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December 6, 2024 This article has been reviewed according to Science X's editorial process and policies . Editors have highlightedthe following attributes while ensuring the content's credibility: fact-checked peer-reviewed publication trusted source proofread by Kyushu University Researchers at Kyushu University have revealed how spatial distance between specific regions of DNA is linked to bursts of gene activity. Using advanced cell imaging techniques and computer modeling, the researchers showed that the folding and movement of DNA, as well as the accumulation of certain proteins, changes depending on whether a gene is active or inactive. The study, published on December 6 in Science Advances , sheds insight into the complicated world of gene expression and could lead to new therapeutic techniques for diseases caused by improper regulation of gene expression. Gene expression is a fundamental process that occurs within cells, with two main phases: transcription, where DNA is copied into RNA, and translation, where the RNA is used to make proteins. For each cell to carry out its specific functions in the body, or to respond to changing conditions, the right amount of a protein must be produced at the right time, meaning genes must be carefully switched on and off. Previously, gene transcription was thought to occur in a continuous, smooth process. But with better technology to observe individual cells , scientists now know that transcription occurs in short, unpredictable bursts. "A gene will randomly switch on for a few minutes and large amounts of RNA will be produced. Then, the gene will suddenly switch off again," says Professor Hiroshi Ochiai, from Kyushu University's Medical Institute of Bioregulation and the study's senior author. "It happens in nearly all genes, and in all living things, from plants, to animals, to bacteria." This erratic and dynamic nature of transcription, known as transcriptional bursting, is a key mechanism for controlling gene activity in individual cells. It's one reason why cells within the same tissue or culture environment show variability in their gene expression levels, which is crucial for processes like early embryonic development and cancer evolution. However, the exact mechanisms behind bursting remains unknown. In this study, the researchers decided to look into the role of DNA sequences known as enhancers and promoters, and how their spatial distance impacts transcriptional bursting. The promoter is usually located right next to the gene, and is where the protein that carries out transcription attaches to the DNA. Enhancers, on the other hand, are often many hundreds of thousands of bases away from the gene, but as DNA strands move and fold, enhancers can still end up close to genes in 3D space, amplifying gene activity. "We believe that enhancers play a crucial role in why transcription occurs in bursts of activity, but so far, the research is unclear," says Ochiai. To test this idea, Ochiai and his team used an advanced imaging technique called seq-DNA/RNA-IF-FISH, which labels DNA, RNA and specific proteins with fluorescent probes. This triple-layered technique allowed the researchers to simultaneously capture the location of DNA, RNA and specific proteins in 3D space within individual mouse embryonic stem cells. With that information, the team could determine whether certain genes were on or off, see how the promoters and enhancers were interacting during bursts of activity, and where the proteins were accumulating, at an unprecedented level of detail. As an example, the researchers focused on a gene called Nanog, a 770,000-base length of DNA on chromosome 6, which has a promoter and three enhancer regions and is known to undergo transcriptional bursting in cultured mouse embryonic stem cells. Discover the latest in science, tech, and space with over 100,000 subscribers who rely on Phys.org for daily insights. Sign up for our free newsletter and get updates on breakthroughs, innovations, and research that matter— daily or weekly . The researchers found that in imaged cells where Nanog RNA was present (meaning the gene was active), the most distant enhancer was located in close spatial proximity to the Nanog gene. In contrast, when Nanog was inactive, the imaging showed that the same enhancer region was physically further away. Additionally, the scientists also found that proteins involved in regulating transcription also accumulated in the area around the enhancers and promoters when Nanog was active. To better understand the mechanism, Ochiai and his team used computer modeling to simulate how the different parts of DNA interact and