GM agrees deal to enter F1 with Cadillac in 2026
6 Trade Landing Spots for New York Rangers Star Chris Kreider Amid NHL RumorsChristmas and Boxing Day are more than just festive celebrations—they’re the ultimate moments to snag the best deals of the year. It’s the season when quality meets affordability, and you can treat yourself and your loved ones to premium products at prices that feel like a holiday miracle. Whether you’re shopping for the perfect gift or upgrading your home essentials, these days are your golden opportunity to save big without compromising on value. We all love the holidays, but let’s be honest: between the cooking, hosting, and decorating, keeping the house clean feels like an uphill battle. That’s where the 3i S10 Ultra Robot Vacuum steps in, effortlessly taking over your cleaning duties while you focus on what matters most—spending time with loved ones. 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Click now and make this holiday season cleaner, easier, and more enjoyable.Head coach Vanni Sartini paid the price Monday for the Vancouver Whitecaps’ mediocre results this past season and subsequent first-round playoff exit. His firing came about two weeks after the Major League Soccer team won a play-in game before falling to top-seeded Los Angeles FC in a three-game series that went the distance. “The desperation on my side is absolutely there,” said Axel Schuster, the Whitecaps’ sporting director and chief executive officer. One of the reasons for the change, he said, is everyone in the organization, including himself, needs a reminder that playoff success next year is imperative. “We cannot not get there.” The Whitecaps haven’t reached the conference semifinals since 2017. In a one-hour availability with reporters, Schuster noted the team had the second-worst home record in the Western Conference this year and recorded just two points over its last seven regular-season games. He referenced the need for fresh energy from a new coach and added there was no firm timeline in place for a replacement to be named. “I had to make a professional decision (for) how we can get the biggest impact to make this step forward and to get to a progression,” he said. The Whitecaps’ late-season slump dropped them to eighth place in the West with a record of 13-13-8. Vancouver won a play-in game at Portland before dropping a 1-0 decision at LAFC in the deciding game of the series. Vancouver also won its third-straight Canadian championship this season, beating Toronto FC 4-2 on penalties after the final ended in a 0-0 tie. “I took my time with this decision, and it was not taken lightly,” Schuster said. Sartini, a 47-year-old from Florence, Italy, took over coaching duties on an interim basis in August 2021 after the Whitecaps dismissed Marc Dos Santos. He was officially named head coach that November. “For the last three years and three months, it has been an absolute honour to be the head coach of Vancouver Whitecaps FC,” Sartini said in a release. “I will always be grateful to Axel Schuster and ownership for entrusting me to be the technical lead of this club in such an important time. “Vancouver will always have a special place in my heart and my wife’s heart,” he added. He posted a record of 57-51-39 across all competitions. The exuberant Italian made headlines in November 2023 when he publicly criticized a referee following a playoff game and made a joke about being a suspect if the official were to be found dead. He was suspended for the first six games of the 2024 MLS campaign, fined US$20,000 and ordered to complete a league-approved behavioural assessment. The coach later apologized for the comments and his suspension was cut to four games. Sartini came to Vancouver in 2019 as Dos Santos’ assistant coach and spent two seasons with the first team before being named the club’s “director of methodology” and taking over coaching the U-23 team in 2020. Before joining the Whitecaps, he worked as a coach educator for the Italian Football Federation and the U.S. Soccer Federation, and coached several different clubs in Italy.
Disneyland announces closure date for Red Car Trolley attractionSpecial counsel moves to abandon election interference and classified documents cases against Trump
Noel scores 26 points as Wright State takes down Detroit Mercy 80-72AP News Summary at 4:15 p.m. ESTAllegiant Air announced Thursday that it will resume nonstop flights between the Lehigh Valley and Denver.
