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Judge rejects request to sideline SJSU volleyball player
Judge rejects request to sideline SJSU volleyball player
Lea en español For many people, this time of year is all about the shopping. And there's a fair chance many feel less than joyful about the prospect. If fulfilling your lengthy list feels overwhelming, learning what brain science and evolutionary psychology say about shopping and gift-giving might help you understand exactly why you're stressed – and even point you toward a healthier, happier holiday season. Our reactions are encoded into our nervous system, said Dr. Beth Frates, a part-time associate professor in the department of physical medicine and rehabilitation at Harvard Medical School in Boston. "By understanding these brain responses, people can develop strategies to manage stress better, such as setting realistic expectations, focusing on mindfulness and simplifying holiday preparations," said Frates, who also is the immediate past president of the American College of Lifestyle Medicine. The idea of exchanging gifts at this time of year can be traced back to pagan solstice celebrations. But the drive to share with another is as old as humanity itself, said Dr. Diego Guevara Beltran, a postdoctoral fellow in psychology at the University of Arizona in Tucson who studies cooperation and generosity. The science of generosity is more about survival than stocking stuffers, Guevara Beltran said. Sharing food gave early humans an evolutionary advantage. "Generosity is just one of the ways by which we can accumulate resources, be it wealth itself or friendships or work partners or more attractive, more intelligent mates," he said. Sharing with other people, Guevara Beltran said, is "a signal that communicates how much you value them, their welfare, your relationship with them." Research has shown that helping people makes us feel good. Part of that, he said, is because when someone is part of a community, they feel protected. One way this manifests is through the act of giving gifts. But to derive happiness from gift-giving, the giver needs to feel both that it was not an obligation and that it was effective, according to the 2019 World Happiness Report . That means it could be stressful to be in a culture where gift-giving feels mandatory, or if we can't see that a gift helped someone, Guevara Beltran speculated. It also might be stressful if gift-giving becomes a competition to show that you care about somebody more than the others around them. Our brains on shopping Stressful shopping can cause several physiological responses to kick in, Frates said. First is the "fight or flight" reaction that comes with stress. The release of chemicals that increase our heart rate, raise our blood pressure and intensify our breathing evolved to give us bursts of energy to escape danger. Frates said that while holiday stressors are not life-threatening, they can still trigger the stress response. The pressure to stay within budget could create a sense of scarcity, she said. "This taps into an evolutionary response, where the fear of losing resources like money can feel urgent and distressing." The holiday season also involves a lot of choices. "The brain has limited capacity for decision-making, and making multiple decisions can lead to decision fatigue," Frates said. "This fatigue reduces the ability to self-regulate and cope, which can lead to heightened stress responses when confronted with even minor setbacks, like a long line or out-of-stock item." The stress of needing to complete tasks within a limited time can intensify the fight-or-flight response, she said, as the brain interprets the ticking clock as a sense of urgency or threat. Meanwhile, Frates said, holiday shopping can also trigger brain chemicals that affect our feelings. "Dopamine, a neurotransmitter associated with pleasure and reward, is released when we anticipate something exciting or enjoyable, like finding a great gift or finding a good deal," she said. "This anticipation can feel rewarding even before any actual purchase is made." For some people, this dopamine boost can make shopping a relaxing experience. "It provides a temporary distraction from other stressors and allows them to focus on something positive, creating a 'holiday high,'" Frates said. For some people, that can be problematic. "When shopping becomes a way to chase that next dopamine hit, it can lead to excessive spending or impulsive purchases," she said. "This can become a trap, particularly during the holidays, when deals, sales and gift-giving pressures are everywhere." Understanding how all these processes work can help people recognize why they feel the way they do and adopt strategies to cope, Frates said. Here are some of her suggestions. 1. Start with self-care before shopping Prioritizing self-care means people can be their best selves and make good decisions, Frates said. So, "eat food that is delicious and nutritious. Get seven to nine hours of sleep. Make sure to enjoy physical activity. Take walks when you can and invite friends along. Practice stress reduction like meditation or yoga to help you calm your body and mind." Before going shopping, try taking deep breaths using stress-relieving techniques such as 4-7-8 breathing (inhale through your nose for four counts, hold for seven counts, and exhale through your mouth for eight) or box breathing (inhale through the nose for four counts, hold your breath for four, exhale for four, then hold for four). 2. Be strategic Don't shop when you're hungry, tired, lonely or stressed, Frates said. And don't start shopping 15 minutes before a store closes or a website's online deals end, she said. That's setting yourself up for triggering the fight-or-flight response. 3. Be mindful Before making a purchase, take a moment to consider whether it's truly needed or whether it's an impulsive choice. To avoid overindulging, set a specific budget or limit yourself to a couple of hours or specific shopping days. "This keeps dopamine-driven spending in check while still allowing for the enjoyable aspects of holiday shopping," Frates said. Look for post-shopping activities that provide rewards without the financial cost. That can satisfy your brain's desire for more dopamine in a healthier way. "Plan enjoyable, stress-relieving activities after shopping, like going for a walk, spending time with friends or indulging in a hobby," she said. 4. Bring a friend Not only does this support healthy social connections, Frates said, but if things start feeling stressful, "you have a buddy, and you have a support system right there for you." 5. Rethink the focus of the season "With gift-giving, we need to change mindsets in order to be able to manage the stress," Frates said. The holidays could be used to