X, Ms. Atishi said, “Today, in broad daylight, a BJP worker attacked Arvind Kejriwal ji . The BJP is nervous about losing the Delhi poll for the third time. People of Delhi will take revenge for such cheap acts. Last time, they [BJP] got eight seats, this time, people of Delhi will give them zero seats.” In response, Mr. Kapoor expressed apprehensions over the incident. ‘Doubts proved right’ “Elections are held across the country, and leaders, whether good or bad, participate in campaigns under varying levels of security. However, such incidents occur only with Kejriwal during every Assembly poll,” he said. “The BJP condemns all forms of violent protests. However, Delhi BJP chief Virendra Sachdeva had already said that Kejriwal, now desperate, would orchestrate another spectacle, much like the previous slapping incident. Now, that suspicion has been proven right,” he said. Published - December 01, 2024 01:25 am IST Copy link Email Facebook Twitter Telegram LinkedIn WhatsApp Reddit Delhi / politics
Fifteen of Ukraine's civilian airports have been damaged since Russia invaded the country in February 2022, Ukrainian Prime Minister Denys Shmyhal has been quoted as saying by local media. Ukraine, which the state aviation service says has 20 civilian airports, has been exploring avenues to partially open its airspace. It has been completely closed since the start of the war. Ukrainians who want to fly abroad currently have to go via road or rail to neighbouring countries to catch flights. For those living in the east, the journey out of Ukraine can take a day in itself. "We conducted a risk assessment and determined the needs of the air defence forces to partially open the airspace," local news agency Ukrinform quoted Shmyhal as saying at a transportation conference. "Security issues and the military situation remain key to this decision," he said. Shmyhal added that Russia had attacked Ukraine's port infrastructure nearly 60 times in the last three months, damaging or destroying nearly 300 facilities and 22 civilian vessels. A senior partner at insurance broker Marsh McLennan told Reuters earlier this month that Ukraine could reopen the airport in the western city of Lviv in 2025 if regulators deem it safe and a political decision is made. The Ukrainian military on Saturday reported heavy fighting along the front lines in the eastern Donbas region as Russia continued to launch attacks. Fierce clashes were reported in the key areas of Pokrovsk and Kurakhove, which are the focal point of the Russian advance in eastern Ukraine. A breakthrough would pave the way for the Russian forces to advance towards the strategic cities of Dnipro and Zaporizhzhia. However, Ukrainian military experts say the front in the Donbas region has stabilised after Ukraine deployed reinforcements to the area. In total, the General Staff in Kyiv recorded 153 engagements along the front lines. with DPAHere’s What’s in the $895 Billion Defense Authorization BillAT&T Announces Plan to Phase Out Copper Landline Service by 2029, California Exempted Due to Legal Protections
Nikki Giovanni, poet and literary celebrity, has died at 81Advancements in DNA technology and a surge of public interest are rekindling hope for breakthroughs in the long-unsolved murder of 6-year-old JonBenét Ramsey, a case that has remained a haunting mystery for nearly 28 years. As new techniques emerge and fresh attention is drawn to the evidence, many are eager for answers that could finally bring closure to this tragic story. JonBenét, who was found dead in the basement of her Boulder, Colorado, home in 1996, remains frozen in time. Her father, John Ramsey, has endured nearly three decades without justice, answers or his daughter. "JonBenét's still my 6-year-old blond-headed daughter who I love dearly," Ramsey told ABC News. "I did run into one of her little friends on the street who is now, you know, 30 and an adult. And it was, it was a little bit of a shock. This little girl played with JonBenét at our house all the time. And that was a little bit of a jolt to think, wow, that could have been JonBenét." Watch the full story on the "20/20" episode, "Forever Young: Who Killed JonBenét Ramsey?" featuring a new interview with John Ramsey and never-before-seen footage from the iconic Barbara Walters interview with parents John and Patsy Ramsey. Ramsey, now 81 years old, has renewed hope that his daughter's killer can finally be found. He is confident that advances in DNA technology, including genetic genealogy that has helped to solve several high-profile cold case, are the key to solving this mystery. "Let's do a reverse family tree and see if he had a relative living in Boulder in 1996. The