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2025-01-26
Rishi Sunak sought bigger role before D-Day debacle(All times Eastern) Schedule subject to change and/or blackouts Friday, Dec. 20 COLLEGE BASKETBALL (MEN’S) 4 p.m. ESPNU — Chris Paul HBCU Challenge: Norfolk St. vs. Grambling St., Uncasville, Conn. 6:30 p.m. ESPNU — Chris Paul HBCU Challenge: Delaware St. vs. Alabama St., Uncasville, Conn. 8 p.m. FOX — St. John’s at Providence 8:30 p.m. ESPNU — Cincinnati vs. Dayton, Cincinnati COLLEGE BASKETBALL (WOMEN’S) 8:30 p.m. FS1 — Ohio St. vs. Stanford, San Francisco 11 p.m. FS1 — Creighton vs. UCLA, San Francisco COLLEGE FOOTBALL Noon ESPN — The StaffDNA Cure Bowl: Ohio vs. Jacksonville St., Orlando, Fla. 3:30 p.m. ESPN2 — The Union Home Mortgage Gasparilla Bowl: Tulane vs. Florida, Tampa, Fla. 8:10 p.m. ABC — CFP First Round: Indiana at Notre Dame ESPN — CFP First Round: Indiana at Notre Dame ESPN2 — CFP First Round: Indiana at Notre Dame (Command Center) GOLF 3:30 a.m. GOLF — DP World Tour: The AfrAsia Bank Mauritius Open, Second Round, Mont Choisy Le Golf, Grand-Baie, Mauritius Noon GOLF — PGA Tour: The PNC Championship Pro-Am, Ritz-Carlton Golf Club, Orlando, Fla. 4 a.m. (Saturday) GOLF — DP World Tour: The AfrAsia Bank Mauritius Open, Third Round, Mont Choisy Le Golf, Grand-Baie, Mauritius HORSE RACING 3 p.m. FS2 — NYRA: America’s Day at the Races NBA BASKETBALL 7:30 p.m. NBATV — Milwaukee at Cleveland NBA G-LEAGUE BASKETBALL 11 a.m. ESPNU — Winter Showcase: Texas vs. Motor City, Orlando, Fla. 1 p.m. NBATV — Winter Showcase: San Diego vs. Long Island, Orlando, Fla. 1:30 p.m. ESPNU — Winter Showcase: Mexico City vs. Rip City, Orlando, Fla. 3:30 p.m. NBATV — Winter Showcase: Cleveland vs. Salt Lake, Orlando, Fla. 4 p.m. ESPNEWS — Winter Showcase: Delaware vs. Santa Cruz, Orlando, Fla. TENNIS 6 a.m. TENNIS — Next Gen ATP Finals: Round Robin 11 a.m. TENNIS — Next Gen ATP Finals: Round Robin The Associated Press created this story using technology provided by Data Skrive TV listings provided by LiveSportsOnTV .fortune ox link

SAN FRANCISCO (AP) — Northern California was under a rare and brief tsunami warning alert Thursday that tested local emergency notification systems after a 7.0 magnitude earthquake shook part of the state. The National Weather Service canceled its alert after roughly an hour and before the tsunami was expected to arrive. In that hour, some cities and counties ordered evacuations while others relied on social media and text messages to inform people of the warning. Some people headed for higher ground, while others drove to the beach to get a better view. Javascript is required for you to be able to read premium content. Please enable it in your browser settings.



