Video of the suspected shooter leaving the scene of the shooting Wednesday showed him riding a bicycle to Central Park and later taking a taxi cab to a bus depot, Chief of Detectives Joseph Kenny told CNN. Here's the latest: Police believe gunman who killed UnitedHealthcare CEO has left New York City The gunman who killed the CEO of the largest U.S. health insurer may have fled the city on a bus, New York City police officials told CNN on Friday. Video of the suspected shooter leaving the scene of the shooting Wednesday showed him riding a bicycle to Central Park and later taking a taxi cab to a bus depot, Chief of Detectives Joseph Kenny told CNN. “We have reason to believe that the person in question has left New York City,” Commissioner Jessica Tisch said. Gunman’s steps after killing UnitedHealthcare’s CEO give police new clues The gunman who killed the CEO of the largest U.S. health insurer made sure to wear a mask during the shooting yet left a trail of evidence in view of the nation’s biggest city and its network of security cameras that have aided authorities piecing together his movements and his identity. A law enforcement official said Friday that new surveillance footage shows the suspect riding the subway and visiting establishments in Manhattan and provided more clues about his actions in the days before he ambushed UnitedHealthcare CEO Brian Thompson . The gunman’s whereabouts and identity remain unknown Friday, as did the reason for Wednesday’s killing. New York City police say evidence firmly points to it being a targeted attack . ▶ Read more about the search for the gunman For many companies, investor meetings are seen as a risk In many companies, investor meetings like the one UnitedHealthcare CEO Brian Thompson was walking to when he was fatally shot are viewed as very risky because details on the location and who will be speaking are highly publicized. “It gives people an opportunity to arrive well in advance and take a look at the room, take a look at how people would probably come and go out of a location,” said Dave Komendat, president of DSKomendat Risk Management Services, which is based in the greater Seattle area. Some firms respond by beefing up security. For example, tech companies routinely require everyone attending a major event, such as Apple’s annual unveiling of the next iPhone or a shareholder meeting, to go through airport-style security checkpoints before entering. Others forgo in-person meetings with shareholders. ▶ Read more about how companies protect their leaders Police have obtained other surveillance images of the person wanted for questioning Those images include New York’s subway system, a law enforcement official said. In establishments where the person was captured on camera, he always appeared to pay with cash, the official said. The official wasn’t authorized to discuss details of the ongoing investigation and spoke to The Associated Press on condition of anonymity. — Mike Balsamo Another health insurer taking precautions after the shooting Medica, a Minnesota-based nonprofit health care firm that serves 1.5 million customers in 12 states, said it’s temporarily closing all six locations. The firm has offices in Minnesota, Wisconsin, Nebraska and North Dakota, and employs about 3,000 people. Employees will work from home, Medica spokesman Greg Bury said in an email Friday. “The safety of Medica employees is our top priority and we have increased security both for all of our employees,” a statement from Medica said. “Although we have received no specific threats related to our campuses, our office buildings will be temporarily closed out of an abundance of caution.” Bury also said biographical information on the company’s executives was taken down from its website as a precaution. Government health insurance provider Centene Corp. says its Investor Day will now be virtual The insurer cited the fatal shooting of UnitedHealthcare CEO Brian Thompson in its announcement about the Dec. 12 event. “All of us at Centene are deeply saddened by Brian Thompson’s death and want to express our support for all of those affected. Health insurance is a big industry and a small community; many members of the CenTeam crossed paths with Brian during their careers,” Centene CEO Sarah M. London said in a news release. “He was a person with a deep sense of empathy and clear passion for improving access to care. Our hearts are with his family and his colleagues during this difficult time.” Centene Corp. has grown in recent years to become the largest insurer in Medicaid, the state- and federally funded program that covers care for people with low incomes. Insurers manage Medicaid coverage for states, and Centene has more than 13 million people enrolled in that coverage. UnitedHealth Group says it’s focused on supporting Brian Thompson’s family The insurance company also said it’s focused on ensuring the safety of employees and assisting investigators. “While our hearts are broken, we have been touched by the huge outpouring of kindness and support in the hours since this horrific crime took place,” the company said. NY Mayor Eric Adams provided no new information on investigation’s progress during interviews But he said Friday that he’s confident police will