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Josh Allen passed for two touchdowns and rushed for one more as the Buffalo Bills clobbered the New York Jets 40-14 on Sunday afternoon in Orchard Park, N.Y. The Bills clinched the No. 2 seed in the AFC with the victory. Allen was showered with "M-V-P" chants after putting the game away with a pair of third-quarter touchdown passes -- a 30-yard connection with Amari Cooper and a 14-yard strike to a leaping Keon Coleman with 12 seconds left in the frame. Those scores sandwiched a 1-yard touchdown run by James Cook. Buffalo (13-3) took a 33-0 lead into the fourth quarter thanks to its 21-point third. Allen, who turned things over to backup quarterback Mitchell Trubisky for the final 15 minutes, finished with 182 yards on 16-for-27 passing. Trubisky hit Tyrell Shavers for a 69-yard TD on his first pass of the contest to make it 40-0 with 12:37 to go. It marked Shavers' first career catch. The Bills' defense was in the spotlight just as much as Allen, forcing three turnovers and racking up four sacks. Aaron Rodgers struggled under center for New York (4-12), completing 12 of 18 passes for 112 yards. He was picked off twice. Second-string signal-caller Tyrod Taylor broke the shutout with a 9-yard touchdown pass to Garrett Wilson with 6:59 left in the game. The Jets proceeded to convert a two-point try to trim their deficit to 40-8. Wilson hauled in seven receptions for 66 yards and the TD. Tyler Conklin grabbed a 20-yard touchdown with 1:55 remaining to complete the scoring. Taylor ended up with 83 yards and the two TDs on 11-of-14 passing. A.J. Epenesa gave the Bills a boost just before the break, sacking Rodgers for a safety that put Buffalo up 9-0 with 2:31 remaining in the second quarter. Tyler Bass extended the Bills' lead with a 39-yard field goal as time expired in the first half. The teams combined for five penalties on the game's first drive, with a 5-yard defensive pass interference call setting Buffalo up at the Jets 1. Allen then got pushed into the end zone for his franchise-record-tying 65th rushing touchdown. --Field Level MediaNEW ORLEANS (AP) — A Louisiana civil court judge on Monday halted state agencies' plans to forcibly clear homeless encampments in New Orleans. Orleans Parish Civil District Court Judge Ethel Julien issued a temporary restraining order blocking state police and two other agencies from evicting homeless people from their encampments in New Orleans or seizing their property without following city laws and due process. Republican Gov. Jeff Landry had called earlier this month for the City of New Orleans to remove a large encampment before Thanksgiving and warned he would intervene if the city did not comply. “If a judge believes that people have a right to be on whatever public space they choose, maybe that judge should have them move into her chambers and courtroom," Landry said after the judge issued the restraining order Monday. Louisiana State Police spokesperson Sgt. Katharine Stegall said the agency’s legal team and the state Attorney General’s Office are reviewing the order. State police have “promptly halted activities” and are “complying with the restrictions” of the order, Stegall said. Landry and New Orleans officials have repeatedly clashed over how to address the issue of homelessness in the city. New Orleans City Councilmember Lesli Harris said Monday that directing more resources towards moving homeless people into stable housing was “infinitely more effective than punitive sweeps” of encampments. “Coordination between the government and service providers on the housing of people is imperative, and continuously moving people only makes it that much harder to house them,” Harris said. But the governor has pushed to clear homeless encampments. In late October, Louisiana State Police, the Department of Wildlife and Fisheries and the Department of Transportation and Development converged on a homeless encampment under a highway to remove and relocate dozens of people prior to pop star Taylor Swift’s concerts in the nearby Superdome. Some people who had been away at the time of the clearances returned to the area to find they had lost their personal property including family heirlooms, identification documents and medication, according to testimony in court documents. City officials and advocates for homeless people decried the evictions and said they disrupted ongoing efforts to secure long-term housing for these individuals because they became harder to locate. A judge later granted a temporary restraining order preventing more clearances but declined to extend it beyond early November after lawyers representing the state police indicated in court that removals tied to the Taylor Swift concerts had ceased. But on Friday, homeless people began receiving flyers from state police officers ordering them to leave their encampments within 24 hours, according to a motion for relief filed on behalf of two homeless plaintiffs by the Southern Poverty Law Center and two other legal groups. The planned sweeps preceded the Bayou Classic football game on Saturday between Southern University and Grambling State University at the Superdome. “Your presence is considered a violation,” the flyers stated, according to the motion for relief. However, they were halted by the new temporary restraining order. On Dec. 3, the judge is scheduled to deliberate on whether to issue a preliminary injunction against the three state agencies. “The vulnerable people with disabilities who make up the vast majority of people living in the street deserve to be treated with sensitivity and compassion,” said Joe Heeren-Mueller, director of community engagement for Unity of Greater New Orleans, a homeless outreach organization. There are about 1,450 homeless people in New Orleans and neighboring Jefferson Parish, according to a January survey by the nonprofit Unity of Greater New Orleans. The city has committed to securing housing for these individuals by the end of 2025. Brook is a corps member for The Associated Press/Report for America Statehouse News Initiative. Report for America is a nonprofit national service program that places journalists in local newsrooms to report on undercovered issues. Follow Brook on the social platform X: @jack_brook96
