Amazon investing another $10 billion in Ohio-based data centers
As the saying goes, you are what you eat. In today’s digital age, this adage holds for the content we consume online. The type of media we engage with can significantly influence our mental health. A study by UCL researchers, published in Nature Human Behaviour, sheds light on the bi-directional relationship between mental health and online browsing habits, revealing how exposure to negative content can perpetuate a cycle of emotional distress. The Link Between Negative Content and Mental Health The study analyzed the web-browsing patterns of over 1,000 participants, focusing on the emotional tone of the web pages they visited. Participants also reported their existing mental health concerns and mood. The findings uncovered a troubling pattern: people with poor mental health symptoms were more likely to seek out and engage with negative content, which, in turn, worsened their mood. This creates a feedback loop—exposure to negative content heightens emotional distress, which leads to more consumption of such material, further increasing mental health challenges. Professor Tali Sharot, co-lead author of the study, explained, "Our results show that browsing negatively valenced content not only mirrors a person's mood but can also actively worsen it. This creates a feedback loop that can perpetuate mental health challenges over time." Breaking the Cycle: Content Labeling To counteract this harmful cycle, the researchers proposed an innovative solution: content labels. Much like nutritional labels on food, these labels provide insights into the likely impact of a webpage on mood, functionality, and informativeness. This tool empowers users to make informed choices about the content they consume, potentially mitigating the effects of negative material on mental health. How to Protect Your Mental Health While Browsing Engaging with negative content is sometimes unavoidable, but there are steps you can take to maintain a healthy balance: - Set Boundaries: Limit your screen time and designate specific periods for online browsing. Avoid late-night scrolling, which can disturb your sleep and exacerbate anxiety. - Curate Your Feed: Follow positive and uplifting accounts on social media. Unfollow or mute sources of negativity, even temporarily, to reduce exposure. - Practice Mindfulness: Be conscious of your emotional state while browsing. If you notice a shift toward negativity, take a break or switch to lighter, uplifting content. - Diversify Your Activities: Balance online browsing with offline hobbies like reading, exercising, or spending time with loved ones. - Seek Professional Support: If online content consistently worsens your mood, consider seeking guidance from a mental health professional. - Use Tools to Monitor Content: Leverage browser extensions or apps designed to filter or label content based on its emotional tone. Get Latest News Live on Times Now along with Breaking News and Top Headlines from Mental Health, Health and around the world.
LUQUE, Paraguay — Sake is perhaps more Japanese than the world-famous sushi. It's brewed in centuries-old mountaintop warehouses, savored in the country’s pub-like izakayas, poured during weddings and served slightly chilled for special toasts. The smooth rice wine that plays a crucial role in Japan's culinary traditions was enshrined on Wednesday by UNESCO on its list of the “intangible cultural heritage of humanity." At a meeting in Luque, Paraguay, members of UNESCO’s committee for safeguarding humanity's cultural heritage voted to recognize 45 cultural practices and products around the world, including Brazilian white cheese, Caribbean cassava bread and Palestinian olive oil soap. Unlike UNESCO’s World Heritage List, which includes sites considered important to humanity like the Pyramids of Giza in Egypt, the Intangible Cultural Heritage designation names products and practices of different cultures that are deserving of recognition. Japan's Takehiro Kano, ambassador to UNESCO, reacts after the traditional Japanese brewing of sake was officially named to UNESCO's "intangible cultural heritage of humanity" list during a World Heritage Convention in Asuncion, Paraguay on Wednesday. A Japanese delegation welcomed the announcement in Luque. “Sake is considered a divine gift and is essential for social and cultural events in Japan,” Kano Takehiro, the Japanese ambassador to UNESCO, told The Associated Press. The basic ingredients of sake are few: rice, water, yeast and koji, a rice mold that breaks down the starches into fermentable sugars like malting does in beer production. The whole two-month process of steaming, stirring, fermenting and pressing can be grueling. The rice — which wields tremendous marketing power as part of Japan's broader cultural identity — is key to the alcoholic brew. For a product to be categorized Japanese sake, the rice must be Japanese. Japanese sake, a nominee for UNESCO's "intangible cultural heritage of humanity" list, are displayed on Japan's delegation table, during a UNESCO World Heritage Convention in Asuncion, Paraguay, on Wednesday. The UNESCO recognition, the delegation said, captured more than the craft knowledge of making high-quality sake. It also honored a tradition dating back some 1,000 years — sake makes a cameo in Japan’s famous 11th century novel, “The Tale of Genji,” as the drink of choice in the refined Heian court. Now, officials hope to restore sake's image as Japan's premier alcoholic drink even as the younger drinkers in the country switch to imported wine or domestic beer and whiskey. Japanese breweries also expressed hope the listing could give a lift to the country's export economy as the popularity of sake booms around the world and in the United States amid heightened interest in Japanese cuisine. Sake exports, mostly to the U.S. and China, now rake in over $265 million a year, according to the Japan Sake and Shochu Makers Association, a trade group. Japan's Takehiro Kano, ambassador to UNESCO, reacts as the traditional Japanese brewing of sake was named to UNESCO's "intangible cultural heritage of humanity" list during a World Heritage Convention in Asuncion, Paraguay on Wednesday. Japan's delegation appeared ready to celebrate Wednesday — in classic Japanese style. After the announcement, Takehiro raised a cypress box full of sake to toast the alcoholic brew and cultural rite. “It means a lot to Japan and to the Japanese,” he said of the UNESCO designation. "This will help to renew interest in traditional sake elaboration.” In Tokyo, Japanese Prime Minister Shigeru Ishiba said he was “delighted” by