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2025-01-24
LOS ANGELES — Until he sustained a season-ending knee injury last week in the Western Conference final, Galaxy playmaker Riqui Puig was having a tremendous season. So I heard. I watched Puig play only twice this year, once in the Galaxy's season-opening 1-1 draw with Inter Miami and a second time in his team's Fourth of July defeat to LAFC at the Rose Bowl. Outside of short highlight clips on social media, I never saw the former Barcelona prospect, not even when he assisted on the goal that sent the Galaxy to the MLS Cup final. That wasn't a reflection of my interest. Some of my friends will make fun of me for publicly admitting this, but I like Major League Soccer. I covered the league in my first job out of college and have casually kept up with it since. I take my children to a couple of games a year. My 11-year-old son owns Galaxy and LAFC hats but no Dodgers or Lakers merchandise. When flipping through channels in the past, if presented with the choice of, say, college football or MLS, I usually watched MLS. But not this year. While the MLS Cup final between the Galaxy and New York Red Bulls will be shown on Fox and Fox Deportes, the majority of games are now exclusively behind a paywall, courtesy of the league's broadcasting deal with Apple. MLS Season Pass subscriptions were reasonably priced — $79 for the entire season for Apple TV+ subscribers, $99 for non-subscribers — but I was already paying for DirecTV Stream, Netflix, Amazon Prime, PlayStation Plus and who knows what else. MLS became a casualty in my household, as well as in many others, and the possibility of being out of sight and out of mind should be a concern for a league that is looking to expand its audience. Which isn't to say the league made a mistake. This was a gamble MLS had to take. Now in the second year of a 10-year, $2.5 billion deal with Apple, MLS did what Major League Baseball is talking about doing, which is to centralize its broadcasting rights and sell them to a digital platform. Regional sports networks have been decimated by cord cutting, making traditional economic models unsustainable. The move to Apple not only increased the league's broadcast revenues — previous deals with ESPN, Fox and Univision were worth a combined $90 million annually, according to multiple reports — but also introduced a measure of uniformity in the league. The quality of the broadcasts are better than they were under regional sports networks. Viewers know where to watch games and when, as every one of them is on Season Pass and most of them are scheduled to start at 7:30 p.m. local time either on Wednesday or Saturday. "That's been fueling our growth and driving our fan engagement," MLS Commissioner Don Garber said Friday at his annual state of the league address. Apple and MLS declined to reveal the number of League Pass subscribers, but the league provided polling figures that indicated 94% of viewers offered positive or neutral reviews of League Pass. The average viewing time for a game is about 65 minutes for a 90-minute game, according to Garber. In other words, the League Pass is well-liked — by the people who have it. The challenge now is to increase that audience. The launch of League Pass last year coincided with the arrival of Lionel Messi, which presumably resulted in a wave of subscriptions. But the league can't count on the appearance of the next Messi; there is only one of him. MLS pointed to how its fans watch sports on streaming devices or recorded television than any other U.S. sports league, as well as how 71% of its fans are under the age of 45. The league also pointed to how it effectively drew more viewers to the Apple broadcast of Inter Miami's postseason opener with a livestream of a "Messi Cam' on TikTok, indicating further collaborations with wide-reaching entities could be in its future. Garber mentioned how Season Pass is available in other countries. The commissioner also made note of how Apple places games every week in front of its paywall. "What we have, really, is a communication problem," Garber said. "This is new, and we've got to work with Apple, we've got to work with our clubs and we've got to work with our partners to get more exposure to what we think is a great product." The greatest benefit to the league could be Apple's vested interest in improving the on-field product. MLS insiders said Apple has not only encouraged teams to sign more high-profile players but also pushed the league to switch to a fall-to-spring calendar more commonplace in other parts of the world, reasoning that doing so would simplify the process of buying and selling players. The on-field product is what matters. The on-field product is why MLS continues to face competition for viewers from overseas leagues. The on-field product is why the league hasn't succeeded in converting every soccer fan into a MLS fan. And ultimately, if casual viewers such as myself are to pay to watch the Galaxy or LAFC on a screen of some kind, the on-field product will be why. ©2024 Los Angeles Times. Visit latimes.com . Distributed by Tribune Content Agency, LLC.Trump's casting call as he builds out his administration: TV experience preferredharga spring bed ocean magical