arrest the shooter. “We are on the right road to apprehend him and bring him to justice,” Adams said on TV station WPIX. Hours after the shooting, UnitedHealthcare removed photographs of its executives from its website Later, it removed their names and biographies entirely. Investigators believe the suspect may have traveled to NY last month on a bus that originated in Atlanta Police and federal agents have been collecting information from Greyhound in an attempt to identify the suspect and are working to determine whether he purchased the ticket to New York in late November, a law enforcement official said. Investigators were also trying to obtain additional information from a cellphone recovered from a pedestrian plaza through which the shooter fled. Killing of UnitedHealthcare CEO spotlights complex challenge companies face in protecting top brass The fatal shooting of Brian Thompson while walking alone on a New York City sidewalk has put a spotlight on the widely varied approaches companies take to protect their leaders against threats. Experts say today’s political, economic and technological climate is only going to make the job of evaluating threats against executives and taking action to protect them even more difficult, experts say. Some organizations have a protective intelligence group that uses digital tools such as machine learning or artificial intelligence to comb through online comments to detect threats not only on social media platforms such as X but also on the dark web, says Komendat. They look for what’s being said about the company, its employees and its leadership to uncover risks. ▶ Read more about the steps companies take to protect their leadership Police test DNA and fingerprints on discarded bottle as they hunt for UnitedHealthcare CEO’s killer Police said Thursday they found a water bottle and protein bar wrapper from a trash can near the scene of the ambush and think the suspect bought them from a Starbucks minutes before the shooting. The items were being tested by the city’s medical examiner.Wall Street closes higher after business activity data
Israel leaves Palestinian bodies in Gaza for dogs to eat, accuses Gaza Civil DefenseORRVILLE, Ohio , Dec. 2, 2024 /PRNewswire/ -- The J.M. Smucker Co. (NYSE: SJM) ("Company") announced today the closing of the transaction to divest the Voortman ® business to Second Nature Brands. The Company previously announced the signing of a definitive agreement for the transaction on October 22, 2024 . The all-cash transaction is valued at approximately $305 million , subject to a working capital adjustment, and reflects the Company's continued commitment to optimizing its portfolio and reallocating resources to its core growth brands. The transaction includes all Voortman ® trademarks and the Company's leased manufacturing facility in Burlington, Ontario, Canada . In addition, approximately 300 employees will transition with the business. The Company updated its full-year fiscal 2025 net sales guidance to reflect the impact of the divested business. Net sales is anticipated to increase 7.5 to 8.5 percent compared to the prior year. The updated net sales guidance reflects the removal of approximately $65 million of divested net sales in fiscal 2025, with the estimated net sales impact evenly distributed throughout the remainder of the fiscal year. On a comparable basis, net sales is expected to increase 1.0 to 2.0 percent, which excludes noncomparable sales in the current year from the acquisition of Hostess Brands and noncomparable sales in the prior year related to the divestitures of the Voortman ® , Canada condiment, and Sahale Snacks ® businesses. The Company maintains its fiscal 2025 adjusted earnings per share, free cash flow, capital expenditures, and adjusted effective income tax rate outlook as communicated in its most recent quarterly earnings announcement on November 26, 2024 . The J.M. Smucker Co. Forward Looking Statements This press release ("Release") includes certain forward-looking statements within the meaning of federal securities laws. The forward-looking statements may include statements concerning our current expectations, estimates, assumptions and beliefs concerning future events, conditions, plans and strategies that are not historical fact. Any statement that is not historical in nature is a forward-looking statement and may be identified by the use of words and phrases such as "expect," "anticipate," "believe," "intend," "will," "plan," "strive" and similar phrases. Federal securities laws provide a safe harbor for forward-looking statements to encourage companies to provide prospective information. We are providing this cautionary statement in connection with the safe harbor provisions. Readers are cautioned not to place undue reliance on any forward-looking statements, which speak only as of the date made, when evaluating the information presented in this Release, as such statements are by nature subject to risks, uncertainties and other factors, many of which are outside of our control and could cause actual results to differ materially from such statements and from our historical results and experience. We do not undertake any obligation to update or revise these forward-looking statements to reflect