emphasize social connections, she said. "Thinking about the connection with the person and making gift-giving more about deepening the connection than anything else, I think, will really help to reduce the stress around the process," she said. So instead of scouring shops and websites for the "perfect" gift, think about making a meaningful and personal one, she suggested. It could be a poem, a painting, a song or a framed photograph that captured a special time. 6. Lessons for children It's easy to get caught up in the hunt for a hard-to-get item, Frates said. But ask yourself what the holiday means in your family's traditions. "Is it about getting that perfect gift for the child? Or is it about celebrating the meaning of that holiday?" So instead of having children ask for one specific toy, or a specific brand of clothing, teach them to leave a little leeway on their lists. "It is a good reminder to express to children that this season is about giving and sharing what we can in the best way that we can," she said, "and sometimes the exact gift is not available." Encouraging such an attitude can be a tall order, Frates said, but it's a place to start. "A simple mindset shift could be the difference between a stressful holiday shopping season or a joyful journey to find meaningful gifts for people you care about." American Heart Association News covers heart and brain health. Not all views expressed in this story reflect the official position of the American Heart Association. Copyright is owned or held by the American Heart Association, Inc., and all rights are reserved. Sign up here to get the latest health & fitness updates in your inbox every week!
Pep Guardiola’s side avoided the indignity of a sixth successive defeat in all competitions and looked on course for a welcome victory thanks to a double from Erling Haaland – the first from the penalty spot – and a deflected effort from Ilkay Gundogan. Yet Guardiola was left with his head in hands as Feyenoord roared back in the last 15 minutes with goals from Anis Hadj Moussa, Sergio Gimenez and David Hancko, two of them after Josko Gvardiol errors. FULL-TIME | A point apiece. 🩵 3-3 ⚫️ #ManCity | #UCL pic.twitter.com/6oj1nEOIwm — Manchester City (@ManCity) November 26, 2024 Arsenal delivered the statement Champions League win Mikel Arteta had demanded as they swept aside Sporting Lisbon 5-1. Arteta wanted his team to prove their European credentials, and goals from Gabriel Martinelli, Kai Havertz, Gabriel, Bukayo Saka and Leandro Trossard got their continental campaign back on track in style following the 1-0 defeat at Inter Milan last time out. A memorable victory also ended Sporting’s unbeaten start to the season, a streak of 17 wins and one draw, the vast majority of which prompted Manchester United to prise away head coach Ruben Amorim. Putting on a show at Sporting 🌟 pic.twitter.com/Yi9MgRZEkl — Arsenal (@Arsenal) November 26, 2024 Paris St Germain were left in serious of danger of failing to progress in the Champions League as they fell to a 1-0 defeat to Bayern Munich at the Allianz Arena. Kim Min-jae’s header late in the first half was enough to send PSG to a third defeat in the competition this season, leaving them six points off the automatic qualification places for the last 16 with three games to play. Luis Enrique’s side, who had Ousmane Dembele sent off, were deservedly beaten by Bayern who dominated chances and possession. 🔔 FULL TIME – Victory at home! +3 in the #UCL 👏❤️ #FCBayern #MiaSanMia | #FCBPSG #UCL pic.twitter.com/BYE23dXXih — FC Bayern (@FCBayernEN) November 26, 2024 Elsewhere, Atletico Madrid were 6-0 winners away to Sparta Prague, Julian Alvarez and Angel Correa each scoring twice whilst there were also goals from Marcos Llorente and Antoine Griezmann. Barcelona ended tournament debutants Brest’s unbeaten start with a 3-0 victory courtesy of two goals from Robert Lewandowski – one a penalty – and Dani Olmo. Lewandowski’s first was his 100th Champions League goal, only the third man to reach the mark after Cristiano Ronaldo and Lionel Messi. A Castello Lukeba own goal saw Inter Milan go top of the standings with a narrow 1-0 win over RB Leipzig at San Siro, whilst Bayer Leverkusen were emphatic victors against Red Bull Salzburg, Florian Wirtz scoring twice to move Xabi Alonso’s side into the automatic qualification places. Atalanta continued their strong start, albeit whilst conceding a first goal in Europe this season in a 6-1 win away to Young Boys, whilst Tammy Abraham scored the decisive goal as AC Milan beat Slovan Bratislava 3-2.1. "Pocket World," a stress relief coloring book for adults full of whimsical miniature Polly Pocket-esque worlds to color, with no two alike. I'm talking fairy gardens, tiny hygge-style living rooms, quirky restaurants, and more. Psst — Coco Wyo has a *ton* of other cozy stress relief coloring books with different themes in their Amazon storefront ! Another psst — you can pick up a cult-fave colored pencil set on Amazon for $11.99! Promising review: "One of my favorites ever!!! The idea is perfect, and the pages are all unique and fun to color, with no repetition, and the details aren't too tiny. Great for anxiety if you're doing coloring for mental health. (I hate the pages that are just tiny patterns repeated endlessly. Makes my anxiety worse.)" — Ezra Johnson Get it from Amazon for $7.99 . 2. A mini inflatable tube guy for your desk to cheer you on (or remind you to take a lil' dance break whenever you overwork yourself). Promising review: "OMG! I love this guy! These things, large and small, will ALWAYS make me laugh. My husband bought the desk version for me, and I can always count on it to make me laugh. My co-workers love it, too. People just stop by to turn him on for a quick pick-me-up. I would recommend getting the AC plug since batteries can run down fast. I think we should create a community of fellow air-dancer-havers and post clips of our little guys dancing to our favorite songs. Anyone in?" — Mark Get it from Amazon for $8.58 . 3. A rechargeable, dimmable Dodo Duck Night-Light so cute that it won't be *that* much of a surprise when you imprint on it and start calling it your son. (Psst — this is the new baby cousin of the viral Depressed Duck Night-Light , if that's more your speed.) Check out a TikTok of the duck night-light in action. Promising review: "This little lamp is so cute! Gently squeeze it to turn it off or on. It leaves a nice soft glow. Purchased for a teenager, and she loves it." — WendyAnne Get it from Amazon for $15.99 . 