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HUNTSVILLE, Dec. 02, 2024 (GLOBE NEWSWIRE) -- Serina Therapeutics, Inc. (“Serina”) (NYSE American: SER), a clinical-stage biotechnology company, today announced a $10 million equity financing with strategic shareholder JuvVentures (UK) Limited. The transaction provides Serina with funding to continue advancing SER-252 (POZ-apomorphine), enabled by its proprietary POZ Platform TM drug optimization technology, into a Phase 1 clinical trial in advanced Parkinson's disease patients in the second half of 2025. Under the terms of the funding agreement, Serina will issue one million shares of common stock at $10 per share, a 120% premium to the closing price on November 26, 2024. The financing will be delivered in two tranches: the first $5.0 million tranche was received November 27, 2024, and the second $5.0 million tranche by January 31, 2025. Serina filed a Form 8-K with the SEC on December 2, 2024 that provides additional information regarding this transaction. About SER-252 (POZ-apomorphine) SER 252 is an investigational apomorphine therapy developed with Serina’s POZ platform and designed to provide continuous dopaminergic stimulation (CDS). CDS has been shown to reduce the severity of levodopa-related motor complications (dyskinesia) and enable greater on time, with reduced off time, in advanced Parkinson’s patients. SER-252 leverages strategic partner Enable Injections’ enFuse TM wearable drug delivery platform to enhance patient comfort and convenience, providing CDS to patients via an easy-to-administer, long-acting subcutaneous injection without skin reactions. About the POZ Platform TM Serina’s proprietary POZ technology is based on a synthetic, water soluble, low viscosity polymer called poly(2-oxazoline). Serina’s POZ technology is engineered to provide greater control in drug loading and more precision in the rate of release of attached drugs delivered via subcutaneous injection. The therapeutic agents in Serina’s product candidates are typically well-understood and marketed drugs that are effective but are limited by pharmacokinetic profiles that can include toxicity, side effects and short half-life. Serina believes that by using POZ technology, drugs with narrow therapeutic windows can be designed to maintain more desirable and stable levels in the blood. Serina’s POZ platform delivery technology has potential for use across a broad range of payloads and indications. Serina intends to advance additional applications of the POZ platform via out-licensing, co-development, or other partnership arrangements, including the non-exclusive license agreement with Pfizer, Inc. to use Serina’s POZ polymer technology for use in lipid nanoparticle drug (LNP) delivery formulations. About Serina Therapeutics Serina is a clinical-stage biotechnology company developing a pipeline of wholly owned drug product candidates to treat neurological diseases and other indications. Serina’s POZ Platform TM provides the potential to improve the integrated efficacy and safety profile of multiple modalities including small molecules, RNA-based therapeutics and antibody-based drug conjugates (ADCs). Serina is headquartered in Huntsville, Alabama on the campus of the HudsonAlpha Institute of Biotechnology. For more information, please visit https://serinatherapeutics.com . Cautionary Statement Regarding Forward-Looking Statement This release contains forward-looking statements within the meaning of federal securities laws. These statements are based on management’s current expectations, plans, beliefs or forecasts for the future, and are subject to uncertainty and changes in circumstances. Any express or implied statements in this press release that are not statements of historical fact, including statements about the potential of Serina’s POZ polymer technology, are forward-looking statements that involve substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. Risks and uncertainties include, among other things, the uncertainties inherent in research and development, including the ability to meet anticipated clinical endpoints, commencement and/or completion dates for clinical trials, regulatory submission dates, regulatory approval dates and/or launch dates, as well as the possibility of unfavorable new clinical data and further analyses of existing clinical data; the risk that clinical trial data are subject to differing interpretations and assessments by regulatory authorities; whether regulatory authorities will be satisfied with the design of and results from our clinical studies; whether and when any applications may be filed for any drug or vaccine candidates in any jurisdictions; whether and when regulatory authorities may approve any potential applications that may be filed for any drug or vaccine candidates in any jurisdictions, which will depend on a myriad of factors, including making a determination as to