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Wedbush initiated coverage on Solid Biosciences, Inc. SLDB , a gene therapy company focused on treating Duchenne muscular dystrophy (DMD). DMD is a genetic disease that causes progressive muscle weakness and wasting. SGT-003 is the leading program in Solid Biosciences' pipeline, with plans to advance additional projects toward clinical trials in 2025. The therapy uses the AAV-SLB101 capsid and a specialized cargo (nNOS binding domain) to potentially boost dystrophin expression compared to earlier-generation treatments. While first-generation gene therapy for Duchenne muscular dystrophy (DMD) opens new treatment possibilities, there is still room for improvement. The analyst writes that Solid Biosciences' innovative approach and novel capsid technology could enhance microdystrophin delivery. Although the company's pipeline offers multiple opportunities, current projections focus only on SGT-003 for DMD. The most significant near-term milestone for Solid Biosciences is the initial Phase 1/2 INSPIRE DUCHENNE trial results, expected in the first quarter of 2025. Approving Sarepta Therapeutics Inc's SRPT Elevidys was a key milestone in treating Duchenne muscular dystrophy (DMD), but it's only the beginning. Newer treatments with better and more reliable results are still needed. Wedbush analyst writes, "We see Solid Biosciences in a "solid" position to deliver a next-gen therapeutic option." Wedbush writes that Solid Biosciences' stock trade at around $5 each, with about $4 per share in cash providing some downside protection. Assuming Solid Biosciences' SGT-003 program follows a timeline similar to Sarepta's Elevidys, even a one-year delay would lower the price target to $11 per share (current price target of $16)—still above the current trading price. With other programs yet to be included in the valuation, the analyst sees strong potential and initiates with an Outperform rating . Solid Biosciences ended the third quarter of 2024 with approximately $171.1 million in cash, cash equivalents, and available-for-sale securities, with an anticipated cash runway into 2026. Price Action: SLDB stock is up 3.21% at $4.83 at the last check on Friday. Read Next: Gilead Unveils New Yearly HIV Injection To Offer Hope for Less Frequent Preventive Dosing © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.Expanding universal health care in schoolsRachel Reeves has been dealt a fresh blow as damning new graphs reveal the UK's flatlining economy and decline in multiple industries since Labour has been in government. The new data, released today by the Office for National Statistics (ONS), shows the economy shrinking for a second month in a row in October, despite analysts previously predicting 0.1% growth. The period covers the four weeks prior to Reeves' highly controversial Budget and marks the first back-to-back decline since the start of the COVID -19 pandemic. Gross domestic product (GDP) - the value of goods and services produced by a country - fell by 0.1% between August and September, and another 0.1% between September and October. Since Labour won the election in July, the economy has stagnated or declined every month except August, which puts pressure on the Bank of England to reduce interest rates in order to stimulate the economy and increase consumer spending. Looking closer at the ONS figures, they reveal that production, construction, and the services sector all declined during the same period. Factories and mining firms are also becoming less economically viable ; both experience output production delcines of 0.6% after a 0.5% shrinkage in September. Construction companies' output also declined by 0.4%, which may make reaching Labour's taregt of building 1.5 million new homes across the country even harder to reach. Reeves was forced to respond to the "disappointing" figures, realsing a statement maintaining her government has a plan for "long-term economic growth". She said: "While the figures this month are disappointing, we have put in place policies to deliver long-term economic growth." The Tories were quick to hit back at the recent economic downturn under the new Labour government, accusing Reeves of poor decision making. Mel Stride, the party's spokesperson on the economy, said: "It is no wonder businesses are sounding the alarm. This fall in growth shows the stark impact of the chancellor's decisions and continually talking down the economy."si on ou s'on 。