new events or circumstances. The risks, uncertainties, important factors, and assumptions listed and discussed in this press release, which could cause actual results to differ materially from those expressed, include: the Company's ability to successfully integrate Hostess Brands' operations and employees and to implement plans and achieve financial forecasts with respect to the Hostess Brands' business; disruptions or inefficiencies in the Company's operations or supply chain, including any impact caused by product recalls, political instability, terrorism, geopolitical conflicts (including the ongoing conflicts between Russia and Ukraine and Israel and Hamas), extreme weather conditions, natural disasters, pandemics, work stoppages or labor shortages (including potential strikes along the U.S. East and Gulf coast ports and potential impacts related to the duration of a recent strike at the Company's Buffalo, New York manufacturing facility), or other calamities; risks related to the availability of, and cost inflation in, supply chain inputs, including labor, raw materials, commodities, packaging, and transportation; the impact of food security concerns involving either the Company's products or its competitors' products, including changes in consumer preference, consumer litigation, actions by the U.S. Food and Drug Administration or other agencies, and product recalls; a disruption, failure, or security breach of the Company or its suppliers' information technology systems, including, but not limited to, ransomware attacks; and risks related to other factors described under "Risk Factors" in other reports and statements filed with the Securities and Exchange Commission, including the Company's most recent Annual Report on Form 10-K. About The J.M. Smucker Co. At The J.M. Smucker Co., it is our privilege to make food people and pets love by offering a diverse family of brands available across North America . We are proud to lead in the coffee, peanut butter, fruit spreads, frozen handheld, sweet baked goods, dog snacks, and cat food categories by offering brands consumers trust for themselves and their families each day, including Folgers ® , Dunkin ' ® , Café Bustelo ® , Jif ® , Uncrustables ® , Smucker's ® , Hostess ® , Milk-Bone ® , and Meow Mix ® . Through our unwavering commitment to producing quality products, operating responsibly and ethically, and delivering on our Purpose, we will continue to grow our business while making a positive impact on society. For more information, please visit jmsmucker.com . The J.M. Smucker Co. is the owner of all trademarks referenced herein, except for Dunkin ' ® , which is a trademark of DD IP Holder LLC. The Dunkin ' ® brand is licensed to The J.M. Smucker Co. for packaged coffee products sold in retail channels such as grocery stores, mass merchandisers, club stores, e-commerce and drug stores, and in certain away from home channels. This information does not pertain to products for sale in Dunkin ' ® restaurants. View original content to download multimedia: https://www.prnewswire.com/news-releases/the-jm-smucker-co-completes-the-divestiture-of-voortman-brand-to-second-nature-brands-and-updates-fiscal-year-2025-net-sales-outlook-302319978.html SOURCE The J.M. Smucker Co.
Marvel's Spider-Man 2 for PS5 is down in price for Cyber Monday to the lowest we've ever seen it, as Best Buy has taken nearly $30 off the market price - down to just $39.99 (was $69.99) . This is one of those deals that you'll want to be quick on the money for; not just when it comes to available stock (though anything with Spider-Man in the title is always at risk for that), but because Cyber Monday itself is only hours away from ending at time of writing. Best Buy doesn't specify an endpoint for this deal, but it doesn't seem likely that it'll be around for long. Marvel's Spider-Man 2 is the most recent of the PS5 Spider-Man adaptations, and the first in the series to let players switch between both the Peter Parker and Miles Morales versions of the character. In our Marvel's Spider-Man 2 review we gave it the full five stars, and that it was "as good as superhero gaming gets. It's the quintessential costume caper, larger than life in more ways than one, and whose blockbuster boss battles and mob-fighting forays have set new standards in not just superhero games, but AAA action-adventure games in general moving forward." Should you buy Marvel's Spider-Man 2? The PS5 Spider-Man games are definite crowd-pleasers across the board, built from big budgets and ambitions that cheerfully throw in everything but the kitchen sink. Marvel's Spider-Man 2 takes this philosophy to its furthest point yet, arguably for better and worse. It's full to bursting with ideas - some of which are fantastic, like the ability to create weblines, and some that could probably have remained on the cutting room floor... like the three separate occasions in which you go on gentle bicycle rides. Still, if you enjoyed the last two Spider-Man games, or indeed those on the PS2 back in the day, or even the Batman Arkham games to some extent, you'll find a lot of reasons to enjoy this particular entry in the series, especially as a way to satiate yourself on Insomniac hero antics until Wolverine eventually comes out. For more gaming deals and discounts, check out our guide to Cyber Monday PS5 deals to see all the offers flooding through in real time!The Latest: Police believe gunman who killed UnitedHealthcare CEO has left New York CityOur view: No Saturday, no Sunday and no city employee free parking