whether the product’s benefits outweigh its known risks and determination of the product’s efficacy and, if approved, whether any such drug or vaccine candidates will be commercially successful; decisions by regulatory authorities impacting labeling, manufacturing processes, safety and/or other matters that could affect the availability or commercial potential of any drug or vaccine candidates; and competitive developments. These risks as well as other risks are more fully discussed in the company’s Annual Report on Form 10-K for the year ended December 31, 2023, the company’s Current Report on Form 8-K that was filed with the SEC on April 1, 2024, and the company’s other periodic reports and documents filed from time to time with the SEC. The information contained in this release is as of the date hereof, and Serina assumes no obligation to update forward-looking statements contained in this release as the result of new information or future events or developments. For inquiries, please contact: Investor.relations@serinatherapeutics.com (256) 327-9630Manager Steve Watson hailed Hermes’ “unbelievable” Morrison Motors (Turriff) Aberdeenshire Shield comeback against Buckie Thistle as the best result of his time at the club. The trailed the Breedon Highland League champions 4-0 at Lochside Park, but battled back to triumph 5-4 and set-up a semi-final tie against Formartine United at North Lodge Park. Conditions played a big part in this tie. The Jags had a strong wind at their backs in the first period, but after half-time the home side also used the stiff breeze to their advantage. Hermes only became This is the first time they’ve reached the semi-finals of either tournament. Watson has been with the club since 2012 as player, coach, assistant manager and now manager. He said: “This is the best result in my time with Hermes. We’ve beaten Beith, Cumnock and other Highland League teams here, but to beat the Highland League champions with the talent they’ve got is unbelievable. “The conditions weren’t good, but getting two goals against the wind and going in at 2-4 at half-time, I was happy because we were still in the game. “Second half we knew, if we pressed, it would be hard for Buckie to get out, and for us to get through is unbelievable.” Nine-goal thriller Buckie took the lead after two minutes courtesy of Jack MacIver’s superb free-kick from 35 yards. In the 17th minute, Josh Peters crossed from the right and Cohen Ramsay converted at the back post. Ten minutes later, Liam Harvey finished clinically from the edge of the box to make it 0-3. In the 36th minute, MacIver grabbed the fourth after intercepting a poor throw-out from Hermes goalkeeper Jacob Otto. But Hermes’ comeback began before half-time. On 41 minutes, James McMahon’s shot from 18 yards was parried by Mark Ridgers and Aaron Angus scored on the rebound. Three minutes later, Craig Mackie got in behind and finished neatly . Mackie – making his first start for Hermes – was at it again on 55 minutes, scoring at the second attempt after Ridgers blocked his initial effort. Four minutes later Ryan Fyffe felled McMahon inside the area, and referee Owen Lawrence awarded the penalty, Paul Esslemont finding the bottom right corner to restore parity. Buckie’s Fyffe was sent off on 75 minutes. After being booked for conceding the penalty, he received a second caution for taking too long with a throw-in. Eight minutes later, Hermes’ Joe Burr received a straight red card for hacking down MacIver from behind. In the second minute of stoppage time, Hermes won it as Mackie completed his hat-trick from Liam Cheyne’s corner on the right. Buckie Thistle boss left furious Buckie were without Sam Pugh, Kevin Fraser, Joe McCabe, Dale Wood and Fraser Robertson, but boss Lewis MacKinnon pulled no punches. He said: “I’m disappointed, angry and embarrassed. When we’re 4-0 up we should manage the game correctly. “Conceding the goals when we were playing with the wind in the first half was a disgrace. “The way we started the second half was disgusting. It wasn’t good enough and it’s an absolute disgrace. “Players missing isn’t an excuse – the players that played are more than capable of getting a result.”
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Officers were called to an address on Greenland Quay, Surrey Quays, at about 3pm on Friday after reports that a woman had been stabbed, the Metropolitan Police said. The London Ambulance Service and London’s Air Ambulance also attended, and the woman was taken to hospital where she later died. A 61-year-old man was arrested on suspicion of murder and remains in custody. Detective Chief Inspector Kate Blackburn, who is leading the investigation, said: “We received multiple calls from members of the public close to the scene with concerns for the victim yesterday afternoon. “Officers, together with the London Ambulance Service and London’s Air Ambulance, responded quickly but, sadly, the woman in her 60s died in hospital yesterday evening. “Our specialist crime command are continuing inquiries today and, at this stage, we believe that this was an isolated incident with the man and woman known to each other.” A police cordon remained in place at the scene on Saturday evening, and forensic officers were still at the waterfront property. Anyone with information is asked to call police on 101 or message @MetCC ref CAD 4235/29November on the social media platform X.No ruling by 9th Circuit in Ex-Councilmember Mark Ridley Thomas’ appealQatari Prime Minister: Trump Wants Hostage Deal by Inauguration
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