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Even with technology taking over much of our day-to-day lives, board games still offer quality entertainment that can’t be beaten. Of course, the popular board games of today are a far cry from the games your parents grew up playing. are perfect for encouraging your family to work together or for bringing your group of friends around the table for an evening. If you’d like to start up a weekly game night, let this helpful list of the most popular board games be your guide. This game will have every player rolling in stitches with each ridiculous phrase that’s uttered. Combine crazy accents and hilarious phrases to impress the Nonsense Judge and win the round. The player with the highest number of wins ultimately wins the game, but the true fun of this card game is listening to your fellow players trying to say some of the most entertaining phrases of all time. This game is perfect for game nights or parties. This hilarious game is perfect if you have teenagers or are hosting a party with all adults. To play, you insert a mouthpiece that alters the sound of your speech, making every word sound silly. Set the timer and read one of the phrases on the cards and try to help your teammate guess what you’re saying. Speak Out easily provides hours of fun that even grandparents will love. What’s the next best thing to trying to break out of a room? Escape Room in a Box, of course. This thrilling, immersive game involves solving 2D and 3D puzzles in order to prevent a mad scientist from turning you and your friends or family into werewolves. Work together to escape your fate and use Amazon Alexa to enhance the experience. This fun strategy game is perfect for anyone with teenagers. Form two teams and select a spymaster on each team. Using clues, spymasters try to help their teammates find all 25 of the agents they’re in contact with, hopefully without selecting the other team’s agents or running into the deadly assassin. This innovative game offers a challenging and rewarding time working together. Excite your kids on game night with this modern twist on a classic. Play as six recognizable Hogwarts characters — Harry, Hermione, Ron, Luna, Ginny or Neville — to solve the mystery behind a fellow student’s disappearance. It’s up to you to figure out who attacked the student, what bewitching spell they used and where it occurred. Watch out for the Dark Mark, moving staircases and secret passages as you travel along in this magical family game. If you’ve ever wanted to save humanity from a deadly outbreak, you’ll love spending an hour playing Pandemic. You and your teammates must fight to contain four deadly diseases threatening the human race. Players must learn to work with their teammates to control outbreak hotspots and treat diseases. Win the game by curing all diseases without wiping out humanity first. This tactical 60-minute game will push your imagination to its limits as you embark on a journey across Catan. Acquire crucial resources as you travel, build roads, buildings, and cities, and be wary of the ruthless robber and other players halting you on your own road. Through careful trading and clever decisions, you can lead your travelers to victory in this role-playing game of limitless possibilities. Play again and again. Every game is different. Train lovers will enjoy this innovative board game which has won numerous awards. This cross-country train adventure game mimics the concept of traveling around the world in 80 days. Collect train cars and claim railways across the country. Players earn the most points by establishing long train routes and connecting distant cities. Each game takes roughly 30 to 40 minutes to complete, and every adventure is different. This quick-paced game gives each player five seconds to name items on a certain topic. Although the topics are objectively easy —“Name 3 Mountains,” “Name 3 Types of Hats” or “Name 3 Super Heroes,” the pressure of the time crunch is likely to put you on edge. Race the clock and remain composed to win this game. You can even make up your own topics if you prefer. Half the fun is just hearing what other people blurt out, whether it’s relevant to the topic or not.Now, Sacramento State is leading similar charges statewide. For one, the university is hosting the Cal State system’s new Office for the Advancement of Black Student Success , which oversees efforts to better serve Black students throughout the Cal State system. Secondly, on a wider scope, this office will soon manage a special designation for California colleges and universities that demonstrate a strong dedication to their Black students. A new law taking effect Jan. 1, enacted as SB 1348 , creates the first official Black-Serving Institution designation in the country. The designation will be given to qualifying colleges that vow to take a more aggressive approach to address California’s systemic obstacles that have kept Black students at the lowest college-going and graduation rates. Though it’s not stated in the law explicitly, the intent is that both public and private nonprofit institutions are allowed to apply, according to the office of Democratic state Sen. Steven Bradford of Inglewood , who authored the law. This designation is not federally recognized nor will campuses receive federal funding. Besides meeting other student support requirements, the designation is only available to institutions that have a Black student enrollment of at least 10%. For campuses that can’t meet the 10% threshold, they must have at least 1,500 students who are Black. Students like Phillips find comfort in these numbers. “I feel like it pushes me further, just seeing a lot of motivated people, our colors, trying to (succeed) in college,” Phillips said. This is not the reality for most Black college students who find themselves a minority in the majority of California classrooms. California colleges and universities educate over 217,000 Black college students in a pool of over 3.4 