UNESCO's recognition of traditional sake-making techniques, and he congratulated those dedicated to preserving and promoting the tradition. A tasting party is all about sampling different wines and evaluating and hopefully enjoying them—and there are a variety of ways to do that. Would you like to host a playful gathering where each guest brings a mystery bottle of wine within a certain price range—a BYOB affair? Or would it be better to have more control over which wines are featured by curating and supplying all the wines as a host? This decision sets the tone—a tasting where guests contribute wine can be a bit of a free-for-all, whereas one where you select wines you supply allows guests to sit back and simply enjoy. And you don't have to break the bank to buy excellent wines—there are lots of wine experts ready to share their affordable picks. How much folks know about wine differs—and that's a good thing. Tastings are group learning experiences. Expertise isn't necessary to host or attend a tasting, but it is helpful to think about what will keep guests comfortable and having fun. Decide whether the vibe will be relaxed and laid-back, like friends sipping wine fireside, or more upbeat and formal. Think about elements like the atmosphere and the location, and consider whether folks will be seated or standing. Will you have a spirited playlist (couldn't resist) or live music? Do you want an expert to introduce each wine, or will you be that expert? Consider how guests will share their thoughts on what they are tasting. Do you want to just talk about them or do something more organized, like take notes or give ratings? Then supply notebooks or notecards and pencils, with categories or questions established ahead of time—all of which can reflect your evening's tone as well. How many people to invite is a question largely informed by the answers to tip #1: Are you having a big, formal affair or an intimate catch-up with close friends? Or something in between? Whatever the case, an RSVP is essential because not only do you need to plan the setup of the space, but you must also make sure there's enough wine for everyone to taste, including each of the wines featured. There's nothing worse than a tasting that runs dry! The math to determine how much wine you need considers the size of the tasting pours—a full glass of wine at a restaurant is usually around 5 ounces, which yields around five glasses of wine from a standard bottle. For tastings, you'll want to do less, depending on how many wines you are featuring—say, 2 ounces if you'll be trying a lot of different wines. Experts agree, having more wine than you need is always a good idea—that way you can send guests home with a bottle should there be a prize at the end of the night. Don't let food be an afterthought for the festivities—after all, food can enhance particular qualities of wine and vice versa. There are many rules around what foods to pair with which wines, but consider this simple advice from Alder Yarrow's Vinography : "Stick with eating good food and drinking good wine." Since the focus is on the wines, allow the drinks to determine what food makes sense, but don't overthink it. Food is a supporting character here—at the very least, guests will need something to soak up all the alcohol (unless you are spitting it out). Eating foods that contain a mixture of protein, fats, and carbs when drinking helps increase the rate of alcohol elimination . Whether it's a full meal or heavy hors d'oeuvres, thoughtful noshes are necessary. The bottom line is, however you do it, hosting the ultimate wine tasting should be fun. Wine can feel intimidating to many people, but most wine experts are passionate, inspired folks who want to share what they know and help you find wines you like. So visit your local wine store or winemaker and ask questions. There are good guides specifically concerning how to taste wine. Dig a little, taste a lot, and have fun. It's all research for your next ultimate wine tasting. Story editing by Carren Jao. Additional editing by Kelly Glass. Copy editing by Kristen Wegrzyn. Photo selection by Lacy Kerrick. This story originally appeared on Peerspace and was produced and distributed in partnership with Stacker Studio. The crisp autumn air ushers in more than just pumpkin spice latte season. Consider cozying up inside with friends for a wine tasting and sharing delicious food and drinks with more complex flavors than cinnamon and sugar. Perhaps once thought of as stuffy affairs only for wine connoisseurs, today a tasting can be as casual as pouring a few bottles while doing another activity—say, bar games like darts or art activities like painting. The tasting can also be more traditional, especially if held at a winery or local wine shop, which is a great way to learn about what wines you might like to later serve at home. To host the ultimate wine tasting, it pays to do some R&D. One of the best aspects of hosting a wine tasting at home is that you get to establish the mood, tone, and guest list for the gathering—you can't pick a playlist when you sample wines at a bar or wine shop or make the dress code loungewear. So whether the mood is serious or playful, sophisticated or laid-back, the key to a successful tasting is enjoying and appreciating the wine and having fun with friends and family. Of course, there are a few other things to figure out along the way. Peerspace put together a few tips for hosting your wine-tasting party. Picking a theme is essential to curating the selection of wines—it's the organizing principle behind your selections. Otherwise, your tasting might as well be just walking down the wine aisle at the grocery store and taking sips from random bottles. There's too much wine out there not to be strategic about this. Plus, a theme helps you to tell the story of each wine better—it's the plot line of the night, if you will. Common themes are types of wine, regions they are from, or even price points—really, one can get as creative as they wish. For inspiration, check out local wine shops and see what they do for tastings. Often, they will follow seasonality and group wines in novel ways for their own in-house tastings. Be the first to know Get local news delivered to your inbox!Aaron Judge of the New York Yankees secured the American League's Most Valuable Player award on Thursday, receiving a unanimous nod from voters. Judge, a key figure in Major League Baseball, outperformed with leading statistics in homers and RBIs. He triumphed over competitors Juan Soto and Bobby Witt Jr. to claim his second MVP award, following his first win in 2022. (With inputs from agencies.)