4. A shaker of Thin Mint seasoning you need to buy as a favor to all your taste buds immediately. Allow me to paint a picture for you: Thin Mint coffee, Thin Mint pudding, Thin Mint popcorn, Thin Mint anything your dessert gremlin heart desires. I stared at this for months online before caving and buying it, and when I tell you!! It jazzes up my morning coffee in a way that makes my little '90s baby heart sing. I've also loved it on Greek yogurt, oatmeal, and mug cakes. Plus, when I am feeling lonely for a real Thin Mint, and we're not in Girl Scout cookie season, I'll shake this on an Oreo Thin to stave off the despair. Get it from Amazon for $4.98 (and try their s'mores seasoning blend, too!). 5. A set of mini Stanley-inspired shot glasses for when it's THAT kind of party — do everyone a favor and roll up to the bachelorette, birthday, and themed shenanigan with these cheeky "bottles" in tow. Promising review: "Perfect for tastings. These were a hit at a paint-and-sip party that I attended. I made a couple of cocktails and carried them to the event in larger containers, but gifted each of the attendees one of these little cups so that they could sample each. They loved them." — SoBeGaPe Get a set of six from Amazon for $19.99 (clip the 20% off coupon on the product page for this price; also available in a pack of three and a pack of eight). 6. A miniature arcade Atari so you can spend your day off in a time machine to the '80s — this itty bitty console is loaded up with ten playable retro-style games, including Pac-Man, Breakout, Asteroids, and more. Reviewers also mention how much they love giving them as gifts! Promising review: "I've put probably 10 hours in playing with this little system . It's an excellent little Atari clone, the screen is crystal clear, the games play exactly as expected , the sound is great the controller is a joy. This is an absolute must for anyone that loves retro games." — Doug Welyczko Get it from Amazon for $25.76 . 7. A set of Minnie Mouse ear scrunchies for anyone whose permanent spiritual address is "Magic Kingdom," even if their physical address is somewhere else. Promising review: "I bought these at the last minute prior to a school trip to Disney. They came in a two-pack. I wore them EVERY DAY of the trip. They are so dang cute and durable. Standing in lines for the ride, almost EVERYONE asked me about them. They thought I bought them there, but surprisingly, NOT ONE shop at any of the Disney properties sold this. I sold one to someone in the line!" — Melissa Rae Get a two-pack from Amazon for $8.89 (available in 13 styles). 8. A wildly hilarious "screaming goat" button that has surprised reviewers by becoming a legit staple in their routine — people use it to get the attention of a classroom or break tension in the office or just to generally announce to anyone in your vicinity, "I've had it up to HERE and someone better get me a little treat IMMEDIATELY." Novelty888 is a small business that specializes in delightfully and oddly specific talking buttons. Promising review: "Got this for my wife to keep on her desk. She said it’s been a big hit in the office! If she or her coworkers are having a tough time, this lightens the mood with just the press of a button." — Daniel Get it from Amazon for $17.99 . 9. A sweet Nessie sugar spoon reviewers are obsessed with, and for good reason. It infuses just the right amount of ~whimsy~ into the best parts of their day (read: that first cup of coffee, the first bite of oatmeal, that lil' bowl of ice cream before bed). It also has a very satisfying weight and curve for optimum sipping. Promising review: "This little silly spoon makes me happy. It is now the #1 spoon everyone looks for in the silverware drawer at our house. Often found in a container of ice cream or a mug of tea living its best little life." — Emily Get it from Amazon for $7.95 (also available in sets of four and eight). 10. A Goldfish cracker-themed candle , because it's not enough to just eat the snack that smiles back. You have to watch it BURN. Promising review : "Smells SO good — and the fish crackers look so real! ! Be careful if you have little ones or guests who might not realize it at first or they'll get eaten! The candle burns nicely — we actually take the fish off while we're burning it, and sprinkle them back on when we blow out the candle. They're too cute to melt!" — KeWEE Get it from Amazon for $24.99 (available in 17 styles). 11. A set of glow-in-the-dark "tree elves" so the next time you take an enchanted midnight stroll through your front walkway to get home at night, you'll have a whole host of magical critters to welcome you back. Promising review : "I have actually bought a couple of packs of these. I think they’re so cute and fit so well in a little plant or around the house. Sometimes, I like to let my friends pick out some little guys as members of their families. Plus, did I mention how cute they are? And they glow in the dark very well." — Jen Get a set of 20 from Amazon for $13.98 (available in green or green and blue as well as a set of 10). 12. An bunny and bear egg mold set because, respectfully, life is short, and we have no business ignoring opportunities to make it as adorable as possible. Reviewers mention this also works well for rice! Promising review : "Love this! This does exactly what it’s supposed to! My daughter's face lit up, seeing her hard-boiled eggs look like bunnies. So easy and a breeze to clean." — Karen Get a set of two from Amazon for $5.99 . 13. A shaved sheep plushie that is so! darn! FLUFFY!!!! that you will not be able to resist the adorable siren call of zipping its fuzzy little "coat" on and off when your brain needs a cozy vacation. Promising review: "I love him. He is so cute and so well-made. He is the perfect size and shape. I named him Banana Peel Son since his wool comes off like a banana peel. Adorable. Would recommend to everyone." — Aerebys Stare Get it from Amazon for $13.99 . 14. A cult-favorite ~secret~ popcorn salt anyone in the movie theater industry will tell you is a perfect at-home alternative for that oh-so-savory buttery goodness you love to inhale before the previews begin. Not to be dramatic about popcorn on main, but this stuff is game changing. Our family unearthed this because beloved To All The Boys I've Loved Before author Jenny Han mentioned that it was her secret to delicious popcorn, and it may have just wrecked me for other at-home popcorn for the rest of my life . It genuinely tastes just as salty and buttery and savory as fresh movie theater popcorn. I inhaled it so fast that every single one of my organs lit up in mild alarm. Promising review: "I am a person who will make myself sick eating buckets of popcorn (I have no self control). This has by far been my favorite 'TikTok made me buy' item. My at-home popcorn is now my favorite thing to make and I don't need to go the theater for popcorn. Very much worth the purchase and this will last me such a long time." — S Martinez Get it from Amazon for $9.20+ (available in three flavors/styles) 15. A shaker of edible cocktail glitter , because why go through life without taking advantage of every opportunity to make it sparkle??