move inside the cell, both when the Nanog gene is active and inactive. They developed their model by using data from their imaging experiments to make a "map" of how frequently different regions of DNA interacted with each other and how the DNA was folded in space. Using this map, the model then simulated how the DNA chain might randomly move. The model predicted that when in the active state , each enhancer region interacted for more than twice as long with the promoters, compared to when the gene was inactive. The model showed that these longer periods of interaction occurred due to "friction" around the DNA. Due to the accumulation of proteins and RNA when Nanog was active, the fluid became more viscous, and caused the modeled DNA strand to move slowly. Therefore, the gene was able to stay active for longer bursts of time. In contrast, the simulated DNA moved quicker when Nanog was inactive, meaning that the promoter and enhancers didn't have time to interact. "The modeling suggests that bursting is stabilized due to these reinforcing loops," concludes Ochiai. "Of course, this is just a simulation. The next step is to prove this mechanism also occurs in cells." More information: Hiroaki Ohishi et al, Transcription-coupled changes in genomic region proximities during transcriptional bursting, Science Advances (2024). DOI: 10.1126/sciadv.adn0020 . www.science.org/doi/10.1126/sciadv.adn0020 Journal information: Science Advances Provided by Kyushu UniversityAtalanta tops Serie A after late win over AC Milan while Inter goes 13 games unbeaten
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LONG ISLAND -- A plan to regionalize some public school services in New York state has set off alarm bells among many parents and educators on Long Island who fear loss of control of their school districts. But state education officials say that's not the goal, nor the plan. At issue is a directive rolled out as an emergency regulation by the state Board of Regents. It asks districts to fill out a strengths and needs survey about their ability to address disparities, so that all students can excel. Districts already share some services, but the Department of Education says it's looking for more opportunities. "When we talk about opportunities, we are talking about advanced course work, shared staff, extracurricular activities, a range of subjects," an official said back in early September. The regionalization initiative is not sitting well with many on Long Island. "We want to maintain local control over our students over our decisions," Cold Spring Harbor Schools Superintendent Joe Monastaro said. "It is our tax money. We have a say in this. Stay your hands away from my children," Great Neck parent Mimi Xu said. "It's our money, our rule. It has nothing to do with the state," one parent said. Fourteen Long Island school districts have filed a lawsuit to stop the plan. Language in the fine print says a regional superintendent can compel a district to make a change. "It is clear that that document makes it mandatory that our schools coordinate, regionalize and give up authority to a regional authority," said state Sen. Jack Martins, who represents Old Westbury. Long Island's 124 school districts, including some of the best in the nation, value highly their elected boards and independence. "We will not stand by and let the Department of Education gut our school districts," Nassau County Executive Bruce Blakeman said. "It will be a complete power shift from what we have today," said Margaret Marchand, a member of the Locust Valley School Board. "We will fight for local control until we win," Bellmore state Sen. Steve Rhoads added. "If they don't agree to do it, or it didn't come from them, they do not have to sign off on doing anything," Deputy Commissioner Jeff Matteson said. "But what we're not interested in doing is taking away excellent programs from anyone, or watering down the excellent programs." But parents fear sharing resources will mean taking away from some. "If you're in a top-three school district, you probably stand to lose more than you gain. If this goes through, there will be winners and losers," one Great Neck parent said. New York State Board of Regents member Roger Tilles told CBS News New York no district has to do anything that's not in its district's interest. The only thing mandatory is to begin the conversation. The regionalization initiative is supposed to be implemented in 2026 and be re-evaluated every decade. Carolyn Gusoff has covered some of the most high profile news stories in the New York City area and is best known as a trusted, tenacious, consistent and caring voice of Long Island's concerns.Deepak Venkatachalam: A Seasoned Leader in Data Engineering and AI Innovation