interesting thing about these cold cases," Ramsey said. "The ultimate first arrest came out of nowhere. They were on no one's radar. They've done this horrible crime and nobody said that that guy's a suspect. That's what we're asking the police to do." Over the years, Ramsey expressed frustration with the police for not solving his daughter's case. He was unhappy with being a prime suspect for 12 years and that the department rejected offers of help to find viable evidence.He recently took part in a new Netflix docuseries, "Cold Case: Who Killed JonBenét Ramsey?" The series dives into lingering mysteries surrounding the tragic case, exploring evidence, interviews and theories that have emerged over the years. Ramsey collaborated with director Joe Berlinger, who aimed to illuminate what he described as one of the most victimized families in American history. "Obviously, he wasn't legally wrongfully convicted, but he was wrongfully convicted," Berlinger said. "And his wife Patsy -- the family were wrongfully convicted in the court of public opinion." The popular docuseries ignited a new wave of interest among viewers. Ramsey is hopeful that recent changes in the Boulder Police Department's leadership and better communication with his family may lead to a resolution in the case. The Boulder police department has addressed the recent scrutiny. Last month, the current police chief released a video statement. "So much of how law enforcement works has changed in the last 30 years," Stephen Redfearn said. "There are a number of things that people have pointed to throughout the years that could have been done better and we acknowledge that as true. However, it is important to emphasize that while we cannot go back to that horrible day in 1996, our goal is to find JonBenét Ramsey's killer." That tragic day in 1996 began in the picturesque Boulder neighborhood where the Ramsey family lived. On Dec. 26, John and Patsy Ramsey woke up to find that JonBenét, a child beauty queen, was missing. A handwritten ransom note demanding $118,000 -- the exact sum of John's bonus that year -- was discovered on the kitchen stairs. Seven hours later, John found his daughter's lifeless body in a small basement room. An autopsy determined JonBenét was sexually assaulted and strangled, and her skull was fractured. Unknown DNA was found under her fingernails and in her underwear. The Ramseys quickly became suspects, even though no evidence connected them to the crime. The family has always denied any involvement in JonBenét's murder. However, the Boulder District Attorney's Office took 12 years to fully exonerate the Ramseys and their son Burke, who was 9 years old when his sister died. As weeks went by without any arrests in the case, a media frenzy began to build, fueled by relentless tabloid images of JonBenét participating in beauty pageants. A number of leads emerged, including a man named John Mark Karr, who confessed to the killing in 2006. However, his DNA did not match the evidence and he was not in Boulder at the time of the murder, so he was eliminated as a suspect. The case remained unsolved. John Ramsey believes that a cloud still hangs over his family, as he thinks there are people in the country who think he and his late wife, Patsy, who died in 2006, are responsible for JonBenét's murder. Investigator Lou Smit, who was initially brought into the case by Boulder County District Attorney Alex Hunter, came to believe early in his investigation that the Ramseys were innocent. He thought that the police should be looking at the possibility of an intruder. "I'm not saying parents don't kill their kids ... parents do kill their children," Smit said in his tapes. "But [ the police ] are trying to say Patsy did it. ... Their actions before, during and after [ JonBenét's death ] are all consistent with innocent people. ... They didn't do it." As the investigation progressed Smit became increasingly concerned that authorities had completely ruled out the chance of an intruder being responsible for JonBenét's death. As a result, they weren't searching for evidence that might support this possibility. Smit continued to maintain that an unidentified intruder was responsible for JonBenét's murder. However, he was running out of time due to his colon cancer diagnosis in 2010. Before Smit died on Aug. 11 of that year, he diligently compiled a detailed list of persons of interest, hoping that his years of investigative work would eventually pay off. Smit passed his files to his surviving children, including a spreadsheet with 887 names of potential suspects to be investigated.That list is extensive, but Smit's family is determined to continue their search. Since his death, the team has cleared several individuals from that list, according to Smit's granddaughter Jessa Van Der Woerd. However, the process is slow due to the time and costs involved in locating each person, obtaining their DNA and testing it. "We've let the killer walk for more than 28 years," John Ramsey said. "I think it's imperative that we investigate every credible suspect that's been provided."