✨ Reviewers add a touch to glam up their Prosecco or jazz up colorful-themed cocktails. Bakell is a small business established in 2016 that specializes in edible glitters for food and drink. Promising review: "Don’t think any further and just buy it. This was so cool and everyone loved it! I got the clear one because it will go with any drink. I will be the one to put this in all my friends' drinks. Also had no taste so it was just the look. Sooooooo cool!" — gigi Get it from Amazon for $9.40+ (available in 17 colors). 16. A 5-pound bucket of Crayola Air Dry Clay to let you finally follow your inner pottery dreams without all the mess and effort of taking classes. After you pull the clay out to shape it, it'll harden on its own — no oven or any effort required! From there you can leave it as is or paint over it for a fun vibe. Psst — a lot of reviewers use silicone or plastic molds to get specific shapes! Promising review: "It’s honestly just a really nice material to work with! If you want to create things with clay, this is definitely a good choice! It’s definitely not for professional use, but I feel like that’s a given? I mean, it is Crayola. But all in all, great for those who want to use it for fun!" — Amazon Customer Get it from Amazon for $10.96 . 17. A set of TikTok-famous Globbles , which are about to be your favorite stress-relieving fidget toy. These colorful balls are squishy, stretchy, and stick to pretty much any flat surface you throw them at *without* leaving any messy residue. TikTokers have a blast tossing these at walls and ceilings to see the satisfying way they glom onto them. Promising review: "I have bought these over and over again for gifts. My own children have played with these balls repeatedly. We even left one on the ceiling to see how long it would stay for. It lasted four months before we decided to take it down. Since they are so sticky, they get dirty pretty quickly. All you have to do is a quick rinse in the sink and an air dry, then you are good to go. Great for adults and children! Will be buying again. " — Valerie Young Get a set of six from Amazon for $10.69 . 18. A pair of glowing lightsaber chopsticks to bring balance to The Force *and* to your sushi. As you can see from the above GIF, I bought these for myself, and I love them to pieces. TBH, I use them as decor every bit as much as I use them to eat. Sometimes I just keep them in my work area to light them up during the day to feel fancy. They toggle back and forth between a bunch of different colors, like red, blue, yellow, purple, and multicolor, so you can either make them match *or* have a red and blue one together and bring ~balance~ to the Force. Get it from Amazon for $9.97 . 19. A set of quirky ceramic mini espresso cups so cute that from the moment you start sipping from them, it'll be like one touch and they brand new'd it for you ✨. Promising review: "These espresso cups are the cutest. They are very different and unique. I was scared about the handle being hard to hold, but it is just fine." — Sandra Vehabovic Get a set of two from Amazon for $8.49 (available in 10 styles and in packs of four). 20. A set of wooden flower pot magnets to bring the whole trend of "fridgescaping" to an entirely new, adorable level, or brighten up your desk area at work. I dare anyone to be grumpy with these cute lil' blooms in their eyeline. Promising review : "The magnets look good! I have them displayed at work and receive so many compliments. Perfect addition!" — Amazon Customer Get a set of four from Amazon for $9.99 ( also available in five other styles, including quirky food boards ). 21. A cult-fave, high-quality 100-piece Dog Park Puzzle so full of adorable details that it's just going to be a constant stream of serotonin every time you push another piece into place. Reviewers love not just the whimsical art style, but the fact that it's so well-made that there's never any glare on the image or "puzzle dust" when they put it together. Antelope is a small business that specializes in high-quality, unique jigsaw puzzles. Promising review : "This was my first time putting a 1000-piece puzzle together myself. Once I sorted the pieces out in sorting trays (highly recommend), I thought maybe this was a bit much for me. I started it a week ago and worked a little bit each day. I really enjoyed this. The pieces are very good quality. The details and colors are outstanding. I was constantly discovering something new I hadn’t noticed before . I’m actually kinda sad I’m done, but I’ll pack it away and bring it out again in about six months and have fun all over again." — ScubaReader Get it from Amazon for $22.99 (available in six other whimsical designs and in multisets). 22. A set of cat-themed tarot cards purrrfect for first-timers, complete with a guide on how to pull the cards and how to interpret them. You'll be doing readings for everyone from yourself to your BFF to your actual cat by the end of the week. Promising review: "Honestly, I saw this tarot deck and thought I needed this for ha ha’s. But man. This deck’s images are hilarious. It’s so much fun, and I felt so drawn to it as soon as it was in my hands. I am smitten over these kittens. 😍 10000% worth the purchase!" — Kathryn Prouty Get it from Amazon for $17.46 . 23. A lil' reversible octopus plush that is, literally and figuratively, a Mood — you can prop this on your desk or somewhere in your home just to let everyone know how you're vibin' (or even just to check in with yourself ❤️). Also, these come in a TON of different colors and emotions (from angry to sad to, uh, murderous??), so you're guaranteed to find one to express yourself. Promising review: "I saw this on TikTok like everyone else but I quickly realized, when I got one, how helpful this is to my family. Now they don't have to guess when they shouldn't bother me, they'll just KNOW. It's saving lives and it's adorable. The perfect thing. :)" — MCalms Get it from Amazon for $10.49 (available in 45 styles). 24. A ridiculously fun Tiki Toss ring game for anyone who wants to humble their jock friends REAL fast — this game is super easy to set up and learn, but tricky enough to get juuuust right that it will even the whole playing field. Reviewers love that is is a fun-for-all-ages game (but aren't not using it as a a drinking game too 👀 ). Tiki Toss is a small business that specializes in family-friendly games for home and outdoor use. Promising review: "We all love this game. Everyone who comes over cannot stop playing Tiki Toss. So simple and so fun. Quality and design of product is fantastic. Also makes a great gift." — jzek Get it from Amazon for $9.99 (available in two sizes). 