With its rich cultural history, stunning landscapes, and vibrant modernity, South Korea has become a favoured travel destination for families from Qatar and across the GCC. Often referred to as “The Land of Morning Calm,” South Korea offers much more than just calm mornings. It is a country where tradition meets innovation, and where every family member can find something exciting, enriching, and memorable to enjoy. From its thriving K-culture scene to its world-class medical tourism offerings, South Korea’s allure continues to captivate travelers from the Middle East. Here are ten reasons why South Korea should top your family’s travel list: 1. Safe and welcoming environment Renowned for its safety and hospitality, South Korea provides a reassuring sense of security for families travelling from the GCC. The Korean culture values respect, warmth, and kindness, which creates a welcoming atmosphere for visitors. Whether you’re exploring bustling markets or strolling through tranquil parks, you’ll experience the generosity of the Korean people. Basic Korean etiquette, such as showing respect to elders and polite interactions with strangers, enhances the visitor experience and ensures that families feel comfortable and embraced. 2. Natural beauty The Songaksan Mountain on Jeju Island, a famous coastal drive with breathtaking scenic views, South Korea. South Korea offers a diverse range of landscapes, perfect for families who appreciate nature. From the snow-capped mountains of the winter season to the vibrant autumn foliage, the country’s natural beauty is awe-inspiring. The eastern coast features beautiful beaches, ideal for a family vacation by the sea, while the western coastline offers expansive shores perfect for water sports and outdoor activities. Jeju Island, a UNESCO World Heritage site, boasts lush gardens and volcanic landscapes, making it a paradise for nature lovers. The changing seasons provide a variety of experiences, ensuring that every visit to South Korea offers something new. 3. Diverse seasons The country’s four distinct seasons offer unique experiences throughout the year. In the summer, temperatures range from 23°C to 30°C, providing ideal conditions for sightseeing and outdoor adventures. The winter transforms South Korea into a winter wonderland, perfect for activities like skiing, snowboarding, and ice fishing. Spring and autumn bring moderate temperatures and stunning scenery, with cherry blossoms in spring and brilliant fall colors making for unforgettable family moments. Whether you visit in the warmth of summer or the chill of winter, South Korea’s climate accommodates all kinds of travel experiences. 4- Variety of accommodations Accommodations in South Korea range from traditional Korean houses (hanok) to luxurious international hotels, offering a variety of experiences to suit every traveler’s needs. For a truly immersive experience, families can stay in a hanok, which allows them to explore Korea’s traditional architecture and lifestyle. Alternatively, modern hotels and guesthouses cater to international travelers seeking comfort and convenience. Whether you’re looking for a high-end experience or a more authentic stay, South Korea offers options that cater to families of all preferences. 5. Kids-friendly attractions South Korea is packed with family-friendly attractions that cater specifically to children. Amusement parks such as Everland and Lotte World offer a wealth of exciting rides, parades, and themed attractions suitable for all ages. These parks also feature educational elements, combining fun with learning. Kids can dress up in traditional Korean hanbok, explore royal palaces, or visit museums like the Samsung Innovation Museum, which introduces young visitors to the world of technology through interactive exhibits. South Korea ensures that young travellers will have an enriching and exciting experience. 6- Public transportation South Korea is known for its efficient and affordable public transportation system. The subway systems in cities like Seoul are world-renowned for their punctuality, cleanliness, and ease of use. Travellers can easily navigate the city using a rechargeable T-money card, which works for both buses and subways. The transportation system’s ease of use and widespread accessibility make it incredibly convenient for families to travel around the country. For added convenience, taxis are also readily available, including luxury taxis for a more comfortable experience. 7- Korean shopping South Korea is a paradise for shoppers, offering everything from street markets to high-end malls. Myeongdong in Seoul is a bustling shopping district filled with fashionable boutiques, cosmetics stores, and street food vendors. For luxury shopping, districts like Gangnam feature high-end international brands and sleek modern malls. What sets South Korea apart is its combination of tradition and innovation—families can shop for both cutting-edge products and traditional Korean goods. K-beauty products, Korean fashion, and unique handicrafts are just some of the items you can discover while exploring the local shopping scene. 