Ousted Syrian leader Assad flees to Moscow after fall of Damascus, Russian state media say
(BPT) - This article was sponsored and developed by Neurocrine Biosciences, Inc. Cerebral palsy (CP) is a neurodevelopmental disorder affecting movement and posture that begins in early childhood development. It is the most common cause of motor disability in children, affecting about one in 345 children in the United States. 1-2 It may happen as a result of lack of oxygen during or around birth, stroke, infection, a problem with metabolism or other problems that cause injury or affect the development of parts of the brain involved in movement control in the first few years of life. 3 CP is a permanent condition, affecting a person for their entire life. People living with CP typically have motor problems, which may include spasticity (abnormal muscle tightness), dyskinesia (uncontrolled movements) or ataxia (poor muscle control), and many people have a mix of these motor disorders. 4 Dyskinesia due to CP (DCP) is one of the most disabling forms of CP and impacts approximately 10% to 20% of people living with CP. 5-6 According to the Cerebral Palsy Foundation (CPF), the combination of irregular and unpredictable movements (chorea) and twisting and repeating movements (dystonia) often disrupt activities and cause significant functional impairment, including the ability to maintain balance, walk or fine motor control. 7 Heather Riordan, M.D., Neurologist and Movement Disorders Specialist, Director of the Phelps Center for Cerebral Palsy at the Kennedy Krieger Institute, discusses the symptoms of chorea and impact on patients in a video shared on the CPF website here . About 30% of people with DCP are affected mostly by these involuntary and irregular movements (chorea), while dystonia is the predominant motor finding in the remaining 70%. 8 However, it is common for both chorea and dystonia movements to be present together. 6 For people living with DCP, these movements can occur in any region of the body, including the arms and legs, torso and face and may vary in severity. They are often triggered or made worse by stimulation or stress. Because dyskinesia can occur at rest and/or when actively using the body, the problems with movement are very burdensome in day-to-day living, with discomfort and pain affecting the quality of life for people and their caregivers. 9 Jen Lyman, mom to a son with DCP, highlights how dyskinesia makes communicating more difficult. "The most difficult thing about dyskinesia is watching my son struggle to do things that he wants to do, but the extra movements get in the way...special things, such as using a touch screen to video chat with his grandmother, are nearly impossible despite his best efforts to use his hands and fingers. Something so simple, yet so special for him should be effortless." DCP has a wide-ranging impact on the individual, including lifelong challenges with movement, a higher risk of other medical issues, a higher rate of mental health challenges and difficulties with communication. 10-12 "Those of us who have the privilege to serve patients with dyskinetic, hyperkinetic or mixed cerebral palsy see the functional impact of this very challenging type of tone every day," said Susan Biffl, M.D., Rehabilitation Medicine Specialist at Rady Children's Hospital-San Diego and Assistant Professor at UC San Diego School of Medicine. "Patients face challenges with self-care, independence, mobility, communication, fine motor skills that affect occupational and recreational activities, swallowing, social interactions and even sleep. As this tone is variable, it is much more challenging to treat than more consistent tone issues, such as spasticity." Treatment Options There are currently no Food and Drug Administration-approved treatments for DCP. Dystonia and chorea are often managed separately as they respond differently to various treatments, which can make treatment challenging. 3 Most drugs being investigated for DCP have focused on dystonia, and more research is needed to determine potential treatments for chorea. New treatment options are needed to help manage these movement disorders and improve daily function and quality of life for those affected. "After 20 years of caring for individuals with cerebral palsy, I continue to find those with dyskinetic cerebral palsy among the most challenging to treat, largely due to the limited effectiveness of available pharmacologic options," said Joyce Oleszek, M.D., Professor, Department of Physical Medicine and Rehabilitation, University of Colorado School of Medicine. "There is an urgent need for more robust evidence to support pharmacologic treatments for this condition, given its profound impact on function, comfort and quality of life." Ongoing Research Clinical studies are important in the development of treatment options, allowing researchers to evaluate the safety and effectiveness of new medicines. The data from clinical