For more than eight years, Peter Siebert has led Lake Forest’s Fire Department guiding the personnel as they fought fires and provided paramedic service. However, that run is about to come to an end as Siebert is now in his last few weeks on the job as he plans to retire on Jan. 3. “It was time and I have done everything I wanted to do. When you get to a certain age and time, it doesn’t matter when you go,” Siebert, 58, said. “It is time for me to move on and I want other people to step up and have new blood in there with new ideas to move the place forward.” On Dec. 2, the City Council approved the appointment of Deputy Chief Andrew Rick as Siebert’s successor. He is set to be sworn in on Jan. 6. “I really look forward to the opportunity of leading a young group and continue to serve this community in the way we have been and uphold the standards that we (have),” Rick told the City Council. “I couldn’t have asked for a better situation.” Mayor Stanford “Randy” Tack offered plaudits for Siebert and the entire 35-employee department at the meeting. “Our fire department stands as a shining example of service and readiness and we are incredibly fortunate to have such an exceptional team safeguarding our community,” Tack said. In an interview, Siebert reflected on what he has seen and done in his public service. Born in Northbrook, Siebert was living in California in the 1990s when he became interested in firefighting as a career. He asked a local fire chief about how to chart that career path and was informed about the higher education requirements associated with the position. As he earned the degrees, Siebert moved back to the area. Initially, he was hired as a paid on-call firefighter at the Countryside Fire Department in Vernon Hills in December 1994, before moving over to Lake Forest in May 1996. He steadily received a series of promotions until being named acting chief in September 2016 and permanent chief in April 2017. He ticked off some memorable experiences such as fighting a December 2005 fire of a house under construction on Briar Lane. “I remember coming in over the Tri-Sate Tollway and seeing the glow at 3 in the morning,” Siebert said. He added the firehose bed cover on the top of the first engine reporting to the scene almost burned off from the embers landing on it. Then there was the December 2009 fire that severely damaged the house of former Mayor Frank Farwell on a private stretch off of Waukegan Road. All the responding personnel had to lay down roughly 1000 feet of firehose to extinguish it, as there weren’t any hydrants close by. The effort was hampered as the fire engine skidded into a ditch due to the icy and snowy conditions. Reminiscing about his time as chief, Siebert is proud the city modernized equipment and replaced aging vehicles, even if sometimes took repeated requests from city officials. “I was pretty persistent about things and I think I got a lot of things done,” he said. He specifically points to the acquisition of a rescue boat, that was used during the search for a resident who fell into Lake Michigan in October. (The body was later recovered in Michigan.) “It has paid off well and it can get out in any condition,” he said. “That boat goes through anything.” A major change in responsibility for the department officially started in 2018 when the Rockland Fire Protection District stopped using the volunteer force of the Knollwood Fire Department the protect the unincorporated area. The RFPD leadership entered into an outsourcing agreement with Lake Forest to provide services on one part of the area, Libertyville on the other. The issue was controversial at the time, but Siebert believes it has worked out well. “I think we came up with a good idea,” he said. He concedes there have been some mistakes at the administrative level along the way. “Those are some who learn the most out of,” he said. “You pick yourself up and find another way to go at it.” Siebert also noted the evolution of the modern fire department, pointing to technological advances. When he started in the ’90s, there was one computer in the station that kept all the calls in a logbook with a pen and paper. Now he said every single desk and rig has a computer in it and iPads are commonplace features. He added the department’s medical