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Julen Lopetegui lasted nine months at Wolverhampton Wanderers, 10 weeks at Real Madrid and, prior to Monday's trip to Newcastle, looked in real danger of adding a short reign at West Ham to his CV. But the Hammers produced their best performance of the season at the perfect time, deservedly winning 2-0 at St James' Park to move six points clear of the relegation zone. Prior to the match, former Crystal Palace striker Clinton Morrison said Lopetegui was "the most under pressure manager in the Premier League", and while that pressure has not been wiped away, it has significantly eased. "A huge result for the manager," ex-Liverpool defender Jamie Carragher said on Sky Sports. "I did not see how West Ham could win this game, they have to use this as a springboard now." Ex-Spain boss Lopetegui arrived at West Ham in the summer tasked with moving the Hammers away from the pragmatic football played under David Moyes, who left at the end of last season, and introducing a more attacking style. But in Moyes' final campaign they reached the Europa League quarter-finals and finished ninth in the Premier League. The minimum target for Lopetegui, therefore, will be to improve on that. He was allowed to spend in the region of £125m on improving the quality of his squad but, prior to Monday, there was little sign of that layout paying dividends. The attacking football West Ham fans hoped Lopetegui would introduce was rarely there to be seen as they struggled to score goals - their tally of 13 in their first 11 games was among the lowest in the Premier League with only Everton, Crystal Palace and bottom club Southampton scoring fewer. But against Newcastle they showed glimpses of what they are capable of going forwards, attacking with pace and in numbers while they were clinical with their chances. The West Ham team played with a confidence not always seen this season and as they passed the ball around in the final few minutes there were shouts of "ole" from the away end, something few of their fans would have expected to happen on their journey to the north east. "Rewarding the 3,000 West Ham fans who made the 600-mile round trip to Newcastle, knowing they would not get home until the early hours, is priceless for Julen Lopetegui," BBC Sport's chief football news reporter Simon Stone said. "Any club’s away supporters are the true barometer of backing for a manager and after the three-goal hammering at Nottingham Forest three weeks ago, they were really not happy. "West Ham delivered their best performance of the season at St James’ Park. This was a deserved win, unlike their last success, against Manchester United, which even club officials accepted was only possible because the visitors failed to take a ridiculous number of excellent first-half chances. "The Hammers were solid enough at the back. Carlos Soler was excellent in midfield on only his second Premier League start. Lucas Paqueta was something like his old self, Jarrod Bowen was a threat and Michail Antonio a battering ram in attack." West Ham fans will have hoped the arrival of Lopetegui would have emulated the impact Unai Emery had at Aston Villa. His start has perhaps been more like that of Andoni Iraola at Bournemouth. He too endured a slow beginning as he tried to implement his style of football but eventually it took hold. Lopetegui and the West Ham fans will know its too soon to suggest this has been a corner turned. Despite this win, they are still averaging fewer points and goals per game than Moyes managed in his final campaign, which saw some fans turn against him. West Ham averaged 1.58 goals per game last term but that has dropped to 1.25 this season. But defensively there has been improvement, with 1.73 goals conceded per game this term compared to 1.95 in 2023-24. "We have to build as a team if we are to work and know what we want to do," Lopetegui told Sky Sports after Monday's win. "I think about the play. That is the thing that we try to do. We have a lot of matches that we need to do and I believe in the future this team is going to be able to do the things and show the style as a team." A loss for West Ham at Newcastle would have left their fans looking nervously over their shoulder but now they are looking up. The Hammers are just three points off the top 10 and, although they face a tough test at the weekend with the visit of Arsenal, they then head into a favourable run of fixtures in December. They face managerless Leicester on 3 December, before games that they will see as winnable against Wolves and Southampton. "We have to take responsibility and do our work and we haven't done that to a high enough ability this year," West Ham forward Jarrod Bowen told Sky Sports. "[Beating