TRE 3.0: Over 12k declared successfulSANTA CLARA, Calif. (AP) — Dan Campbell stood at the podium after Detroit blew a 17-point lead to San Francisco in last season's NFC title game and talked about how that might have been the Lions' only shot at reaching the Super Bowl. The coach knew how difficult it would be to maintain that high level of play through injuries, attrition and with a target on their back as a top contender in the NFC. Eleven months later as Campbell and the Lions prepare to return to Levi's Stadium for the first time since that loss , that has proved to be prophetic — for San Francisco instead of Detroit. The Lions (13-2) head into the rematch Monday night with the inside track at the top seed in the NFC playoffs, while the 49ers (6-9) have already been eliminated from postseason contention . The element of revenge for last season's 34-31 loss is secondary for Detroit, considering what's on the line the last two weeks of the season. The Lions can clinch the top seed in the NFC by winning their final two games or with a win against the Niners if Minnesota loses to Green Bay on Sunday. “Anytime we lose, the thought of losing is going to motivate you to not want to lose again, particularly with where you were at,” Campbell said. “So, that’s always going to bring its own level of motivation to it. But this is where we’re at in the season, we know that we need another win, we understand where we’re at in the division and the NFC, so I think it’s all encompassing.” While the Lions have no need to search for motivation, that's not the case for the 49ers, who are playing out the string of a lost season after making losing back-to-back NFC title games in 2021-22 and the Super Bowl last season. A run of injuries to key players like Christian McCaffrey, Trent Williams, Nick Bosa and Brandon Aiyuk, combined with inconsistent play all season have led to the 49ers having nothing to play for in the final two games. “It’s obviously not where you want to be this time of year,” Bosa said. "It’s different, especially watching where we’re at last year against this team. Just that feeling of December, January football is a feeling that I’ve gotten used to being really competitive and being in the mix. I think we’re doing a good job of staying engaged and obviously this is our job, so we’re going to finish it strong. Detroit’s faith in Jameson Williams is paying off, taking advantage of his game-breaking abilities with big plays. Jared Goff heaved an 82-yard touchdown pass over Williams’ shoulders and into his hands in last week’s win at Chicago. Earlier this season, Goff threw 70-, 64- and 52-yard passes for scores to the third-year receiver. “We work on it a ton, him and I do, and it’s a testament to him,” Goff said. “He’s asking for it. He wants that work, and I’m more than happy to give it to him during the week. It’s good. Our connection continues to grow. He’s obviously one of the best deep threats in our league, even when it’s not perfect.” The 49ers head into the game scrambling to put together an offensive line. Williams has been out for more than a month with an ankle injury and his backup at left tackle, Jaylon Moore, is now sidelined by a quadriceps injury. Left guard Aaron Banks injured his knee last week, while his backup Ben Bartch is already out with an ankle injury. That will leave the Niners with two third-stringers protecting Brock Purdy. But Shanahan said he isn’t thinking of sitting Purdy to protect him. “People deal with that throughout the year on other weeks, too,” he said. “I mean, we’ve got a football team. We’ve got to go out and we’ve got two games here and we’ve got to see what guys we can put out there and whatever we do we’re going to put a game plan together to, as best as we can to give us a chance to win.” Lions offensive coordinator Ben Johnson, who may have a chance for the second straight offseason to be an NFL head coach, routinely pulls off trick plays and his latest was a doozy. Goff intentionally stumbled after taking a snap and Jahmyr Gibbs went to the ground as their teammates yelled, “fumble,” to fool the Bears on a 21-yard touchdown pass to Sam LaPorta. “Those make you feel good because everybody is invested in it,” Campbell said. “It’s fun. It’s different. It’s sound. “I know it sounds crazy, but it’s sound.” San Francisco kicker Jake Moody is having a rough second season after being drafted in the third round a year ago. Moody has missed seven field goals this season, including a 41-yarder last week at Miami. Moody is just 10 for 16 since coming back from a high ankle sprain in his kicking foot, but Shanahan said he still has confidence in him. “I still feel the same about him, that I believe he’ll be our guy,” Shanahan said. "I mean everyone’s got to perform and do things like that. I think he has had a tough year. Before his high ankle sprain, he missed one. ... I think he was 12 of 13 before that, so I thought he was doing really well." AP Sports Writer Larry Lage contributed to this report. AP NFL: https://apnews.com/hub/nfl