Onex Corporation Announces Variation of Price Range and Extension of Its Previously Announced Substantial Issuer BidFORT LAUDERDALE, Fla. (AP) — President-elect Donald Trump promised on Tuesday to “vigorously pursue” capital punishment after President Joe Biden commuted the sentences of most people on federal death row partly to stop Trump from pushing forward their executions. Trump criticized Biden’s decision on Monday to change the sentences of 37 of the 40 condemned people to life in prison without parole, arguing that it was senseless and insulted the families of their victims. Biden said converting their punishments to life imprisonment was consistent with the moratorium imposed on federal executions in cases other than terrorism and hate-motivated mass murder. “Joe Biden just commuted the Death Sentence on 37 of the worst killers in our Country,” he wrote on his social media site. “When you hear the acts of each, you won’t believe that he did this. Makes no sense. Relatives and friends are further devastated. They can’t believe this is happening!” Presidents historically have no involvement in dictating or recommending the punishments that federal prosecutors seek for defendants in criminal cases, though Trump has long sought more direct control over the Justice Department's operations. The president-elect wrote that he would direct the department to pursue the death penalty “as soon as I am inaugurated,” but was vague on what specific actions he may take and said they would be in cases of “violent rapists, murderers, and monsters.” He highlighted the cases of two men who were on federal death row for slaying a woman and a girl, had admitted to killing more and had their sentences commuted by Biden. On the campaign trail, Trump often called for expanding the federal death penalty — including for those who kill police officers, those convicted of drug and human trafficking, and migrants who kill U.S. citizens. “Trump has been fairly consistent in wanting to sort of say that he thinks the death penalty is an important tool and he wants to use it,” said Douglas Berman, an expert on sentencing at Ohio State University’s law school. “But whether practically any of that can happen, either under existing law or other laws, is a heavy lift.” Berman said Trump’s statement at this point seems to be just a response to Biden’s commutation. “I’m inclined to think it’s still in sort of more the rhetoric phase. Just, ‘don’t worry. The new sheriff is coming. I like the death penalty,’” he said. Most Americans have historically supported the death penalty for people convicted of murder, according to decades of annual polling by Gallup, but support has declined over the past few decades. About half of Americans were in favor in an October poll, while roughly 7 in 10 Americans backed capital punishment for murderers in 2007. Before Biden's commutation, there were 40 federal death row inmates compared with more than 2,000 who have been sentenced to death by states. “The reality is all of these crimes are typically handled by the states,” Berman said. A question is whether the Trump administration would try to take over some state murder cases, such as those related to drug trafficking or smuggling. He could also attempt to take cases from states that have abolished the death penalty. Berman said Trump's statement, along with some recent actions by states, may present an effort to get the Supreme Court to reconsider a precedent that considers the death penalty disproportionate punishment for rape. “That would literally take decades to unfold. It’s not something that is going to happen overnight,” Berman said. Before one of Trump's rallies on Aug. 20, his prepared remarks released to the media said he would announce he would ask for the death penalty for child rapists and child traffickers. But Trump never delivered the line. One of the men Trump highlighted on Tuesday was ex-Marine Jorge Avila Torrez, who was sentenced to death for killing a sailor in Virginia and later pleaded guilty to the fatal stabbing of an 8-year-old and a 9-year-old girl in a suburban Chicago park several years before. The other man, Thomas Steven Sanders, was sentenced to death for the kidnapping and slaying of a 12-year-old girl in Louisiana, days after shooting the girl's mother in a wildlife park in Arizona. Court records show he admitted to both killings. Some families of victims expressed anger with Biden's decision, but the