8- Delicious food Korean cuisine is a sensory experience that families can enjoy together. From spicy Tteokbokki (rice cakes) to savory hotteok (pancakes), Korean street food offers delicious flavors in every bite. Family-friendly restaurants serve a range of traditional dishes like bibimbap (mixed rice) and bulgogi (marinated beef), often accompanied by banchan, small side dishes that bring added variety to the meal. Food markets like Gwangjang Market and Jagalchi Fish Market provide an opportunity to savor authentic Korean delicacies while soaking in the vibrant atmosphere of local culture. 9- Medical and beauty tourism South Korea is a leading destination for medical tourism, offering high-quality healthcare services at competitive prices. The country is renowned for its expertise in cosmetic surgery, dermatology, and advanced medical procedures. For families seeking medical care or wellness treatments, South Korea’s hospitals are equipped with the latest technology and staffed by skilled professionals. Moreover, the country’s beauty industry—famous for its innovative skincare products and treatments—attracts many visitors looking to experience the best in self-care and rejuvenation. 10. Year-round festivities South Korea’s calendar is filled with vibrant festivals that celebrate the country’s rich cultural heritage. From the colorful Lantern Festival in the spring to the lively Dano Festival in the summer, there is always something exciting happening. In the fall, the Chuseok harvest festival brings families together to celebrate and share traditional foods, while the winter season lights up with festive events like the Seoul Christmas markets and the Jinju Namgang Yudeung Festival, where glowing lanterns light up the river. These festivals are an excellent way for families to immerse themselves in the culture and traditions of South Korea, with modern K-pop influences adding a dynamic edge to some of the celebrations. Related Story Qatar establishes WEF's Centre for Fourth Industrial Revolution Difi conference explores ways to support familiesDon’t Watch $10K Vanish — Here Are the Top 5 Cryptos to Save Your Portfolio
ST. GALLEN, Switzerland, Dec. 02, 2024 (GLOBE NEWSWIRE) -- Sportradar Group AG (NASDAQ: SRAD) ("Sportradar” or the "Company”), a leading global sports technology company focused on creating immersive experiences for sports fans and bettors, today announced that Craig Felenstein, the Company's Chief Financial Officer, will participate in the Morgan Stanley Consumer & Retail Conference on Wednesday, December 4 th , 2024. The fireside chat will take place at 2:15 pm eastern time. The webcast can be accessed at investors.sportradar.com. About Sportradar Sportradar Group AG (NASDAQ: SRAD), founded in 2001, is a leading global sports technology company creating immersive experiences for sports fans and bettors. Positioned at the intersection of the sports, media and betting industries, the company provides sports federations, news media, consumer platforms and sports betting operators with a best-in-class range of solutions to help grow their business. As the trusted partner of organizations like the ATP, NBA, NHL, MLB, NASCAR, UEFA, FIFA, and Bundesliga, Sportradar covers close to a million events annually across all major sports. With deep industry relationships and expertise, Sportradar is not just redefining the sports fan experience, it also safeguards sports through its Integrity Services division and advocacy for an integrity-driven environment for all involved. For more information about Sportradar, please visit www.sportradar.com CONTACT: Investor Relations Contact: Jim Bombassei [email protected] Press Contact : Sandra Lee [email protected]PM Modi praises surge in ‘Made in India’ products in Kuwait, emphasises trade as important pillar of bilateral relationship
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As part of efforts to ensure public safety and guide against occurrence of stampede during philanthropic gestures by individuals and organisations in the state, Governor Lucky Aiyedatiwa of Ondo state has issued series of directives outlining improved crowd control measures. The governor’s directive which was contained in a statement signed by the Attorney General and Commissioner for Justice, Dr. Olukayode Ajulo, said clearance must be sought from security agencies and other relevant authorities while thorough risk assessments must also be conducted before any planned gatherings. According to the statement, some factors are to be put into consideration before such gathering could be approved, saying such factors must include, expected attendance, location, and potential for unrest, while the venue must be well-equipped to ensure that such events do not turn tragic. Ajulo emphasized that the guidelines prioritise public safety while respecting citizens’ constitutional rights to peaceful assembly. He said “The guidelines, documented in Directive No. 01-1224, are aimed at regulating public gatherings and ensuring the protection of lives and property during events. “These directives