PC Accessories: Best Offers on Keyboards and MiceBaltimore (7-4) at Los Angeles Chargers (7-3) Monday, 8:15 p.m. EST, ESPN/ABC BetMGM NFL odds: Ravens by 3. Against the spread: Ravens 5-5-1; Chargers 7-3. Series record: Ravens lead 9-5. Last meeting: Ravens beat Chargers 20-10 in Inglewood, Calif., on Nov. 26, 2023. Last week: Ravens lost to Pittsburgh 18-16; Chargers beat Cincinnati 34-27. Ravens offense: overall (1), rush (2), pass (3), scoring (2). Ravens defense: overall (3), rush (26), pass (2), scoring (23). Chargers offense: overall (18), rush (12), pass (19), scoring (18). Chargers defense: overall (11), rush (11), pass (12), scoring (1). Turnover differential: Ravens plus-2; Chargers plus-8. K Justin Tucker missed two field goals last week and is under pressure after spending most of his career beyond reproach. He’s missed six field goals on the season and is 4 for 12 from 50-plus yards since the start of last season. WR Ladd McConkey had a career-high 123 yards on six receptions against Cincinnati. The rookie came up with clutch catches of 28 and 27 yards to set up the game-winning touchdown. Chargers RB J.K. Dobbins vs. Ravens’ run defense. Dobbins showed promise during his time in Baltimore, but he never was able to live up to that potential because of injuries. Now in Los Angeles on a one-year “prove it” contract, Dobbins has nearly matched his most productive season as a professional with 726 yards and eight touchdowns in 10 games. After seeing Pittsburgh run the ball 34 times last week, the Chargers will be glad to copy that bruising approach with Dobbins. The Ravens are allowing 77.5 rushing yards per game, but even the sturdiest defense can buckle against that volume of work, so getting off the field will be critical. Baltimore’s defense has one significant injury concern, with LB Roquan Smith (hamstring) questionable to go this week after he was hurt against the Steelers. The good news is S Kyle Hamilton does not have an injury designation. He has been nursing an ankle problem, although he played against Pittsburgh. ... Chargers OLB Khalil Mack (groin) is questionable after the veteran pass rusher didn’t play against Cincinnati. ... McConkey is also questionable because of a shoulder injury. The Ravens have won four straight over the Chargers in the regular season, but Los Angeles did earn a 23-17 AFC wild-card round upset in January 2019. ... Baltimore cruised to a 34-6 win over the Chargers in its first visit to SoFi Stadium on Oct. 17, 2021. Ravens RB Derrick Henry leads the NFL with 1,185 yards rushing and 15 total TDs (13 rushing and two receiving). He’s also run for a league-high 52 first downs. ... Henry is one rushing TD shy of the Ravens’ single-season record, set by Jamal Lewis in 2003. ... Baltimore QB Lamar Jackson is 6-2 on “Monday Night Football” with 20 TD passes and no interceptions. ... Henry is one of four players in the Super Bowl era to score a TD in each of the first 11 games of a season. The others are O.J. Simpson (1975), John Riggins (1983) and Jerry Rice (1987). ... The Ravens have scored touchdowns on a league-best 77.8% of their red zone trips. ... Jackson needs 124 yards passing and 16 yards rushing for a second consecutive season with 3,000 passing and 600 rushing. Since the AFL-NFL merger, only Randall Cunningham (1988-1990), Cam Newton (2011-12), Josh Allen (2021-22) and Jalen Hurts (2021-23) have accomplished that feat. ... Dobbins ran for two touchdowns against Cincinnati, giving him multiple scores in two of his past three games. He did it twice in 24 games as a Raven. ... OLB Tuli Tuipulotu had 1 1/2 sacks of Bengals QB Joe Burrow, his third straight game with more than one. All seven of Tuipulotu’s sacks this season have come in the past four games, and six of his eight tackles for loss have come in that span. ... The Chargers allowed a season-worst 27 points to Cincinnati after holding each of their previous nine opponents to 20 points or fewer. ... QB Justin Herbert has thrown one interception in 277 attempts this season. That lone pick came in Week 2 at Carolina. ... The Chargers lost their fifth turnover of the season when Herbert fumbled to start the fourth quarter. It was their first turnover at home. ... Los Angeles does not have a takeaway in its past two games. Herbert has heated up after a slow start in terms of fantasy production, having thrown for multiple touchdowns in three of his past four games. He is likely to keep that success going this week. Baltimore has allowed 22 scores through the air, which is tied with Houston for second most in the league, and Herbert should have plenty of chances to add to that total in what could be another high-scoring matchup. AP NFL: https://apnews.com/hub/NFL Copyright 2024 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed without permission. Get local news delivered to your inbox!