president had faced pressure from advocacy groups urging him to make it more difficult for Trump to increase the use of capital punishment for federal inmates. The ACLU and the U.S. Conference of Catholic Bishops were some of the groups that applauded the decision. Biden left three federal inmates to face execution. They are Dylann Roof, who carried out the 2015 racist slayings of nine Black members of Mother Emanuel AME Church in Charleston, South Carolina; 2013 Boston Marathon bomber Dzhokhar Tsarnaev ; and Robert Bowers, who fatally shot 11 congregants at Pittsburgh’s Tree of Life Synagogue in 2018 , the deadliest antisemitic attack in U.S history. _______ Associated Press writers Jill Colvin, Michelle L. Price and Eric Tucker contributed to this report.With Syrian rebels edging ever-closer to the capital, President Bashar Assad is making a last-ditch attempt to remain in power, including indirect diplomatic overtures to the U.S. and President-elect Donald Trump, according to people with direct knowledge of the situation. Assad is ordering his army to fall back to defend Damascus, essentially ceding much of the country to insurgents, who seized the major cities of Aleppo and Hama in a lightning offensive over the past week. They’re now on the outskirts of Homs, less than 100 miles to the north. As his remaining troops dig in, Syria’s longtime ruler is signaling his willingness to reach a deal that would allow him to hold on to the rump territory his army controls, or guarantee his safe passage into exile if needed, said the people. They spoke on condition of anonymity to discuss secret meetings. One offer Assad made to the U.S. via the United Arab Emirates is for Syria to cut all involvement with Iran-backed militant groups, such as Hezbollah, if Western powers wield influence to stem the fighting, the people said. Another initiative saw Assad dispatch a senior Christian leader to meet Hungarian Prime Minister Viktor Orban to relay what he sees as an existential threat to Syria’s Christian minority if Islamist rebels prevail, according to other people familiar with the plan. The intention was that Orban, a Trump ally, would convey this danger to the incoming U.S. president, they said. Trump, who finds himself in Paris, has responded to events on the ground. He took to X to say: “There was never much of a benefit in Syria for Russia, other than to make Obama look really stupid. In any event, Syria is a mess, but is not our friend, & THE UNITED STATES SHOULD HAVE NOTHING TO DO WITH IT. THIS IS NOT OUR FIGHT. LET IT PLAY OUT. DO NOT GET INVOLVED!” It’s a dramatic turn of events for a dynasty that’s ruled Syria with an iron fist for half a century, crushed peaceful protests in 2011 and clung to power through years of civil war that spurred one of the worst humanitarian crises of modern times. Iranian and Russian military support was crucial to the survival of the 59-year-old president, but both are now distracted and stretched thin by other conflicts. “Assad is in huge danger — it’s almost like in 2015 when the insurgents were at the gates of Damascus,” said Sergei Markov, a political consultant close to the Kremlin, referring to the year Russia intervened to save him. Western nations were equally surprised, including the US, which had largely relinquished much of its influence in Syria to Iran, Russia and Turkey but has reacted to protect its interests, according to senior officials. Multiple Western officials said it was difficult to see Assad remaining in power. The fall of Homs, Syria’s third-largest city, could cut the highway linking Damascus and the country’s west and Mediterranean coast — the stronghold of the Assads and loyalists from their Alawite sect. South of Damascus, rebels have seized parts of Daraa province bordering Jordan and in the capital residents of some districts took to the streets and tore down billboards of Assad. In one area people destroyed a statue of Assad’s father Hafez. The president’s whereabouts are unclear, although he’s believed to be in Damascus or his hometown of Qardaha, close to Russia’s Khmeimim air base. It’s also possible he’s in the Iranian capital, Tehran, a person familiar with U.S. policy said Saturday. Assad’s office issued a statement condemning “rumors and fake news,” saying the president remains in the capital. Assad has ordered the bulk of Syria’s remaining army — estimated at between 30,000 to 40,000 fighters — to rush to defend Damascus, according to two people familiar with the matter. An army spokesman said in a TV address on Saturday that it was strengthening its defenses in the countryside around the city. The main rebel offensive has been led by Hayat Tahrir al-Sham, or HTS, a former al-Qaida affiliate, and various armed groups backed by Turkey. Other fighters have joined in, including army defectors who’d fought the regime and laid down arms in previous ceasefires, said the people. As rebels converge on Damascus from the north and south, Iran has drawn back its presence in Syria, leaving its military advisers concentrated around the capital, according to the people. Some Tehran-backed Iraqi militias have also returned to their country after the government ceded the eastern city of Deir Ezzor to U.S.