are anchored in the powers vested in the Attorney General under Section 195 of the Constitution of Nigeria 1999 (as amended), Sections 62 and 95 of the Administration of Criminal Justice Law of Ondo State 2015, and Sections 2 and 4 of the Nigeria Police Act 2020” He stated that the directives include, “assessment of crowds which means law enforcement agencies are to conduct thorough risk assessments of any planned gatherings, while factors to consider include expected attendance, location, and potential for unrest. “Notification Requirements entails that organizers of public events must notify local authorities prior to the event. “Notifications should include details such as date, time, venue, and expected number of attendees. “Deployment of Personnel: Adequate police and security personnel must be deployed to gather intelligence and maintain order before and during events. Crowd management teams will be responsible for monitoring the event and addressing any issues that arise. “Communication Protocols: Establish clear communication channels between event organizers and law enforcement. Regular updates should be shared to ensure swift responses to any crowd-related incidents. “Use of Technology: Utilize surveillance and monitoring technology to observe crowd dynamics in real-time. Drones and CCTV cameras may be employed where necessary to enhance security” Other measures include, Public awareness campaigns: Conduct campaigns to educate the public on safety measures during gatherings. Promote peaceful assembly and discourage violence or unlawful behaviour. “Emergency Response Plans: Develop and disseminate emergency response plans for potential incidents. All personnel must be trained on these protocols. “Medical and Emergency Preparedness: Ensure a qualified medical team, emergency preparedness team, ambulances, and security personnel are present for events with over 300 participants, whether spiritual, physical, political, or social” Organisers of such events are charged to “Position medical teams and security personnel strategically within and outside the venue. ALSO READ: 22 died in Anambra Christmas rice stampede — Police “They are also to provide essentials, provide accessible packs of drinking water for participants, ensure mobile toilets are available, with a sanitation team to maintain cleanliness. “The venue must be accessible. Avoid venues with only one entrance or exit to facilitate smooth crowd movement” Ajulo said “All actions taken must comply with all the laws in operations in Nigeria with full adherence and respect to the Constitutional rights of citizens to assemble peacefully “Any violations of these directives may result in legal action against the organizers or participants” Dr. Ajulo stated that the directives also call for enhanced collaboration between event organizers, law enforcement agencies, and local government authorities. He stressed the importance of proactive measures, such as communication protocols and venue accessibility, to prevent incidents and ensure public safety. The Chief Law Officer of the State reiterated that these measures are designed to protect lives and property, urging full compliance from all parties involved. “These crowd control measures are a testament to Governor Lucky Orimisan Aiyedatiwa’s commitment to fostering a secure environment for public gatherings in Ondo State. “Stakeholders are advised to familiarize themselves with the directives to avoid legal repercussions and contribute to a safer society,” Ajulo stated. NIGERIAN TRIBUNE
For the second time in as many days, Missouri flipped the commitment a four-star recruit. On Sunday night, it was Kentucky running back commit Marquise Davis. On Monday, DaMarion Fowlkes — a wide receiver out of Maryland — announced that he was joining Mizzou's 2025 class. He joins Donovan Olugbode and Shaun Terry as receivers who have pledged to the Tigers. Fowlkes had been committed to Pittsburgh since June, but Mizzou extended the receiver an offer Friday and had him in town for a visit for the Tigers' regular-season finale against Arkansas. He is the 230th-ranked player and the 22nd-ranked receiver in his class, according to 247Sports. Fowlkes held offers from Boston College, Indiana and Wake Forest, among others. The 5-foot-10, 175-pound receiver out of Good Counsel High School in Olney, Maryland, caught 47 passes for 761 yards and five touchdowns this season, and his elite, breakaway speed also made him a dangerous return man. He added five punt return touchdowns and one kick return touchdown, totaling 11 TDs and 1,247 all-purpose yards this season. Fowlkes was named to the Washington Catholic Athletic Conference first team as a receiver and returner. Five-star OT Rogers decommits from Mizzou On Monday afternoon, hours after Fowlkes joined the 2025 class, Mizzou saw firsthand that flip season goes both ways. Five-star offensive tackle Lamont Rogers announced on his X account that he was decommiting from the Tigers. Rogers, who had been committed to the Tigers since early July, has taken multiple game-day visits to College Station, Texas, this fall, leading many to assume the five-star offensive tackle will end up at Texas A&M. He played his high school ball at Mesquite Horn in Mesquite, Texas, which