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Unlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It’s a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It’s all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person’s response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn’t happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It’s not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn’t respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I’m hoping it’s slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” ___ The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.NexOptic Technology Corp. ( CVE:NXO – Get Free Report )’s stock price dropped 20% during mid-day trading on Saturday . The company traded as low as C$0.02 and last traded at C$0.02. Approximately 480,200 shares were traded during mid-day trading, an increase of 387% from the average daily volume of 98,644 shares. The stock had previously closed at C$0.03. NexOptic Technology Trading Down 20.0 % The firm has a 50-day moving average of C$0.03 and a 200 day moving average of C$0.02. The company has a market cap of C$3.90 million, a P/E ratio of -1.00 and a beta of 1.14. The company has a current ratio of 0.07, a quick ratio of 0.01 and a debt-to-equity ratio of 56.33. NexOptic Technology Company Profile ( Get Free Report ) NexOptic Technology Corp., a technology company, develops artificial intelligence and imaging products. It engages in developing All Light Intelligent Imaging Solutions (ALIIS), a suite of intelligent imaging solution that processes raw images and video in real time; and NexCompress technological solutions. 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In this video, Motley Fool contributors Jason Hall and Tyler Crowe explain why First Solar ( FSLR 2.25% ) is starting to look like a very good buy. *Stock prices used were from the afternoon of Nov. 21, 2024. The video was published on Nov. 23, 2024.Justin Paget/DigitalVision via Getty Images Thesis Summary When Palantir Technologies Inc. ( NASDAQ: PLTR ) was trading at $38, I called for it to rally to $100 . The stock has almost doubled since then. In my last article, however, I also outlined potential problems with the company, including limitations to This is a high-risk/high-reward opportunity, which is exactly what I look for in my YOLO portfolio. Joint the Pragmatic Investor today to get insight into stocks with high return potential. You will also get: - Weekly Macro newsletter - Access to the End of The World and YOLO portfolios - Trade Ideas - Weekly Video James Foord is an economist by trade and has been analyzing global markets for the past decade. He leads the investing group The Pragmatic Investor where the focus is on building robust and truly diversified portfolios that will continually preserve and increase wealth. Learn more Analyst’s Disclosure: I/we have a beneficial long position in the shares of PLTR either through stock ownership, options, or other derivatives. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article. Seeking Alpha's Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.BATON ROUGE, La. — Josh Williams had a pair of rushing touchdowns and Garrett Nussemeier threw for 332 yards as LSU defeated Vanderbilt 24-17 Saturday night at Tiger Stadium. The Tigers (7-4, 4-3 SEC) snapped a three-game losing streak, their longest since the 2021 season. Leading 14-10 at the end of the first half, LSU saw its lead shrink to 14-10 after a 47-yard field goal by Brock Taylor on the Commodores first possession of the third quarter. In arguably its most important drive of the game, the much-maligned Tigers offense, which had been held to 29 combined points the last two weeks, completed an impressive 77-yard, 10-play scoring drive, culminating in a Nussmeier 12-yard touchdown pass to Kyren Lacy to make it 21-10. The key play of the drive was a 24-yard pass from Nussemeier to C.J. Daniels on a fourth down inside Vanderbilt territory. Lacy finished with 85 yards receiving and a touchdown on six catches. Forcing a Vanderiblt punt on its ensuing possession, LSU made it a two-score game on a 28-yard field goal by Damian Ramos, extending its lead to 24-10. Vanderbilt quarterback Diego Pavia made it a 24-17 game late in the game on a 1-yard touchdown run, but LSU was able to keep the ball for the final 5:47 of the game, sealing the victory. LSU quarterback Garrett Nussmeier (13) passes in the first half of an NCAA college football game against Vanderbilt in Baton Rouge, La., Saturday, Nov. 23, 2024. Credit: AP/Gerald Herbert Pavia finished with 43 yards rushing on six carries for Vanderbilt (6-5, 3-4) and was13-of-24 passing for 186 yards. The LSU defense, which had given up 107 points during the three-game losing streak, had its best performance since an Oct. 19 victory over Arkansas. Vanderbilt was held to 308 yards of total offense. Seeking its first victory over LSU in Baton Rouge since 1951, Vanderbilt scored on the first play from scrimmage on a 63-yard touchdown pass from Pavia to Quincy Skinner. Williams scored the first of his two touchdowns on LSU’s second possession of the game, capping off a 90-yard scoring drive for the Tigers with a 20-yard touchdown. Vanderbilt wide receiver Quincy Skinner Jr. (3) scores on a touchdown reception in the first half of an NCAA college football game against LSU in Baton Rouge, La., Saturday, Nov. 23, 2024. Credit: AP/Gerald Herbert After stopping Vanderbilt on fourth down deep inside LSU territory, an 80-yard, nine-play drive was finished off by a 21-yard touchdown run by Williams to give LSU the lead for good at 14-7. He finished with 90 yards rushing on 14 carries. The takeaway Vanderbilt: The Commodores had their fair share of chances early in the game after the first-play score, but a failed fourth down conversion near the end of the first half deep inside LSU territory led to the go-ahead touchdown for the Tigers. LSU: It was one of the most balanced performances for a Tigers offense that has struggled to produce points during the losing streak. LSU had 129 yards rushing and 332 yards passing, but more importantly didn’t turn the ball over for the first time in three games en route to the victory Up next Vanderbilt: Hosts Tennessee on Saturday. LSU: Hosts Oklahoma on Saturday. ___ Get alerts on the latest AP Top 25 poll throughout the season. Sign up here