Canine-friendly bar Bark Social in Manayunk closed abruptly Thursday after the business declared bankruptcy, leaving dogs with one fewer social spot in Philly. The company explained in an Instagram post that its demise is the result of financing it had expected not materializing . The Manayunk bar, opened in April 2023 along the Schuylkill River next to Regal UA movie theater in the shopping center at 3720 Main St. It was one of five Bark Social locations. Others were in Baltimore and suburban Maryland and Washington, D.C. A sixth location had been planned to open in Los Angeles in 2025. "We know this is abrupt, but as a small start-up, Bark Social relies on investors to fuel its growth," the Instagram post states. The company also said it wanted to "do right by its team members." Fast Company reported Friday that Bark Social's employees were not offered severances . The company also will not be offering refunds to dog owners who had bought memberships to the bar, and Bark Social's director of marketing, Chris Rubacha, suggested members contact their banks to "inquire about chargebacks." Basic memberships for dog owners ranged from $50 per month and to $365 a year, and a premium membership, with additional perks, cost as much as $1,000 per year. The online calendar for the Manayunk Bark Social showed a comedy show, White Claw tasting and pet portraits had been scheduled to take place Friday. The location had indoor and outdoor spaces for guests and their pets. Bark Social also offered daycare services for dogs.

Cade Lucas This story was one of the top stories from 2024 and was originally published in February. Visiting the graves of loved ones is usually an emotional experience, something Hoppers Crossing’s Margherita Loviscotto knows better than most. Since her son Gabriele’s death in 1985, Ms Loviscotto has visited his burial site at Werribee Cemetery on countless occasions, often attending two to three times a week. But after nearly 40 years, the 86 year old has had to scale back her cemetery visits, with a recent illness forcing her to go three weeks without tending to Gabriele’s grave, her longest absence since his passing. Her eventual return on Tuesday January 30 left Ms Loviscotto more emotional than ever. “Werribee Cemetery is a disgrace,” she said of the condition she found it in. “The grass was my height, there was grass everywhere. The weeds were everywhere. “I felt like crying.” Ms Loviscotto is far from alone in being upset with the condition of the cemetery. A subsequent social media inquiry by the Star Weekly attracted a stream of angry responses from Wyndham residents, with the cemetery variously described as ‘a disgrace’, ‘disgraceful,’ ‘crap,’ ‘grim and very unkept,’ and ‘not good enough.’ Like Ms Loviscotto, many remarked on the amount of grass and weeds that have been allowed to grow on the cemetery grounds. Vegetation overgrowth has been an issue across many public green spaces throughout Wyndham following unseasonably heavy summer rains. Wyndham council recently advised that it was struggling to deal with the amount of vegetation growth over the Christmas and New Year period and that mowing and lawn maintenance would take longer than usual. However, Werribee Cemetery is no longer the responsibility of Wyndham council, with The Greater Metropolitan Cemeteries Trust (GMCT), that also operates cemeteries in Altona and Fawkner, taking over management in 2010. Margherita Loviscotto said she’d noticed a decline in the condition of the cemetery ever since. “Since the trustee took it over, the cemetery is neglected,” she said. “Before when the it was the council in charge, they cut the grass every two weeks and it was nice and clean.” Chief operations and people officer at GMCT, Dimi Patsisas, said the cemetery was mowed only days before Ms Loviscotto’s January 30 visit. “We are committed to maintaining Werribee Cemetery with care and respect,” he said. “We deployed additional staff there last Thursday (25 January) for maintenance, as a result of grass and weeds growing faster due to the unusually wet summer.” While GMCT is responsible for public spaces at the cemetery, care and maintenance of individual grave sites is up to family members, with many using their own equipment to cut grass around them. Despite criticism, few complaints about the condition of Werribee Cemetery are believed to have been lodged with GMCT.Shares of Rover Group, Inc. ( OTCMKTS:NEBCU – Get Free Report ) rose 6.1% during mid-day trading on Friday . The stock traded as high as $11.00 and last traded at $11.00. Approximately 2,900 shares traded hands during trading, a decline of 98% from the average daily volume of 118,677 shares. The stock had previously closed at $10.37. Rover Group Price Performance The stock has a 50-day simple moving average of $11.00 and a 200-day simple moving average of $11.00. About Rover Group ( Get Free Report ) Nebula Caravel Acquisition Corp. does not have significant operations. It intends to effect a merger, share exchange, asset acquisition, share purchase, reorganization, or related business combination with one or more businesses or entities. The company was incorporated in 2020 and is based in San Francisco, California. Read More Receive News & Ratings for Rover Group Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Rover Group and related companies with MarketBeat.com's FREE daily email newsletter .

