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2025-01-25
Even with access to blockbuster obesity drugs, some people don’t lose weight5 wow in english

The Boston Bruins hope to continue their winning start to Joe Sacco's tenure as interim coach as they begin a stretch of three games in four nights around Thanksgiving on Tuesday against the Vancouver Canucks. Sacco has emphasized shoring things up defensively and his team has delivered, allowing a combined 42 shots on goal across only their second set of back-to-back regulation wins all season on Thursday against Utah (1-0 score) and Saturday in Detroit (2-1). There are positive offensive signs as well. Captain Brad Marchand netted the latter game-winner in the third period against the Red Wings, which was Boston's first at 5-on-5 in a three-game span. The first goal in Detroit came from Justin Brazeau and the second power-play unit. "We need contributions from everybody right now," Sacco said. Entering a busy stretch that continues Wednesday with a visit to the New York Islanders, Marchand likes the team's current direction. "We seem to be a little bit more comfortable right now. Effort seems higher," he said. "I like the way we closed the last couple of games, being tight, playing very well defensively." After giving up 12 goals in his previous two starts, Jeremy Swayman -- who signed an eight-year, $66 million contract last month -- returned to the net following Joonas Korpisalo's shutout of Utah and stopped 19 of 20 shots in Detroit. The beginning of the season has been a struggle for Swayman (3.30 goals-against average, .887 save percentage), but the coach affirmed that "he's still (the Bruins') guy" following their latest victory. "I am happy for his response," Sacco said. "I'm sure that he's starting to feel better about himself. It's only a matter of time before ‘Sway' starts to find his groove consistently." Meanwhile, Korpisalo has gone 3-0-1 in November. The Canucks have gone just 3-4-0 since beginning this month on a three-game win streak, but they arrive in Boston for the second of a six-game trip after beating Ottawa 4-3 Saturday. It was their seventh victory in eight road games this season. It was a key team win after center J.T. Miller was added to Vancouver's list of absentees due to an indefinite personal leave last Wednesday and defenseman Quinn Hughes was ejected in the first period for a major boarding penalty. "That's a lot to throw at the team, and I thought we handled it well," coach Rick Tocchet said. "I'm proud of the guys. We hung in there and grinded out the win. ... In an 82-game schedule, you're going to go through a lot of adversity and it's about the way you handle it." Brock Boeser (upper-body injury) has missed the previous seven games, but returned to practice Monday in a regular jersey. In the absence of aforementioned stars, the top line of Jake DeBrusk, Elias Pettersson and Kiefer Sherwood stepped up for a combined seven points against the Senators. DeBrusk scored two of the trio's three goals and added an assist. A Bruin for his first seven NHL seasons, DeBrusk scored his first three goals of the season in consecutive games before entering Saturday on a six-game drought. The winger will look to ride the momentum into his first game in Boston since moving to Vancouver as a free agent in July. "I think it's more so my game is kind of building," DeBrusk said. "I knew I was going to break through." The Canucks also recalled Max Sasson from AHL affiliate Abbotsford for his first NHL game on Saturday. He recorded an assist. "I really liked his game," Tocchet said. "To just get called up out of the blue, he seized the moment." This article first appeared on Field Level Media and was syndicated with permission.North Yorkshire farm shop praised for 'delicious' eggs revealed among UK's best

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South Korean Finance Minister Choi Sang-mok released a join statement with economy-related ministers on Sunday. The meeting was held in the aftermath of President Yoon Suk Yeol's brief declaration of martial law Tuesday. "The government will mobilize all resources available in accordance with contingency plans and take bold and swift measures, if necessary" "We have experienced some confusing incidents in the past, but their impact on the economy was limited," Choi said. "The government will put forth all-out efforts to maintain our sovereign rating under any circumstances." Government and Bank of Korea are taking measures to respond to market volatilities government vowed to inject "unlimited liquidity" for the time being Bank of Korea (BOK) has begun repo operations for financial institutions *** USD/KRW update - KRW to a 2-year low during the political turmoil:Cornelious Brown IV throws 5 TD passes to lead Alabama A&M past Mississippi Valley State 49-35Synopsys Inc SNPS reported fourth-quarter financial results after the market close on Wednesday. Here’s a rundown of the report . Q4 Revenue: $1.64 billion, versus estimates of $1.63 billion Q4 Adjusted EPS: $3.40, versus estimates of $3.30 “The fourth quarter was a strong finish to a transformational year for Synopsys. We achieved record financial results while doubling down on our strategy with the sale of our Software Integrity business and the pending acquisition of Ansys,” said Sassine Ghazi , president and CEO of Synopsys. “Looking ahead, the AI-driven reinvention of compute is accelerating the pace, scale and complexity of technology R&D, which expands our opportunity to solve engineering challenges from silicon to systems.” Synopsys said its previously announced acquisition of Ansys is expected to close in the first half of 2025. The company is working cooperatively with the Federal Trade Commission (FTC) to conclude the investigation and the staff’s review of Synopsys’ proposed remedies. Outlook: Synopsys expects first-quarter revenue to be in the range of $1.435 billion to $1.465 billion versus estimates of $1.643 billion, according to Benzinga Pro . The company sees first-quarter adjusted earnings between $2.77 and $2.82 per share versus estimates of $3.53 per share. Synopsys noted that its outlook reflects a change in the company’s fiscal year from a 52/53-week period ending on the Saturday nearest to Oct. 31 of each year to Oct. 31 of each year. As a result of this change, there will be 10 fewer days in the first half of fiscal year 2025. “In 2025, we expect to deliver double-digit revenue growth grounded in pragmatism given continued macro uncertainties and the impact of our fiscal year calendar change,” said Shelagh Glaser , CFO of Synopsys. SNPS Price Action: Synopsys shares were down 6.23% in after-hours, trading at $551.37 at the time of publication Wednesday, per Benzinga Pro . Read Next: ChargePoint Stock Rallies After Q3 Results: EPS In Line, Revenues Beat Photo: Courtesy of Synopsys. © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.