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Vikings thrive under coach of year favorite O'Connell, a relatable state for Packers with LaFleur

NFL Christmas Day Games on Netflix Drew 65M US Viewers; Sets League Streaming Record30 Nov 2024 Counting underway in Ireland election Paraic O'Brien Foreign Affairs Correspondent In Ireland, the two large centre right parties, Fianna Fáil and Fine Gael, look set to return to power after Friday’s election, but may well need to form a coalition with at least one junior party to win a majority. Both parties have ruled out a coalition with Sinn Fein. Share on Facebook Share Share on Twitter Tweet Share on WhatsApp Send Share on WhatsApp Send Share on WhatsApp Email Load more share options"Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua. Ut enim ad minim veniam, quis nostrud exercitation ullamco laboris nisi ut aliquip ex ea commodo consequat. Duis aute irure dolor in reprehenderit in voluptate velit esse cillum dolore eu fugiat nulla pariatur. Excepteur sint occaecat cupidatat non proident, sunt in culpa qui officia deserunt mollit anim id est laborum." Section 1.10.32 of "de Finibus Bonorum et Malorum", written by Cicero in 45 BC "Sed ut perspiciatis unde omnis iste natus error sit voluptatem accusantium doloremque laudantium, totam rem aperiam, eaque ipsa quae ab illo inventore veritatis et quasi architecto beatae vitae dicta sunt explicabo. Nemo enim ipsam voluptatem quia voluptas sit aspernatur aut odit aut fugit, sed quia consequuntur magni dolores eos qui ratione voluptatem sequi nesciunt. Neque porro quisquam est, qui dolorem ipsum quia dolor sit amet, consectetur, adipisci velit, sed quia non numquam eius modi tempora incidunt ut labore et dolore magnam aliquam quaerat voluptatem. Ut enim ad minima veniam, quis nostrum exercitationem ullam corporis suscipit laboriosam, nisi ut aliquid ex ea commodi consequatur? Quis autem vel eum iure reprehenderit qui in ea voluptate velit esse quam nihil molestiae consequatur, vel illum qui dolorem eum fugiat quo voluptas nulla pariatur?" 1914 translation by H. Rackham "But I must explain to you how all this mistaken idea of denouncing pleasure and praising pain was born and I will give you a complete account of the system, and expound the actual teachings of the great explorer of the truth, the master-builder of human happiness. No one rejects, dislikes, or avoids pleasure itself, because it is pleasure, but because those who do not know how to pursue pleasure rationally encounter consequences that are extremely painful. Nor again is there anyone who loves or pursues or desires to obtain pain of itself, because it is pain, but because occasionally circumstances occur in which toil and pain can procure him some great pleasure. To take a trivial example, which of us ever undertakes laborious physical exercise, except to obtain some advantage from it? But who has any right to find fault with a man who chooses to enjoy a pleasure that has no annoying consequences, or one who avoids a pain that produces no resultant pleasure?" 1914 translation by H. Rackham "But I must explain to you how all this mistaken idea of denouncing pleasure and praising pain was born and I will give you a complete account of the system, and expound the actual teachings of the great explorer of the truth, the master-builder of human happiness. No one rejects, dislikes, or avoids pleasure itself, because it is pleasure, but because those who do not know how to pursue pleasure rationally encounter consequences that are extremely painful. Nor again is there anyone who loves or pursues or desires to obtain pain of itself, because it is pain, but because occasionally circumstances occur in which toil and pain can procure him some great pleasure. To take a trivial example, which of us ever undertakes laborious physical exercise, except to obtain some advantage from it? But who has any right to find fault with a man who chooses to enjoy a pleasure that has no annoying consequences, or one who avoids a pain that produces no resultant pleasure?" Thanks for your interest in Kalkine Media's content! To continue reading, please log in to your account or create your free account with us.

Srinagar: National Conference president Farooq Abdullah welcomed on Saturday the ceasefire deal between Israel and Lebanon, hailing it as a beacon of hope for peace and the preservation of lives in West Asia. Applauding the de-escalation of tensions between Israel and Lebanon, he called upon the global community to step in and aid Lebanon in its reconstruction and relief efforts, the party said in a statement. The NC president urged the world powers to swiftly mobilise international efforts to broker a deal and put an end to the even more devastating and brutal conflict in Gaza, the statement said.