25. A pound of cereal marshmallows because truly I think we're all hard-pressed to think of a scenario that *doesn't* warrant having an emergency bag of these to whip out for the occasion. Pro-tip to refrigerate these babies if you want 'em extra crunchy. Medley Hills Farm is an Ohio-based, family-owned small business that specializes in unique candies, snacks, and baking supplies. Promising review: "Buying these charms was one of the best decisions of my life. The bag is twice the size of my head. The marshmallows are aesthetically pleasing and delicious . It's everything I ever wanted in a snack." — Amazon Customer Get it from Amazon for $12.99 . 26. A ~Magical Flame~ colorant you can use in your fireplace at home or in outdoor campfires to basically flex to everyone on Instagram that you are, in fact, a wizard now. Magical Flames is a small business that specializes in color-changing fire products. Note: You shouldn't cook food or roast s'mores over the open flame after using this product. Promising review: "This product is so easy to use. Just toss a packet into the fire and watch the flames change color. The colors were beautiful and received a lot of oooooos and ahhhhhhs. Surprisingly, it lasted for quite a while. We will enjoy this addition to our campfires this summer." — Debra L. Musselman Get a pack of 10 from Amazon for $12.99 . 27. A " Liquipen ," aka what happens when a pen and a lava lamp have an intriguing and functional baby. This is technically a toy, but a lot of adults swear by it for calm or for helping spur creative ideas when they're in a rut! Promising review: "I broke up the three pack and gave one pen as a gift for a class gift exchange and put the other two in stocking for Christmas. Good quality and approved by both the 8-year-old and 49-year-old husband who is a kid at heart! Definitely recommend." — Kindle Customer Get a set of three from Amazon for $17.99 . 28. A mildly alarming if not adorable flexible flower vase that will fascinate guests when they can bend its limbs and hang it from any fixture they choose. That says if this thing *does* come to life in the middle of the night and starts singing and dancing all over your room, well. That's on you for buying whatever the heck this is. Promising review: "An affable, squishy, bendy, happy little vase! The consensus on my social media page is that everyone should have one of these. I finally got a chance to try it out with some daffodils, and really, it's hard not to smile when you see them." — Susy Lundy Get it from Amazon for $19.99 (available in three colors). 29. A teensy candy vending machine for your desk to make the endless grind of capitalism a little sweeter (and to establish yourself as the Coolest Employee In The Office). Promising review: "Keep this on my desk to snack on M&Ms. It’s perfect for smaller sized candy. Love the color. Glad it fits in with my aesthetic." — Dunn Get it from Amazon for $22.99 . 30. A retro radio tissue holder so old-timey precious that you'll be a little bit?? EXCITED??? For allergy season??? Because you'll get to spend quality time with your favorite piece of home decor. 🎵 Psst — this is compatible with tissues from a small cube box, or just tissues pulled out of the box, not a full size one! Promising review: "It's adorable! I currently have it filled with tissues from a small cube box. Works great! Perfect addition to my teal and gold bedroom decor!" — Michelle W. Get it from Amazon for $14.99+ (available in four colors). 31. A pack of mini rainbow scratch art notes that will transport you back to your youth so fast that you will suddenly have a craving for Goldfish crackers and apple juice so aggressive it CANNOT BE IGNORED. Promising review: "I love this little scratch art pad. Sometimes I just need a break and a little distraction to let my brain breathe, so I pull this out and make all sorts of designs. You do get a little of a mess by scratching the black off but I usually have a big mess cause I end up scratching the whole thing off. Can't help it. Kid at heart, I guess." — Jane Get a pack of 125 notes from Amazon for $12.99 (available in five styles). 32. A northern lights projector for anyone whose heart is in the magic of the cosmos, but whose butt would much rather be snuggled on a couch than freezing by a glacier. Bonus: This also plays soothing noises and doubles as a Bluetooth speaker! Promising review: "I love this light! The stars are beautiful, the colors are beautiful. I like that it shuts off in four hours. I use it in my house so I don’t have to turn the lights on all the time. I like it so much. I just ordered three more to give to my grandchildren. It also has sounds like the sound of rain, or ocean waves. And you can even play your regular music on it . Don’t be afraid to try it! It’s like having the northern lights anytime you want." — Amy J Nelson Get it from Amazon for $39.99 (available in five colors). 33. A criminally cute teddy bear water bottle that takes "emotional support water bottle" to a WHOLE other level. Reviewers especially love that it comes with a handy shoulder strap, and that the leakproof lid pops off to let you drink from a straw! Promising review: "My daughter uses this as her school water bottle. It’s great because it has a strap and she doesn’t have to squeeze it in her backpack! No leaks. Easy to clean but we only put water in it!" — Sarah Witt Get it from Amazon for $9.99 (available in two styles). 34. Kinetic Sand , a delightful ~magic~ sensory toy that flows through your fingers like actual sand, but holds a shape, doesn't stick to things, and doesn't dry out. It's like infinite sand castles and beachy shenanigans in one little package. Promising review: "This sand is great for indoor sandboxes. It molds well and cleans easily and it stays the same consistency for years. I know this because we’ve had some of ours for that long. It’s also great for sensory stimulation and can entertain my son for a long time, which is rare for him unless it’s electronic. I like the educational aspect of it and the durability." — Nef Get it from Amazon for $14.30 . 35. A set of light up bath fizzes , because life is short and bath time is nothing if not an opportunity for an underwater rave!! Bonus: these are made with natural essential oils and moisturizing shea butter and coconut oil for a real ~spa~ experience. These come in six different scents: lavender, aloe, ocean, rose, milk, and olayer. Promising review : "Disco in my bath! This product is such a nice distraction from a stressful life! The scents are not overpowering light and soothing, they don’t seem to deposit rings a real plus with a soaker tub! But the best part save the little center bit and set aside for a real party with wine and candles . Sending these out to stressed family now as random pick me ups." — Katrin Sullivan Get a set of six from Amazon for $19.98 . 36. A delightfully nonstick smiley face pancake pan reviewers use for mini pancakes and eggs to instantly ~pizzazz~ what is indisputably the most delicious meal of the day. Promising review: "So much fun to make pancakes on this pan. Since it makes such small pancakes, they cook very quickly. My kids love the emoji designs and it makes breakfast fun." — Rosa D. Get it from Amazon for $24.99 . Reviews have been edited for length and/or clarity.