is roughly three hours from College Station. He visited Texas A&M on Oct. 5 and saw the Aggies' 41-10 rout of the Tigers in person. Mizzou running back commit Jamarion Morrow is another recruit who might be looking elsewhere. The four-star prospect visited Georgia for the Bulldogs' 31-17 win over Tennessee and was at Texas A&M on Saturday to watch the Aggies' 17-7 loss to Texas. Morrow has yet to decommit, but if he does end up going elsewhere, Mizzou may have another option to turn to. Brendon Haygood, a three-star running back out of Sachse, Texas, visited Columbia for the Arkansas game and decommitted from Boise State shortly before kickoff. Haygood confirmed to the Columbia Missourian that he is announcing his commitment at 8:45 p.m. Tuesday on his Instagram account and will choose between Mizzou and Texas Tech. With the addition of Fowlkes and the loss of Rogers, Mizzou currently sits at 16 commits in the Class of 2025. The Tigers' class is ranked No. 19 in the country, according to 247Sports.December 24, 2024 This article has been reviewed according to Science X's editorial process and policies . Editors have highlightedthe following attributes while ensuring the content's credibility: fact-checked peer-reviewed publication trusted source proofread by Liu Jia, Chinese Academy of Sciences A research team led by Prof. Nie Guangjun from the National Center for Nanoscience and Technology (NCNST) of the Chinese Academy of Sciences (CAS) and collaborators have demonstrated a tumor membrane antigens-based nanovaccine derived from liposomal doxorubicin treated tumor tissues, which is efficacious in inducing a potent immunological defense against tumors. The study is published online in Cell Reports Medicine . For solid tumor surgeries, challenges remain in postoperative tumor recurrence and metastasis. The correlation between postoperative tumor recurrence and metastasis and the host's antitumor immune status is well-established. Personalized cancer vaccines, using the patient's own tumor as an antigen source, stimulate a robust immune response that is efficacious in eliminating residual neoplastic foci following surgical intervention as well as in targeting metastatic lesions at a distance, significantly reducing the risk of postoperative tumor recurrence and metastasis. The efficacy of autologous tumor cells in clinical trials has been limited by their weak immunogenicity. The tumor membrane contains tumor-presented antigens and associated antigens, which can be developed into a personalized antigen library that more accurately reflects the expression of tumor antigens. Vaccines based on autologous tumor cell membrane antigens have been developed. In clinical practice, patients administered autologous tumor cell membrane-based vaccines (TMVs) frequently have a history of prior therapeutic interventions with chemotherapy being the predominant modality. However, chemotherapy has the potential to alter the immunogenic properties of tumor cell membranes, consequently impacting the therapeutic efficacy of the TMVs. In this study, researchers investigated the effects of preoperative chemotherapy on the efficacy of TMVs employing nano-formulated liposomal doxorubicin (NP-Dox) as a preoperative medication. For the formulation of the TMVs, they obtained the tumor membrane as the antigen, and resiquimod (R848), a potent dual Toll-like receptor 7/8 agonist with excellent efficacy, was encapsulated in Poly (lactide-co-glycolic acid) (PLGA) nanoparticles to act as the adjuvant of the vaccine. The TMVs formulated from liposomal doxorubicin-treated tumors induced superior dendritic cell maturation and T cell activation compared to doxorubicin, demonstrating better efficacy in preventing recurrence and metastasis in the postoperative murine model, as well as in extending postoperative survival. Mechanistically, researchers demonstrated that NP-Dox, as a paradigmatic inducer of immunogenic cell death in tumors, upregulates the expression of immune-related molecules on the tumor cell membrane, enhancing the immunogenicity of tumor membrane antigens. Moreover, they showed that NP-Dox improves the immunological status of the tumor microenvironment, creating favorable conditions for subsequent nanovaccine immunization. "In a previous study, we developed an integrated vaccine formulation based on autologous tumor membrane antigens and bacterial cytoplasmic membrane adjuvants, which could achieve enhanced antitumor immune responses with a favorable biosafety profile," said Assoc. Prof. Zhao Ruifang from NCNST and the first author of this study. "However, for its clinical applications, we found that patients had undergone various treatments before using autologous tumor membrane vaccines with chemotherapy being relatively common." "This study provides valuable insights into the clinical application of TMVs, demonstrating its potential in solid tumor treatments. Concurrently, in this study, we employ nano-drugs both pre-and postoperatively, and showcase the superiority of nanotechnology in the integrated application of neoadjuvant chemotherapy and tumor immunotherapy," said Prof. Nie Guangjun from NCNST and another first author of this study. More information: Yang Chen et al, Neoadjuvant chemotherapy by liposomal doxorubicin boosts immune protection of tumor membrane antigens-based nanovaccine, Cell Reports Medicine (2024). DOI: 10.1016/j.xcrm.2024.101877 Journal information: Cell Reports Medicine Provided by Chinese Academy of SciencesLookman speaks on CAF POTY nomination after helping Atalanta beat AC Milan