GCC Summit: Strengthening ties amid multiple regional challengesACM Research Comments on Updated U.S. Export Restrictions

Protests in the streets, turmoil at City Hall, corruption trials galore, historically bad baseball and a massive influx of buzzing arthropods unlike any seen since the 1800s. No wonder so many Chicagoans sought peace at the sidewalk altar of a once-airborne rodent that imprinted itself into a slab of concrete — and into the city’s heart. In a year that had the national spotlight squared on Chicago, the Sun-Times saw it all. Here’s how we’ll remember 2024. Chicago shines for DNC Even Chicago’s famously mercurial weather cooperated through all four days of the Democratic National Convention , which went off without a hitch despite weeks of intraparty uncertainty heading into the spectacle. Mayor Brandon Johnson earned high marks for shepherding a smooth week for thousands of delegates and media from around the world, while Chicago Police Supt. Larry Snelling enjoyed rave reviews for keeping a reasonable lid on massive protests that mostly focused on the war in Gaza. The made-for-TV pep rally took on heightened excitement following President Joe Biden’s late withdrawal from the race, while some local flair was injected into the national conversation. The party’s new nominee, Vice President Kamala Harris, vetted Gov. JB Pritzker as her potential running mate . Pritzker fell short of the ticket and Harris fell short of the White House, leaving Democrats scratching their heads — just like some local business owners, who felt left out of the convention’s much ballyhooed economic boost . Brandon Johnson’s sophomore slump The DNC provided a rare highlight for the first-term mayor, who could warrant his own top-10 list for bad news cycles in 2024. Fault lines started showing early in the year when voters rejected Johnson’s Bring Chicago Home referendum, nixing higher taxes on expensive real estate transactions — money that would have been used to help shelter the city’s unhoused population — and delivering the first major roadblock to his progressive agenda. Johnson saw his City Council support erode as he moved to shut down the city’s controversial ShotSpotter gunshot detection system, and again when he had to defend elevating a top aide with “a history of calling the police “f---ing pigs.” A revolving door on the fifth floor of City Hall included Johnson’s firing of a longtime confidant and spokesman accused of sexual harassment and antisemitism. And don’t forget Johnson’s pick for school board president who lasted all of one week before a troubling history of social media posts — inexplicably missed by Johnson’s office during the hiring process — led to a swift ouster . The political chaos came to a crescendo late in the year as an emboldened Council, by a stunning 50-0 vote, shot down the $300 million property tax hike Johnson had included in his proposed 2025 budget — breaking a campaign promise not to raise them. After a series of budget concessions, Johnson scrapped any property tax hike to win Council approval for a budget that relies heavily on one-time revenues and nickel-and-dime fee increases. Meanwhile, Johnson worked for months to force Chicago Public Schools CEO Pedro Martinez out of his post , installing an entire school board that voted Dec. 21 to fire him — before the city’s first-ever elected board members had a chance to weigh in. The move raised fresh questions about the overwhelming influence of the Chicago Teachers Union. Preparing for Trump’s return Donald Trump’s resounding victory to retake the White House put officials on notice in Democratic-dominated Illinois, where the Republican president-elect saw a marginal uptick in voter support . Advocates for Illinois’ thousands of undocumented residents braced for the wave of legal questions raised by Trump’s promise of mass deportations, as the incoming administration’s border czar declared Chicago ground zero immigration enforcement raids. The city’s LGBTQ community grappled with similar concerns about the effect of a second Trump term on marriage and parental rights , while health care providers prepared for Illinois to take on an even greater role as the Midwest’s main island of abortion rights . Officials also raced to lock up key federal transit funding for an extension of the CTA Red Line, the type of assistance from Washington that Democrats say Trump may be keen on withholding from the city that has served as his preferred political punching bag. Landmark corruption cases One multi-generational poster boy of Chicago politics saw his federal corruption case come to a head while the fate of another hung in the balance to close out 2024. Ed Burke reported to a downstate prison to begin serving his two-year sentence for racketeering, bribery and attempted extortion convictions , tied to the longtime 14th Ward alderman’s strong-arming of developers to hire his private law firm. Mike Madigan spent weeks in a courtroom listening to federal prosecutors map out his sprawling web of influence as speaker of the Illinois House for jurors who will soon be tasked with deciding if Madigan wielded it to squeeze companies for payments to his political cronies. Natural wonders Cicadas and tornadoes and geomagnetic storms, oh my! Mother Nature kept things interesting for Chicagoans with the first dual-emergence of periodical broods of cicadas in more than 200 years, inundating some parts of the area with the very noisy , mostly harmless and debatably tasty insects. They crawled out of the ground shortly after the latest solar eclipse bedazzled the Midwest, drawing thousands of people to the path of totality that just narrowly missed the city. Some of the freshly