-backed Kurdish fighters, they said. Russian personnel now remain mainly around the capital and at the Khmeimim air base and Tartous naval base, they said. After a meeting with his Iranian and Turkish counterparts in Doha on Saturday, Russian Foreign Minister Sergei Lavrov said Moscow is “trying to do everything not to allow terrorists to prevail.” “We don’t want them to follow the fate of Iraqis, Libyans and other nations who were disturbed by the people desiring to keep their domination,” he said. Trump said Saturday a withdrawal from Syria might “be the best thing that can happen” to Russia and that troops shouldn’t get involved in the fighting. Back channels Russia has launched airstrikes around Homs to try and stall the rebel advance. But with signs the Kremlin’s help may not be enough, Assad is pressing on with back-channel negotiations. A key goal would be retaining control of a portion of the country and addressing Turkey’s demands for a political transition and the potential return of millions of Syrian refugees, a major issue for Ankara. Assad is also proposing a new constitution and talks with the mostly exiled political opposition, according to the people familiar with the outreach. It’s unclear if the efforts will bear fruit. Events on the battlefield have their own momentum, and even countries such as Turkey that have influence over the rebels may not be able to fully control events. “I don’t think any of these outside powers have the leverage over their proxies to change the course of what is happening on the ground,” said Andreas Krieg, director of London-based MENA Analytica Ltd. “At this moment most bets are that the Assad regime may not be able to hold out.” Patriarch visit It was against that backdrop that Assad sent Syriac Orthodox Patriarch Ignatius Aphrem II to Hungary on Monday to relay his fears. Syria’s Christian community makes up about 10% of the country’s 24 million population. The plan to have Orban relate this message to Trump was described by an aide to the patriarch and another person with knowledge of the encounter. People close to Trump couldn’t immediately comment, but said he had dispatched his in-law and Middle East adviser, Massad Boulos, to the UAE on Saturday to discuss the situation in the region. Assad has pursued similar tactics before. HTS leader Abu Mohammed al-Golani and other rebels have in recent days attempted to allay the fears of Christians and Syria’s other minorities that they envision a form of Islamic rule. Assad’s own Alawite community, which has stuck by him since 2011 and paid a heavy price to defend the regime, also appears to sense the end may be near. Nariman, an Alawite woman reached by phone in Damascus on Friday said she, her husband who’s in the security forces and their 23-year-old son were fleeing to their ancestral village near Jableh in western Syria. She said there were many families like hers. Nobody is going to fight for Assad this time, she said, asking not to be identified by her last name for reasons of safety. ©2024 Bloomberg L.P. Visit bloomberg.com. Distributed by Tribune Content Agency, LLC.

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Vanguard Total International Bond ETF (NASDAQ:BNDX) Shares Acquired by Thrivent Financial for LutheransMENLO PARK, Calif. , Dec. 5, 2024 /PRNewswire/ -- The Meta Platforms, Inc. (Nasdaq: META) board of directors today declared a quarterly cash dividend of $0.50 per share of the company's outstanding Class A common stock and Class B common stock, payable on December 27, 2024 to stockholders of record as of the close of business on December 16, 2024 . Contacts Investors: Kenneth Dorell investor@meta.com / investor.fb.com Press: Ryan Moore press@meta.com / about.fb.com/news/ View original content to download multimedia: https://www.prnewswire.com/news-releases/meta-announces-quarterly-cash-dividend-302324358.html SOURCE Meta