( MENAFN - GlobeNewsWire - Nasdaq) Faruqi & Faruqi, LLP Securities Litigation Partner James (Josh) Wilson Encourages Investors Who Suffered Losses Exceeding $50,000 In Applied Therapeutics To Contact Him Directly To Discuss Their Options If you suffered losses exceeding $50,000 in Applied Therapeutics January 3, 2024 and December 2, 2024 and would like to discuss your legal rights, call Faruqi & Faruqi partner Josh Wilson directly at 877-247-4292 or 212-983-9330 (Ext. 1310) . [You may also click here for additional information] NEW YORK, Dec. 26, 2024 (GLOBE NEWSWIRE) -- Faruqi & Faruqi, LLP , a leading national securities law firm, is investigating potential claims against Applied Therapeutics, Inc. (“Applied Therapeutics” or the“Company”) (NASDAQ: APLT) and reminds investors of the February 18, 2025 deadline to seek the role of lead plaintiff in a federal securities class action that has been filed against the Company. Faruqi & Faruqi is a leading national securities law firm with offices in New York, Pennsylvania, California and Georgia. The firm has recovered hundreds of millions of dollars for investors since its founding in 1995. See . As detailed below, the complaint alleges that the Company and its executives violated federal securities laws by making false and/or misleading statements and/or failing to disclose that defendants provided positive statements to investors while, at the same time, disseminating false and materially misleading statements and/or concealing material adverse facts concerning the true state of Applied Therapeutics' Phase III INSPIRE trial; notably, electronic data capture issues and a dosing error in the dose-escalation phase of the study. Such statements absent these material facts caused Plaintiff and other shareholders to purchase Applied Therapeutics' securities at artificially inflated prices. On November 27, 2024, Applied Therapeutics issued a press release announcing "that the U.S. Food and Drug Administration (FDA) has issued a Complete Response Letter (CRL) for the New Drug Application (NDA) for govorestat, a novel, central nervous system (CNS)-penetrant aldose reductase inhibitor (ARI), for the treatment of Classic Galactosemia." According to the Company, "[t]he CRL indicates that the FDA completed its review of the application and determined that it is unable to approve the NDA in its current form, citing deficiencies in the clinical application." On this news, Applied Therapeutics' stock price fell $1.64 per share, or 16.06%, to close at $8.57 per share on November 27, 2024. Then, on December 3, 2024, the FDA posted on its website a Warning Letter to Applied Therapeutics, the contents of which indicated that the Company was aware at least as early as May 2024 that the FDA had identified significant issues in the govorestat NDA. On this news, Applied Therapeutics' stock price fell $0.31 per share, or 18.34%, to close at $1.38 per share on December 4, 2024. The court-appointed lead plaintiff is the investor with the largest financial interest in the relief sought by the class who is adequate and typical of class members who directs and oversees the litigation on behalf of the putative class. Any member of the putative class may move the Court to serve as lead plaintiff through counsel of their choice, or may choose to do nothing and remain an absent class member. Your ability to share in any recovery is not affected by the decision to serve as a lead plaintiff or not. Faruqi & Faruqi, LLP also encourages anyone with information regarding Applied Therapeutics' conduct to contact the firm, including whistleblowers, former employees, shareholders and others. To learn more about the Applied Therapeutics class action, go to /APLT or call Faruqi & Faruqi partner Josh Wilson directly at 877-247-4292 or 212-983-9330 (Ext. 1310) . Follow us for updates on LinkedIn , on X , or on Facebook . Attorney Advertising. The law firm responsible for this advertisement is Faruqi & Faruqi, LLP ( ). Prior results do not guarantee or predict a similar outcome with respect to any future matter. We welcome the opportunity to discuss your particular case. All communications will be treated in a confidential manner. A photo accompanying this announcement is available at . MENAFN26122024004107003653ID1109033428 Legal Disclaimer: MENAFN provides the information “as is” without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the provider above.Atria Investments Inc bought a new position in Davis Select International ETF ( BATS:DINT – Free Report ) during the 3rd quarter, HoldingsChannel reports. The fund bought 8,798 shares of the company’s stock, valued at approximately $211,000. Several other institutional investors have also added to or reduced their stakes in DINT. Signature Estate & Investment Advisors LLC bought a new position in Davis Select International ETF during the second quarter valued at approximately $523,000. Bellevue Asset Management LLC lifted its holdings in shares of Davis Select International ETF by 2.1% during the 3rd quarter. Bellevue Asset Management LLC now owns 27,686 shares of the company’s stock valued at $665,000 after buying an additional 565 shares during the period. Silver