SARAJEVO, Nov. 21 (Xinhua) -- Bosnia and Herzegovina's (BiH) economy is forecast to grow by 2.5 percent in 2024 and 3 percent in 2025, driven by increased private consumption, wage growth, and slight investment gains, according to a senior expert with the International Monetary Fund (IMF). Presenting the IMF's "Regional Economic Outlook for Europe" in Sarajevo on Thursday, IMF Resident Representative Andreas Tudyk highlighted risks to BiH's economic forecast, including Europe's economic slowdown, political tensions, and fiscal challenges. Goran Mirascic, economic advisor to the BiH prime minister, noted BiH's moderate debt and said most borrowing supports infrastructure projects. While weaker demand from key trading partners like Germany and Italy affects exports, BiH's gross domestic product (GDP) growth is expected to remain between 2.5 percent and 2.8 percent in 2024, he said.Diffuse Glioma Vorasidenib (Voranigo) or ivosidenib (Tibsovo) administered before and after surgery demonstrated sustained clinical benefit in patients with predominantly non-enhancing IDH1 -mutant diffuse glioma, according to updated findings from a phase 1 trial (NCT03343197) presented at the 2024 Society for Neuro-Oncology (SNO) Annual Meeting . At a data cutoff date of September 23, 2023, 64% of evaluable patients who received vorasidenib (n = 22) and 45.4% of evaluable patients who received ivosidenib experienced tumor reduction. The overall response rate (ORR) among evaluable patients who received vorasidenib (n = 22) was 45.5%, including partial response (PR), minor response (MR), stable disease (SD), and progressive disease (PD) rates of 18.2%, 27.3%, 36.4%, and 18.2%, respectively. The median time to response in this arm was 9.2 months (range, 2-20), and the median duration of response (DOR) was not evaluable (NE; range, 14.7 months-NE). The median duration of treatment was 44.67 months (range, 0.9-62.7). The ORR among evaluable patients who received ivosidenib (n = 22) was 31.8%, including PR, MR, SD, and PD rates of 22.7%, 9.1%, 59.1%, and 9.1%, respectively. The median time to response in this arm was 5.6 months (range, 2-13), and the median DOR was 42.4 months (range, 1.8-NE). The median duration of treatment was 23.92 months (range, 0.0-62.7). “With additional [follow-up of approximately] 3.5 years from previously published results, vorasidenib and ivosidenib continue to show clinical benefit immediately after surgery in patients with predominantly non-enhancing glioma,” presenting author Timothy F. Cloughesy, MD, and coauthors wrote in a presentation of the data. “Vorasidenib resulted in durable disease control including objective responses, consistent with phase 3 INDIGO study [NCT04164901] results.” Cloughesy is a professor and director in the Department of Neurology, Neurological Services, and the Neuro-Oncology Program, as well as a physician in the Department of Neurology and a member of the Brain Research Institute at the UCLA Health Jonsson Comprehensive Cancer Center in Los Angeles, California. Vorasidenib, an oral, brain-penetrant dual mIDH1/2 inhibitor, was FDA approved in August 2024 for the treatment of patients at least 12 years of age with grade 2 astrocytoma or oligodendroglioma harboring a susceptible IDH1 or IDH2 mutation who have previously undergone surgery, including biopsy, subtotal resection, or gross total resection. 2 Ivosidenib, a first-in-class, oral, small-molecule mIDH1 inhibitor, is FDA approved for the treatment of patients with diseases harboring a susceptible IDH1 mutation as detected by an FDA-approved test, including in combination with azacitidine for patients newly diagnosed acute myeloid leukemia (AML) who are at least 75 years of age or have comorbidities precluding the use of intensive induction chemotherapy; as monotherapy for adult patients with relapsed/refractory AML ; as monotherapy for adult patients with relapsed/refractory myelodysplastic syndromes ; and as a single agent for adult patients with locally advanced or metastatic cholangiocarcinoma . 3 In cohort 1 of the phase 1 perioperative trial, patients with grade 2/3 non-enhancing IDH1 R132H–mutant gliomas were randomly assigned 2:2:1 to receive vorasidenib at 50 mg once daily (n = 12), ivosidenib at either 500 mg once daily or 250 mg twice daily (n = 12), or no treatment (control arm; n = 5) for 4 weeks prior to planned surgery. 1 Patients from cohort 1 with evidence of target engagement could continue to cohort 2, where they were randomly assigned 1:1 to receive either vorasidenib at 10 mg once daily (n = 10) or ivosidenib at 250 mg twice daily (n = 10). Patients had the option to continue treatment with vorasidenib or ivosidenib after surgery. The primary end point was 2-hydroxyglutarate (2-HG) concentration in tumors that were resected following neoadjuvant treatment with vorasidenib or ivosidenib compared with untreated control tumors. Secondary end points included safety; pharmacodynamics of 2-HG in plasma; pharmacokinetics in plasma and tumor; and preliminary clinical activity per Response Assessment in Neuro-Oncology criteria for low-grade gliomas. Exploratory end points included 2-HG concentration in tumors before and after treatment; and the pharmacokinetic/pharmacodynamic relationship of vorasidenib and ivosidenib in tumor, plasma, and cerebrospinal fluid. This trial was initiated in March 2018, and enrollment was completed in April 2019. In total, 49 patients were randomly assigned before surgery, all of whom proceeded to surgery without unplanned delays. Forty-six patients (oligodendroglioma, n = 24; astrocytoma, n = 20; anaplastic oligoastrocytoma, n = 1; anaplastic oligodendroglioma, n = 1) received treatment with either vorasidenib (n = 24) or ivosidenib (n = 22) following surgery. At baseline, patients in the vorasidenib arm had a median age of 49 years (range, 31-75), and most were male (66.7%). Karnofsky performance status (KPS) scores included 100% (33.3%), 90% (54.2%), and 80% (12.5%). Most patients had WHO grade 2 tumors (91.7%). Histological subtypes in this arm included oligodendroglioma (54.2%) and astrocytoma (45.8%). Additionally, 1p19q status was co-deleted, intact, or not determined in 50.0%, 41.7%, and 8.3% of patients, respectively. All patients had received prior surgery. In total, 29.2% and 41.7% of patients had received prior radiation therapy and prior systemic therapy, respectively. At baseline among patients in the ivosidenib arm, the median age was 37 years (range, 19-66), and most were male (68.0%). KPS scores included 100% (44.0%), 90% (48.0%), and 80% (4.0%); One patient (4.0%) had a missing KPS score. Most patients had WHO grade 2 tumors (84.0%). Histological subtypes in this arm included oligodendroglioma (48.0%), astrocytoma (44.0%), anaplastic oligodendroglioma (4.0%), and anaplastic oligoastrocytoma (4.0%). Furthermore, 1p19q status was co-deleted, intact, or not determined in 52.0%, 36.0%, and 12.0% of patients, respectively. All patients had received prior surgery. In total, 28.0% and 56.0% of patients had received prior radiation therapy and prior systemic therapy, respectively. Previously reported findings from this phase 1 trial showed that 2-HG concentrations were reduced by 92.6% (95% credible interval [CrI], 76.1%-97.6%) and 91.1% (95% CrI, 72.0%-97.0%) in patients who received vorasidenib at 50 mg once daily or ivosidenib at 500 mg once daily, respectively. 