protocol book has nearly doubled in length since he started in the 1990s. “To be both a firefighter and a paramedic, it takes a lot and a special person to do it. We’ve been lucky to have really good people,” he said, Siebert said he stayed on along a little longer to assist Rick, who was promoted to deputy chief in September 2023, to get acclimated and fully supports his promotion. “He has done nothing but succeed at everything we have tasked him with at every level,” Siebert said. “He is a younger guy but he has some good experience and I think he will be a breath of fresh air for the department and do a great job of putting a new spin on things.” As for his own future, Siebert said he and his wife have purchased a house in central Tennessee and they plan to move there next year with the first priority of getting settled. After that, he is not certain. “I’ll find what I want to do,” he said. “I have worked my whole life and haven’t had that much time off except for a week’s vacation here and there. My plan is to take some time off and enjoy life and figure out what I want to do if I want to do anything.” Siebert will leave with praise from the community including City Manager Jason Wicha. “Chief Siebert has been instrumental in elevating training programs, establishing exceptional service standards, and always going above and beyond to serve our residents,” Wicha wrote in an e-mail. “His leadership and dedication have left a lasting impact on the Lake Forest Fire Department, our organization, and the community.” Siebert’s retirement marks another change in local public safety leadership as Karl Walldorf retired as police chief earlier this year . Up north in Lake Bluff, David Graf stepped down as that department’s chief last month . Daniel I. Dorfman is a freelance reporter for Pioneer Press.These results were presented today after market close at an AACR Special Conference in Cancer Research. The company will also hold a webinar on December 10 at 6:30 AM MT / 8:30 AM ET / 1:30 PM GMT to present the preliminary data broadcast from Recursion's X (formerly Twitter), LinkedIn, and YouTube accounts with an opportunity to submit questions here . "Cell cycle dysregulation and transcriptional 'addiction' are both hallmarks of many aggressive cancers," said David Hallett, Ph.D., Chief Scientific Officer of Recursion. "By inhibiting CDK7, we have the potential to target both mechanisms while fine tuning the therapeutic index. Using our precision design platform, we created a molecule with rapid oral absorption to reduce GI tissue exposure, a suitable half life to manage side effects, and target engagement covering the IC80 level." ELUCIDATE is an ongoing Phase 1/2 study evaluating the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and maximum tolerated dose (MTD) of REC-617 in patients with advanced solid tumors. As of the November 15, 2024 data cutoff, preliminary findings include 18 patients with advanced solid tumors who were response evaluable in the monotherapy dose-escalation phase. Doses ranged from 2 mg to 20 mg once daily (QD) and 1 mg twice daily (BID). REC-617 was generally well-tolerated across all dose levels, with no discontinuations due to adverse events (AEs). Adverse events to date were predominately Grade 1-2, on-target, and reversible. An MTD has not yet been reached. While efficacy was not an endpoint in this Phase 1 study, or anticipated in monotherapy, a confirmed durable partial response (PR) by RECIST on REC-617 monotherapy was achieved in a patient with metastatic, platinum-resistant ovarian cancer. The response is on-going after more than 6 months of treatment. This patient had progressed following 4 lines of prior therapy in the advanced setting. In addition, four patients achieved a best response of stable disease (SD) across multiple dose levels for up to 6 months of treatment. "These initial findings for REC-617 represent an exciting step forward in the development of CDK7 inhibitors, with a favorable PK/PD profile and a durable confirmed partial response observed in dose escalation in a highly pre-treated patient population," said Najat Khan, Ph.D., Chief R&D Officer and Chief Commercial Officer, Recursion. "Designed using our AI-powered OS platform, REC-617 reflects our focus on enhancing the therapeutic index to deliver more effective and safer treatment options for patients. We are eager to continue this momentum in dose escalation and to initiate the next phase of the program next year." In parallel to the ongoing monotherapy dose escalation (QD and BID), combination studies are expected to initiate for ELUCIDATE in H1, 2025. The company expects to present additional ELUCIDATE as well as preclinical