Bluesky Finds With Growth Comes Growing Pains — and BotsSHENZHEN, China, Dec. 24, 2024 (GLOBE NEWSWIRE) -- EVDANCE, a trusted name in electric vehicle (EV) charging solutions, is proud to announce its 5th anniversary and the successful completion of a significant brand upgrade. To celebrate this milestone, EVDANCE is launching an exciting Mega Sale, offering exclusive deals to its valued customers. Exclusive Anniversary Offers From December 10 to December 31, EVDANCE invites all EV enthusiasts to visit its enhanced website at https://evdances.com/ and take advantage of the following special promotions: Products Designed for Real-Life Scenarios EVDANCE is committed to delivering innovative products that address the everyday needs of EV owners, enhancing convenience and reliability. As it celebrates five years of innovation, the brand continues to meet real-world needs with products like portable chargers, durable extension cables, and versatile adapters, enhancing every EV charging experience. Portable EV Chargers: Lightweight and compact, these chargers are designed for ultimate convenience, allowing you to charge your EV wherever an outlet is available-be it at home or on the road. With IP66-rated protection against water, dust, and cold, these chargers perform reliably in temperatures ranging from -22°F to 122°F. Advanced safety features and fast charging capabilities ensure your EV is always ready to hit the road. Extension Cables: Built with high-strength TPE and silver-plated copper, EVDANCE's IP66-rated extension cables deliver exceptional durability and performance. Perfect for scenarios where outlets are far from parking spots or when navigating shared charging stations, these cables ensure seamless charging without constant vehicle rearrangements-ideal for road trips or multi-EV households. Adapters: EVDANCE's Tesla-to-J1772 and J1772-to-Tesla adapters ensure compatibility across diverse EV models, making them essential for families with multiple electric vehicles or those charging at public stations. Made from high flame-resistant PC material, these adapters are built to endure over 10,000 plug-in/out cycles, offering long-lasting reliability. The secure locking mechanism prevents accidental disconnections, ensuring a safe charging process. With an IP65 weatherproof rating, they operate efficiently in temperatures ranging from -22°F to 122°F, delivering consistent performance in extreme conditions. 5 Years of Excellence: EVDANCE's Commitment to EV Charging Innovation Since its founding in 2019, EVDANCE has been dedicated to developing reliable, high-quality, and innovative EV charging solutions. Its focus on safety, efficiency, and customer satisfaction has earned the trust of EV owners in over 40 countries. This global reach reflects EVDANCE's mission to support sustainable mobility through advanced technology. Brand Upgrade: A Milestone for the Future EVDANCE's 5th anniversary celebrates five years of relentless innovation and a transformative brand upgrade, designed to meet the evolving needs of its growing customer base. Guided by a mission to make EV charging seamless, efficient, and accessible, the brand introduces an enhanced website(https://evdances.com) with improved navigation, detailed product information, and a more intuitive shopping experience-making it easier than ever for customers to discover cutting-edge solutions. This milestone reflects EVDANCE's dedication to staying ahead in the rapidly advancing EV market while continuing its focus on quality, sustainability, and customer satisfaction. With these improvements, the brand reaffirms its commitment to driving sustainable mobility for a greener future. About EVDANCE Founded in 2019 by a team of visionary engineers and environmental enthusiasts, EVDANCE was born out of a passion for solving the challenges of EV charging. Frustrated with the limitations of existing infrastructure, the team set out to create innovative, intelligent, and reliable solutions that elevate the EV ownership experience. Since its inception, EVDANCE has remained at the forefront of EV charging technology, delivering fast and efficient solutions designed with sustainability in mind. By using eco-friendly materials and energy-efficient technology, the company aligns its products with a broader mission to protect the environment. As EVDANCE continues to grow, it works closely with communities, businesses, and organizations to expand EV infrastructure, empowering a global shift toward sustainable mobility. Guided by the vision of "Electric Vehicle Quick Charge," EVDANCE is committed to driving progress in the EV industry and helping customers embrace a more sustainable future. For more information, please visit: https://evdances.com/ Media Contact: Wumi at [email protected] A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/bfe05f92-c1b0-4a74-ad3b-17c9ecb97440Fianna Fail and Fine Gael eye independent TDs as option to secure Dail majority