The secret to making successful financial New Year’s resolutionsEntries sought for 2026 W.Va. Wildlife Calendar
Energy bulls are looking for top energy stocks that pay good and offer a shot at decent long-term total returns. Oil and gas price outlook Natural gas is trading near its high point for the year, while oil prices continue to face headwinds. Analysts expect the trend to continue into 2025. International demand for Canadian and U.S. natural gas soared after the start of the war between Russia and Ukraine. Europe historically relied on natural gas from Russia to fuel its manufacturing and household energy needs. In an effort to secure reliable supplies, Europe and other international buyers are seeking out liquified natural gas (LNG) shipments from North American producers. The United States already has several LNG export facilities in operation. Canada is in the process of building new sites on the coast of British Columbia. Increased access to global markets should be positive for Canadian natural gas producers. Domestic natural gas demand is also expected to be strong. Gas-fired power generation is forecast to grow due to rising electricity demand from new artificial intelligence data centres. Oil’s outlook over the medium term is less positive. Weak demand from China is combining with growing supply from non-OPEC countries, including the United States and Canada. OPEC just announced it will delay a planned supply increase until next spring, citing the soft demand outlook. That being said, an escalation in the conflict in the Middle East could quickly send oil prices higher. For example, an attack by Israel on Iranian oil facilities or the blocking of the Strait of Hormuz by Iran would severely disrupt oil markets. Given the market uncertainties, it makes sense for energy investors to look for companies that have diversified revenue streams and solid balance sheets to ride out volatility. Suncor ( ) is known for its oil sands production, but the company also owns refineries that turn crude oil into gasoline, diesel fuel, jet fuel, plastics, and asphalt. In addition, Suncor operates Petro-Canada retail locations. The downstream businesses, as the refineries and service stations are known, provide a good hedge against dips in oil prices that reduce margins on the production side of the business. Suncor is making good progress on its turnaround efforts. Costs are down, production is growing, and the refineries are running at near capacity. The slowdown in the adoption of electric vehicles by consumers will prolong the need for gasoline and diesel fuel. Airlines are adding planes and routes, so jet fuel demand should remain robust. Suncor recently raised its dividend by 5%. The stock is down from $58 a few weeks ago to about $44 at the time of writing. Investors who buy SU stock at the current level can get a dividend yield of 4.2%. Canadian Natural Resources ( ) is a major natural gas producer in Canada, along with being an oil giant. The company has production operations that span the hydrocarbon spectrum, including oil sands, conventional heavy oil, conventional light oil, offshore oil, natural gas liquids, and natural gas. CNRL recently announced a US$6.5 billion deal to buy Chevron’s Alberta assets. The purchase will boost revenue and reserves. The anticipated cash flow growth should support the 7% dividend increase the board is giving shareholders for 2025. Investors who buy CNQ stock at the current level can get a dividend yield of 4.9%. The share price is down about 7% in the past six months, so there is an opportunity to take advantage of a pullback. The bottom line on energy stocks In the current market conditions, it makes sense for energy investors to look for big names that pay solid dividends. If you are searching for energy stocks to add to your portfolio, Suncor and CNRL deserve to be on your radar.THERE’S HOPE! I love Pampanga. Living here is an experience filled with cultural richness, historical depth, and vibrant community life. As a resident of this storied province, I know its streets, stories, and spirit like the back of my hand. The pride in calling Pampanga home comes not only from its scenic landscapes and strategic location but also from its unique contributions to the Philippines’ cultural and economic tapestry. I’m even prouder seeing Pampanga scoring wins left and right these days. Last week, we celebrated the commendable leadership of Coach and Governor Dennis “Delta” Garcia Pineda and the Pampanga Giant Lanterns’ securing of the North Division title in the Maharlika Pilipinas Basketball League (MPBL) for the second consecutive year. And