Newcastle] was a real big moment and this is a really big turning point in our season."Extensive confidential documents in the lead-up to the collapse of Northern Ireland’s institutions in 2002 have been made available to the public as part of annual releases from the Irish National Archives. They reveal that the Irish Government wanted to appeal to the UK side against “manipulating” every scenario for favourable election results in Northern Ireland, in an effort to protect the peace process. In the years after the landmark 1998 Good Friday Agreement, a number of outstanding issues left the political environment fraught with tension and disagreement. Mr Trimble, who won a Nobel Peace Prize with SDLP leader John Hume for their work on the Agreement, was keen to gain wins for the UUP on policing, ceasefire audits and paramilitary disarmament – but also to present his party as firmer on these matters amid swipes from its Unionist rival, the DUP. These issues were at the front of his mind as he tried to steer his party into Assembly elections planned for May 2003 and continue in his role as the Executive’s first minister despite increasing political pressure. The documents reveal the extent to which the British and Irish Governments were trying to delicately resolve the contentious negotiations, conscious that moves seen as concessions to one group could provoke anger on the other side. In June 2002, representatives of the SDLP reported to Irish officials on a recent meeting between Mr Hume’s successor Mark Durkan and Prime Minister Tony Blair on policing and security. Mr Blair is said to have suggested that the SDLP and UUP were among those who both supported and took responsibility for the Good Friday Agreement. The confidential report of the meeting says that Mr Durkan, the deputy First Minister, was not sure that Mr Trimble had been correctly categorised. The Prime Minister asked if the SDLP could work more closely with the UUP ahead of the elections. Mr Durkan argued that Mr Trimble was not only not saleable to nationalists, but also not saleable to half of the UUP – to which Mr Blair and Northern Ireland Secretary John Reid are said to have laughed in agreement. The SDLP leader further warned that pursuing a “save David” campaign would ruin all they had worked for. Damien McAteer, an adviser for the SDLP, was recorded as briefing Irish officials on September 10 that it was his view that Mr Trimble was intent on collapsing the institutions in 2003 over expected fallout for Sinn Fein in the wake of the Colombia Three trial, where men linked to the party were charged with training Farc rebels – but predicted the UUP leader would be “in the toilet” by January, when an Ulster Unionist Council (UUC) meeting was due to take place. A week later in mid September, Mr Trimble assured Irish premier Bertie Ahern that the next UUC meeting to take place in two days’ time would be “okay but not great” and insisted he was not planning to play any “big game”. It was at that meeting that he made the bombshell announcement that the UUP would pull out of the Executive if the IRA had not disbanded by January 18. The move came as a surprise to the Irish officials who, along with their UK counterparts, did not see the deadline as realistic. Sinn Fein described the resolution as a “wreckers’ charter”. Doubts were raised that there would be any progress on substantive issues as parties would not be engaged in “pre-election skirmishing”. As that could lead to a UUP walkout and the resulting suspension of the institutions, the prospect of delaying the elections was raised while bringing forward the vote was ruled out. Therefore, the two Governments stressed the need to cooperate as a stabilising force to protect the Agreement – despite not being sure how that process would survive through the January 18 deadline. The Irish officials became worried that the British side did not share their view that Mr Trimble was not “salvageable” and that the fundamental dynamic in the UUP was now Agreement scepticism, the confidential documents state. In a meeting days after the UUC announcements, Mr Reid is recorded in the documents as saying that as infuriating as it was, Mr Trimble was at that moment the “most enlightened Unionist we have”. The Secretary said he would explore what the UUP leader needed to “survive” the period between January 18 and the election, believing a significant prize could avoid him being “massacred”. Such planning went out the window just weeks later, when hundreds of PSNI officers were involved in raids of several buildings – including Sinn Fein’s offices in Stormont. The resulting “Stormontgate” spy-ring scandal accelerated the collapse of powersharing, with the UUP pulling out of the institutions – and the Secretary of State suspending the Assembly and Executive on October 14. For his part, Irish officials were briefed that Mr Reid was said to be “gung ho” about the prospect of exercising direct rule – reportedly making no mention of the Irish Government in a meeting with Mr Trimble and Mr Durkan on that day. The Northern Ireland Secretary was given a new role and Paul Murphy was appointed as his successor. A note on speaking points for a meeting with Mr Murphy in April showed that the Irish side believed the May elections should go ahead: “At a certain stage the political process has to stand on its own feet. “The Governments cannot be manipulating and finessing every scenario to engineer the right result. “We have to start treating the parties and the people as mature and trusting that they have the discernment to make the right choices.” However, the elections planned for May did not materialise, instead delayed until November. Mr Trimble would go on to lose his Westminster seat – and stewardship of the UUP – in 2005. The November election saw the DUP emerge as the largest parties – but direct rule continued as Ian Paisley’s refused to share power with Sinn Fein, which Martin McGuinness’ colleagues. The parties eventually agreed to work together following further elections in 2007. – This article is based on documents in 2024/130/5, 2024/130/6, 2024/130/15sports magazine 。

West Ham boss Julen Lopetegui believes his side “deserved to win” as they sealed a 2-0 victory over Newcastle at St James’ Park. Lopetegui came into the game under pressure following some poor displays from the Hammers in recent weeks but they earned a hard-fought victory to end the Magpies’ three-game winning spell. Despite a promising opening from the hosts, Tomas Soucek headed West Ham in front before Aaron Wan-Bissaka’s first goal for the club after the break wrapped up victory. Lopetegui was pleased with his side’s display following a “tough match”. He said: “I am happy for the three points and am very happy against a good team like Newcastle, who have good players and a fantastic coach. “I think today was a tough match and we were able to compete as a team. “I think we deserved to win. Today they had many moments in the first half, but I think the second half we deserved to win and we are happy because you have to do these kind of matches against this type of team if you want to overcome them.” Newcastle started brightly and had plenty of chances in the first half especially, but the visitors responded after the break by retaining possession well. The win eases the pressure on Lopetegui, whose West Ham side face Arsenal on Saturday, and he believes the victory is an important feeling for his players. He said: “I think the only thing that is under our control is to play football, to improve, to defend well, to convince the players we are able to do better. “Today we did, but I think the only thing we can do is to do the things that are under our control, not today but every day. “So we had to keep with this mentality, but above all let me say we are happy for the players because they need this kind of feeling as a team to believe that we are able to do well as a team, to put the best for each player of the team.” Newcastle boss Eddie Howe admitted defeat was a missed opportunity for his side. The Magpies missed a series of chances in the first half, including efforts from Joe Willock and Sean Longstaff, before Alexander Isak blasted a chance off target. Anthony Gordon also rolled an effort just wide of the post after the break and Isak headed wide of goal. Three points could have seen Newcastle move into the top six and Howe admitted his side need to learn from the match. “Yes, massive because the league is so tight that a couple of wins and the whole picture looks very different,” Howe said. “We’ll kick ourselves tonight because we knew the opportunity we had, a home game, Monday night, a great moment for us potentially in our season, so we have to learn from that and come back stronger.”TV’s Dr. Oz invested in businesses regulated by agency Trump wants him to lead