Miami of Ohio and Colorado State will try to overcome notable transfer-portal defections during Saturday's Arizona Bowl at Tucson, Ariz. Miami (8-5) enters the game without its top two wide receivers Javon Tracy and Reggie Virgil after the duo elected to play elsewhere. Tracy, a redshirt sophomore who caught 57 passes for 818 yards with seven touchdowns, is moving on to Minnesota. Virgil, a junior who tallied 816 yards on 41 receptions with nine touchdowns, is bound for Texas Tech. "It's kind of insane, to be honest," Miami coach Chuck Martin said. "We'll lose some real good kids in the portal, but we'll also gain some good ones. It's just crazy. "In some ways, it stinks, but in some ways, it's fun, too. We're looking at a lot of some good ones." Miami has also lost two cornerbacks, including sophomore Raion Strader to Auburn. Strader had 53 tackles with two interceptions and a team-best 17 passes broken up. Will Jados, a redshirt junior offensive tackle who started 38 games for Miami, is transferring to Texas Tech. Colorado State (8-4) also lost its two top receivers in the portal. Sophomore Caleb Goodie committed to Cincinnati and sophomore Jamari Person remains undecided. Goodie caught 21 passes for 436 yards with four touchdowns, and Person had 36 receptions for 386 yards and a touchdown. Another sophomore, linebacker Buom Jock, also is in the transfer portal after he led the Rams with 100 tackles. "They lost a couple receivers in the portal, just like us, so they've adjusted, just like most teams in the bowl season have adjusted to the team that they have available," Colorado State coach Jay Norvell said. Redshirt sophomore Armani Winfield, who had 37 catches for 338 yards and two touchdowns, is the top available receiver for the Rams. Miami's leading receiver entering the game is fifth-year senior Cade McDonald (49 catches for 606 yards and three touchdowns). Miami won seven straight games before losing to Ohio in the MAC championship game behind sixth-year quarterback Brett Gabbert, who has completed 57.6 percent of his passes (204 of 354) for 2,737 yards and 21 touchdowns. Gabbert has been prone to throw interceptions, with 11, including one against Ohio in the conference title game. He did not throw an interception in a 30-20 victory over Ohio earlier this season. Keyon Mozee is Miami's featured running back with 1,073 yards on 170 carries with four touchdowns. Matt Salopek, a sixth-year linebacker, leads Miami with 113 tackles. He is the first player in program history with four 100-tackle seasons. Colorado State won six of its last seven games -- committing only seven turnovers in that span. Senior running back Avery Morrow has 956 yards on 166 attempts with nine touchdowns. Brayden Fowler-Nicolosi, a redshirt sophomore, has thrown for 2,475 yards while completing 207 of 335 attempts (61.8 percent) with 13 touchdowns and seven interceptions. Chase Wilson, a fifth-year senior linebacker, has 91 tackles this season, three for loss. --Field Level MediaAnge Postecoglou says he understands the frustration of Tottenham 's travelling supporters following an altercation with fans following the 1-0 defeat at Bournemouth on Thursday. The Spurs head coach approached the away end after the final whistle and appeared to exchange angry words with supporters in the front rows. "They’re disappointed and rightly so and they gave me some direct feedback, which is taken on board," Postecoglou said. Asked about the direct feedback, he said: “Probably not for here. "I didn’t like what was being said because I’m a human being but you’ve got to cop it. "I’ve been around long enough to know when things don’t go well you’ve got to understand the frustration and disappointment. And they’re rightly disappointed because we let a game of football get away from us. But that’s OK. I’m OK with all that. “All I can say is I’m really disappointed and I’m determined to get it right and will keep fighting until we do.” Dean Huijsen, 19, headed home the game's only goal from a corner on 17 minutes, ghosting in unmarked at the back post after Destiny Udogie misjudged the flight of the ball. Bournemouth were much the better side for the rest of the match, with Spurs' stand-in goalkeeper Fraser Forster making a string of saves and the Cherries missing several chances. Postecoglou felt his depleted side "shot themselves in the foot" after a bright start and says they must "get a real grip" on their season ahead of Sunday's crunch visit of rivals Chelsea. "It is not good enough," Postecoglou said. "We again fell into the trap of starting the game really well, we were in control and then we conceded a really poor goal. "Then we kind of lost our way a little bit and allowed Bournemouth to play the game that they wanted to. We had our moments in the second half but we could not get a goal. "I don't know if they had more urgency but we have this sort of propensity to shoot ourselves in the foot when we should be controlling games. "They are hard to beat here and what you should not do is give them a goal that gives them the momentum they need. "We started to play with a bit more conviction at the beginning of the second half and made some good chances. Again we made things difficult for ourselves by allowing the opposition to take the game in the direction that they want. "They are all big games coming up. We have to get ourselves out of the space we are in at the minute where we can't get a real grip on the season."