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Palo Alto Networks ( NASDAQ: PANW ) reported a beat and raise during its q1’25 earnings on November 20, 2024, resulting in relatively mixed price action, dropping -5% post-earnings before recovering the following day. Guidance for eq2’25 and eFY25 came in Analyst’s Disclosure: I/we have a beneficial long position in the shares of CRWD either through stock ownership, options, or other derivatives. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article. Seeking Alpha's Disclosure: Past performance is no guarantee of future results. No recommendation or advice is being given as to whether any investment is suitable for a particular investor. Any views or opinions expressed above may not reflect those of Seeking Alpha as a whole. Seeking Alpha is not a licensed securities dealer, broker or US investment adviser or investment bank. Our analysts are third party authors that include both professional investors and individual investors who may not be licensed or certified by any institute or regulatory body.NBA hand out suspensions after fracas in Phoenix5 Of The Worst F1 Cars In History

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NEW YORK (AP) — U.S. stock indexes drifted lower Tuesday in the runup to the highlight of the week for the market, the latest update on inflation that’s coming on Wednesday. The S&P 500 dipped 0.3%, a day after pulling back from its latest all-time high . They’re the first back-to-back losses for the index in nearly a month, as momentum slows following a big rally that has it on track for one of its best years of the millennium . The Dow Jones Industrial Average fell 154 points, or 0.3%, and the Nasdaq composite slipped 0.3%. Tech titan Oracle dragged on the market and sank 6.7% after reporting growth for the latest quarter that fell just short of analysts’ expectations. It was one of the heaviest weights on the S&P 500, even though CEO Safra Catz said the company saw record demand related to artificial-intelligence technology for its cloud infrastructure business, which trains generative AI models. AI has been a big source of growth that’s helped many companies’ stock prices skyrocket. Oracle’s stock had already leaped more than 80% for the year coming into Tuesday, which raised the bar of expectations for its profit report. In the bond market, Treasury yields ticked higher ahead of Wednesday’s report on the inflation that U.S. consumers are feeling. Economists expect it to show similar increases as the month before. Wednesday’s update and a report on Thursday about inflation at the wholesale level will be the final big pieces of data the Federal Reserve will get before its meeting next week, where many investors expect the year’s third cut to interest rates . The Fed has been easing its main interest rate from a two-decade high since September to take pressure off the slowing jobs market, after bringing inflation nearly down to its 2% target. Lower rates would help give support to the economy, but they could also provide more fuel for inflation. Expectations for a series of cuts through next year have been a big reason the S&P 500 has set so many records this year. Trading in the options market suggests traders aren’t expecting a very big move for U.S. stocks following Wednesday’s report, according to strategists at Barclays. But a reading far off expectations in either direction could quickly change that. The yield on the 10-year Treasury rose to 4.22% from 4.20% late Monday. Even though the Fed has been cutting its main interest rate, mortgage rates have been more stubborn to stay high and have been volatile since the autumn. That has hampered the housing industry, and homebuilder Toll Brothers’ stock fell 6.9% even though it delivered profit and revenue for the latest quarter that topped analysts’ expectations. CEO Douglas Yearley Jr. said the luxury builder has been seeing strong demand since the start of its fiscal year six weeks ago, an encouraging signal as it approaches the beginning of the spring selling season in mid-January. Elsewhere on Wall Street, Alaska Air Group soared 13.2% after raising its forecast for profit in the current quarter. The airline said demand for flying around the holidays has been stronger than expected. It also approved a plan to buy back up to $1 billion of its stock, along with new service from Seattle to Tokyo and Seoul . Boeing climbed 4.5% after saying it’s resuming production of its bestselling plane , the 737 Max, for the first time since 33,000 workers began a seven-week strike that ended in early November. Vail Resorts rose 2.5% after the ski resort operator reported a smaller first-quarter loss than analysts expected in what is traditionally its worst quarter. All told, the S&P 500 fell 17.94 points to 6,034.91. The Dow dipped 154.10 to 44,247.83, and the Nasdaq composite slipped 49.45 to 19,687.24. In stock markets abroad, indexes were mixed in China after the world’s second-largest economy said its exports rose by less than expected in November. Stocks rose 0.6% in Shanghai but fell 0.5% in Hong Kong. Indexes fell across much of Europe ahead of a meeting this week by the European Central Bank, where the widespread expectation is for another cut in interest rates. AP Business Writers Matt Ott and Elaine Kurtenbach contributed.Cornelious Brown IV throws 5 TD passes to lead Alabama A&M past Mississippi Valley State 49-35