million. California’s Black students trail behind their peers academically. Two-thirds of the state’s Black students start at community colleges yet only 35% transfer to a four-year university within six years, compared to 45% for white students, according to an independent study using California Community Colleges data. Cal States lag in graduating their Black students at 49% within six years compared to 62% overall , according to U.S. Department of Education data. At the UCs, where Black enrollment is the lowest, 78% of Black students graduate in six years but are still 8 percentage points behind the general population. Bradford finds those statistics “concerning,” further noting that Black undergraduate enrollment nationwide has declined 25% between 2010 and 2020 . Bradford hopes this new law will reverse the enrollment decline by recognizing colleges that are “accepting and open and there to support African American students.” In California, no colleges or universities meet either of the two primary federal designations for serving Black students: Predominantly Black Institutions, which must have at least a 40% Black student population, and Historically Black Colleges and Universities, which apply to schools established before 1964 with a primary mission to educate Black students. How campuses will qualify as Black-Serving Institutions The Office of Black Excellence will oversee the applications from campuses seeking the Black-Serving Institution designation. Designees will be selected by a governing board consisting of the lieutenant governor, the chair of the California Legislative Black Caucus, two members of the public, and college and university officials representing public and private, nonprofit higher education institutions. To qualify for the designation, schools must have established programs dedicated to Black student success, a yet-to-be-determined track record with Black retention and graduation rates, and a five-year plan to boost those rates. Bradford’s office says the governing board will clarify ambiguities in the law regarding application requirements and determine the logistics once it convenes in January. The law does not outline the requirements for two-year nonprofit private institutions applying to the designation nor does it stipulate a deadline for when the first Black-Serving Institution will be recognized. The law is also unclear about which student enrollment data, self-reported or federal, schools will use to show eligibility and whether they can include both undergraduate and graduate students. Self-reported data introduces the potential for inconsistency in how the board vets the institutions — in some cases the numbers nearly double. For example, the UC system indicates that 4.5% of its undergraduate students are Black. However, according to federal Department of Education data, that number is just 2.3%. According to 2022 federal counts of undergraduates and graduate students, 60 California colleges and universities meet one or both of the student population requirements to be a Black-Serving Institution. Of those schools, 32 are private nonprofits, 24 are community colleges, three are Cal States, and only one is a UC — UCLA with 3.6%, or 1,681, Black students. However, according to UC’s self-reported data in 2022, two of the 10 UCs reported more than 1,500 Black students. That number jumped to four in 2023. This is because the UC system counts a person of mixed race as a single race based on a hierarchy that places the highest priority on Black students. UC data rules state that a student who self-identifies as Black and any other group will be reported in UC’s system as Black. Meanwhile, federal data counts mixed-race students in a separate “two or more” category. The Cal State and community college systems also publish internal demographic numbers that vary somewhat from federal data. Unlike the UC, these systems use a category of two or more racial groups. Private, nonprofit institutions operate independently, making it difficult to assess each college’s internal methodology. Some California campuses are already dedicated to Black student success A few campuses that have confronted inequities served as the blueprint for the new Black-Serving Institution designation. Keith Curry, president of Compton College, and Luke Wood, president of Sacramento State, worked closely with Bradford’s office to conceptualize the law. Both presidents say they recognize the limitations imposed by Proposition 209 , passed in 1996 to ban race-based admissions and education programs, and emphasize that their programs focus on minority students but are open to everyone. In 2022, Curry proclaimed Compton College a Black-Serving Institution, encouraging educational leaders to serve Black students “unapologetically” in an Op-Ed for Diverse magazine. Located south of Los Angeles, Compton College has 1,204 Black students, a quarter of its population. Curry said he harnesses the power of culture to boost student interest with events such as Black Welcome and Black Graduation. This past spring, rapper Kendrick Lamar spoke at graduation, creating some social buzz. In 2021, Compton College created a new leadership role, director of Black and Males of Color Success. In the role, Antonio Banks connects students to tutoring services, basic needs resources, and specialized programming. He also oversees the Men’s Leadership Academy, which hosts weekly events dedicated to community building, such as the recent “Babyboy: Building Emotional Intelligence to Combat Toxic Masculinity.” Banks said they focus on fostering community and “helping students become advocates, both in their own fight for education, (and) the fight for others.” Curry believes his Black-centered approach is already working. During the 2023-24 academic year, returning Black full-time equivalent students increased 34.6% from the previous year, according to Compton’s data. Banks says it will take one to three years to fully reveal the impact of their programs on