now, turning our attention to culinary achievements, the bill to officially designate Pampanga as the “Culinary Capital of the Philippines” has advanced to the Senate plenary and has received sponsorship. This recognition speaks volumes about the province's deep-rooted influence and expertise in Philippine cuisine, cementing its reputation as a hub of culinary excellence. In line with the celebration of local flavors, I recently joined the grand opening of Side Eye Cafe, a new establishment that perfectly embodies Pampanga’s vibrant culinary landscape. Founded by the charismatic entrepreneur Jeio Rivera, whom I know from our shared service in the Philippine Coast Guard, the café reflects the diligence and dedication characteristic of our corps. These qualities are evident in the owner, whose meticulous attention to detail and commitment to excellence shines through in every aspect of the store. With his bright eyes and infectious enthusiasm, Jeio is the ideal host for such a venture. He’s a business management graduate from the University of the Cordilleras and is currently pursuing a Master of Science in Entrepreneurship at the De La Salle University in Manila. Raised by his father, retired AFP Brigadier General Ferdinand Jose G. Rivera, and supported by his mother, Hope Castro Rivera, a former hotel manager, Jeio’s commitment to quality and community values is clear. These personal influences enrich the café’s atmosphere, fostering a culture of respect and open-mindedness—a fitting tribute, especially since the opening coincided with The International Day for Tolerance. Many familiar faces attended the event including Department of Human Settlements and Urban Development Assistant Secretary Rosve Henson, former Pampanga District Board Member and Mayor Mylyn Pineda-Cayabyab, and Clark Development Corporation Director Helen Nicolette Henson. After all, Side Eye Café shows a lot of promise. Its name, a clever nod to the power of non-verbal communication, captures the essence of the café—a venue designed for meaningful exchanges, anchored the subtleties of gesture and glance. The restaurateur told me, “We aim to create an environment where conversations unfold effortlessly, enabling patrons to forge deep connections through the subtle art of non-verbal cues, making each interaction rich with intimacy and insight.” As a communications professional, it’s rare for me to be easily impressed, yet Jeio’s perspective struck a chord. His focus on non-verbal communication reminded me of Department of Budget and Management Secretary Amenah “Mina” F. Pangandaman's leadership style, which similarly values subtlety and understanding in interactions. The aesthetic of the coffee house is minimalistic and elegant, mirroring Jeio’s refined and understated style. Artworks featuring iconic characters with signature side-eye gazes adorn the walls giving the place a more chic, fun, and welcoming vibe. Spacious enough to accommodate up to 80 guests, the café offers ample room for comfortable seating and social interaction. Beyond coffee, the tantalizing menu consists of inventive dishes from Seafood Alavar Pasta to Balut Sisig, to delectable desserts like Matcha Dream Cakes and Cheesecakes in a jar. Jeio also told me that they source their coffee beans from local farmers in the Northern Philippines, supporting regional agriculture. For those with a taste for international flavors, they also bring in beans from Brazil. In essence, they help local farmers while providing a global flair to their coffee choices. These beans are exclusively roasted in Pampanga, further supporting local livelihoods. The café’s approach of blending local flavors with international standards establishes a new benchmark for coffee quality in the region. Congratulations to Jeio and Pampanga for another milestone! Through Side Eye Café, we are reminded that even in our fast-paced, often polarized world, there are still spots where dialogue and respect can brew together beautifully. It is located at CJG Bldg, Brgy. Baliti, San Fernando, Pampanga, near His Life City Church. There is hope!