unearthed cicadas were still around for the first in a series of rare aurora borealis displays powered by intense solar storms, igniting the northern lights over Lake Michigan even downtown. But the natural marvels weren’t all friendly. Thirty-one Chicago-area tornadoes in July set a new record as more frequent bouts of heavy rain and flooding provided a sobering reminder of the looming impacts of climate change. Up-and-down year for CPD It was a mixed bag for Snelling in his first full year at the helm of the Chicago Police Department. Overseeing a seamless DNC earned the freshman superintendent a growing drumbeat of support from Council members across the political spectrum, especially with his department on pace for fewer than 600 homicides , the lowest yearly toll since before the COVID-19 pandemic. But the killing of 26-year-old Dexter Reed in a hail of 96 bullets during a traffic stop raised new questions about the use of force in the ranks, and a federal monitor last month reminded officials that the department is far behind in its long-running reform effort, reaching full compliance with just 9% of the steps laid out in a consent decree . Domestic violence questions Horrific murder cases put officials’ handling of domestic violence under the microscope, highlighting issues that advocates say have persisted for decades. After 11-year-old Jayden Perkins was killed while defending his mother from an ex-boyfriend who’d been released on parole a day earlier, Gov. Pritzker pushed out two Illinois Prisoner Review Board members and tried to bolster that panel’s domestic violence training . Dozens of elected officials have joined a chorus calling for the reassignment of the Cook County judge who could’ve detained a man before he allegedly killed his wife, Lacramioara Beldie , in Portage Park. Advocates say there has been a spike in such attacks in the past year , increasing the lawmakers’ urgency to pass long-stalled legislation that would require law enforcement to promptly remove firearms while serving orders of protection. Ebb in new arrivals of asylum seekers The influx of thousands of migrants from the southern border that once overwhelmed the city’s social safety net slowed to a trickle under tighter Biden administration deportation policies, ending months of acrimony over city spending that highlighted racial divides in Chicago. Concerns over Texas Gov. Greg Abbott sending busloads of migrants to Chicago to embarrass the city during the DNC never materialized. By year’s end the city had closed its migrant landing zone completely as it merged shelter systems for newly arrived asylum seekers and homeless people who have long lived on Chicago’s streets and in its alleys, parks and viaducts. Chicago teams struggle inside and outside the stadium White Sox owner Jerry Reinsdorf threw his hat in the public financing ring with a splashy pitch for a new South Loop ballpark , but got shut out by state lawmakers who have rejected giving a dime to either them or the Bears — who rolled out their own renderings of a shiny new lakeside dome . That sent the McCaskeys back to the drawing board to consider the old Michael Reese Hospital site, or Arlington Heights, where the team finally reached a property tax deal with local school districts that could grease their suburban wheels. Neither team helped make their case on the field, either, with a pitiful Sox lineup recording the worst season in modern Major League Baseball history and the Bears firing a coach midseason for the first time while squandering what was supposed to be a competitive rookie season for quarterback Caleb Williams , who was drafted first overall in April. Rat hole Rat hole ( noun ) — rodent-shaped imprint on a Roscoe Village sidewalk that drew hordes of curious onlookers for several months in 2024 to the glee of Chicago social media users and chagrin of neighborhood residents. The latest entry into the Chicago lexicon was inscribed in January when photos of the four-legged sidewalk stamp — which some argue was actually left by a squirrel — went viral online, drawing tourists to the 1900 block of West Roscoe with offerings of coins, and prompting at least one couple to tie the knot . The city removed (but preserved) the pseudo-sacred sidewalk in April at the request of nearby residents none too pleased with round-the-clock foot traffic. What’s next for the rat hole? We’ll see in 2025. Other major 2024 stories CTA President Dorval Carter ’s seat got hotter as head of a transit agency beset by long wait times, understaffing and looming budget crises. The city mourned Chicago police officers Luis Huesca and Enrique Martinez , killed on duty in separate shootings. Tipped workers saw their minimum base wages increase en route to eventual parity with the standard minimum wage, in a win for Mayor Johnson and his progressive allies and a loss for restaurant owners . Plans moved forward to transform the long-vacant U.S. Steel South Works into a sprawling quantum computing campus as Illinois positions itself as the Silicon Valley of the nascent technology. Hackers stole the personal data of more than 800,000 people in a cyberattack on the Lurie Children’s Hospital network, causing months of headaches for patients and their families. Chicago rap star Lil Durk was charged in a California murder-for-hire plot. The Illinois Supreme Court overturned actor Jussie Smollett ’s conviction for staging a hate crime, sparing him five months’ jail time. And Dolton Mayor Tiffany Henyard’s south suburban media circus played on, with federal investigators circling her push for no-bid contracts to a construction company linked to multiple corruption investigations, among other questionable spending.

