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Next year could be the year for reforming the federal tax system, and while we’re optimistic, we also recognize the high stakes for our country’s future. President-elect Donald Trump has pledged to extend his signature Tax Cuts and Jobs Act, a 2017 law that revised the tax code and provided some sweet breaks to favored constituents. Many of those provisions are set to expire at the end of 2025 and, given the GOP’s control of Congress and the White House, the pressure will be on to act fast. Failure to extend the measures would mean increases for most taxpayers in 2026, and they would have no one to blame but Trump & Co. During his campaign, the president-elect teased additional giveaways, vowing to eliminate taxes on tips, which doesn’t make much sense, as well as Social Security income. Apparently, all kinds of ideas are on the table, which makes the complex job of rewriting tax law even more challenging. Throughout the 2000s, the U.S. has lived far beyond its means, as both major parties embraced deficit spending. Extending the Trump tax cuts will jack up the deficit by something like $5 trillion through fiscal 2035. Sweetening the pot with additional goodies would add still more to the tab. We send our best wishes to the much-ballyhooed Department of Government Efficiency, to be run by tech bosses Elon Musk and Vivek Ramaswamy. We’re all for eliminating waste, fraud and abuse. But given governmental instincts for self-preservation, experience teaches us to keep expectations modest. That leaves the national debt at $36 trillion and counting, threatening to increase inflation, raise interest rates, weaken the dollar and reduce the government’s capacity to make strategic investments. It’s disappointing to see the GOP , which always claimed to be the party of fiscal discipline when Democrats were in power, freeze out its deficit hawks when it controls the nation’s wallet. Trump has nominated some smart people for his economic team, including Scott Bessent for Treasury secretary, and we’re hopeful that grown-up thinking will prevail. Other Trump nominees could work against that, however. Consider Billy Long, a former GOP congressman from Missouri, whom Trump has proposed to head the Internal Revenue Service. The colorful Long is a professional auctioneer who went into business peddling a fraud-plagued tax credit after leaving public office. During his tenure, he joined other opportunists in scoring cheap political points by demonizing the IRS and pushing attention-getting tax ideas, evidently for effect . Exhibit A is Long’s effort to scrap the federal tax code, and the IRS along with it, while replacing the lost revenue with a regressive national sales tax. That would raise the cost of goods and services by anywhere from 30 to 44 cents for every dollar spent. It doesn’t take a political genius to recognize that raising the cost of a $1 item to as much as $1.44 would never work. Yet Long pushed for it, and now this unserious nominee is in line to run one of the most serious government agencies. Rather than promising to tear down the IRS for the sake of sound bites, the GOP needs to get real about change. This agency that everyone loves to hate will be crucial to carrying out its tax plan in 2025 and beyond. And, as Bessent and some of the better Trump nominees surely recognize, the GOP has a precious opportunity to bring about reform, if its more credible leaders are willing to put in the work instead of voicing fantasies about eliminating essential government services. The complexity of the federal tax code imposes an estimated $546 billion in annual costs on the U.S. economy, including billions of hours in lost productivity and out-of-pocket compliance costs, according to the center-right Tax Foundation. ... If the incoming Trump administration wants its tax-change plans to be carried out effectively, it should retire its anti-IRS rhetoric and give the agency the tools it needs to get the job done. After all, it’s a matter of following the law. Be the first to know Get local news delivered to your inbox!lol 464 。

The alleged perpetrator of the deadly car-ramming attack on a Christmas market in Germany had been contacted by police just weeks before the incident. or signup to continue reading The attack in the central city of Magdeburg on Friday evening, which killed five people including a nine-year-old boy, is believed to have been carried out by a Saudi national identified only as Taleb A according to German privacy laws. The number of people injured in the rampage has climbed to 235. The suspect has been living in Germany since 2006 and was granted political refugee status in 2016. He was most recently working as a doctor in the town of Bernburg, south of Magdeburg. Taleb A was detained at the scene and is being held in police custody, with investigators searching for a motive amid suggestions that authorities failed to heed warnings about the man. Tamara Zieschang, the interior minister of the eastern state of Saxony-Anhalt, told MPs in Magdeburg on Monday that police met the man twice - in September 2023 and October 2024 - to warn him about his