graduation rates. In the Cal State system, Wood has been a leading advocate in supporting Black students. A 2023 report by the chancellor’s Black Student Success Workgroup acknowledged the university system’s failure to produce equal outcomes for its Black students. The report made recommendations to all Cal State universities, including recruiting faculty with a high record of success in serving their Black students, implementing inclusive curriculum, and establishing a Black Resource Center on every campus. Much of what the report entails, Sacramento State has already established. Sacramento State hosts over a dozen groups and resources dedicated to supporting Black and marginalized students. “We’re trying to create an experience outside of the classroom that celebrates Black history, life and culture in a way that you would only see at an institution that is a HBCU,” Wood said. An example is the Black Honors College, which focuses entirely on Black academia and culture. Select students receive specialized staffing and resources for seminars, coursework, therapy, research opportunities, housing, and more. The university has also started establishing pipelines with some community colleges with large Black student populations, including Merritt College in Oakland and Compton College. Business major Phillips attended predominantly white grade schools in Tracy, California. One of the reasons he chose Sacramento State was the community it has built for Black students. He said initiatives like the Black Honors College have special impact on “kids who are very strong in academics, but may not have that home life that really supports them, or for kids who have a lot of capability, potential and talent, but (are not) being promoted or pushed through all the way to see that full potential.” Wood says their efforts have already helped in recruiting and graduating Black students. Applications overall were up by around 4,000 this fall, with a 17% increase for enrolled Black freshmen and a 40% increase among Black community college transfers. Four-year graduation rates for Black students rose to 1 in 4 graduating in 2024, compared to 1 in 5 in 2019 . Students have mixed feelings about campus support Universities that pursue the new Black-Serving Institution designation seek to attract students like Nora Thompson, who is studying administration of justice at Merritt College and has always wanted the HBCU experience. Merritt serves a 20.4% Black student population. Thompson has plans to transfer to North Carolina Central University, an HBCU, in the spring. She dreams of becoming a judge like her grandfather. “I had to work 30 times harder to be seen as a student and as someone who cared about their education,” Thompson said. “For most people, their HBCU changes their life ... I wanted to experience feeling like being part of a community in every possible way, not just education wise.” She lamented having to leave the state — and pay out-of-state tuition — just to experience a flourishing Black academic setting. Thompson says that even with the Black-Serving designation, California’s Black student populations are not enough to keep her here. Further north in a more remote area of the state, junior journalism major and Black Student Union president at Cal Poly Humboldt, Kaylon Coleman, is not satisfied with his experience at the university — from the subtle racism by his classmates to the few opportunities to learn from Black scholars. Cal Poly Humboldt is a predominantly white institution. Federal data as of 2022 shows that of the 6,025 students enrolled, only 179 were Black — far below the minimum to qualify as a Black-Serving Institution. As a freshman, Coleman was told by counselors that the Black Student Union had a history of disbanding due to low Black student enrollment. He turned to the Umoja Center for Pan African Student Excellence, the university’s cultural center for those who are Black identifying or of African descent. A friend of Coleman’s revived the union, and he joined. Like many students attending universities with small Black populations, Coleman said it’s exhausting to speak up about the behavior of those around him. “It’s hard to be that one person — Black person — in your class, or the one to explain why this was a microaggression, or why this was racist, or why you can’t touch my hair, stuff like that,” Coleman said. Coleman feels that students attending schools without the Black-Serving Institution title will be left behind. He believes that Black students at every California college deserve to reap the benefits that would come with the label. Kyira Todmia, a senior in neurobiology, physiology, and behavior at UC Davis, shared a slightly different experience. In 2022, federal data reported Davis had 783 Black students, representing 2% of over 39,000 students total. However, it self-reports 1,472 Black students, or 3.7% of the population. She says that while her school may not have a large Black student population, the student resources are strong. Todmia built her social circle around the African American “learning community” in student housing as a freshman. She also hangs out at the Center for African Diaspora, where students have access to study spaces, tutors, peer advisors and events. During Todmia’s four years at Davis, she’s only had one Black professor. Because few Black students are in STEM majors, at times she is the only Black student in classes of 300 to 500 people. At least in her learning community, she said, she was able to see rooms full of Black folks every day — even if they weren’t in most of her classes. For Sen. Bradford, now 64, the new law is personal. Bradford reflected on his own experience as a biology student at Cal State Dominguez Hills in the 1980s. For a campus that earns the Black-Serving Institution designation, Bradford said, “It’s going to be an environment that’s going to be welcoming, that’s going to be supportive. I only wish that had existed when I entered college over 40 years ago.