Shohei Ohtani wins third MVP award, first in NL. Aaron Judge earns second AL honor in 3 seasonsNASSAU, Bahamas (AP) — Justin Thomas was long off the tee and made a few long putts on the back nine to overtake Scottie Scheffler with a 6-under 66 and build a one-shot lead Saturday over golf’s best player going into the final round of the Hero World Challenge. Thomas is trying out a 46-inch driver — a little more than an inch longer than normal — that he previously used for practice at home to gain speed and length. He blasted a 361-yard drive to 8 feet on the par-4 seventh hole and led the field in driving distance. But it was a few long putts that put him ahead of Scheffler, who had a 69. Thomas was on the verge of falling two shots behind when he made an 18-foot par putt on the par-3 12th hole. On the reachable par-4 14th, he was in a nasty spot in a sandy area and could only splash it out to nearly 50 feet. He made that one for a most unlikely birdie, while behind him Scheffler muffed a chip on the 13th hole and made his lone bogey of a windy day. Scheffler never caught up to him, missing birdie chances on the reachable 14th and the par-5 15th. Thomas hit his approach to 3 feet for birdie on the 16th after a 343-yard drive. Scheffler made an 18-foot birdie putt on the 16th to close within one. RELATED COVERAGE Scottie Scheffler goes on a run of birdies in the Bahamas and leads by 2 Scottie Scheffler has new putting grip and trails Cameron Young by 3 in Bahamas Kevin Kisner will be the lead analyst for NBC’s golf coverage Scheffler missed birdie chances on the last two holes from the 10-foot and 15-foot range, while Thomas missed an 8-foot birdie attempt at the last. “I had a stretch at 13, 14, 15 where I felt like I lost a shot or two there, but outside of that I did a lot of really good things today,” Scheffler said. Thomas hasn’t won since the 2022 PGA Championship at Southern Hills, and a victory at Albany Golf Club wouldn’t count as an official win. But the two-time major champion has made steady progress toward getting his game back in order. “I’m driving it great. I’ve had a lot of confidence with it,” Thomas said of his longer driver. “I feel like I’ve been able to put myself in some pretty good spots going into the green. I’m still not taking advantage of some of them as much as I would like, but that’s golf and we’re always going to say that.” Thomas was at 17-under 199 and will be in the final group Sunday with Scheffler, who is trying to end his spectacular season with a ninth title. Tom Kim put himself in the mix, which he might not have imagined Thursday when he was 3 over through six holes of the holiday tournament. Kim got back in the game with a 65 on Friday, and then followed with 12 birdies for a 62. He had a shot at the course record — Rickie Fowler shot 61 in the final round when he won at Albany in 2017 — until Kim found a bunker and took two shots to reach the green in making a double bogey on the par-3 17th. Even so, he was only two shots behind. Ryder Cup captain Keegan Bradley (68) was four back. “Feel like I’ve been seeing signs of improvement, which is what you want and that’s all I can do,” Thomas said. “I can’t control everybody else or what’s going on, I’ve just got to keep playing as good as I possibly can and hope that it’s enough come Sunday.” ___ AP golf: https://apnews.com/hub/golfHalf-centuries by Farhan Yousuf, Haroon Arshad, Shahzaib Khan and Usman Khan helped Pakistan beat UAE by 191 runs in the fifth match of the U19 tri-series tournament at the ICC Cricket Academy Ground in Dubai on Friday. The win also confirms Pakistan’s place in the final, scheduled against Afghanistan U19 on Tuesday, 26 November at the same venue. The match will begin at 09.30am local time, said a press release. This was Pakistan’s second successive win over UAE in the tournament, after beating them by 10 wickets in the opening match. The Saad Baig-led side also defeated Afghanistan in their previous encounter by 13 runs but faced a defeat against Afghanistan earlier in the tournament. After opting to bat first, Pakistan scored 314 for five in 50 overs – their best score in the series. The left-handed opening pair of Shahzaib Khan and Usman Khan continued their fine form, knitting a 96-run partnership for the first wicket. Usman (50, 64b, 7x4s) and Shahzaib (71, 84b, 5x4s, 2x6s) made fluent half-centuries. Following the duo’s departure, Farhan Yousaf (63, 50b, 3x4s, 4x4s) and Haroon Arshad (54, 34b, 4x4s, 2x6s) added 75 runs for the fourth wicket. Faham-ul-Haq chipped in with 37 off 48 balls, which included one four and two sixes. For UAE, Noorullah Ayubi and Uddish Suri bagged two wickets apiece. In turn, UAE were beset by a top-order collapse as they were reduced to 52 for five in 16 overs. At that stage, Ayaan Misbah (17, 46b, 1×4) and Suri (32 not out, 61b, 4x4s) added a 21-run partnership for the sixth wicket before Misbah got out to Umar Zaib in the 26th over. UAE were eventually dismissed for 123 in the 37th over. Naveed Ahmed Khan bagged three wickets, while Umar ended up with figures of four for 51. The last group match of the tri-series will be played between Afghanistan and UAE on Sunday, November 24. Scores in brief: Pakistan 314-5, 50 overs (Shahzaib Khan 71, Farhan Yousaf 63, Haroon Arshad 54, Usman Khan 50, Faham-ul-Haq 37, Muhammad Riazullah 23 not out; Noorullah Ayubi 2-53, Uddish Suri 2-54). UAE 123 all out, 36.5 overs (Uddish Suri 32 not out, Noorullah Ayubi 28; Umar Zaib 4-51, Naveed Ahmed Khan 3-17, Faham-ul-Haq 2-20).