Trump Team Weighs Creating First-Ever ‘Crypto Czar’

Liverpool boss Arne Slot reveals true feelings about Pep Guardiola in six-word messageOpinion editor’s note: Strib Voices publishes a mix of commentary online and in print each day. To contribute, click here . ••• Republicans already wield the gavel in the House. Soon, the Senate will also be led by the GOP. And with incoming President-elect Donald Trump and six of nine justices on the Supreme Court selected by GOP presidents, by Inauguration Day the federal government will be under full Republican control. But full control might not necessarily mean in control, as recently evidenced by brinkmanship budget negotiations between Capitol Hill and Mar-a-Lago (the current White House occupant, President Joe Biden, played a minor role in the melodrama that almost led to a meltdown). While the government did not shut down, Democrats were depended on for the third and final vote, taken just hours before the deadline, demonstrating the differences between governing and campaigning — something that veteran leaders like Trump, House Majority Leader Mike Johnson, and incoming Senate Majority Leader John Thune should already know. But knowledge and wisdom are distinct. And Trump’s instinct for chaos instead of cohesion soon took precedence over presidential leadership. He scuttled earlier versions of the bill by trashing it on Truth Social, which he owns, and allowing Elon Musk, whose early emergence as the most prominent presidential influencer is already problematic, to trash it (often with immediately identifiable inaccuracies) on X, the social network he owns. A president-elect taking such a leading role in a congressional debate before taking office is clearly “unusual,” said Kathryn Pearson , a University of Minnesota associate professor of political science. Regarding Musk, “What’s happening now is unprecedented and alarming, because of course Musk was not elected by the voters.” The intervention did not serve Trump, Congress or, most profoundly, the country. And the worst may be yet to come. “A faction within the Republican Party is going to make governing difficult for a Republican speaker, even in the context of unified party control,” said Pearson. “It’s going to be particularly challenging on budget issues; tax cuts will be easier for Republicans than passing appropriation bills, continuing resolutions and increasing the debt limit.” And yet the very same tax cuts are likely to deepen the deficit and hasten the need to raise the debt ceiling yet again, something that about three dozen Republican representatives refused to do despite Trump’s popularity and public prodding. Don’t look for Democrats to rescue Republicans again. Which means that Johnson’s already tenuous, albeit tenacious, hold on the House may not last. Previous Speakers Kevin McCarthy, Paul Ryan and John Boehner were similarly squeezed, Pearson said, adding that while “the Republican Party is Trump’s party to a much greater extent than it was the first time he was elected,” that “still doesn’t mean that they were willing to vote with a bipartisan coalition to pass a continuing resolution.” Accordingly, what’s needed politically and fiscally isn’t just a continuing resolution but resolve to arrive at a permanent solution. One was proposed in the previous Congress: Establishing a bipartisan, bicameral commission on fiscal reform and responsibility. Unfortunately, the Fiscal Commission Act of 2023 languished in the House, just as the Fiscal Stability Act of 2023 did in the Senate. Both were based on previous successful models, including the mid-1980s Greenspan Commission tasked to stabilize Social Security, the Base Realignment and Closure (BRAC) Commission in 2005 to right-size resources in the Defense Department, and even the ill-fated but well-intentioned National Commission on Fiscal Responsibility and Reforms, known as Simpson-Bowles, in 2010. Congress may not be ready. But the people they represent just might be, according to a recently released poll from the nonpartisan Peterson Foundation , whose mission is “to increase public awareness of the nature and urgency of the key fiscal challenges threatening America’s future and to accelerate action on them.” Using both a Republican and Democratic polling firm, the foundation found that 55% of voters “oppose extending expiring provisions of the Tax Cuts and Jobs Act (TCJA) if it would add to the debt.” That majority jumps to 64% after respondents heard that “borrowing for tax cuts could contribute to higher inflation.” Other poll data demonstrate more public resolve than is commonly considered, including 92% of Republicans and 86% of Democrats urging Trump and Congress “to begin addressing the $36 trillion and rising national debt in the first 100 days of the new administration.” For his part, Trump seemed more focused on the current administration, writing amid the wrangling that “If there is going to be a shutdown of government, let it begin now, under the Biden administration, not after January 20th, under ‘TRUMP.’ This is a Biden problem to solve, but if Republicans can help solve it, they will!” Actually, and ultimately, the debt, which was created under Democratic and Republican governance, is an American problem to solve. And while Democrats can and should play a constructive role, Republicans will soon have a complete governing majority. In other words, the gavel — which is shaped like a hammer, a tool that can be used to build or destroy. Now is the time to use that gavel to end the fiscal and political destruction and instead build an enduring solution to America’s unsustainable debt.Fox News royalty Sean Hannity and Ainsley Earhardt celebrate Christmas with engagement at their home church

Incumbent centre-right in ‘driving seat’ in Irish vote

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knows there are tons of questions about his future with the . He might get traded, he might leave as a free agent next summer, he might exercise a $52.4 million option to return to the Heat, or he might get a new contract. "Who knows?" Butler asked. The Heat forward, who has led the team to a pair of NBA Finals trips in his Miami tenure, said Wednesday that he doesn't mind his name being in the rumor mill. The Heat are open to listening to offers for Butler and making a deal if the proposal is right, earlier this week. That wouldn't be surprising, given Butler's contract status and the possibility that he might leave with the Heat getting nothing in return next summer. "I actually like it," said Butler, who is averaging 19 points per game this season. "It's good to be talked about. I don't think there's such a thing as bad publicity -- to a point." The Heat could have offered an extension last summer and chose not to, presumably for a variety of reasons including Butler's age -- he's 35 -- and the fact that he missed 26% of Miami's games over his first five seasons with the team. He still clearly impacts winning: Miami is 8-2 this season when he scores at least 18 points. And the Heat aren't new to trade speculation; has been the centerpiece of rumors in each of the past three summers. Butler said Wednesday that money doesn't really matter to him at this point, adding that he's not fixated on extensions or trades. "My kids matter, my happiness matters, my well-being matters and my family matters," Butler said. "Right now, it's all about competing, staying healthy, playing some great basketball. I think I've done that so far, so we'll see what we got." He stopped short of saying that he wants to absolutely remain in Miami. "I'm pretty sure y'all are going to get a report that's going to say otherwise anyways, so there's no sense in me answering that question," Butler said. It has been social media fodder for a few days, with some even suggesting that Butler's hair dye in recent weeks -- sometimes yellow, sometimes blue, sometimes red -- has matched the teams some of the trade speculation links him to like , and . That said, he has insisted since arriving in Miami that he wants to bring the team another championship. That stance has not changed. "We're going to continue to win and I'm proud of the guys," Butler said. "You see everybody out here working and we know what we're capable of."( MENAFN - ACN NewsWire) Hua medicine Announces Successful U.S. Phase I Results on Its 2nd Generation GKA Candidate SHANGHAI, Nov 30, 2024 - (ACN Newswire) - Hua Medicine (the“Company”, HKEx stock code: 2552) announced today that the Company has successfully completed a Phase I clinical trial on its 2nd generation GKA candidate in U.S. at the 9th China BioMed Innovation and investment conference (CBIIC). The Phase Ia clinical trial of the second-generation GKA (HM-002-1005) was conducted in the United States in 40 subjects with Type 2 diabetes (T2D). This trial was randomized, double-blind, placebo-controlled, single-dose, focusing on safety, tolerability, and pharmacokinetics. The second-generation GKA is a novel molecular entity with optimized physicochemical properties, holding new patents, and serving as the prodrug of dorzagliatin (HMS5552). This study designed for once-daily oral administration. Its aim is to extend the drug's action duration in the body through sustained-release technology, enhance patient compliance, and prolong the stimulation