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By WYATTE GRANTHAM-PHILIPS NEW YORK (AP) — A ransomware attack that hit a major software provider last week caused disruptions for a handful of companies over recent days, from Starbucks to U.K. grocery giant Morrisons. Blue Yonder, which provides supply chain technology to a range of brands worldwide, said that it experienced disruptions to services it manages for customers on Thursday, which the third-party software supplier determined to be “the result of a ransomware incident.” Some systems went offline, impacting clients using Blue Yonder’s software. A spokesperson for Starbucks, for example, said that the chain’s ability to manage barista schedules and track hours was disrupted — meaning store leaders across North America are currently being instructed to use manual workarounds. Starbucks maintained that the outage is not impacting how customers are served and that ensuring workers get paid for all hours worked is a top priority. While the company continues to work towards full recovery, the spokesperson added that Starbucks was able to process payroll again as of Tuesday morning. Two of the U.K.’s biggest grocers, Morrisons and Sainsbury’s, were also affected — with both telling CNN over the weekend that they had turned to contingency plans to keep operations flowing. A spokesperson for Morrisons confirmed to The Associated Press that the outage “impacted our warehouse management systems for fresh and produce” and that it was continuing to operate on back up systems Tuesday. Sainsbury’s, meanwhile, said Tuesday that its service was restored. Related Articles National News | Man found guilty of holding down teen while he was raped at a youth center in 1998 National News | What Black Friday’s history tells us about holiday shopping in 2024 National News | New rule allows HIV-positive organ transplants National News | Walmart becomes latest – and biggest – company to roll back its DEI policies National News | Today in History: November 26, Mumbai terror attacks of 2008 begin Blue Yonder declined to disclose how many of its customers were impacted by the hack. In a statement sent to the AP, a spokesperson maintained that it had notified “relevant customers” and would continue to communicate as needed. The spokesperson also maintained that recovery efforts were still underway — noting that Blue Yonder “has been working diligently together with external cybersecurity firms to make progress,” including the implementation of several defensive and forensic protocols. Blue Yonder’s website touts an extensive global roster of customers — including Gap, Ford and Walgreens. Walgreens and Gap were not impacted following the ransomware attack, spokespeople for the companies said. Ford shared that it was investigating whether the incident affected its operations earlier this week, but had no further updates when reached Tuesday. Blue Yonder, based in Arizona, is a subsidiary of Japan’s Panasonic Corp. Panasonic acquired the supply chain software firm in September 2021.The Harvest Christian Academy Eagles’ Paul Ray spared his first two frames, then rolled 10 consecutive strikes to set a new high school single-game record on Thursday at Central Lanes Bowling Center in Tamuning. Although the Guam Bowling High School League is just underway, Ray, who rolled a 279, has emerged as one of the league’s top bowlers. Despite Ray’s record-setting performance, the Eagles couldn’t clinch the win as the Okkodo High School Bulldogs upset the previously undefeated Eagles. (Daily Post Staff)
Rivalry Closes Non-Brokered Private Placement Of Approximately $2.0 MillionMUMBAI: A 53-year-old Andheri resident working in an insurance firm was duped of ₹ 5.70 crore in an online share trading cyber fraud. The professional has been transferring money from September in an app he was asked to download under the assumption that he was investing. A case was registered by cyber police on Saturday in connection with the matter. According to the police, the complainant works in an insurance firm. On September 12, he allegedly received a WhatsApp message from someone who went by Aman Malik. Malik offered guidance on stock market investment promising high returns. The victim expressed interest in this and received a call from an unknown person who claimed to be a representative of an investment firm. He then sent him a link to join a WhatsApp group which was named ‘Y21-VIP-WTIC World Top Investor Competition’, where Malik was the group admin. Malik sent messages in the group with tips and guides to invest. Other members of the group allegedly posted screenshots showing they received huge returns on their investments. Convinced by the screenshots and lured by high returns, the complainant decided to invest through the firm and downloaded an app from a link Malik sent. He transferred ₹ 5 lakh through the app and in two days, he saw a profit of ₹ 70 thousand and began trusting the app, said a police officer. From October 18 to November 8, he transferred a total ₹ 5.70 crore in over 20 transactions to the scammers. On November 11, when he tried to withdraw money, he was asked to pay more under the pretext of processing fee among others. He found this suspicious and contacted cyber helpline number. An FIR was registered in the West Cyber police station on Saturday and investigation is underway, said the officer.Burt, the huge Australian crocodile who had a cameo in ‘Crocodile Dundee,’ dies at 90