behaviour. Meanwhile, the Interior Ministry of the northern state of Mecklenburg-Vorpommern said that Taleb A became known to authorities as a potential suspect in 2015. Regional authorities had informed the Federal Criminal Police Office at the Joint Counter-Terrorism Centre, which is supported by Germany's federal and regional government, about the man's possible intention to carry out an attack on February 6, 2015, it said. The report concerned threats to carry out actions that would attract international attention against a medical association in Mecklenburg-Vorpommern in April 2013 and one year later against a local authority in the northern German city of Stralsund. The Mecklenburg-Vorpommern interior minister, Christian Pegel, said the 50-year-old suspect had lived in the state from 2011-16 and had completed parts of his specialist medical training in Stralsund. He said the man had been involved in a dispute with the medical association about the recognition of examination results and had later threatened the social services in Stralsund in an attempt to obtain assistance with living costs. A district court fined Taleb A for threatening the medical association, Pegel said. However, he added, the previous investigations had not revealed any evidence of real preparations for an attack or Islamist connections. The man was warned by the police and told that he would be monitored more closely but was not classified as a threat, Pegel said. DAILY Today's top stories curated by our news team. WEEKDAYS Grab a quick bite of today's latest news from around the region and the nation. WEEKLY The latest news, results & expert analysis. WEEKDAYS Catch up on the news of the day and unwind with great reading for your evening. WEEKLY Get the editor's insights: what's happening & why it matters. WEEKLY Love footy? We've got all the action covered. WEEKLY Every Saturday and Tuesday, explore destinations deals, tips & travel writing to transport you around the globe. WEEKLY Going out or staying in? Find out what's on. WEEKDAYS Sharp. Close to the ground. Digging deep. Your weekday morning newsletter on national affairs, politics and more. TWICE WEEKLY Your essential national news digest: all the big issues on Wednesday and great reading every Saturday. WEEKLY Get news, reviews and expert insights every Thursday from CarExpert, ACM's exclusive motoring partner. TWICE WEEKLY Get real, Australia! Let the ACM network's editors and journalists bring you news and views from all over. AS IT HAPPENS Be the first to know when news breaks. DAILY Your digital replica of Today's Paper. Ready to read from 5am! DAILY Test your skills with interactive crosswords, sudoku & trivia. Fresh daily! Advertisement Advertisement

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PLEASANTON, Calif. , Dec. 23, 2024 /PRNewswire/ -- 10x Genomics, Inc. (Nasdaq: TXG), a leader in single cell and spatial biology, announced today it had secured a permanent injunction in the U.S. District Court for the District of Delaware against the GeoMx products sold by Bruker Corporation (Nasdaq: BRKR), which acquired the product line from NanoString Technologies. To minimize the risk of disruption to ongoing research, 10x Genomics requested a carve-out for GeoMx users who installed an instrument prior to the trial in November 2023 . The injunction, which the Court said it will enter in January 2025 , is expected to prohibit Bruker from making, using, selling or offering to sell in the United States its GeoMx Digital Spatial Profiler and associated instruments, reagents and services for RNA and protein detection. At the request of 10x Genomics, the injunction will not block ongoing research by researchers who installed a GeoMx instrument prior to November 18, 2023 . Such customers can continue to purchase GeoMx reagents for use with existing GeoMx instruments for purposes of continuing their ongoing research. The Court found that making such an exception for ongoing research strikes a "workable balance between protecting the patentee's rights and protecting the public from the injunction's adverse effects." In addition, the Court affirmed the $31 million damages awarded by the November 2023 jury verdict, as well as supplemental damages and interest that will be added to the total damages when final judgment is entered. "Today's decision helps to safeguard our decade-long investment in innovation and ensures we can continue to develop groundbreaking technologies that help our customers revolutionize science," said Eric Whitaker , Chief Legal Officer at 10x Genomics. "10x exists to fuel scientific progress – not stifle it – and that is why we've done our utmost to ensure this injunction was structured to protect both our intellectual property and existing GeoMx customers' ongoing research." The Court recognized the harm NanoString's infringing conduct caused 10x when it wrote in its ruling, "Having been careful not to license its technology, 10x suffers when it proclaims itself as an innovator in spatial genomics but a competitor is using the same innovative, patented technology." Today's Court decision follows a November 2023 jury verdict that found that NanoString's GeoMx