The slump in the number of people heading to the shops during Boxing Day sales signals a return to declining pre-pandemic levels, an analyst has said. Boxing Day shopper footfall was down 7.9% from last year across all UK retail destinations up until 5pm, MRI Software’s OnLocation Footfall Index found. However, this year’s data had been compared with an unusual spike in footfall as 2023 was the first “proper Christmas” period without Covid-19 pandemic restrictions, an analyst at the retail technology company said. It found £4.6 billion will be spent overall on the festive sales. Before the pandemic the number of Boxing Day shoppers on the streets had been declining year on year. The last uplift recorded by MRI was in 2015. Jenni Matthews, marketing and insights director at MRI Software, told the PA news agency: “We’ve got to bear in mind that (last year) was our first proper Christmas without any (Covid-19) restrictions or limitations. “Figures have come out that things have stabilised, we’re almost back to what we saw pre-pandemic.” There were year-on-year declines in footfall anywhere between 5% and 12% before Covid-19 restrictions, she said. MRI found 12% fewer people were out shopping on Boxing Day in 2019 than in 2018, and there were 3% fewer in 2018 than in 2017, Ms Matthews added. She said: “It’s the shift to online shopping, it’s the convenience, you’ve got the family days that take place on Christmas Day and Boxing Day.” People are also increasingly stocking-up before Christmas, Ms Matthews said, and MRI found an 18% increase in footfall at all UK retail destinations on Christmas Eve this year compared with 2023. Ms Matthews said: “We see the shops are full of people all the way up to Christmas Eve, so they’ve probably got a couple of good days of food, goodies, everything that they need, and they don’t really need to go out again until later on in that week. “We did see that big boost on Christmas Eve. It looks like shoppers may have concentrated much of their spending in that pre-Christmas rush.” Many online sales kicked off between December 23 and the night of Christmas Day and “a lot of people would have grabbed those bargains from the comfort of their own home”, she said. She added: “I feel like it’s becoming more and more common that people are grabbing the bargains pre-Christmas.” Footfall is expected to rise on December 27 as people emerge from family visits and shops re-open, including Next, Marks and Spencer and John Lewis that all shut for Boxing Day. It will also be payday for some as it is the last Friday of the month. A study by Barclays Consumer Spend had forecast that shoppers would spend £236 each on average in the Boxing Day sales this year, but that the majority of purchases would be made online. Nearly half of respondents said the cost-of-living crisis will affect their post-Christmas shopping but the forecast average spend is still £50 more per person than it was before the pandemic, with some of that figure because of inflation, Barclays said. Amid the financial pressures, many people are planning to buy practical, perishable and essential items such as food and kitchenware. A total of 65% of shoppers are expecting to spend the majority of their sales budget online. Last year, Barclays found 63.9% of Boxing Day retail purchases were made online. However, a quarter of respondents aim to spend mostly in store – an 11% rise compared with last year. Karen Johnson, head of retail at Barclays, said: “Despite the ongoing cost-of-living pressures, it is encouraging to hear that consumers will be actively participating in the post-Christmas sales. “This year, we’re likely to see a shift towards practicality and sustainability, with more shoppers looking to bag bargains on kitchen appliances and second-hand goods.” Consumers choose in-store shopping largely because they enjoy the social aspect and touching items before they buy, Barclays said, adding that high streets and shopping centres are the most popular destinations. We do not moderate comments, but we expect readers to adhere to certain rules in the interests of open and accountable debate. Last Updated: Are you sure you want to delete this comment?
OTTAWA — Two senior members of the federal cabinet were in Florida Friday pushing Canada's new border plan with Donald Trump's transition team, a day after Trudeau himself appeared to finally push back at the president-elect over his social media posts about turning Canada into the 51st state. Both Trudeau and former Bank of Canada governor Mark Carney, who Trudeau has been courting to become Canada's next finance minister, shared posts on X Thursday, a day after Trump's latest jab at Canada in his Christmas Day message. It isn't clear if Finance Minister Dominic LeBlanc, who has repeatedly insisted Trump's 51st state references are a joke, will raise the issue with Trump's team when he and Foreign Affairs Minister Mélanie Joly meet with them in Palm Beach. The two are there to discuss Canada's new $1.3 billion border plan with just under four weeks left before Trump is sworn in again as president. He has threatened to impose a new 25 per cent import tariff on Canada and Mexico the same day over concerns about a trade imbalance, as well as illegal drugs and migration issues at the borders. The broad strokes of