4 However, the ratios of tumor to plasma were higher in patients who received vorasidenib vs those who received ivosidenib. Reductions in 2-HG were associated with lower tumor cell proliferation, reversal of IDH1/2 mutation–associated gene expression programs, increased DNA 5-hydroxy-methylcytosine, and increased tumor-infiltrating lymphocyte levels. The dose of vorasidenib at 50 mg once daily was associated with the most consistent mutant enzyme inhibition and the most preliminary antitumor activity. As of the data cutoff date for the updated analysis, 11 patients remained on treatment with vorasidenib, and 5 patients remained on treatment with ivosidenib. 1 Among the patients in the safety analysis set who had received vorasidenib (n = 24), 13 had discontinued treatment due to either disease progression (n = 10), adverse effects (AEs; n = 1), or investigator decision (n = 2). Among the patients in the safety analysis set who had received ivosidenib (n = 25), 20 had discontinued treatment due to either disease progression (n = 14), AEs (n = 2), or investigator decision (n = 1); 3 patients in this group did not continue therapy post-surgery. The median progression-free survival (PFS) was 41.4 months (95% CI, 9.3-NE) in the vorasidenib arm and 38.6 months (95% CI, 18.3-NE) in the ivosidenib arm. Among patients who had only undergone prior surgery, the median PFS was 55.2 months (95% CI, 2.4-NE) in the vorasidenib arm (n = 9) and 38.6 months (95% CI, 24.0-NE) in the ivosidenib arm (n = 9). Investigators reported no new safety signals and noted that the safety profiles of the agents in this analysis were consistent with those observed in previously published studies. In the vorasidenib arm, any-grade treatment-emergent AEs (TEAEs) occurred in 100.0% of patients, and treatment-related TEAEs were seen in 66.7% of patients. Serious TEAEs and treatment-related serious TEAEs were seen in 41.7% and 4.2% of patients, respectively. Grade 3 or higher TEAEs, treatment-related grade 3 or higher TEAEs, and AEs of special interest were observed in 62.5%, 12.5%, and 12.5% of patients, respectively. TEAEs led to treatment discontinuation, dose reduction, and dose interruption in 4.2%, 4.2%, and 37.5% of patients, respectively. In the ivosidenib arm, any-grade TEAEs occurred in 100.0% of patients, and treatment-related TEAEs were seen in 72.0% of patients. Serious TEAEs were seen in 32.0% of patients, and no patients had treatment-related serious TEAEs. Grade 3 or higher TEAEs and treatment-related grade 3 or higher TEAEs were observed in 32.0% and 4.0% of patients, respectively. No AEs of special interest were reported. TEAEs led to treatment discontinuation, dose reduction, and dose interruption in 8.0%, 4.0%, and 20.0% of patients, respectively. Notably, no TEAEs led to on-treatment deaths in either arm. “Safety profiles remain favorable with no new risk identified for either drug,” the authors concluded. Disclosures : Dr Cloughesy reported being the cofounder of Katmai Pharmaceuticals; holding stock holder in Katmai Pharmaceuticals, Chimerix, Erasca; serving as a consultant for Katmai Pharmaceuticals, 501c3 Global Coalition for Adaptive Research, Sagimet, Clinical Care Options, Ideology Health, Servier, Jubilant, Immvira, Gan & Lee, BrainStorm, Sapience, Inovio, Viego Therapeutics, DNATrix, Tyme, SDP, Novartis, Roche, Kintara, Bayer, Merck, Boehringer Ingelheim, VBL, Amgen, Kiyatec, Odonate Therapeutics, QED, Medefield, Pascal Biosciences, Tocagen, Karyopharm, GW Pharma, AbbVie, VBI, Deciphera, Agios, Genocea, Celgene, Puma, Lilly, BMS, Cortice, Wellcome Trust, Novocure, Novogen, Boston Biomedical, Sunovion, Human Longevity, Insys, ProNai, Pfizer, Notable Labs, Medqia Trizel, and Medscape; serving as a board member for Katmai Pharmaceuticals, 501c3 Global Coalition for Adaptive Research, Break Through Cancer and Cure Brain Cancer Foundation; receiving milestone payments and possible future royalties from Chimerix; serving as a member of Break Through Cancer and Cure Brain Cancer Foundation; and that the Regents of the University of California have licensed intellectual property coinvented by Dr Cloughesy to Katmai Pharmaceuticals.
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Ardelyx CEO Michael Raab sells $153,328 in common stock
CYPRESS LAKE, Fla. (AP) — Robert McCray scored 21 points as Jacksonville beat Siena 75-64 on Tuesday. McCray added eight rebounds and five assists for the Dolphins (4-3). Zach Bell scored 11 points, going 3 of 5 and 4 of 4 from the free-throw line. Zimi Nwokeji went 3 of 7 from the field (2 for 4 from 3-point range) to finish with 10 points, while adding six rebounds. Gavin Doty finished with 21 points and nine rebounds for the Saints (3-4). Major Freeman added 12 points and four assists for Siena. Tajae Jones also had 11 points. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .WARSAW, Ind. , Nov. 25, 2024 /PRNewswire/ -- Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH), a global medical technology leader, today announced U.S. Food and Drug Administration (FDA) Premarket Approval Application (PMA) Supplement approval for the Oxford ® Cementless Partial Knee. The approval is based on safety and effectiveness data from an Investigational Device Exemption (IDE) study and non-clinical testing for cementless partial knee replacement (PKR). 