Ethereum (ETH) Could Double in Price by Early 2025, Here's How It'll Get There

Black Friday is fast approaching, and shoppers are gearing up. The National Retail Federation expects more than 183 million people to shop over the weekend spanning Thanksgiving to Cyber Monday this year. But fraudsters are preparing for Black Friday too, looking for opportunities to steal your money or personal information. Before you dive into holiday shopping, learn how to spot common scams and protect yourself. Fraudsters commonly send phishing emails and text messages impersonating delivery services or popular retailers like Amazon. These messages, which typically claim there’s an issue with processing or delivering the order, may request payment information or include malicious links. A message might say something like, “Part of your address is missing. Please click on this link to complete the address,” says Raj Dasgupta, senior director of global advisory at BioCatch, a fraud prevention firm. If you get a similar message when you’re not expecting a package, that should raise doubts, Dasgupta says. But even if you have ordered something, don’t overlook warning signs. It's unusual for delivery services to hold up packages or seek payment, because shipping costs are almost always charged to the shipper, not the receiver, says Cliff Steinhauer, director of information security and engagement at the nonprofit National Cybersecurity Alliance. Avoid clicking on links in texts or emails, and don’t share personal or payment details. To verify whether an order update is genuine, “go back to your original order on the site,” Steinhauer says. You can log in and check the order status and reach out to customer service directly if there's a problem, he says. When shopping online, carefully scrutinize sellers and products to avoid winding up with counterfeit items — or nothing at all. Sponsored ads on social media sites and search engines aren’t always vetted enough, Steinhauer says, which means you may come across scams. Fraudsters buy Google ads for popular search terms like “Black Friday deals” or desirable products, such as exercise equipment, Dasgupta says. When people click on these ads, they might land on a “sophisticated-looking fake website” that mimics a well-known site, such as Macy’s, or on a made-up company’s page, he says. Shoppers never receive the product they’re attempting to purchase, or they get an inferior product. Ignore “sponsored” links, and read URLs closely. There will usually be “something off,” Steinhauer says, such as a slight misspelling or dashes in the website name that aren’t normally there. “The best thing is to go to the legitimate website or app that you know is the right one, and just shop there,” he says. Watch for ​​ third-party seller scams on legitimate websites, too. Some companies, such as Walmart and Target, allow outside vendors to sell merchandise through their platforms — and the reliability can vary. Reading seller reviews before you buy can help you avoid bad actors. Be wary of sellers who ask for gift cards or peer-to-peer payments . If a service like Venmo or Cash App is the only payment method accepted, that’s an immediate red flag, Dasgupta says. And if a deal seems too good to be true, it probably is. A QR code, or quick response code, is a barcode that usually leads to a website when scanned with a smartphone camera. “Quishing” is when scammers create QR codes that link to fraudulent websites or install malware on devices. These codes may show up on parking meters, in mysterious packages delivered to your physical address or in your email inbox. For example, a scammer posing as your bank might email you a code and instruct you to update your login credentials. Email services often filter out known malicious links or domains and send them to your spam folder, Steinhauer says, but a QR code can get past these filters because it’s an image. Don't scan codes you receive unexpectedly, and closely inspect QR codes in public places for signs of tampering. Heed the advice above, and follow these additional steps to guard against fraudsters. More Black Friday content from NerdWallet Lauren Schwahn writes for NerdWallet. Email: lschwahn@nerdwallet.com . Twitter: @lauren_schwahn. The article Holiday Shoppers Beware: 3 Traps to Avoid as Scammers Prepare originally appeared on NerdWallet. Get local news delivered to your inbox!