'If it was down to me' - Lauren Price makes Natasha Jonas admission as 'respect' claim madeThe states that saw the most active attacks against election certification two years ago certified the results of this year’s races without controversy this week, prompting the Arizona secretary of state to proclaim that “election denialism” is a thing of the past. Others said they weren’t so sure. Certification proceeded normally this year in part because Donald Trump won the presidential race, quieting his supporters after he had spent the campaign making unsubstantiated claims that he could lose only through widespread cheating . The statewide certification votes Tuesday in Nevada and New Mexico follow a vote Monday to certify the results in Arizona. In all three states, the certification process was tumultuous during the 2022 midterms when Democrats won most statewide offices. Those controversies followed attempts by Trump and his allies to halt or challenge certification in Michigan, Georgia and other battleground states in 2020, disrupting what until then had been a routine administrative process. This year, some who have been the most vocal in questioning the integrity of elections have instead been celebrating Trump’s victory. “The results are being accepted in the manner that they are, in part, because those who have been eroding trust or casting doubt on the integrity of U.S. elections have a result they feel good about,” said David Levine, a former local election official in Idaho who now advises on election administration issues. “Hopefully we can get back to a place where Americans can feel confident in the results even if it’s one they disagree with.” On Tuesday, Nevada and New Mexico certified their statewide results with little discussion. During Monday’s certification in Arizona, Secretary of State Adrian Fontes reflected on the lack of controversy this year. “I think the age of election denialism, for all intents and purposes, is dead,” he said. Sitting next to Fontes, state Attorney General Kris Mayes, a fellow Democrat, said she was more skeptical. Her Republican opponent in 2022 spent two years challenging his loss . “Do I think election denialism is dead? No, I don’t,” she said. “We’ll see over the next couple of election cycles what happens, but I don’t think we’re there yet.” Public confidence in elections has dropped since Trump challenged his loss in 2020 and made false claims of widespread fraud, particularly among Republicans . Some Republicans began targeting the certification process, when local and state boards certify the results after local election officials provide them with the final tally of votes. A firestorm erupted in Georgia over the summer when the state election board, with a new pro-Trump majority, attempted to politicize the certification process with changes later blocked by the courts. While certification battles did not surface after the Nov. 5 election , a vocal segment within the Republican Party remains deeply skeptical of election processes, particularly of the availability of mail ballots and the use of ballot scanners to tally votes. During a forum Monday on the social platform X led by the group Cause of America, the group's director expressed doubt about voting equipment. Shawn Smith, who also is a retired Air Force colonel, argued the certification process suppresses legitimate concerns and goes against “the sovereignty of the people.” Story continues below video Although not as widespread as four years ago, this sentiment did surface sporadically at the local level this month. In Washoe County, Nevada, which includes Reno and voted narrowly for Vice President Kamala Harris, the vote to certify the results was 3-1 with one abstention. Commissioner Jeanne Herman has consistently voted against certification and did not make a public comment about her vote this year. Commissioner Mike Clark, a staunch Trump supporter who had also previously voted against certification, said he would abstain and left before the vote. “I am not an election denier and clearly the person I wanted to win, won this state,” Clark said before leaving the meeting. “However, that does not mean that all the protocols were followed and that we can truly certify the election.” Such skepticism, whether in Nevada or elsewhere, leaves the door open to certification disputes during future elections. The questioning of election results isn't limited to Republicans. Even though Harris quickly conceded after losing all seven presidential battleground states , online posts among