REC-617 data at future medical meetings. Summary of Interim REC-617 Monotherapy Dose Escalation Results Study Design & Demographics REC-617 is a potential best-in-class CDK7 inhibitor, precision designed using AI-led approaches, with only 136 novel molecule synthesized from hit to candidate identification in less than 12 months. The molecule is designed to maximize its therapeutic index by enabling the tight control of both the extent and duration of target inhibition. CDK7 inhibition combines many potential benefits such as transcription inhibition, reduction of aberrant kinome activation, cell cycle inhibition, and modulation of estrogen receptor activity. This makes it an attractive target to overcome common resistance pathways associated with CDK4/6 inhibition, which only targets the cell cycle. About ELUCIDATE REC-617 is currently being evaluated as a monotherapy in the ELUCIDATE trial. ELUCIDATE is a multicenter, open-label, two-stage clinical trial to evaluate safety, pharmacokinetics, pharmacodynamics, and efficacy of REC-617 in advanced solid tumors, including non-small cell lung cancer (NSCLC), colorectal cancer, breast cancer, pancreatic cancer, ovarian cancer, head and neck cancer. Both the monotherapy and combination therapy dose escalation portion of the trial will enroll patients across multiple dose levels to determine the optimal biological dose (OBD). The dose expansion phase of the trial will commence upon identification of the OBD. The primary efficacy endpoint of the expansion phase is objective response rate (ORR). About Recursion Recursion (NASDAQ: RXRX) is a clinical stage TechBio company leading the space by decoding biology to radically improve lives. Enabling its mission is the Recursion OS, a platform built across diverse technologies that continuously generate one of the world's largest proprietary biological and chemical datasets. Recursion leverages sophisticated machine-learning algorithms to distill from its dataset a collection of trillions of searchable relationships across biology and chemistry unconstrained by human bias. By commanding massive experimental scale - up to millions of wet lab experiments weekly - and massive computational scale - owning and operating one of the most powerful supercomputers in the world, Recursion is uniting technology, biology and chemistry to advance the future of medicine. Recursion is headquartered in Salt Lake City, where it is a founding member of BioHive, the Utah life sciences industry collective. Recursion also has offices in Toronto, Montréal, New York, London, Oxford area, and the San Francisco Bay area. Learn more at www.Recursion.com , or connect on X (formerly Twitter) and LinkedIn. Media Contact [email protected] Investor Contact [email protected] Forward-Looking Statements This document contains information that includes or is based upon "forward-looking statements” within the meaning of the Securities Litigation Reform Act of 1995, including, without limitation, those regarding the potential efficacy of REC-617; timing of the Phase 1/2 clinical trial of REC-617; early and late stage discovery, preclinical, and clinical programs; licenses and collaborations; prospective products and their potential future indications and market opportunities; Recursion OS and other technologies; business and financial plans and performance; and all other statements that are not historical facts. Forward-looking statements may or may not include identifying words such as "plan,” "will,” "expect,” "anticipate,” "intend,” "believe,” "potential,” "continue,” and similar terms. These statements are subject to known or unknown risks and uncertainties that could cause actual results to differ materially from those expressed or implied in such statements, including but not limited to: challenges inherent in pharmaceutical research and development, including the timing and results of preclinical and clinical programs, where the risk of failure is high and failure can occur at any stage prior to or after regulatory approval due to lack of sufficient efficacy, safety considerations, or other factors; our ability to leverage and enhance our drug discovery platform; our ability to obtain financing for development activities and other corporate purposes; the success of our collaboration activities; our ability to obtain regulatory approval of, and ultimately commercialize, drug candidates; our ability to obtain, maintain, and enforce intellectual property protections; cyberattacks or other disruptions to our technology systems; our ability to attract, motivate, and retain key employees and manage our growth; inflation and other macroeconomic issues; and other risks and uncertainties