Canada's plan were made public Dec. 17, including a new aerial intelligence task force to provide round-the-clock surveillance of the border, and improved efforts using technology and canine teams to seek out drugs in shipments leaving Canada LeBlanc's spokesman, Jean-Sébastien Comeau, said the ministers will also emphasize the negative impacts of Trump's threatened tariffs on both Canada and the U.S. Comeau said the ministers will build on the discussions that took place last month when Trudeau and LeBlanc met Trump at Mar-a-Lago just days after Trump first made his tariff threat. It was at that dinner on Nov. 29 when Trump first raised the notion of Canada becoming the 51st state, a comment LeBlanc has repeatedly since insisted was just a joke. But Trump has continued the quip repeatedly in various social media posts, including in his Christmas Day message when he said Canadians would pay lower taxes and have better military protection if they became Americans. He has taken to calling Trudeau "governor" instead of prime minister. Trudeau had not directly responded to any of the jabs, but on Thursday posted a link to a six-minute long video on YouTube from 2010 in which American journalist Tom Brokaw "explains Canada to Americans." The video, which originally aired during the 2010 Vancouver Olympics, explains similarities between the two countries, including their founding based on immigration, their trading relationship and the actions of the Canadian Army in World War 2 and other modern conflicts. "In the long history of sovereign neighbours there has never been a relationship as close, productive and peaceful as the U.S. and Canada," Brokaw says in the video. Trudeau did not expand about why he posted a link to the video, posting it only with the words "some information about Canada for Americans." Carney, who is at the centre of some of Trudeau's recent domestic political troubles, also called out Trump's antics on X Thursday, calling it "casual disrespect" and "carrying the 'joke' too far." "Time to call it out, stand up for Canada, and build a true North American partnership," said Carney, who Trudeau was courting to join his cabinet before Chrystia Freeland resigned as finance minister last week. Freeland's sudden departure, three days after Trudeau informed her he would be firing her as finance minister in favour of Carney, left Trudeau's leadership even more bruised than it already was. Despite the expectation Carney would assume the role, he did not and has not made any statements about it. LeBlanc was sworn in as finance minister instead the same day Freeland quit. More than two dozen Liberal MPs have publicly called on Trudeau to resign as leader, and Trudeau is said to be taking the holidays to think about his next steps. He is currently vacationing in British Columbia. This report by The Canadian Press was first published Dec. 27, 2024. Alessia Passafiume, The Canadian Press
Jones accounts for 4 TDs, defense adds two TDs, NC Central swamps Delaware State 52-10Kwame Asare Obeng, also known as A Plus and MP-elect, has taken aim at senior police officer Christian Yohonu, accusing him of lobbying to replace Inspector-General of Police (IGP) Dr. George Akuffo Dampare following the National Democratic Congress (NDC)’s electoral victory. A Plus alleged that Yohonu, who was promoted to Deputy IGP by President Akufo-Addo, had been strategically positioned to undermine Dr. Dampare due to the latter’s firm stance on maintaining fairness during elections, as reported by 3News. He expressed concern that Yohonu is now aligning with the NDC to secure the IGP position. In a social media post on December 27, 2024, A Plus suggested that such political maneuvering within the police force undermines its integrity and professionalism. He highlighted the Ghana Police Service’s critical role in ensuring peaceful elections and cautioned against appointing individuals who prioritize party loyalty over national development. “The Ghana Police Service is arguably one of the best in Africa when it comes to elections. The institution’s efforts are commendable and worthy of praise,” A Plus noted. However, he warned that the presence of a few “bad apples” could tarnish its reputation. He further criticized Yohonu’s alleged involvement in election-related schemes, accusing him of aligning with political agendas that could compromise the independence of the police service. The allegations have triggered public discussions, with many calling for transparency and fairness in the selection of the next IGP. A Plus’s remarks have added to the growing scrutiny surrounding the leadership of Ghana’s law enforcement institutions during this political transition.