Decision follows observations of liver transaminitis without clinically significant symptoms in some subjects on azelaprag Company will evaluate data from patients enrolled to date and share updated plans for azelaprag in Q1 2025 In parallel to evaluating azelaprag, Company will continue to advance earlier platform-derived programs, including IND submission for CNS penetrant NLRP3 inhibitor anticipated in the second half of 2025 RICHMOND, Calif., Dec. 06, 2024 (GLOBE NEWSWIRE) -- BioAge Labs (Nasdaq: BIOA) (“BioAge”, “the Company”), a clinical-stage biopharmaceutical company developing therapeutic product candidates for metabolic diseases by targeting the biology of human aging, today announced that the Company has made the decision to discontinue the ongoing STRIDES Phase 2 study of its investigational drug candidate azelaprag as monotherapy and in combination with tirzepatide after liver transaminitis without clinically significant symptoms was observed in some subjects receiving azelaprag. No transaminase elevations were observed in the tirzepatide only treatment group. “Patient safety is our top priority in the conduct of our clinical studies,” said Kristen Fortney, PhD, CEO and co-founder of BioAge. “We made the difficult decision to discontinue the STRIDES Phase 2 study of azelaprag because it became clear that the emerging safety profile of the current doses tested is not consistent with our goal of a best-in-class oral obesity therapy. While this outcome is a significant disappointment, we remain encouraged by azelaprag’s promising preclinical and Ph1b efficacy profile. We remain committed to our focus on developing therapies for metabolic aging. In parallel to assessing the next steps for the azelaprag program, we will continue to advance our NLRP3 inhibitor program as well as additional research programs with novel mechanisms emerging from our platform.” STRIDES is a randomized, double-blind, placebo-controlled Phase 2 clinical trial of azelaprag as monotherapy and in combination with tirzepatide that planned to enroll approximately 220 individuals with obesity aged 55 years and older ( link ). The trial was designed to evaluate the efficacy as measured by body weight reduction and other outcomes, safety, and tolerability of two oral doses of azelaprag (300 mg, once or twice daily) in combination with tirzepatide (5 mg subcutaneous injection once weekly). An azelaprag monotherapy arm was included to provide additional safety information. Of 204 subjects enrolled in STRIDES as of today, 11 subjects in the azelaprag treatment groups were observed to have transaminase elevations with no clinically significant symptoms. Dosing of all subjects will be discontinued, and no additional subjects will be enrolled. Clinical follow-up of enrolled subjects will continue off drug. The Company intends to further analyze available STRIDES clinical data from all enrolled subjects. The Company has notified all study investigators and regulatory authorities including the U.S. Food and Drug Administration (FDA) of the Company’s decision to discontinue enrollment. The Company intends to share updated plans for azelaprag in Q1 2025. BioAge continues to advance its pipeline of therapeutic candidates targeting the biology of aging to treat metabolic diseases. The Company's novel class of brain-penetrant NLRP3 inhibitors, which have demonstrated high potency and a novel binding site, are progressing toward IND submission, anticipated in the second half of 2025. The NLRP3 inhibitor program targets neuroinflammation, which is linked to both metabolic and neurodegenerative diseases. In addition, BioAge is advancing multiple targets derived from its proprietary discovery platform, which analyzes molecular data spanning over 50 years of human aging trajectories. About BioAge Labs, Inc. BioAge is a clinical-stage biopharmaceutical company developing therapeutic product candidates for metabolic diseases, such as obesity, by targeting the biology of human aging. BioAge’s lead product candidate, azelaprag, is an orally available small molecule agonist of APJ that was observed to promote metabolism and prevent muscle atrophy on bed rest in a Phase 1b clinical trial. BioAge is also developing orally available small molecule brain penetrant NLRP3 inhibitors for the treatment of diseases driven by neuroinflammation. BioAge’s preclinical programs, based on novel insights from the company’s discovery platform built on human longevity data, address key pathways in metabolic aging. Forward-looking statements This press release contains “forward-looking statements” within the meaning of, and made pursuant to the safe harbor provisions of, the Private Securities Litigation Reform Act of 1995. All statements contained in this press release that do not relate to matters of historical fact should be considered forward-looking statements, including, but not limited to, statements regarding our plans to develop and commercialize our product candidates, our business strategy, results of our ongoing or planned clinical trials, the timing of any future updates to our programs and the clinical utility of our product candidates. These forward-looking statements may be accompanied by such words as “aim,” “anticipate,” “believe,” “could,” “estimate,” “expect,” “forecast,” “goal,” “intend,” “may,” “might,” “plan,” “potential,” “possible,” “will,” “would,” and