Concerns raised over hospitality staff after smoking curbs ditchedFinland beats US 4-3 in OT in world junior hockey; Canada rebounds from loss to top Germany 3-0It’s been a horror year for many Australian brands forced to close their doors amid rising costs, with 40 per cent more businesses filing for insolvency since before the Covid-19 pandemic. CreditorWatch chief economist Ivan Colhoun said businesses were facing ongoing financial pressures much like their customers who were finding ways to cut their budget amid cost-of-living pressures. “Together with some greater caution in discretionary spending and softness in interest rate sensitive sectors of the economy, this unsurprisingly has led to higher voluntary business closures and some rise in insolvencies,” Mr Colhoun said. “We’re yet to see the extent to which the 1 July tax cuts now flowing through the economy will ease some of the pressures on consumers and businesses.” The latest CreditorWatch business risk index found that Aussie businesses were failing at their highest rate (5.04 per cent) since the height of the Covid-19 pandemic in October 2020 (5.08 per cent). The average failure rate for Australian businesses has climbed from 3.97 per cent in October last year. The food and beverage sector recorded the highest failure rate of all industries in October, increasing to 8.5 per cent from 8.3 per cent in the 12 months up to September this year. Administrative and support services were next with a 6.0 per cent failure rate in October, followed by arts and recreation services (5.9 per cent) and transport, postal and warehousing (5.8 per cent). Meanwhile, both the retail and construction industries look to be levelling out after each recorded a 5.5 per cent increase in insolvencies or business deregistrations during the same time period. Big brands under pressure During the 2023-2024 financial year, 2832 construction companies went into insolvency in Australia, according to ASIC data. Some of those failed companies will have lasting impacts on vital infrastructure and business projects across the country. Quasar Construction is just one of the construction companies that fell into administration this year. It continues to owe an estimated $60m to 600 creditors after its collapse earlier this year. The company’s collapse potentially impacts 10 projects across NSW, including a Bunnings, a $50m shopping centre and parts of the new Western Sydney Airport. Financial woes have also impacted the retail sector this year, with international brands like Dion Lee collapsing despite the company’s best efforts. Not even dressing US megastar Taylor Swift at the 2024 Super Bowl helped the popular fashion brand survive the horror year in fashion retail. Queensland University of Technology marketing professor Gary Mortimer told NewsWire that high-end fashion brands like Dion Lee had a “very small footprint and market size” that was hard to compete against brands such as Burberry or Chanel. “When you think about the likes of Chanel, even if their fashion business isn’t doing so well, they can certainly draw business from other revenue like make-up and cosmetics,” Mr Mortimer said. “Big brands like Louis Vuitton, Moet, and Hennessy have very differential business models, so if one element of the model or one element of the business isn’t working so well, they pull money from other businesses. “Dion Lee wasn’t able to do that.” Mr Mortimer said brands were having to come up with ways to beat their competition, but that didn’t always work out for the best. He said brands like Mosaic Brands, which went into voluntary administration in October owing $250m to creditors, tended to fall prey to “self cannibalisation”. Mosaic Brands confirmed it was in trouble earlier this year when it announced it would shut down its entities Autograph, BeMe, Crossroads, Rockmans and W.Lane in a bid to improve investment in its other brands Katies, Millers, Noni B and Rivers. Mosaic Brands had more than 700 stores and 10 online shops. Mr Mortimer said this type of retailing structure could be problematic in the long run. “Mosaic has five or six brands that are all targeting the same customer of the middle-aged woman,” he said. “It was all essentially the same type of product. “In a centre where you’d have two or three of the same brands, you’re all competing against yourself for the same customer.” Cost-of-living pressures The University of Sydney retail expert Lisa Asher said the cost-of-living crisis continuing to impact consumers’ discretionary spending was a major issue going against smaller Australian brands. “Those below 65, they’re going into savings, but those over 65 have the money (to spend),” Ms Asher told NewsWire. “Because of that, what it’s done is people have to priorities spend, and it’s shelter and food and basic necessities.” Mr Mortimer said consumers who were tightening their budgets could have a lasting impact on businesses. “Where we see discretionary spending categories like fashion, footwear or accessories sales have flatlined or in some cases have declined, it’s because households are more concerned about the cost of food, the cost of rent, servicing their mortgage, electricity bills going up and utilities bills going up,” he said. “In that certain economic climate, certain categories tends to trade less and decline in sales.” Ms Asher said consumers were more willing to turn to fast