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Thanksgiving dinner — a time for family, food, and a colorful cast of personalities. But let’s face it, not everyone you’d want at your Thanksgiving table would make it a relaxing meal. Some TV characters would turn it into an evening of laughter and camaraderie, while others, well, let’s just say they’d leave you reaching for another glass of wine. This list might have you scrambling to reconsider your own list of invitees! In the spirit of fantasy Thanksgiving invites, we’re taking a look at the dream guests who’d make this holiday one to remember and the nightmare guests who’d have you silently planning their exit strategy. Here’s our list of ten characters who’d be Thanksgiving dinner nightmares and five who’d be a dream. Nightmare Guests: The Thanksgiving Terrors You’d Rather Avoid Some Thanksgiving guests bring joy to the table, while others — well, they bring chaos. These TV characters might be fascinating to watch on-screen, but around the dinner table, they’d have you counting down the minutes until they’re out the door. From overly opinionated to downright disruptive, these are the guests who would turn Thanksgiving into a survival test. Imagine sitting down for Thanksgiving dinner, expecting some lighthearted banter, only to find Morgan Gillory from High Potential at your table. Sure, she’s brilliant and has a knack for solving crimes, but her social skills? Practically nonexistent. You’d spend most of the night watching her dissect every detail of the meal, analyzing everyone’s behavior with that intense stare, and pointing out the “clues” that grandma used canned cranberry sauce instead of homemade. And don’t even think about having a normal conversation; she’ll hijack it to dissect your personal habits. Morgan’s sharp mind may be an asset in a case, but at the dinner table? It’s a recipe for awkward silence, overly scrutinized guests, and more than a few raised eyebrows. Watch High Potential Online Thanksgiving is supposed to be a relaxing day, but with Dr. Ethan Choi from Chicago Med around, forget about indulgence. While everyone’s loading up on stuffing and pie, he’ll be there with his strict health advice and dietary warnings, eyeing every dish like it’s a biohazard. The second someone reaches for a second helping of mashed potatoes, expect a lecture on cholesterol, portion control, and the dangers of processed foods. And heaven forbid anyone mentions a minor ache or pain — Dr. Choi will have you cornered, diagnosing you on the spot with a list of ailments you didn’t even know existed. A great doctor? Absolutely. A great Thanksgiving guest? Hard pass. Watch Chicago Med Online Thanksgiving with Oliver Putnam from Only Murders in the Building would be quite an experience. But probably not the one you were hoping for. As soon as he arrives, he’d treat your family gathering like the opening night of a Broadway play. He’d direct everyone’s “roles” at the dinner, setting up dramatic entrances for each dish and dropping hints about a “mysterious twist” coming up with the turkey. His flair for the dramatic doesn’t stop there. He’ll insist on a post-dinner “murder mystery” game and might even go so far as to invent a crime on the spot just to keep the evening “interesting.” Oliver’s enthusiasm is admirable, but after his third monologue about cranberry sauce and an endless stream of “plot twists,” you’ll be begging for an intermission. Watch Only Murders in the Building Online There’s uncomfortable, and then there’s Thanksgiving with Leland Townsend from Evil . From the moment he walks through the door, the atmosphere will shift. He’ll sidle up to Aunt Martha with a chilling grin, casually slipping dark little comments into the conversation to make everyone squirm. Expect a healthy dose of cynicism about the whole holiday — he’ll talk about the “pointlessness” of gratitude, probably bring up some disturbing historical fact, and might even “joke” about sinister traditions. And just when you think it can’t get worse, he’ll cast that eerie stare around the table, hinting that he knows everyone’s darkest secrets. Thanksgiving with Leland would be less of a family gathering and more of a psychological endurance test. Pass the potatoes — and the sage to ward off his energy. Watch Evil Online Thanksgiving with Dr. Miranda Bailey from Grey’s Anatomy would be like having a no-nonsense chief of surgery running your holiday meal. She’d take one look at your cooking setup and start reorganizing the kitchen “for efficiency,” barking orders at anyone who dared wander in to help. The turkey isn’t basting fast enough? She’ll let you know. Are the mashed potatoes a little lumpy? Brace yourself for a lecture on consistency and standards. And if she’s not impressed with the level of hygiene, expect her to whip out hand sanitizer and possibly offer a lecture on cross-contamination. Bailey is a powerhouse in the OR but at Thanksgiving? She’d leave you feeling more like an