studies are used to determine if an investigational treatment can be approved for use to treat certain disorders. There are ongoing clinical studies evaluating potential treatments for DCP, including one for chorea. Neurocrine Biosciences is conducting the KINECT ® -DCP clinical study, a Phase 3, randomized, double-blind placebo-controlled study investigating the study drug, valbenazine, for the treatment of DCP. The clinical study is currently enrolling children, adolescents and adults six to 70 years of age who have been diagnosed with DCP. "The Cerebral Palsy Foundation is excited to partner with Neurocrine Biosciences on this study," said Rachel Byrne, Executive Director of the Cerebral Palsy Foundation. "We are proud to support strong research that can potentially bring meaningful change to the lives of those living with cerebral palsy." If you or someone you know may be eligible for this research study, please visit the study website for additional information here: FindADCPStudy.com . REFERENCES Krigger KW. Cerebral palsy: a review. Am Fam Physician . 2006;73(1):91-100. Michael-Asalu A, Taylor G, Campbell H, Lelea LL, Kirby RS. Cerebral palsy: diagnosis, epidemiology, genetics, and clinical update. Adv Pediatr2019;66:189-208. doi:10.1016/j.yapd.2019.04.002 Monbaliu E, Himmelmann K, Lin JP, et al. Clinical presentation and management of dyskinetic cerebral palsy. Lancet Neurol. 2017;16(9):741-749. doi:10.1016/S1474-4422(17)30252-1 Christine C, Dolk H, Platt MJ, Colver A, Prasauskiene A, Krägeloh-Mann I; SCPE Collaborative Group. Recommendations from the SCPE collaborative group for defining and classifying cerebral palsy. Dev Med Child Neurol Suppl. 2007;109:35-38. doi:10.1111/j.1469-8749.2007.tb12626.x Lumsden DE, Crowe B, Basu A, et al. Pharmacological management of abnormal tone and movement in cerebral palsy. Arch Dis Child . 2019;104(8):775-780. doi:10.1136/archdischild-2018-316309 Monbaliu E, de Cock P, Ortibus E, Heyrman L, Klingels K, Feys H. Clinical patterns of dystonia and choreoathetosis in participants with dyskinetic cerebral palsy. Dev Med Child Neurol. 2016;58(2):138-144. doi:10.1111/dmcn.12846 Dyskinetic cerebral palsy. Cerebral Palsy Foundation. Published December 20, 2022. Accessed October 29, 2024. https://cpresource.org/understanding-cerebral-palsy/types-cerebral-palsy/dyskinetic-cerebral-palsy Himmelmann K, Hagberg G, Wiklund LM, Eek MN, Uvebrant P. Dyskinetic cerebral palsy: a population-based study of children born between 1991 and 1998. Dev Med Child Neurol. 2007;49(4):246-251. doi:10.1111/j.1469-8749.2007.00246.x Masson R, Pagliano E, Baranello G. Efficacy of oral pharmacological treatments in dyskinetic cerebral palsy: a systematic review. Dev Med Child Neurol . 2017; 59:1237-1248. doi:10.1111/dmcn.13532 What is cerebral palsy? Cerebral Palsy Foundation. Accessed November 13, 2024. https://cpresource.org/topic/what-cerebral-palsy Adults & adolescence. Cerebral Palsy Foundation. Accessed November 13, 2024. https://cpresource.org/topic/adults Communication. Cerebral Palsy Foundation. Accessed November 13, 2024. https://cpresource.org/topic/communication © 2024 Neurocrine Biosciences, Inc. All Rights Reserved. CAP-NBI-US-0115 12/2024 NBI-98854-DCP3018_11DecMatRelease_v1.0_25November2024
Ohio State senior quarterback Will Howard performed to high expectations in the Buckeyes’ 38-15 win over No. 5 Indiana, but his stat line wasn't what had social media talking. Instead, it was a sideline celebration that tapped deep into internet culture, pretending to light and stomp out an imaginary joint that polarized football fans and started debates about sportsmanship vs bravado in college athletics. The Buckeyes remained in control throughout the game after overcoming an early seven-point deficit caused by a two-yard yard from senior Hoosier running back Ty Son Lawton. Encircled by teammates and coaches in a sea of red jerseys, Howard simulated putting a fake joint to his mouth, flicking it away, and stomping it out, a nod to the viral “putting them in a pack” meme used to mock defeated opponents. Cameras quickly panned to Indiana head coach Curt Cignetti , who waved off the gesture in visible disgust. On X, the reactions ranged from amused to outraged.One fan wrote, "Bro, have some sportsmanship geez," while another chimed in, "IU talked a lot [Curt specifically] the past few weeks. Many people, OSU fans or not, enjoyed seeing how they fared against a good team." Shedeur Sanders drops huge hint at NFL future after Daniel Jones release from Giants Dave Portnoy pokes fun at Ohio State after helping Michigan flip star QB recruit Bryce Underwood Indiana came into the matchup as heavy underdogs with sportsbooks, giving the Hoosiers a 10.5-point cushion. Cignetti was bold to the press as he talked his team up before the game, taking direct aim at critics of his program. "We’ve got the largest scoring margin, victory margin in college football , right?" Cignetti said. "There’s a narrative