her supporters continue to raise concerns about her loss. One Reddit community that has amassed 23,000 members features a steady drumbeat of Democrats scrutinizing a result they can’t believe is real. Some posting in the group have issued calls to contact Harris and her running mate to ask them to demand a recount or otherwise object to the outcome. Among the battlegrounds, Michigan was among those where Trump and his allies pressed to halt certification of the 2020 election for Democrat Joe Biden amid false claims of fraud and manipulation. Two Republican members of the Wayne County Board of Canvassers who initially opposed certification eventually relented. The state board of canvassers eventually voted to certify, even after one Republican member abstained. This year, the state board voted unanimously on Nov. 22 in favor of certifying and praised the state’s election workers. In Georgia, Secretary of State Brad Raffensperger certified his state’s results on Nov. 22. Four years ago, the Republican state official was facing immense pressure from Trump and his allies to investigate their unsubstantiated claims of fraud. Also certifying results Tuesday, and doing so unanimously, was the state Board of Elections in North Carolina. It was the only presidential battleground state won by Trump in 2020 — and the only one where he and his allies didn't make claims of fraud. Cassidy reported from Atlanta. Associated Press writers Susan Montoya Bryan in Albuquerque, New Mexico, Ken Ritter in Las Vegas, Scott Sonner in Reno, Nevada, and Ali Swenson in New York contributed to this report.
Data from the ongoing Phase 1/2 ATALANTA-1 study in a heavily pretreated R/R NHL patient population demonstrate high antitumor activity and an encouraging safety profile in all NHL subtypes studied. 96% of patients received an infusion of fresh, fit, stem-like, early memory CD19 CAR T-cell therapy with a median vein-to-vein time of seven days, avoiding the need for cryopreservation and bridging therapy. These data reinforce the potential of Galapagos' decentralized cell therapy manufacturing platform to deliver fresh, fit cells, fast, driving positive patient outcomes. Mechelen, Belgium; December 7, 2024, 18:30 CET; Galapagos NV ((Euronext &, NASDAQ: GLPG ) today announced additional data from the ongoing Phase 1/2 ATALANTA-1 study of its CD19 CAR T-cell therapy, GLPG5101. The results, featured in an oral presentation at the 66 th American Society of Hematology (ASH) Annual Meeting and Exposition, demonstrate an encouraging efficacy and safety profile in patients with relapsed/refractory non-Hodgkin lymphoma (R/R NHL). Most patients in the study received GLPG5101 as a fresh, fit, stem-like, early memory CD19 CAR T-cell therapy, with a median vein-to-vein time of seven days. "Shorter vein-to-vein time can lead to improved patient outcomes and remains an important unmet need in CAR-T therapy," said Marie José Kersten, MD, ATALANTA-1 Principal Investigator and Professor of Hematology at the Department of Hematology at Amsterdam University Medical Center. "I am impressed by the latest data on GLPG5101, which demonstrate a promising efficacy and safety profile. With a median vein-to-vein time of just seven days, GLPG5101 has the potential to offer speed and scheduling flexibility, comparable to off-the-shelf therapies." "CAR-T therapies are highly personalized treatments that currently undergo a time-intensive manufacturing process taking multiple weeks to months. For many patients with rapidly progressing cancers, every day counts, and treatment delays can be detrimental," said Jeevan Shetty, MD, Head of Clinical Development Oncology at Galapagos. "We are steadfast in our commitment to bring innovation to cell therapies to address the most significant medical challenges. Our latest data at ASH strongly support the feasibility of our innovative decentralized cell therapy manufacturing platform in delivering fresh, fit cells with a median vein-to-vein time of just seven days, driving positive patient outcomes." The new ATALANTA-1 data are summarized below: The ongoing ATALANTA-1 study included updated data on patients with mantle cell lymphoma (MCL), marginal zone lymphoma (MZL), follicular lymphoma (FL), and diffuse large B-cell lymphoma (DLBCL). As of the April 25, 2024, data cut-off, 49 patients received CD19 CAR T-cell therapy infusion, and safety and efficacy results were available for 45 patients and 42 patients, respectively. High objective response rates (ORR) and complete response rates (CRR) were observed in the pooled Phase 1 and Phase 2 efficacy analysis set, split by indication: In patients with MCL, all 8 of 8 efficacy-evaluable patients responded to treatment (ORR and CRR 100%). In patients with MZL, FL, objective and complete responses were observed in 20 of 21 efficacy-evaluable patients (ORR and CRR 95%). In patients with DLBCL, 9 of 13 efficacy-evaluable patients responded to treatment (ORR 69%), with 7 patients achieving a complete response (CRR 54%). Of the 7 patients with DLBCL who received the higher dose, 6 responded to treatment (ORR 86%) with 5 achieving a complete response (CRR 71%). Of the 15 minimal residual disease (MRD)-evaluable patients with a complete response, 12 patients (80%) achieved MRD negativity and remained in complete response at data cut-off. The median study follow-up was 3.3 months for FL and DLBCL with a range of 0.9-21.2 months, and 4.4 months for MCL with a range of 1-24.4 months. GLPG5101 showed an encouraging safety profile, with the majority of Grade ≥ 3 treatment emergent adverse events being hematological. One case of CRS Grade 3 was observed in Phase 1 and one case of ICANS Grade 3 was observed in Phase 2. 