products willfully infringed seven patents exclusively licensed to 10x Genomics by Prognosys. During the trial, the jury heard testimony from the sole inventor of the patents, Illumina co-founder Mark Chee , and NanoString CEO Brad Gray and NanoString CSO Joe Beechem. After hearing all of the evidence, the jury determined that all seven patents had been infringed by NanoString, that each patent was valid, that NanoString willfully infringed those patents and that monetary damages were owed to 10x for the infringement of all seven patents. In affirming the jury's finding that NanoString willfully infringed, the Court relied on the evidence showing that NanoString knew or was willfully blind that its acts would cause infringement of 10x's rights. The asserted patents in Case No. 21-cv-653-MFK include (a) U.S. Patent No. 10,472,669; (b) U.S. Patent No. 10,961,566; (c) U.S. Patent No. 10,983,113; (d) U.S. Patent No. 10,996,219; (e) U.S. Patent No. 11,001,878; (f) U.S. Patent No. 11,008,607 and (g) U.S. Patent No. 11,293,917. About 10x Genomics 10x Genomics is a life science technology company building products to accelerate the mastery of biology and advance human health. Our integrated solutions include instruments, consumables and software for single cell and spatial biology, which help academic and translational researchers and biopharmaceutical companies understand biological systems at a resolution and scale that matches the complexity of biology. Our products are behind breakthroughs in oncology, immunology, neuroscience and more, fueling powerful discoveries that are transforming the world's understanding of health and disease. To learn more, visit 10xgenomics.com or connect with us on LinkedIn or X (Twitter) . Forward Looking Statements This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 as contained in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, which are subject to the "safe harbor" created by those sections. All statements included in this press release, other than statements of historical facts, may be forward-looking statements. Forward-looking statements generally can be identified by the use of forward-looking terminology such as "may," "might," "will," "should," "expect," "plan," "anticipate," "could," "intend," "target," "project," "contemplate," "believe," "see," "estimate," "predict," "potential," "would," "likely," "seek" or "continue" or the negatives of these terms or variations of them or similar terminology, but the absence of these words does not mean that a statement is not forward-looking. These forward-looking statements include statements regarding litigation and remedies as well as possible outcomes of litigation. These forward-looking statements do not reflect that our success will depend on our ability to obtain, maintain and protect our intellectual property rights, intellectual property litigation could be expensive, time-consuming, unsuccessful and could interfere with our ability to develop, manufacture and commercialize our products or technologies, litigation outcomes are unpredictable or there may be changes in our litigation strategy. These statements are based on management's current expectations, forecasts, beliefs, assumptions and information currently available to management. Actual outcomes and results could differ materially from these statements due to a number of factors and such statements should not be relied upon as representing 10x Genomics, Inc.'s views as of any date subsequent to the date of this press release. 10x Genomics, Inc. disclaims any obligation to update any forward-looking statements provided to reflect any change in 10x Genomics' expectations or any change in events, conditions or circumstances on which any such statement is based, except as required by law. The material risks and uncertainties that could affect 10x Genomics, Inc.'s financial and operating results and cause actual results to differ materially from those indicated by the forward-looking statements made in this press release include those discussed under the captions "Risk Factors" and "Management's Discussion and Analysis of Financial Condition and Results of Operations" in the company's most recently-filed 10-K for the fiscal year ended December 31, 2023 and elsewhere in the documents 10x Genomics, Inc. files with the Securities and Exchange Commission from time to time. Disclosure Information 10x Genomics uses filings with the Securities and Exchange Commission, our website ( www.10xgenomics.com ), press releases, public conference calls, public webcasts and our social media accounts as means of disclosing material non-public information and for complying with our disclosure obligations under Regulation FD. Contacts Investors: investors@10xgenomics.com Media: media@10xgenomics.com View original content to download multimedia: https://www.prnewswire.com/news-releases/us-district-court-awards-10x-genomics-permanent-injunction-in-patent-infringement-lawsuit-against-bruker-corporations-geomx-products-302338627.html SOURCE 10x Genomics, Inc.

6,000 inmates escaped from a high-security prison in Mozambique. What to know

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