fashion, like Temu or Shein, when they want to buy something new instead of spending money on quality items. “What has happened because of this, within apparel, there’s been lot of changes within apparel and clothing,” she said. “Fast fashion and it’s actually killing off traditional apparel brands we’ve seen historically.” Trying to find a way forward Unfortunately, more businesses are likely to shut up shop in 2025. CreditorWatch forecasts food and beverage businesses are likely to fail at 9.1 per cent in the next 12 months. Mr Mortimer said retailers normally liked to rely on Christmas spending to help boost their profits as they head into the new year. “We still spend about $36bn in the month across the retail sector but that’s not more than what we spent last year,” he said. “As we move into the busy Christmas period, it’s projected that we will spend $69.7bn in the six weeks leading up to Christmas but that’s essentially what we spent last year. “Retailers aren’t expecting a significant kick in these sales as we move into the busy Christmas period.” But all eyes will be on the Reserve Bank of Australia in the new year as people look to see if interest rate relief is on the way. “A slowdown in the inflation rate will certainly help businesses, but we must remember this just means that price rises have slowed down, so the cost pressures remain,” CreditorWatch chief executive officer Patrick Coghlan, said. “In most cases, you won’t see the cost of goods and services coming down. “Businesses desperately need interest rates to come down so households have some relief in cost-of-living pressures and start spending more.” Originally published as Thousands of Australian businesses collapse during 2024 amid rising costs

MELBOURNE, Australia and INDIANAPOLIS , Dec. 30, 2024 /PRNewswire/ — Telix Pharmaceuticals Limited (ASX: TLX; Nasdaq: TLX, Telix, the Company) today announces that it has submitted its Biologics License Application (BLA) to the United States (U.S.) Food and Drug Administration (FDA) for TLX250-CDx (Zircaix®[1], 89 Zr- girentuximab) kidney cancer imaging[2]. TLX250-CDx is an investigational PET[3] drug product for the non-invasive diagnosis and characterisation of clear cell renal cell carcinoma (ccRCC), the most common and aggressive form of kidney cancer. If approved, TLX250-CDx will be the first and only targeted PET agent specifically for kidney cancer to be commercially available in the U.S., further building on Telix’s successful urology imaging franchise. The FDA is expected to advise the PDUFA[4] goal date following the 60-day administrative review of the application. Kevin Richardson , Chief Executive Officer, Precision Medicine at Telix, stated, “We are pleased to be progressing the BLA for TLX250-CDx, which has been granted Breakthrough designation, and may therefore be eligible for priority review. Telix continues to target a full U.S. commercial launch in 2025 addressing a major unmet medical need for patients with suspected ccRCC.” About TLX250-CDx TLX250-CDx (Zircaix® 1 ) is an investigational PET agent that is under development for the diagnosis and characterisation of ccRCC. Telix’s pivotal Phase III ZIRCON trial (ClinicalTrials.gov ID: NCT03849118 ) evaluating TLX250-CDx in 300 patients, of whom 284 were evaluable, met all primary and secondary endpoints, including showing 86% sensitivity and 87% specificity and a 93% positive-predictive value for ccRCC across three independent radiology readers[5]. Telix believes this demonstrated the ability of TLX250-CDx to reliably detect the clear cell phenotype and provide an accurate, non-invasive method for diagnosing and characterising ccRCC. Confidence intervals exceeded expectations amongst all three readers, showing evidence of high accuracy and consistency of interpretation. About Telix Pharmaceuticals Limited Telix is a biopharmaceutical company focused on the development and commercialisation of diagnostic and therapeutic radiopharmaceuticals and associated medical technologies. Telix is headquartered in Melbourne, Australia , with international operations in the United States , Europe ( Belgium and Switzerland ), and Japan . Telix is developing a portfolio of clinical and commercial stage products that aims to address significant unmet medical needs in oncology and rare diseases. Telix is listed on the Australian Securities Exchange (ASX: TLX) and the Nasdaq Global Select Market (Nasdaq: TLX). Telix’s lead imaging product, gallium-68 ( 68 Ga) gozetotide injection (also known as 68 Ga PSMA-11 and marketed under the brand name Illuccix®), has been approved by the U.S. Food and Drug Administration (FDA)[6], by the Australian Therapeutic Goods Administration (TGA) [7], and by Health Canada [8] . No other Telix product has