96% of patients (47 of 49) received an infusion with fresh, fit, stem-like early memory CD19 CAR T-cell therapy, with 91.5% (43 of 47) achieving a vein-to-vein time of seven days, thereby avoiding cryopreservation, and eliminating the need for bridging therapy. Strong and consistent in vivo CAR-T expansion levels and products consisting of stem-like, early memory phenotype T cells were observed in all doses tested. About the ATALANTA-1 study (EudraCT 2021-003272-13) ATALANTA-1 is an ongoing Phase 1/2, open-label, multicenter study to evaluate the safety, efficacy and feasibility of decentralized manufactured GLPG5101, a CD19 CAR-T product candidate, in patients with relapsed/refractory non-Hodgkin lymphoma (R/R NHL). GLPG5101 is a second generation anti-CD19/4-1BB CAR-T product candidate, administered as a single fixed intravenous dose. The primary objective of the Phase 1 part of the study is to evaluate the safety and preliminary efficacy to determine the recommended dose for the Phase 2 part of the study. Secondary objectives include assessment of efficacy and feasibility of decentralized manufacturing of GLPG5101. The dose levels that were evaluated in Phase 1 are 50×10 6 (DL1), 110×10 6 (DL2) and 250×10 6 (DL3) CAR+ viable T cells. The primary objective of the Phase 2 part of the study is to evaluate the objective response rate (ORR), while the secondary objectives include complete response rate (CRR), duration of response, progression free survival, overall survival, safety, pharmacokinetic profile, and the feasibility of decentralized manufacturing. Each enrolled patient will be followed for 24 months. About Galapagos' cell therapy manufacturing platform Galapagos' innovative decentralized cell therapy manufacturing platform has the potential for the administration of fresh, fit, stem-like, early memory T-cells within a median vein-to-vein time of seven days, greater physician visibility, and improved patient experience. The platform consists of an end-to-end xCellit® workflow management and monitoring software system, a decentralized, functionally closed, automated manufacturing platform for cell therapies (using Lonza's Cocoon®) and a proprietary quality control testing and release strategy. About Galapagos We are a biotechnology company with operations in Europe and the U.S. dedicated to transforming patient outcomes through life-changing science and innovation for more years of life and quality of life. Focusing on high unmet medical needs, we synergize compelling science, technology, and collaborative approaches to create a deep pipeline of best-in-class small molecules and cell therapies in oncology and immunology. With capabilities from lab to patient, including a decentralized cell therapy manufacturing platform, and the financial strength to invest strategically for the near- and long-term, we are committed to challenging the status quo and delivering results for our patients, employees, and shareholders. Our goal is not just to meet current medical needs but to anticipate and shape the future of healthcare, ensuring that our innovations reach those who need them most. For additional information, please visit www.glpg.com or follow us on LinkedIn or X . For further information, please contact: Media inquiries: Marieke Vermeersch +32 479 490 603 Jennifer Wilson + 44 7539 359 676 media@glpg.com Investor inquiries: Srikant Ramaswami +1 412 699 0359 Sandra Cauwenberghs +32 495 58 46 63 ir@glpg.com Forward-looking statements This press release includes forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, as amended. These statements are often, but are not always, made through the use of words or phrases such as "anticipate," "expect," "plan," "estimate," "will," "continue," "aim," "intend," "future," "potential," "could," "indicate," "forward," "may," as well as similar expressions. Forward-looking statements contained in this press release include, but are not limited to, statements regarding preliminary, interim and topline data from the ATALANTA-1 study and other analyses related to Galapagos' CD19 CAR-T programs, statements related to Galapagos' plans, expectations and strategy with respect to the ATALANTA-1 study, and statements regarding the expected timing, design and readouts of the ATALANTA-1 study, including the expected recruitment for such studies, and the potential benefits