Oak Securities Incorporated boosted its stake in shares of Davis Select International ETF by 249.9% in the 3rd quarter. Silver Oak Securities Incorporated now owns 45,852 shares of the company’s stock worth $1,111,000 after buying an additional 32,746 shares during the last quarter. Sebold Capital Management Inc. grew its holdings in shares of Davis Select International ETF by 4.6% in the third quarter. Sebold Capital Management Inc. now owns 118,289 shares of the company’s stock worth $2,841,000 after acquiring an additional 5,156 shares during the period. Finally, Lunt Capital Management Inc. increased its position in Davis Select International ETF by 8.8% during the third quarter. Lunt Capital Management Inc. now owns 119,019 shares of the company’s stock valued at $2,858,000 after acquiring an additional 9,598 shares during the last quarter. Davis Select International ETF Stock Performance DINT opened at $23.13 on Friday. The business has a 50-day simple moving average of $23.65 and a 200 day simple moving average of $21.60. The stock has a market capitalization of $198.96 million, a P/E ratio of 12.48 and a beta of 1.12. Davis Select International ETF Company Profile The Davis Select International ETF (DINT) is an exchange-traded fund that is based on the MSCI ACWI ex-US index. The fund holds an actively-managed portfolio of international companies outside the US, selected based on prospects for long-term growth of capital. DINT was launched on Mar 1, 2018 and is managed by Davis. Read More Want to see what other hedge funds are holding DINT? Visit HoldingsChannel.com to get the latest 13F filings and insider trades for Davis Select International ETF ( BATS:DINT – Free Report ). 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Atria Investments Inc Makes New $230,000 Investment in Ring Energy, Inc. (NYSEAMERICAN:REI)None
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The Prime Minister insisted the UK will back Ukraine “for as long as it takes” as he made a speech at the Lord Mayor’s Banquet in London, but for the first time acknowledged the conflict could move towards a negotiated end. Ukrainian President Volodymyr Zelensky has in recent weeks suggested he is open to a possible ceasefire with Vladimir Putin’s Russia. Kyiv and its European allies meanwhile fear the advent of Donald Trump’s return to the White House could result in American aid being halted. President-elect Trump has said he would prefer to move towards a peace deal, and has claimed he could end the conflict on “day one” of his time in power. As he attempts to strike up a good relationship with the incoming president, Sir Keir revealed he had told Mr Trump the UK “will invest more deeply than ever in this transatlantic bond with our American friends in the years to come”. In his speech at London’s Guildhall, the Prime Minister said there is “no question it is right we support Ukraine”, as the UK’s aid to Kyiv is “deeply in our self-interest”. Allowing Russia to win the war would mean “other autocrats would believe they can follow Putin’s example,” he warned. Sir Keir added: “So we must continue to back Ukraine and do what it takes to support their self-defence for as long as it takes. “To put Ukraine in the strongest possible position for negotiations so they can secure a just and lasting peace on their terms that guarantees their security, independence, and right to choose their own future.” Mr Zelensky told Sky News over the weekend he would be open to speaking with Mr Putin, but branded the Russian president a “terrorist”. He also suggested Ukrainian territory under his control should be taken under the “Nato umbrella” to try to stop the “hot stage” of the war with Russia. In a banquet speech focused on foreign affairs, the Prime Minister said it was “plain wrong” to suggest the UK must choose between its allies, adding: “I reject it utterly. “(Clement) Attlee did not choose between allies. (Winston) Churchill did not choose. “The national interest demands that we work with both.” Sir Keir said the UK and the US were “intertwined” when it came to commerce, technology and security. The Prime Minister added: “That’s why, when President Trump graciously hosted me for dinner in Trump Tower, I told him that we will invest more deeply than ever in this transatlantic bond with our American friends in the years to come.” He also repeated his commitment to “rebuild our ties with Europe” and insisted he was right to try to build closer links with China. “It is remarkable that until I met President Xi last month there had been no face-to-face meeting between British and Chinese leaders for six years,” the Prime Minister said. “We can’t simply look the other way. We need to engage. To co-operate, to compete and to challenge on growth, on security concerns, on climate as well as addressing our differences in a full and frank way on issues like Hong Kong, human rights, and sanctions on our parliamentarians,” he added. The Prime Minister said he wants Britain’s role in the world to be that of “a constant and responsible actor in turbulent times”. He added: “To be the soundest