other words and terms of similar meaning. These statements involve risks and uncertainties that could cause actual results to differ materially from those reflected in such statements, including: our ability to develop, obtain regulatory approval for and commercialize our product candidates; the timing and results of preclinical studies and clinical trials; the risk that positive results in a preclinical study or clinical trial may not be replicated in subsequent trials or success in early stage clinical trials may not be predictive of results in later stage clinical trials; risks associated with clinical trials, including our ability to adequately manage clinical activities, unexpected concerns that may arise from additional data or analysis obtained during clinical trials, regulatory authorities may require additional information or further studies, or may fail to approve or may delay approval of our drug candidates; the occurrence of adverse safety events; failure to protect and enforce our intellectual property, and other proprietary rights; failure to successfully execute or realize the anticipated benefits of our strategic and growth initiatives; risks relating to technology failures or breaches; our dependence on collaborators and other third parties for the development of product candidates and other aspects of our business, which are outside of our full control; risks associated with current and potential delays, work stoppages, or supply chain disruptions; risks associated with current and potential future healthcare reforms; risks relating to attracting and retaining key personnel; failure to comply with legal and regulatory requirements; risks relating to access to capital and credit markets; and the other risks and uncertainties that are detailed under the heading “Risk Factors” included in BioAge’s Form 10-Q filed with the U.S. Securities and Exchange Commission (SEC) on November 7, 2024, and other filings with the SEC filed from time to time. BioAge undertakes no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise. Contacts PR: Chris Patil, media@bioagelabs.com IR: Elena Liapounova, ir@bioagelabs.com Partnering: partnering@bioagelabs.com Web: https://bioagelabs.com
Head coach Vanni Sartini paid the price Monday for the Vancouver Whitecaps’ mediocre results this past season and subsequent first-round playoff exit. His firing came about two weeks after the Major League Soccer team won a play-in game before falling to top-seeded Los Angeles FC in a three-game series that went the distance. “The desperation on my side is absolutely there,” said Axel Schuster, the Whitecaps’ sporting director and chief executive officer. One of the reasons for the change, he said, is everyone in the organization, including himself, needs a reminder that playoff success next year is imperative. “We cannot not get there.” The Whitecaps haven’t reached the conference semifinals since 2017. In a one-hour availability with reporters, Schuster noted the team had the second-worst home record in the Western Conference this year and recorded just two points over its last seven regular-season games. He referenced the need for fresh energy from a new coach and added there was no firm timeline in place for a replacement to be named. “I had to make a professional decision (for) how we can get the biggest impact to make this step forward and to get to a progression,” he said. The Whitecaps’ late-season slump dropped them to eighth place in the West with a record of 13-13-8. Vancouver won a play-in game at Portland before dropping a 1-0 decision at LAFC in the deciding game of the series. Vancouver also won its third-straight Canadian championship this season, beating Toronto FC 4-2 on penalties after the final ended in a 0-0 tie. “I took my time with this decision, and it was not taken lightly,” Schuster said. Sartini, a 47-year-old from Florence, Italy, took over coaching duties on an interim basis in August 2021 after the Whitecaps dismissed Marc Dos Santos. He was officially named head coach that November. “For the last three years and three months, it has been an absolute honour to be the head coach of Vancouver Whitecaps FC,” Sartini said in a release. “I will always be grateful to Axel Schuster and ownership for entrusting me to be the technical lead of this club in such an important time. “Vancouver will always have a special place in my heart and my wife’s heart,” he added. He posted a record of 57-51-39 across all competitions. The exuberant Italian made headlines in November 2023 when he publicly criticized a referee following a playoff game and made a joke about being a suspect if the official were to be found dead. He was suspended for the first six games of the 2024 MLS campaign, fined US$20,000 and ordered to complete a league-approved behavioural assessment. The coach later apologized for the comments and his suspension was cut to four games. Sartini came to Vancouver in 2019 as Dos Santos’ assistant coach and spent two seasons with the first team before being named the club’s “director of methodology” and taking over coaching the U-23 team in 2020. Before joining the Whitecaps, he worked as a coach educator for the Italian Football Federation and the U.S. Soccer Federation, and coached several different clubs in Italy.