out that’s created another chip for us. People can stick that narrative up their you-know-what." When asked how he planned to slow down Ohio State’s high-powered offense, Cignetti laid out his strategy of controlling the line of scrimmage, stopping the run, and creating turnovers by forcing Howard into tight coverage. He ended the interview with a walk-off, saying, "Google me, I win," which rubbed a portion of Buckeyes nation the wrong way online. Cignetti’s verbal faith didn’t translate to the field. Ohio State controlled the game after Indiana's first-quarter rushing TD as senior running back TreVeyon Henderson led the Buckeyes’ rushing attack with 68 yards and a touchdown. The Buckeyes collectively rushed for 115 yards on the ground, and Howard was nearly perfect, completing 22 of 26 passes for 201 yards, two touchdowns, and just one interception. "I was just having some fun with it. I have a lot of respect for those guys, man. I think what coach Cignetti’s done over there, he’s done a heck of a job," said Howard after admitting that the words he mouthed before the gesture were "Google me," returning the favor to Cignetti. "The Buckeyes are here, and the Buckeyes won," he continued. "So you can Google that." Cignetti’s plan to rattle Howard never materialized. The Buckeye's offensive line held firm without giving up a single sack, and by the end of the third quarter, the team had a 28-7 lead.
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A woman was killed in an auto accident involving a police officer who was en route to respond to a bomb threat against Rep. Marjorie Taylor Greene (R-Ga.), according to the congresswoman. Greene identified the woman as Tammie Pickelsimer. “These violent political threats have fatal consequences. It’s an undue strain on our law enforcement who must treat them seriously. The officer was responding to protect my life. And now, a woman has lost her life because of this despicable act,” said Greene in her post. “I’m sick to my stomach, but I’m also angry. This should have never happened and I pray it never happens again.” The Epoch Times reached out to the police department in Rome, Georgia, for comment but received no response by publication time. The threat had pro-Palestinian language, according to Greene’s office. “Using a 1 x 8 inch threaded galvanized pipe, end caps, a kitchen timer, some wires, metal clips, and homemade black powder, I’ve constructed a pipe bomb which I recently hid in Marjorie Taylor Greene’s mailbox at [redacted address],” stated the threat. “It is set to go off during the weekend but it would also explode the next time anybody opens the mailbox. Even if Marjorie does not open the mailbox herself I’m still satisfied with the prospect of some pig cops losing their lives or being injured. Viva Viva Palestina.” This was not the first time Greene has been threatened.Chelakkara Election Result 2024: LDF candidate UR Pradeep retains seat with 12,201 vote margin
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NEW YORK (AP) — More shoppers than ever are on track to use ‘buy now, pay later’ plans this holiday season, as the ability to spread out payments looks attractive at a time when Americans still feel the lingering effect of inflation and already have record-high credit card debt. The data firm Adobe Analytics predicts shoppers will spend 11.4% more this holiday season using buy now, pay later than they did a year ago. The company forecasts shoppers will purchase $18.5 billion worth of goods using the third-party services for the period Nov. 1 to Dec. 31, with $993 million worth of purchases on Cyber Monday alone. Buy now, pay later can be particularly appealing to consumers who have low credit scores or no credit history, such as younger shoppers, because most of the companies providing the service run only soft credit checks and don’t report the loans and payment histories to the credit bureaus, unlike credit card companies. This holiday season, buy now, pay later users can also feel more confident if a transaction goes awry. In May, the CFPB said buy now, pay later company must adhere to other regulations that govern traditional credit, such as providing ways to demand refunds and dispute transactions. To use a buy now, pay later plan, consumers typically sign up with bank account information or a debit or credit card, and agree to pay for purchases in monthly installments, typically over eight weeks or more. The loans are marketed as requiring no or low interest, or only conditional fees, such as for late payment. Klarna, Afterpay and Affirm are three of the biggest buy now, pay later companies. But consumer advocates warn that shoppers who sign up for the payment plans using a credit card can be hit with more interest and fees. That's because individuals open themselves up to interest on the credit card payment, if it's carried month to month, on top of any late fees, interest, or penalties from the buy now, pay later loan