such as those described under the heading "Risk Factors” in our filings with the U.S. Securities and Exchange Commission, including our Annual Report on Form 10-K and Quarterly Reports on Form 10-Q. All forward-looking statements are based on management's current estimates, projections, and assumptions, and Recursion undertakes no obligation to correct or update any such statements, whether as a result of new information, future developments, or otherwise, except to the extent required by applicable law.Kansas remained solidly entrenched at No. 1 in the AP Top 25 men's college basketball poll Monday ahead of its showdown with No. 11 Duke in Las Vegas, while a pair of schools from the Magnolia State elbowed their way back into the rankings. Kansas center Hunter Dickinson (1) celebrates after dunking the ball during the second half of an NCAA college basketball game against UNC Wilmington, Tuesday, Nov. 19, 2024, in Lawrence, Kan. Ole Miss returned to the poll at No. 23 while Mississippi State made its season debut at No. 25. The Jayhawks received 51 of 62 first-place votes from the national panel of media, putting them well ahead of two-time reigning national champion UConn, which was second with six first-place votes. Gonzaga was third with two first-place votes, Auburn was next with three, and Iowa State rounded out a top five that was unchanged from the previous week. There's a good chance for movement next week, though, with a host of high-profile matchups in holiday tournaments, and that matchup between the Jayhawks and Duke on Tuesday night in the Vegas Showdown. "Oh yeah, I've watched them," said Kansas coach Bill Self, who picked up his 800th career win by beating UNC Wilmington last week. "They're talented across the board. They're starting three freshmen, and everybody's going to talk about the one (Cooper Flagg), but the other two are potential lottery picks, if not lottery picks too." So do the Jayhawks, who have already beaten No. 12 North Carolina and Michigan State this season. Tennessee climbed four spots to No. 7 in this week's poll, followed by SEC rivals Kentucky and Alabama. Marquette was 10th after beating then-No. 6 Purdue and Georgia last week to reach 6-0 for the first time since the 2011-12 season. The Blue Devils and Tar Heels were followed by Purdue, which fell seven spots in the poll. Indiana and Wisconsin made it three straight Big Ten schools, while Cincinnati, Baylor, Florida, Arkansas and Texas A&M rounded out the top 20. The last five were Creighton, Ole Miss, Arizona, Mississippi State and BYU. The Wildcats narrowly extended their run in the AP Top 25 to 61 weeks — the fourth-longest active streak in the nation — after back-to-back losses to Wisconsin and Duke. "We didn't play great," Arizona coach Tommy Lloyd said after the loss to the Blue Devils, "so now we need to take a step back and figure out why. Are there some schematic problems? Are there some problems with how our personnel is kind of put together? And those are the things we're going to take a look at. I love the guys. I mean, I like the plan. But obviously when it's not going as well as you would like, you have to be honest with yourself and try to figure it out." Xavier returned to the poll for the first time since the final poll of the 2022-23 season ahead of its trip to the Fort Myers Tip-Off beginning Monday night. Ole Miss is back in the Top 25 after briefly dropping out, while Mississippi State is back after spending two weeks in the poll last November but just six weeks total over the past six years. Those three entered at the expense of Illinois, St. John's and Rutgers. The Illini lost to Alabama last week, while St. John's fell to Baylor and Georgia. Rutgers lost 79-77 at Kennesaw State, which beat a ranked team for the first time in school history. Marquette made the biggest climb this week, moving up five spots to No. 10. The Golden Eagles catch a breather this week with Stonehill and Western Carolina before back-to-back showdowns with No. 5 Iowa State and No. 15 Wisconsin. Purdue, Creighton and Arizona all dropped seven spots but remained in the poll. The Boilermakers lost to Marquette while the Bluejays lost to in-state rival Nebraska. The Wildcats dropped to 2-2, the first time they have been .500 at any point in a season since they were 3-3 to start the 2017-18 season. The SEC leads the way with nine of the Top 25 teams this week, including four in the top 10: Auburn, Tennessee, Kentucky and Alabama. The Big 12 is next with six, including three of the first six in top-ranked Kansas, Iowa State and Houston. The Big East had four in the poll, the Big Ten three and the ACC two. Get local news delivered to your inbox!