CNN's Dovere: Biden Will Be Remembered as the 'Guy Who Was Just in Between the Trump Terms'

Extendicare Inc. ( OTCMKTS:EXETF – Get Free Report ) declared a dividend on Tuesday, December 24th, investing.com reports. Stockholders of record on Wednesday, January 1st will be paid a dividend of 0.0282 per share on Wednesday, January 15th. This represents a dividend yield of 4.74%. The ex-dividend date of this dividend is Tuesday, December 31st. Extendicare Stock Performance OTCMKTS:EXETF opened at $7.14 on Friday. The company has a fifty day moving average of $7.09 and a 200 day moving average of $6.41. Extendicare has a 52 week low of $4.74 and a 52 week high of $7.80. Extendicare Company Profile ( Get Free Report ) Read More Receive News & Ratings for Extendicare Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Extendicare and related companies with MarketBeat.com's FREE daily email newsletter .Labour’s plans to ban trail hunting ‘completely unjustified’

BLOOMINGTON — Illinois Wesleyan University is partnering with For A Better Tomorrow to host the second STEAM Olympics Competition. The competition will be available to local students in first grade through high school for the multi-day event from Feb. 22-23 and March 1-2. The event will take place at the Center for Natural Sciences, 201 E. Beecher St. in Bloomington, and will feature more than 10 activities in technology, engineering, arts and mathematics to offer hands-on learning with 3D printing, art workshops, essay writing, science and math tests, as well as a science fair. Registered participants and their families will also have access to optional laboratory tours on Illinois Wesleyan and Illinois State university campuses to witness real-world applications of STEAM fields. “New workshops have been added — including the design-a-thon, speech and debate, and the STEAM Quest — each designed to challenge participants and celebrate their talents,” said Dakesa Piña, vice president of inclusion excellence at IWU. Piña is leading the event in partnership with For a Better Tomorrow, which is a Bloomington-based organization that strives to promote social justice through philanthropy and nurturing future generations of servant leaders within the community. "We had 235 registrations and 128 students who participated in the inaugural STEAM Olympics. This is a testament to the need for such an event in our community and the quality of volunteers who brought their enthusiasm to the planning," said Sambisvarao Gurijala, 2025 STEAM Olympics co-chair. The STEAM Olympics will conclude with an award ceremony and keynote address, with medals presented to the top scorers in each grade. The school with the most medals will win a championship trophy and cash prize. Proceeds will benefit both IWU and FBT to support various initiatives, including grants for local and global projects for FBT and needs-based scholarships for IWU students who are actively involved with social justice and community engagement. Registration is available at forbettertomorrow.org/steam . Early registrations are available at a discounted price until Dec. 31. Participation will be granted on a first-come, first-served basis. Event fees will be waived for individuals with financial barriers. For more information about the STEAM Olympics or to inquire about sponsorship opportunities, contact Sam Gurijala at sambasiva306@gmail.com or 309-838-5254. The festival raises money For a Better Tomorrow, which helps children and the needy local and abroad Contact Kaitlyn Klepec at (309) 820-3345. Want to see more like this? Get our local education coverage delivered directly to your inbox. Courts and Public Safety Reporter {{description}} Email notifications are only sent once a day, and only if there are new matching items.

Washington Commanders: Jayden Daniels Shakes Off Losing Streak