itself. Experts advise against using a credit card to pay for these plans for this reason. Consumer watchdogs also say the plans lead consumers to overextend themselves because, for example, not paying full price up front leaves, in the shopper’s mind at least, more money for smaller purchases . They also caution consumers to keep careful track of using multiple buy now, pay later services, as the automatic payments can add up, and there is no central reporting, such as with a credit card statement. “Buy now, pay later can be an innovative tool for purchases you’re going to make anyway,” said Mark Elliott, chief customer officer at financial services company LendingClub. “The challenge is that it does fuel overspending.” For merchants, that’s part of the appeal. Retailers have found that customers are more likely to have bigger cart sizes or to convert from browsing to checking out when buy now, pay later is offered. One report from the Federal Reserve Bank of New York cited research that found customers spend 20% more when buy now, pay later is available. “The reality is that the increased cost-of-living and inflation have put more people in a situation where they’re already relying on revolving credit,” Elliott said. “The psychographics of ‘buy now, pay later’ may be different — people don’t think of it as debt — but it is.” If a consumer misses a payment, they can face fees, interest, or the possibility of being locked out of using the services in the future. Emily Childers, consumer financial expert for personal-finance technology company Credit Karma, said that internal data shows member credit card balances are up more than 50% for Gen Z and millennial members since March 2022, when the Fed started raising interest rates. “Young people are entering this holiday season already in the red,” she said. “And, based on what we’re seeing in the data, they’re continuing to bury their heads in the sand and spend.” The Associated Press receives support from Charles Schwab Foundation for educational and explanatory reporting to improve financial literacy. The independent foundation is separate from Charles Schwab and Co. Inc. The AP is solely responsible for its journalism.None
Trump says he can’t guarantee tariffs won’t raise US prices, won’t rule out revenge prosecutionsMy vegan brother refuses to come to Thanksgiving if it's not meat-free The unnamed 31-year-old shared details of the family feud on Reddit She revealed older brother, Mark, 35, is vegan The woman said that he refused to be around meat - even on Thanksgiving By KELSI KARRULI FOR DAILYMAIL.COM Published: 23:02, 21 November 2024 | Updated: 23:02, 21 November 2024 e-mail View comments A woman has revealed her vegan brother has refused to come to Thanksgiving dinner if there is any meat on the table. The unnamed 31-year-old took to Reddit to reveal that she has never gotten along with her brother, Mark, 35. When Mark turned vegan many years ago, their relationship became even more strained as he attempted to turn them all against meat. Mark has since said he refuses to sit idly by and watch his family munch down on turkey during the holiday season. In a thread titled Am I The A**hole , the woman revealed that her mother made a 100 per cent vegan meal for Thanksgiving last year. However, she is hosting the family's gathering this time around and refuses to ditch meat entirely from her menu. Although there will be vegan dishes available, Mark is insisting that he will abandon his family for the holidays if there are any meat products present. Following her brother's shocking confession, the 31-year-old took to the discussion forum to question if she would be in the wrong if she refused to transform her Thanksgiving meal. A woman has revealed her vegan brother has refused to come to Thanksgiving dinner if there was any meat on the table (stock image) The post was titled: 'Am I the a**hole for refusing to cook a vegetarian Thanksgiving dinner?' She explained: 'I feel like I've slipped into the twilight zone with this whole argument, so tell me what's up, internet folks. 'Background: I (31F) and my brother Mark (35M) do not get along. When he was a teen he saw a documentary on factory farming and decided to become a vegetarian. He got very, very annoying about it quickly, but my dad shut him down when he started trying to get the rest of us to be vegetarian with him. 'Then he went to college, made a bunch of very strange friends, and went militantly vegan. It's his entire personality. I stopped talking to him after he threw a fit about one of my birthday dinners being at a steakhouse and spammed my messages and social media with pictures of abused cows.' The woman noted that her parents have attempted to fix the situation as of late, with her mom even making an entirely meat-free Thanksgiving last year. 'My parents have been trying to repair the situation and for a while, it did seem like Mark was getting better so I've been letting him back into contact gradually. Then he started dating Pam, who is some kind of vegan influencer. 