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Middle East latest: Israeli strikes kill a hospital director in Lebanon and wound 6 medics in GazaFor years, patients in the U.S. healthcare system have grown frustrated with a bureaucracy they don’t understand. Doctors are included in an insurer’s network one year but not the next. Getting someone on the phone to help can be next to impossible. Coverage of care and prescriptions is often unceremoniously denied. This week’s fatal shooting of UnitedHealthcare Chief Executive Brian Thompson has unleashed a wave of public feeling — exasperation, anger, resentment, helplessness — from Americans sharing personal stories of interactions with insurance companies , often seen as faceless corporate giants. In particular, the words written on ammunition found at the shooting scene — “delay,” “deny” and “depose,” echoing a phrase used to describe how insurers dodge claim payouts — amplified voices that have long been critical of the industry. “All of a sudden, I am fired up again,” said Tim Anderson, describing how his wife, Mary, had to deal with UnitedHealthcare coverage denials before she died from Lou Gehrig’s disease, or amyotrophic lateral sclerosis, in 2022. Anderson said they couldn’t get coverage for machines to help his wife breathe or talk — toward the end, she communicated by blinking when he showed her pictures. The family had to rely on donations from a local ALS group, he said. “The business model for insurance is don’t pay,” said Anderson, 67, of Centerville, Ohio. “When Mary could still talk, she said to me to keep fighting this,” he added. “It needs to be exposed.” For Anderson and others, Thompson’s death and the message left at the scene have created an opportunity to vent their frustrations. Conversations at dinner tables, office water coolers, social gatherings and on social media have pivoted to the topic, as police efforts to find the gunman keep the case in the news. Hans Maristela said he understands why the chatter is bubbling up. The 54-year-old caregiver in California was moved to comment on Facebook about UnitedHealthcare’s reputation of denying coverage. As a Catholic, he said, he grieves Thompson’s death and feels for his family, especially with the holidays around the corner. But he sees frustration with insurers even among his clients, most of them wealthy older people who’ve not been shielded from high out-of-pocket costs. “And then you know the CEO of this company you pay a lot of money to gets $10 million dollars a year, you won’t have a lot of sympathy for the guy,” Maristela said, citing Thompson’s compensation package that included base pay and stock options. “Healthcare is a business, I understand, but the obsession with share price, with profit, has to be reevaluated.” University of Pennsylvania researcher Michael Anne Kyle said she’s not surprised by the growth of conversation around insurers. “People are often struggling with this by themselves, and when you see someone else talk about it, that may prompt you to join the conversation,” she said. Kyle studies how patients access care and said she’s seen frustration with the system build for years. Costs are rising, and insurers are using more controls such as prior authorizations and doctor networks to manage them. Patients are often stuck in the middle of disputes between doctors and insurers. “Patients are already spending a lot of money on healthcare, and then they’re still facing problems with the service,” she said. Insurers often note that most of the money they bring in goes back out the door to pay claims, and that they try to corral soaring costs and the overuse of some care. In Ohio, Anderson said his initial reaction to the CEO shooting was to question whether it was connected to a coverage denial, like the ones he’d experienced with his wife. “I definitely do not condone killing people,” he said. “But I read it and said, ‘I wonder if somebody had a spouse whose coverage was denied.’ ” It’s something Will Flanary, a Portland, Ore.-based ophthalmologist and comedian with a large social media following, saw online a lot in the shooting’s immediate aftermath and found very telling. “It’s zero sympathy,” he said. “And the lesson to take away from that is not, ‘Let’s shame people for celebrating a murder.’ No, it’s: ‘Look at the amount of anger that people have toward this system that’s taken advantage of people and do something to try to fix that.’” Flanary’s content, published under the name Dr. Glaucomflecken, started out as niche eye doctor jokes and a way to cope with his own experiences with two cancer diagnoses and a sudden cardiac arrest. But it has evolved, featuring character skits that call attention to and satirize the decisions of large health insurers, including UnitedHealthcare. He said he’s never seen conversations around health insurance policy take off the way they did this week — and he hopes these new voices can help bring about change. “I’m always talking about how powerful social media can be with advocacy,” he said, “because it really is the only way to put a significant amount of pressure on these