of GLP-1 secretion in the intestines. The Single Ascending Dose (SAD) study demonstrates that HM-002-1005 tablets can be rapidly converted to HMS5552 in the human body, with minimal exposure level of prodrug in both blood and urine. The t1/2 (biological half-life) after a single dose of HM-002-1005 tablets was prolonged compared to dorzagliatin tablets. The Cmax of HMS5552 in plasma after a 184.5mg single dose is comparable to the plasma concentration of HMS5552 after a 75mg single dose of dorzagliatin tablet; likewise, the daily AUC of HMS5552 in plasma after a single dose of HM-002-1005 tablets is comparable to the exposure level of HMS5552 after a 75mg BID dose of dorzagliatin tablets. The research indicates that HM-002-1005 tablets are near-completely converted to HMS5552 in human, and its pharmacokinetic characteristics support for once-daily oral administration. The development of HM-002-1005 tablets not only contributes to enhancing patient medication adherence and effectively control blood glucose levels within 24 hours; meanwhile, it also offers the opportunity to explore the Maximum Tolerated Dose above 150mg daily to achieve better efficacy. The 75 mg BID dose regiment was developed under the concept of Minimum Therapeutic Effective Dose in Chinese T2D patients who suffered from an impairment of insulin secretion and significant reduction of early phase insulin. The different disease characters of T2D with obesity in western patient population would benefit dorzagliatin from its effects on GLP-1 secretion and improvement of insulin sensitivity. With the confirmation that the exposure level of HM-002-1005 tablets at 184.5mg is comparable to dorzagliatin tablets at 75mg (BID), we will further optimize the dosage form followed by a Multiple Ascending Dose (MAD) clinical development of the 2nd generation GKA in China and the United States. Dr. Li CHEN, founder and CEO of Hua Medicine, stated,“Hua Medicine has always been committed to treating Type 2 diabetes at its root cause by restoring patients' ability to autonomously regulate blood glucose levels. Over the course of a decade, the Company has selected dosing and clinical research protocols that are safe and effective for the majority of Chinese diabetes patients, leading to the successful development of GKA and the clinical application of dorzagliatin. Building on this foundation, the Company will undergo a strategic upgrade by further exploring the therapeutic potential of GKA, enriching its product pipeline and seeking partners both domestically and internationally, in order to benefit a broader range of patients, expand into global markets, and effectively establish the brand identity of GKA medications while maximizing the commercial potential of our global first-in-class drugs.” About Hua Medicine Hua Medicine (The“Company”) is an innovative drug development and commercialization company based in Shanghai, China, with companies in the United States and Hong Kong. Hua Medicine focuses on developing novel therapies for patients with unmet medical needs worldwide. Based on global resources, Hua Medicine teams up with global high-calibre people to develop breakthrough technologies and products, which contribute to innovation in diabetes care. Hua Medicine's cornerstone product HuaTangNing (Dorzagliatin tablets), targets the glucose sensor glucokinase, restores glucose sensitivity in T2D patients, and stabilizes imbalances in blood glucose levels in patients. HuaTangNing was approved by the National Medical Products Administration (NMPA) of China on September 30th, 2022. It can be used alone or in combination with metformin for adult T2D patients. For patients with chronic kidney disease (CKD), no dose adjustment is required. It is an oral hypoglycemic drug that can be used for patients with Type 2 diabetes with renal function impairment. For more information Hua Medicine Website: Investors E-mail: ... Media E-mail: ... MENAFN30112024002725003249ID1108941842 Legal Disclaimer: MENAFN provides the information “as is” without warranty of any kind. We do not accept any responsibility or liability for the accuracy, content, images, videos, licenses, completeness, legality, or reliability of the information contained in this article. If you have any complaints or copyright issues related to this article, kindly contact the provider above.

Short Sellers Lose $1.4 Billion as Super Micro Computer (SMCI) Stock Rises 53% - TipRanksWhat to know about Northern California's rare tsunami warningCord cutting used to refer to abandoning pay TV and putting up an antenna to watch free over-the-air TV.

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