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Black California students want more support. A new law names colleges that serve them bestSyrian insurgents reach the capital's suburbs. Worried residents flee and stock up on suppliesEven with access to blockbuster obesity drugs, some people don't lose weight

Trump invited China's Xi to his inauguration even as he threatened massive tariffs on BeijingCARSON, Calif. — The LA Galaxy finished 26th in the 29-team Major League Soccer standings just one season ago, and their biggest supporters boycotted certain matches to protest a decade of poor performance. The most successful club in league history seemed light years away from its luminous prime. When the Galaxy raised the MLS Cup again Saturday amid confetti and fireworks, their spectacular transformation was complete. In only one year, a team that was profoundly lost had rediscovered its peerless championship pedigree. "We won this trophy, and it's finally back where it belongs," striker Dejan Joveljic said. Joseph Paintsil and Joveljic scored in the first half, and the Galaxy won their record sixth MLS Cup championship with a 2-1 victory over the New York Red Bulls. After striking twice in the first 13 minutes of the final, the Galaxy nursed their lead through a scoreless second half to raise their league's biggest trophy for the first time since 2014. MLS' most successful franchise struggled through most of the ensuing years, but everything changed after LA spent smartly in the offseason to build a high-scoring new lineup topped by Paintsil, Joveljic and Gabriel Pec. The Galaxy finished second in the Western Conference and streaked through the postseason with an MLS playoff-record 18 goals in five games to win another crown. "I'm just so proud of this group after the challenges that we (had) and the way they bounced back and competed as a group," Galaxy coach Greg Vanney said. "We spent a lot of energy at the start, but I'm just so proud of these guys. They've cemented themselves as legends in this club." The Galaxy even won this title without perhaps their most important player. Riqui Puig, the playmaking midfielder from Barcelona who ran their offense impressively all season long, tore a ligament in his knee last week in the conference final. Puig watched this game in a suit, but the Catalan catalyst's teammates hadn't forgotten him: After his replacement, Gastón Brugman, set up LA's opening goal with a superb pass in the ninth minute, Paintsil held up Puig's jersey to their roaring fans during the celebration. "I was really waiting for this moment," said Paintsil, who scored his 14th goal of an impressive season. "I'm much more, 10 times faster than them, and Gaston saw the space. ... It was really a good thing. We did it for Riqui, and we did it for our family that came, and our supporters." Just four minutes later, Joveljic sprinted past four New York defenders and chipped home his 21st goal. Brugman was named the MLS Cup MVP after a commanding performance in midfield. The Uruguayan hadn't started a match for the Galaxy since Oct. 5 after an injury-slowed season, playing only as a postseason substitute before the final. "I dreamed of that yesterday, of something I could give to the team," Brugman said of his pass to Paintsil. "Today, it happened." Sean Nealis scored for the seventh-seeded Red Bulls, whose improbable postseason charge ended one win shy of their first Cup championship. With the league's youngest roster, New York fell just short of becoming the lowest-seeded team to win the tournament under first-year German coach Sandro Schwarz. "I love these guys," Schwarz said. "Some guys, they are crying. In the big picture, that's a start. Sometimes when you lose the final, it's tough, but you use this experience to create the next energy, the next intensity." Galaxy goalkeeper John McCarthy made four saves to win his second MLS title in three seasons, but Nealis beat the 2022 MLS Cup MVP in the 28th minute when he volleyed from the penalty area. The second half was lively: Red Bulls captain Emil Forsberg hit the outside of the post in the 72nd minute, while Pec and Galaxy substitute Marco Reus nearly converted chances a few moments later. The ball got loose in the Galaxy's penalty area in the third minute of extra time, but two Red Bulls couldn't finish. After Galaxy owner Phil Anschutz received the MLS Cup that bears his name because of his steady financial support of the league during its shaky years, Galaxy captain Maya Yoshida carried the trophy to his teammates for the celebration. The Galaxy extended their lead over DC United (4) for the most MLS Cup championships in league history. The Red Bulls remain one of three original MLS franchises never to win the title, along with FC Dallas and the New England Revolution. The Galaxy finished 17-0-3 this season at their frequently renamed suburban stadium, where the sellout crowd of 26,812 for the final included several robust cheering sections of Red Bulls supporters hoping to see their New Jersey-based club's breakthrough. But this season was about the Galaxy's rebirth. The club famous for employing global stars from David Beckham and Zlatan Ibrahimovic to Robbie Keane and Javier "Chicharito" Hernández swiftly turned itself into a contender again by acquiring young talents without international fame. The Galaxy signed Pec from Brazil and grabbed Paintsil, a Ghanaian playing in Belgium. The duo combined with Joveljic to form a potent attack with orchestration from Puig, one of MLS' best players. "Losing a guy like Riqui after the performance he put in all season was devastating," McCarthy said. "Even if he wasn't on the field, we did it for him." Get local news delivered to your inbox!

Unlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.” The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group. The AP is solely responsible for all content.Arizona WR Tetairoa McMillan declares for 2025 draft

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