ally and to be determined, always, in everything we do. “Every exchange we have with other nations, every agreement we enter into to deliver for the British people and show, beyond doubt, that Britain is back.” Ahead of Sir Keir’s speech, Lord Mayor Alastair King urged the Prime Minister and his Government to loosen regulations on the City of London to help it maintain its competitive edge. In an echo of Sir Keir’s commitment to drive the UK’s economic growth, the Lord Mayor said: “The idealist will dream of growth, but the pragmatist understands that our most effective machinery to drive growth is here in the City, in the hands of some of the brightest and most committed people that you will find anywhere in the world.”STATE COLLEGE, Pa. — Jaylen Reed’s hands were still dirty and his face smeared with eye black as he took a seat in the Beaver Stadium media room. The hard-nosed veteran of nearly 50 college football games looked weary after Penn State pounded Maryland on Saturday, but lit up as he watched media members gather around teammate Audavion Collins next to him. The sophomore was excitedly describing his first career interception. Reed grinned, his pride was evident. One of Penn State’s captains, Reed loves when underclassmen earn playing time. He knows, especially on defense, the No. 3 Nittany Lions (11-1, 8-1 Big Ten, No. 4 CFP) will likely rely on them to make a run at their first national championship since 1986. “Having that type of depth, having that type of guy that can step up and play the game every week, that’s something that’s going to help us down the stretch,” Reed said. “Having depth at all positions, I feel like that’s the main thing and I feel like we have huge depth.” Reed knows Collins is far from the only reserve player who has been effective for Tom Allen’s defense this season. Heading into Saturday’s Big Ten championship game against No. 1 Oregon in Indianapolis, Penn State has used 39 players on a defense that ranks seventh nationally against the run and pass. Meanwhile, the Nittany Lions are fourth overall in total defense (266.8 yards) and sixth in scoring defense (14 points) entering the showdown with the Ducks' 15th-ranked offense with a College Football Playoff first-round bye at stake. It’s not just the starting 11 getting it done. Since mid-October, Penn State has regularly rotated at least nine defensive linemen, six linebackers and nine defensive backs early and midway through games. As a result, seven players have snagged their first interceptions this season, while five others have recorded their first sacks. “We believe in everybody coming in behind us,” linebacker Tony Rojas said. “Our defense, we know what we’re capable of and I feel like our defense is top tier, if not the best.” It technically hasn’t been at full strength since Week 2 of the season. Then, star safety KJ Winston was lost to an unspecified long-term injury. He tried to play at Wisconsin on Oct. 26, but hasn’t seen action since. In the meantime, Winston’s absence has allowed Allen and head coach James Franklin to get a good look at Collins and other young backend players like Eliot Washington, Zion Tracy and Dejuan Lane. Tracy and Lane have seen their snap counts go up since November, and both have interceptions since. The Nittany Lions haven’t been immune to injuries up front, either. Star end Dani Dennis-Sutton was limited midway through the season by an unspecified ailment. Before last weekend’s game against Maryland, Penn State listed defensive tackles Alonzo Ford and Kaleb Artis and defensive end Zuriah Fisher out with injuries. While not near 100% healthy, Dennis-Sutton continued to suit up, but yielded reps to Amin Vanover and Smith Vilbert. Vanover and Vilbert are seniors who were slowed over the years by injuries but have stuck around, and are now shoring up the team’s depth. “I think getting Dani back healthy, that’s been important,” Franklin said. “I think this was his first game back where he was really healthy, Abdul (Carter) the second half of the season, has gotten very comfortable playing defensive end. We’ve been able to rotate and get production out of guys like Amin as well, so I think all those things have been really important.” So is the fact that Penn State’s defense has continued to close out games. The Nittany Lions have allowed just 445 yards on 125 third-quarter plays this season. Meanwhile, they’ve outscored opponents 192-55 in the second half and overtime and held 19 of their last 22 Big Ten opponents to fewer that 100 rushing yards. Like Reed, senior Dvon J-Thomas spent much of the second half against Maryland cheering on his freshman teammates. Notably, tackle Ty Blanding who had his first career tackle for loss in his first defensive series. “I’ve seen a tremendous leap in their attention to detail,” J-Thomas said. “There’s not a lot of moments or times in your career where you’ll have an opportunity like this and I think they realize that." Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college football: https://apnews.com/hub/ap-top-25-college-football-poll and https://apnews.com/hub/college-football