LA Galaxy strike early, hold off New York Red Bulls 2-1 to win their record 6th MLS Cup championshipNone
Lisa Simpson once said during an episode of “The Simpsons:” What could be more exciting than the savage ballet that is pro football? On Monday night, the entire Simpsons universe gets to experience it in a way not many could have imagined. The prime-time matchup between the Cincinnati Bengals and Dallas Cowboys will also take place at Springfield’s Atoms Stadium as part of “The Simpsons Funday Football” alternate broadcast. The altcast will be streamed on ESPN+, Disney+, and NFL+ (on mobile devices). ESPN and ABC have the main broadcast, while ESPN2 will carry the final “ManningCast” of the regular season. The replay will be available on Disney+ for 30 days. Globally, more than 145 countries will have access to either live or on replay. “We’re such huge football fans, and the Simpsons audience and the football audience, I feel, are like the same audience of just American families and football. And the Simpsons are so much a part of the DNA of the American family and culture that for us to, like, mush them together in this crazy video game, it’s so fun,” said Matt Selman, executive producer of “The Simpsons.” While the game is the focal point, the alternate broadcast, in some ways, will resemble a three-hour episode of “The Simpsons.” It starts with Homer eating too many hot dogs and having a dream while watching football. Homer joins the Cowboys in the dream while Bart teams up with the Bengals. Lisa and Marge will be sideline reporters. “That’s the beginning of the story, and the story continues through the entire game until Homer wakes up from his dream at the end of the game. It is like a complete story, and the NFL game will happen in between. It’s just going to be an amazing presentation with tons of surprises,” said Michael “Spike” Szykowny, ESPN’s VP of edit and animation. This is the second year ESPN has done an alternate broadcast for an NFL game. It used the characters from “Toy Story” for last year’s Sunday morning game from London between the Atlanta Falcons and Jacksonville Jaguars. “The Simpsons” has featured many sports-themed episodes during its 35 seasons. Even though “Homer at the Bat” remains the consensus favorite sports episode for many Simpsons fans, there have been football ones such as “Bart Star” and “Lisa The Greek.” There also was a Super Bowl-themed one after Fox’s broadcast of Super Bowl 33 between Denver and Atlanta in 1999. Even though “The Simpsons” remains a staple on Fox’s prime-time schedule, it is part of the Disney family after their acquisition of 20th Century Fox in 2019. All 35 seasons are on Disney+. The show’s creators have worked with ESPN and the NFL to make sure the look and sound is definitely Simpsonsesque. The theme song is a mash-up of “The Simpsons” opening and “Monday Night Football’s” iconic “Heavy Action.” There have also been pre-recorded skits and bits to use during the broadcast featuring Simpson’s legendary voices Hank Azaria, Nancy Cartwright, Dan Castellaneta, Julie Kavner, and Yeardley Smith. The telecast will be entirely animated, with the players’ movements in sync with what is happening in real-time on the field. That is done through player-tracking data enabled by the NFL’s Next Gen Stats system and Sony’s Beyond Sports Technology. While Next Gen Stats tracks where players are on the field with a tracking chip in the shoulder pads, there is skeletal data tracking and limb tracking data — which uses 29 points per player — to get closer to the player’s movements. The other data tracking will allow Beyond Sports and Disney to add special characters to the game. For example, there might be a play where Lisa catches the ball and goes 30 yards instead of Cincinnati’s Tee Higgins. “Lisa is much smaller than the rest of the players. So, in real life, the ball would go over her head, but now, with data processing, we can take the ball and make it go exactly into her hands. So for the viewer, it still looks believable, and it all makes sense,” said Beyond Sports co-founder Nicolaas Westerhof. The other major challenge is making “The Simpsons” two-dimensional cartoon characters into 3-D simulations. Szykowny and his team worked to make that a reality over the past couple of months. “That’s a big leap of faith for them to say, hey, we trust you to make our characters 3-D and work with it. Our ESPN creative studio team has done a wonderful job,” Szykowny said. Lisa, Krusty, Nelson, Milhouse and Ralph will be with Bart and the Bengals; while Carl, Barney, Lenny and Moe join up with with Homer and the Cowboys. The broadcast will also feature ESPN personalities Stephen A. Smith, Peyton Manning and Eli Manning. ESPN’s Drew Carter, Mina Kimes and Dan Orlovsky will call the game from Bristol, Connecticut, and also be animated. They will wear Meta Quest Pro headsets to experience the game from Springfield using VR technology. For Kimes, being part of the broadcast and being an animated Simpsons character is a dream come true. She is a massive fan of the show and has a framed photo of Lisa Simpson — who she said is a personal hero and icon — as part of her backdrop when she makes appearances on ESPN NFL shows from her home in Los Angeles. “I didn’t have any input, and I didn’t see anything beforehand, so I wasn’t sure if it would look like me, but it kind of does, which is very funny,” said Kimes, who drew Simpsons characters when she was a kid. “To see the actual staff turn me into one was a dream.” Even though the Bengals (4-8) and Cowboys (5-7) have struggled this season, Selman thinks both teams have personalities that appeal to “The Simpsons” universe. “We were just so lucky also that the Cowboys are sort of like a Homer Simpson-type team, American team, and Mike McCarthy might be a Homer-type guy, one might imagine,” he said. ”And then you have Joe Burrow on the other side who is a cool young, spiky-haired, blonde bad boy -- he’s like Bart. And that fits our character archetypes so perfectly. “If Homer is mad at Bart and has a hot dog dream while watching ’Monday Night Football’, and then it’s basically McCarthy versus Burrow, Homer versus Bart, and that’s the simple father versus son strangling — Homer strangling Bart dynamic that has been part of the show for 35 years. I don’t know if that would have worked as well if it was like Titans versus Jacksonville. We would have found something. We would have made it work.” ___ AP NFL: https://apnews.com/hub/nfl Joe Reedy, The Associated Press