received a marketing authorisation in any jurisdiction. Visit www.telixpharma.com for further information about Telix, including details of the latest share price, announcements made to the ASX, investor and analyst presentations, news releases, event details and other publications that may be of interest. You can also follow Telix on X and LinkedIn . Telix Investor Relations Ms. Kyahn Williamson Telix Pharmaceuticals Limited SVP Investor Relations and Corporate Communications Email: kyahn.williamson@telixpharma.com This announcement has been authorised for release by the Telix Pharmaceuticals Limited Disclosure Committee on behalf of the Board. Legal Notices You should read this announcement together with our risk factors, as disclosed in our most recently filed reports with the Australian Securities Exchange (ASX), U.S. Securities and Exchange Commission (SEC), including our registration statement on Form 20-F filed with the SEC, or on our website. The information contained in this announcement is not intended to be an offer for subscription, invitation or recommendation with respect to securities of Telix Pharmaceuticals Limited (Telix) in any jurisdiction, including the United States . The information and opinions contained in this announcement are subject to change without notification. To the maximum extent permitted by law, Telix disclaims any obligation or undertaking to update or revise any information or opinions contained in this announcement, including any forward-looking statements (as referred to below), whether as a result of new information, future developments, a change in expectations or assumptions, or otherwise. No representation or warranty, express or implied, is made in relation to the accuracy or completeness of the information contained or opinions expressed in the course of this announcement. This announcement may contain forward-looking statements, including within the meaning of the U.S. Private Securities Litigation Reform Act of 1995, that relate to anticipated future events, financial performance, plans, strategies or business developments. Forward-looking statements can generally be identified by the use of words such as “may”, “expect”, “intend”, “plan”, “estimate”, “anticipate”, “believe”, “outlook”, “forecast” and “guidance”, or the negative of these words or other similar terms or expressions. Forward-looking statements involve known and unknown risks, uncertainties and other factors that may cause our actual results, levels of activity, performance or achievements to differ materially from any future results, levels of activity, performance or achievements expressed or implied by these forward-looking statements. Forward-looking statements are based on Telix’s good-faith assumptions as to the financial, market, regulatory and other risks and considerations that exist and affect Telix’s business and operations in the future and there can be no assurance that any of the assumptions will prove to be correct. In the context of Telix’s business, forward-looking statements may include, but are not limited to, statements about: the initiation, timing, progress and results of Telix’s preclinical and clinical trials, and Telix’s research and development programs; Telix’s ability to advance product candidates into, enrol and successfully complete, clinical studies, including multi-national clinical trials; the timing or likelihood of regulatory filings and approvals for Telix’s product candidates, manufacturing activities and product marketing activities; Telix’s sales, marketing and distribution and manufacturing capabilities and strategies; the commercialisation of Telix’s product candidates, if or when they have been approved; Telix’s ability to obtain an adequate supply of raw materials at reasonable costs for its products and product candidates; estimates of Telix’s expenses, future revenues and capital requirements; Telix’s financial performance; developments relating to Telix’s competitors and industry; and the pricing and reimbursement of Telix’s product candidates, if and after they have been approved. Telix’s actual results, performance or achievements may be materially different from those which may be expressed or implied by such statements, and the differences may be adverse. Accordingly, you should not place undue reliance on these forward-looking statements. ©2024 Telix Pharmaceuticals Limited. The Telix Pharmaceuticals®, Illuccix® and Zircaix® 1 names and logos are trademarks of Telix Pharmaceuticals Limited and its affiliates – all rights reserved. View original content to download multimedia: https://www.prnewswire.com/apac/news-releases/telix-files-tlx250-cdx-zircaix-bla-for-kidney-cancer-imaging-302339972.html SOURCE Telix Pharmaceuticals Limited