corporations who are doing bad things for patients.” Murphy and Shastri write for the Associated Press.Let me take you back to those halcyon days of December 1994, when footballers were still allowed to tackle, just, VAR wasn’t even a twinkle in an evil inventors eye, the offside rule was almost understandable and everyone knew what handball meant. East 17s Christmas Classic, Stay Another Day , was top of the charts in the UK, Dumb & Dumber had just been released in the cinemas, and a certain Eric Cantona was bestriding the Premier League like a colossus. It was also the last time Nottingham Forest won at Old Trafford, or least that was the case until a few hours ago when Manchester United’s fall hit another new low. So, let’s start with some painful home truths for the red half of the city, courtesy of owner Jim Ratcliffe. You know things are bad when a club’s owner is talking about making “difficult and unpopular” decisions, and describing their own team as mediocre. Even before his side’s 3-2 defeat at home to Forest, Jim Ratcliffe was telling fanzine United We Stand that the club “was not elite” and major change was needed to reverse that. Having only just arrived, manager Ruben Amorim can be fairly certain of his position, although whether the same can be said for goalkeeper Andre Onana and the rest of the United defence remains to be seen. Nikola Milenkovic, Morgan Gibbs-White and Chris Wood did the damage for the visitors, with Rasmus Hojlund and Bruno Fernandes scoring for the home side. Defeat left United 13th in the table, and their 19 points from 15 games is the team’s lowest tally at this stage of a season since 1986-87. Forest, in contrast, are up to fifth. Spotting a theme yet? We’ve gone from East 17 to Elvis, which would be a fun six degrees of separation to work out. Anyway, enough of the mournful musings of the king of rock 'n' roll, its time to focus on the suffering of the blue half of Manchester.
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November 22, 2024 This article has been reviewed according to Science X's editorial process and policies . Editors have highlightedthe following attributes while ensuring the content's credibility: fact-checked peer-reviewed publication trusted source proofread by Liu Jia, Chinese Academy of Sciences A research team led by Dr. Du Xuemin from the Shenzhen Institutes of Advanced Technology (SIAT) of the Chinese Academy of Sciences has reported a living interface with unique functionalities of durable secretion of bioactive exosomes with tunable contents and miRNA cargoes, effectively promoting neurovascular remodeling. The study was published in Matter on Nov. 21. Neurovascular remodeling is crucial for restoring normal functions of regenerated tissues or engineered organs, which requires multi-target and phase-specific paracrine regulation. However, existing strategies still cannot mimic such dynamic and complicated paracrine regulation effects in the native physiological processes, hindering synergistic neurovascular remodeling. Exosomes, as key entities in the native paracrine process, show great promise for neurovascular remodeling yet still face challenges. Direct exosome administration is limited by its short lifetime (24–48 hours). In addition, exosome delivery systems struggle with preserving bioactivity and maintaining adaptable miRNA cargoes throughout the entire release period, limiting their effectiveness at different stages of neurovascular remodeling. The proposed living interface in this study for fine-tuned exosome secretion (LIFES) consists of two core elements, a poly(vinylidene fluoride-co-trifluoro ethylene)-based intelligent material layer with rationally designed topographical structures and superior electric properties for cell modulation, and a living cell layer with rat bone marrow-derived mesenchymal stem cells (MSCs) for efficient biogenesis of exosomes. Through the synergistic interactions between the two core elements, LIFES can secrete bioactive exosomes in sustained (~192 hours) and phase-specific manners, with tunable contents (~8-fold increases) and programmable miRNA cargoes (initially pro-angiogenic and later pro-neurogenic). "The phase-specific exosome secretion of LIFES meets physiological requirements, which aligns with the native multi-target and multi-stage paracrine regulation effects observed in physiological neurovascular remodeling processes," said Dr. Du. By mimicking the natural paracrine regulation effects within the native physiological processes of neurovascular remodeling, LIFES effectively promotes the reconstituting of vascular neural networks, even in challenging diabetic wound models. The study will open new avenues for next-generation intelligent materials, revolutionizing biomedical devices, regenerative medicine , and brain-machine interfaces . More information: Mingxing Peng et al, A ferroelectric living interface for fine-tuned exosome secretion toward physiology-mimetic neurovascular remodeling, Matter (2024). DOI: 10.1016/j.matt.2024.10.019 Journal information: Matter Provided by Chinese Academy of SciencesFormer New Orleans priest convicted of raping teen boy dies while serving life sentenceNetflix series re-ignites JonBenet Ramsey case but gives no answers
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