NEW YORK (AP) — U.S. stocks rose Monday, with those benefiting the most from lower interest rates and a stronger economy leading the way. The S&P 500 climbed 0.3% to pull closer to its all-time high set two weeks ago. The Dow Jones Industrial Average added 440 points, or 1%, to its own record set on Friday, while the Nasdaq composite rose 0.3%. Treasury yields also eased in the bond market amid what some analysts called a “Bessent bounce” after President-elect Donald Trump said he wants , a hedge fund manager, to be his Treasury Secretary. Bessent has argued for reducing the U.S. government’s deficit, which is how much more it spends than it takes in through taxes and other revenue. Such an approach could soothe that Trump’s policies may lead to a much bigger deficit, which in turn would put upward pressure on Treasury yields. After climbing above 4.44% immediately after Trump’s election, the yield on the 10-year Treasury fell back to 4.26% Monday, down from 4.41% late Friday. That’s a notable move, and lower yields make it cheaper for all kinds of companies and households to borrow money. They also give a boost to prices for stocks and other investments. That helped stocks of smaller companies lead the way, and the Russell 2000 index of smaller stocks jumped 1.5%. It finished just shy of its all-time high, which was set three years ago. Smaller companies can feel bigger boosts from lower borrowing costs because of the need for many to borrow to grow. The two-year Treasury yield, which more closely tracks the market’s expectations for what the Federal Reserve will do with overnight interest rates, also eased sharply. The Fed began just a couple months ago from a two-decade high, hoping to keep the after bringing to its 2% target. But immediately after Trump’s victory, traders had reduced bets for how many cuts the Fed may deliver next year. They were worried Trump’s preference for lower tax rates and higher spending on the border would balloon the national debt. A report coming on Wednesday could influence how much the Fed may cut rates. Economists expect it to show that an underlying inflation trend the Fed prefers to use accelerated to 2.8% last month from 2.7% in September. Higher inflation would make the Fed more reluctant to cut rates as deeply or as quickly as it would otherwise. Goldman Sachs economist David Mericle expects that to slow by the end of next year to 2.4%, but he said inflation would be even lower if not for expected tariff increases on imports from China and autos favored by Trump. In the stock market, jumped 16.5% after delivering stronger profit for the latest quarter than analysts expected. The seller of personal care products and home fragrances also raised its financial forecasts for the full year, even though it still sees a “volatile retail environment” and a shorter holiday shopping season this year. Much focus has been on how resilient U.S. shoppers can remain, given high prices across the economy and still-high interest rates. Last week, two major retailers sent mixed messages. after giving a dour forecast for the holiday shopping season. It followed , which gave a much more encouraging outlook. Another big retailer, Macy’s, said Monday its sales for the latest quarter were in line with its expectations, but it will delay the release of its full financial results. It found a and it needs more time to complete its investigation. Macy’s stock fell 2.2%. Among the market’s leaders were several companies related to the housing industry. Monday’s drop in Treasury yields could translate into easier mortgage rates, which could spur activity for housing. Builders FirstSource, a supplier or building materials, rose 5.9%. Homebuilders, D.R. Horton, PulteGroup and Lennar all rose at least 5.6%. All told, the S&P 500 rose 18.03 points to 5,987.37. The Dow Jones Industrial Average jumped 440.06 to 44,736.57, and the Nasdaq composite gained 51.18 to 19,054.84. In stock markets abroad, indexes moved modestly across much of Europe after finishing mixed in Asia. In the crypto market, was trading below $95,000 after threatening to hit $100,000 late last week for the first time. AP Business Writer Elaine Kurtenbach contributed.

The Detroit Lions will play without two high draft picks in rookie cornerbacks Terrion Arnold and Ennis Rakestraw Jr. while possibly getting back veteran Emmanuel Moseley against the host Indianapolis Colts on Sunday. Arnold was downgraded Saturday from questionable to out because of a groin injury. He was limited at practice on Thursday and participated in a full practice on Friday. The Lions drafted Arnold with the 24th overall pick of the 2024 NFL Draft out of Alabama. Arnold, 21, has started all 10 games and has 38 tackles and six passes defended. Rakestraw (hamstring) was placed on injured reserve after not practicing all week. He already had been ruled out for Sunday's game. Detroit picked Rakestraw in the second round (61st overall) out of Missouri. He has played in eight games and has six tackles. Rakestraw, 22, has played on 46 defensive snaps (8 percent) and 95 special teams snaps (42 percent). Moseley had full practice sessions all week and was activated from injured reserve on Saturday but was listed as questionable for Sunday. The 28-year-old is in his second season with Detroit and appeared in one game last season before going on IR in October 2023. He was placed on IR on Aug. 27 with a designation to return. Moseley played from 2018-22 for the San Francisco 49ers and had 162 tackles, four interceptions -- one returned for a touchdown -- and 33 passes defensed in 46 games (33 starts). Detroit elevated linebacker David Long on Saturday for game day. Long, 28, signed with the practice squad on Tuesday after the Miami Dolphins released him on Nov. 13. He had started six of eight games for the Dolphins this season and had 38 tackles. In other Lions news, the NFL fined wide receiver Jameson Williams $19,697 for unsportsmanlike conduct for making an obscene gesture during a touchdown celebration in last Sunday's 52-6 home win over the Jacksonville Jaguars, the NFL Network reported Saturday. Williams, 23, scored on a 65-yard pass from Jared Goff with 12:55 remaining in the third quarter. --Field Level Media

Texas AG Ken Paxton investigates GARM ad cartel over boycott ‘conspiracy’Unlike scores of people who for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It’s a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It’s all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person’s response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn’t happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It’s not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn’t respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I’m hoping it’s slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content. Jonel Aleccia, The Associated Press

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