1 The Oxford Cementless Partial Knee allows surgeons to perform a PKR with improved fixation, 2 better long-term implant survival rate 2,3 and improved efficiency in the operating room 4 (OR) compared to the Oxford Cemented Partial Knee procedure. Following more than 20 years of clinical experience and over 300,000 procedures across Canada , Europe , Middle East , Africa , and Asia , 5 the Oxford Cementless Partial Knee is now the only FDA-approved cementless partial knee implant in the U.S. "Cementless knee replacement procedures are increasingly preferred by surgeons seeking to improve surgical efficiency. The Oxford Cementless Partial Knee is coming into the U.S. with a proven track record of retaining more healthy anatomy with a less invasive approach and improved outcomes 6 as compared to a total knee replacement," said Joe Urban , President, Knees at Zimmer Biomet. "We are excited to address the unmet U.S. demand for a cementless partial knee with a new offering which has 20 years of clinical experience in more than 50 countries. 5 " Compared to traditional partial knee replacements that use bone cement to secure the implant in place, a cementless approach allows patients' natural bone growth to secure the implant for better long-term fixation. 2 The Oxford Cementless Partial Knee features a mobile bearing that can move with the femoral component throughout the entire range of motion to mimic natural knee movement. This design provides better range of motion, a more natural feel and a more stable implant-to-bone fixation for improved long-term implant survival. 2,3 The system's tibial and femoral components have a titanium and hydroxyapatite coating to promote bone growth into the implant 7 . The UK national joint registry has more than 33,000 patients treated with Oxford Cementless Partial Knees recorded with a 94.1% rate of implant survival at 10 years after surgery, 3 which is higher than the average 10-year survivorship for all other partial knees (89.9%). 3 Enthusiasm and usage of partial knee replacement continues to grow around the world as published research continues to demonstrate that PKR in appropriate cases provides improved patient outcomes compared to TKR. 6 "For younger and more active patients, the Oxford Cementless Partial Knee amplifies the benefits of a traditional partial knee replacement by offering knee flexion that resembles natural knee movement, and stronger adhesion of the implant to the bone for better long-term durability," said Adolph V. Lombardi Jr. , MD, FACS, President of JIS Orthopedics in New Albany, Ohio . "In my own practice, a cementless approach has increased OR efficiency by shortening my surgery time and reducing costs associated with cement preparation." Since its initial launch in England in 2004, the Oxford Cementless Partial Knee has become the preferred partial knee implant for Zimmer Biomet's European customers. 5 As part of the U.S. nationwide launch in Q1 2025, Zimmer Biomet will provide FDA-required training, focusing on the cementless surgical technique and proper patient selection. For patients in the U.S., the Oxford Partial Knee is the only implant with a lifetime limited warranty that covers the cost of Zimmer Biomet replacement implants.* Important Safety Information: The Cementless Oxford Partial Knee System is intended for use in unilateral knee procedures with osteoarthritis or avascular necrosis limited to the medial compartment of the knee. It is intended to be implanted without the application of cement for patients whose clinical condition would benefit from a shorter surgical time compared to the cemented implant. The Oxford Partial Knee is not indicated for use in the lateral compartment or for patients with ligament deficiency, or for use in simultaneous bilateral surgery or planned staged bilateral procedures. Potential risks include, but are not limited to, loosening, dislocation, fracture, wear and infection, any of which can require additional surgery. For a full list of product indications, contraindications and warnings, as well as further information on product IDE data, please see the associated product Information for Use (IFU) and Surgical Technique available at https://labeling.zimmerbiomet.com/ For more information about the Oxford Cementless Partial Knee, visit www.zimmerbiomet.com/oxfordcementless . About Zimmer Biomet Zimmer Biomet is a global medical technology leader with a comprehensive portfolio designed to maximize mobility and improve health. We seamlessly transform the patient experience through our innovative products and suite of integrated digital and robotic technologies that leverage data, data analytics and artificial intelligence. With 90+ years of trusted leadership and proven expertise, Zimmer Biomet is positioned to deliver the highest quality solutions to patients and providers. Our legacy continues to come to life today through our progressive culture of evolution and innovation. For more information about our product portfolio, our operations in 25+ countries and sales in 100+ countries or about joining our team, visit www.zimmerbiomet.com or follow on LinkedIn at www.linkedin.com/company/zimmerbiomet or X / Twitter at www.twitter.com/zimmerbiomet . Cautionary Statement Regarding Forward-Looking Statements This news release contains forward-looking statements within the meaning of the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Forward-looking statements include, but are not limited to, statements concerning Zimmer Biomet's expectations, plans, prospects, and product and service offerings, including new product launches and potential clinical successes. Such statements are based upon the current beliefs and expectations of management and are subject to significant risks, uncertainties and changes in circumstances that could cause actual outcomes and results to differ materially. For a list and description of some of such risks and uncertainties, see Zimmer Biomet's periodic reports filed with the U.S. Securities and Exchange Commission (SEC). These factors should not be construed as exhaustive and should be read in conjunction with the other cautionary statements that are included in Zimmer Biomet's filings with the SEC. Forward-looking statements speak only as of the date they are made, and Zimmer Biomet disclaims any intention or obligation to update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. Readers of this news release are cautioned not to rely on these forward-looking statements, since there can be no assurance that these forward-looking statements will prove to be accurate. This cautionary statement is applicable to all forward-looking statements contained in this news release. *Subject to terms and conditions set forth within the written warranty References: Media Heather Zoumas-Lubeski 445-248-0577 heather.zoumaslubeski@zimmerbiomet.com Kirsten Fallon 781-779-5561 kirsten.fallon@zimmerbiomet.com Investors David DeMartino 646-531-6115 david.demartino@zimmerbiomet.com Zach Weiner 908-591-6955 Zach.weiner@zimmerbiomet.com View original content to download multimedia: https://www.prnewswire.com/news-releases/zimmer-biomet-receives-fda-approval-for-oxford-cementless-partial-knee-only-cementless-partial-knee-replacement-implant-in-the-us-302315755.html SOURCE Zimmer Biomet Holdings, Inc.