'She is apparently moderately popular online, but I have no idea what she does exactly. I don't know if Mark was trying to impress her or what, but last Thanksgiving he insisted that mom cook at least a vegetarian meal or they wouldn't come on "ethical grounds." 'My mom just wanted everyone to get along on her favorite holiday, so she agreed. It was not a fun meal,' she said. The unnamed 31-year-old took to Reddit to reveal that she has never gotten along with her brother, Mark, 35 However, because her mom is struggling with health issues, the 31-year-old is hosting Thanksgiving this year. The change of hosts has caused her and Mark to enter a fierce debate. She added: 'This year, my parents have downsized for retirement and my mom is having health problems. I bought their house when they moved, so my mom asked me to host Thanksgiving so it would be like usual. 'I told everyone in the group chat so Mark and Pam could make travel arrangements and Pam immediately started gushing about all the vegan replacement recipes she could give me to replace the traditional ones. I said to send me a main dish recipe they like and I would give it a shot, but I'm making the traditional meal otherwise and there should still be plenty of things they can eat. 'Mark and Pam have been arguing about this with me for days and then Mark said that if I wouldn't make a meat-free meal they wouldn't come. This upset my mom, who asked me to just make what she made last year to keep the peace, but I told her that Mark needs to get over himself and I'm not coddling him. I'm having turkey on Thanksgiving.' Although she wants to stay firm in her decision to include meat at their family dinner, she is now questioning if she is in the wrong because she is upsetting her mom by separating the family. At the end of the post, the 31-year-old said: 'My dad privately agrees with me, but Mark threatening to not come is upsetting my mom so much that he's worried it will impact her health. 'There's a not big, but also not zero chance that these might be some of the last family holidays we have with her. My mom thinks I'm putting turkey over my own family and I'm not so sure anymore.' People on the web flooded the comments section and ran to the woman's defense while slamming her brother People on the web flooded the comments section and ran to the woman's defense while slamming her brother. One person said: 'Not the a**hole - You're not putting turkey over family — Mark is putting tofurkey over family. You've reasonably accommodated enough with a vegan option. Mark doesn't get to hold holidays hostage because of his own dietary choices. That's ridiculous. 'If Mark wants to pitch a fit, that's him. I feel very sorry for your mom, she's the one suffering most here. But she needs to realize that Mark is the one causing this family divide, and it isn't fair to everyone else to cater to his demands.' Another user wrote: 'My aunt was vegan, she brought her own meals to family gatherings. Why can't they do the same?' Someone else added: 'You're not in the wrong, if they want it so badly they can make it and bring it for themselves!' 'You've even offered to cook them a vegan main dish, which is pretty above and beyond (I think most people would just tell them to bring their own food). Seems like they are taking the position that not only are they vegan, but they are essentially forcing it on everyone else by refusing to come, which is ridiculous. 'If your mom is getting upset, its because of Mark's actions, not yours... it's not fair for everyone else to have to comply with his demands. If he actually cares about your mom, he would put her feelings first,' a fourth person said. Thanksgiving Reddit Share or comment on this article: My vegan brother refuses to come to Thanksgiving if it's not meat-free e-mail Add commentSuzhou AND Science&Technology Development Corporation: Lumbar Intervertebral Disc Endoscope
Union Culture Minister Gajendra Singh Shekhawat announced considerations for amending the AMSAR Act to enhance heritage preservation with minimal disruption to citizens' lives. Addressing the National Monuments Authority's inaugural foundation ceremony, he underscored the necessity for adaptive regulations in heritage conservation. The AMSAR Act currently governs over 3,690 monuments under the Archaeological Survey of India. Established in 2010, the National Monuments Authority plays a critical role in managing 'prohibited' and 'regulated' zones around these sites. Shekhawat highlighted the challenges of safeguarding India's rich cultural legacy, acknowledging the need for scientific methodologies in balancing preservation efforts with ongoing development. The NMA has leveraged technology advancements like ISRO's SMARAC app to streamline management processes in protected zones. (With inputs from agencies.)
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