of Galapagos' product candidates, including GLPG5101, and partnered programs, including uza-cel. Forward-looking statements involve known and unknown risks, uncertainties and other factors which might cause Galapagos' actual results to be materially different from those expressed or implied by such forward-looking statements. These risks, uncertainties and other factors include, without limitation, the risk that preliminary or interim clinical results may not be replicated in ongoing or subsequent clinical studies, the risk that ongoing and future clinical studies with Galapagos' product candidates, including GLPG5101, may not be completed in the currently envisaged timelines or at all, the inherent uncertainties associated with competitive developments, clinical study and product development activities and regulatory approval requirements (including that data from the ongoing and planned clinical research programs may not support registration or further development of GLPG5101 due to safety, efficacy or other reasons), Galapagos' reliance on collaborations with third parties (including its collaboration partners Lonza and Adaptimmune), and that Galapagos' estimations regarding its GLPG5101 development programs and regarding the commercial potential of GLPG5101 may be incorrect, as well as those risks and uncertainties identified in Galapagos' Annual Report on Form 20-F for the year ended December 31, 2023 filed with the U.S. Securities and Exchange Commission (SEC) and its subsequent filings with the SEC. All statements other than statements of historical fact are statements that could be deemed forward-looking statements. The forward-looking statements contained herein are based on management's current expectations and beliefs and speak only as of the date hereof, and Galapagos makes no commitment to update or publicly release any revisions to forward-looking statements in order to reflect new information or subsequent events, circumstances or changes in expectations. Attachment Galapagos Press Release_ASH ATALANTA-1_ENG_Final © 2024 Benzinga.com. Benzinga does not provide investment advice. All rights reserved.NEW YORK, Dec. 17, 2024 (GLOBE NEWSWIRE) -- Magnite (Nasdaq: MGNI), the largest independent sell-side advertising company, today announced that members of its executive team will host in-person investor meetings at the Needham 27th Annual Growth Conference in New York City on Wednesday, January 15. Company management will participate in a fireside chat at 11:00 a.m ET. A live webcast of the fireside chat will be available in the “Events & Presentations” section of Magnite’s investor relations website at: https://investor.magnite.com . The webcast replay will be available following the conclusion of the live presentation for 90 days. About Magnite We’re Magnite (NASDAQ: MGNI), the world’s largest independent sell-side advertising company. Publishers use our technology to monetize their content across all screens and formats including CTV, online video, display, and audio. The world’s leading agencies and brands trust our platform to access brand-safe, high-quality ad inventory and execute billions of advertising transactions each month. Anchored in bustling New York City, sunny Los Angeles, mile high Denver, historic London, colorful Singapore and down under in Sydney, Magnite has offices across North America, EMEA, LATAM, and APAC. Investor Relations Contact Nick Kormeluk, 949-500-0003 nkormeluk@magnite.com
San Jose Sharks (8-13-5, in the Pacific Division) vs. Seattle Kraken (11-12-1, in the Pacific Division) Seattle; Saturday, 10 p.m. EST BETMGM SPORTSBOOK LINE: Kraken -211, Sharks +174; over/under is 6 BOTTOM LINE: The San Jose Sharks visit the Seattle Kraken after Jake Walman's two-goal game against the Seattle Kraken in the Sharks' 8-5 win. Seattle has gone 11-12-1 overall with a 3-3-0 record against the Pacific Division. The Kraken have a 10-2-1 record in games they score three or more goals. San Jose has gone 8-13-5 overall with a 3-5-0 record in Pacific Division play. The Sharks are 10th in the league serving 8.5 penalty minutes per game. Saturday's game is the second meeting between these teams this season. The Sharks won 8-5 in the last matchup. Walman led the Sharks with two goals. TOP PERFORMERS: Jared McCann has nine goals and 13 assists for the Kraken. Brandon Tanev has four goals and four assists over the past 10 games. Fabian Zetterlund has nine goals and 10 assists for the Sharks. Macklin Celebrini has five goals and four assists over the past 10 games. LAST 10 GAMES: Kraken: 6-4-0, averaging 2.9 goals, 4.3 assists, two penalties and 4.3 penalty minutes while giving up 2.6 goals per game. Sharks: 3-4-3, averaging 3.7 goals, 6.4 assists, 3.1 penalties and 7.3 penalty minutes while giving up 3.2 goals per game. INJURIES: Kraken: None listed. Sharks: None listed. ___ The Associated Press created this story using technology provided by Data Skrive and data from Sportradar . The Associated Press
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