intern scrambling to keep up with her relentless perfectionism. Watch Grey's Anatomy Online Thanksgiving with Jackson Lamb from Slow Horse s would be... pungent, to put it mildly. He’d show up reeking of cigarettes and something mysteriously unidentifiable, plop himself down at the table, and probably start complaining about everything from the decor to the turkey’s lack of “real flavor.” Politeness isn’t exactly his strong suit, so expect him to say exactly what he thinks of your cooking — bluntly and without a trace of tact. And if the conversation turns to family, he’ll snort, make a sarcastic remark, and might even share a few brutally honest opinions that no one asked for. Charming in his own irreverent way? Maybe. But Jackson Lamb as a Thanksgiving guest is about as appealing as cold gravy. Watch Slow Horses Online Thanksgiving with Kate Pearson from This Is Us would be an emotional rollercoaster — whether you’re ready for it or not. One minute, she’s laughing about a childhood memory; the next, she’s getting misty-eyed over the cranberry sauce because it reminds her of a family moment that led to a profound revelation about life. And just when you think the meal’s safe, she’ll start unpacking the family drama right there at the table. She means well, but her tendency to dig deep, get reflective, and spark “heartfelt” discussions could turn a lighthearted Thanksgiving into a therapy session for all. With Kate at the table, you’ll be reaching for extra wine and maybe some tissues. Watch This is Us Online Thanksgiving with Danny Reagan from Blue Bloods would be like sitting down to dinner with a drill sergeant who just got off a tough shift. He’d arrive in full cop mode, constantly scanning the room with that intense look as if he’s waiting for a perp to jump out from behind the turkey. Any attempt at a lighthearted conversation would quickly veer into tales of “the job,” complete with gritty crime stories. He’d also have no problems sharing his hard-nosed opinions on everything from family dynamics to what really constitutes a “good” Thanksgiving meal. And don’t even think about mentioning law enforcement — he’ll turn it into a passionate (and probably loud) debate that you didn’t sign up for. With Danny around, you’ll be thinking about dessert — or the exit. Watch Blue Bloods Online Thanksgiving with Detective Nyla Harper from The Rookie would feel more like an interrogation than a family gathering. She’d scan the table with that sharp gaze, catching every little slip-up or inconsistency in conversation, and you’d quickly realize there’s no such thing as “light small talk” with her. She’d call out anyone’s nonsense in an instant and probably challenge every comment with her matter-of-fact, tell-it-like-it-is attitude. Her heart’s in the right place, but Nyla’s tough-as-nails style would leave everyone on their toes, with conversations feeling less warm and fuzzy and more like a cross-examination over the mashed potatoes. Watch The Rookie Online Thanksgiving with Norma Bates from Bates Motel would be nothing but a nightmare, to say the least. She’d show up with that warm smile, eager to make a good impression, but it wouldn’t take long for her unsettling intensity to seep through. Norma would hover over everyone. She’d offer “helpful” advice on how to carve the turkey or “gently” criticize your recipes, all while casting sidelong glances at anyone she deemed a threat to her family. And heaven forbid someone mention anything slightly personal — she’d immediately turn defensive, spiraling into a dramatic monologue about family loyalty and betrayal. Thanksgiving with Norma would be a psychological thriller, leaving everyone nervously eyeing the exit. Watch Bates Motel Online Dream Guests: The Thanksgiving MVPs After all those nightmares, there are the characters who’d make Thanksgiving feel like a holiday should. These dream guests bring laughter, warmth, and maybe even a dish or two worth remembering. They’re the ones who’d make everyone feel at home, keep the conversation flowing, and turn Thanksgiving into the kind of gathering you’d want to relive every year. Thanksgiving with Gabrielle Solis from Desperate Housewives would be pure entertainment and glam. She’d show up in an effortlessly chic outfit, instantly lighting up the room with her charisma and humor. Gaby’s no stranger to the finer things, so you can bet she’d compliment your cooking as if it’s a five-star meal (whether it actually is or not). Plus, she’s full of hilarious stories, and with a perfect touch of gossip, she’ll keep things lively — just enough to be fun without crossing any lines. She’d bring just the right blend of sass and sweetness, making everyone feel like a VIP at the table. With Gaby around, Thanksgiving would feel like a fabulous social event — minus the drama. Watch Desperate Housewives Online Thanksgiving with Raymond Reddington from The Blacklist would be one of those holidays you never forget. He’d arrive with a bottle of rare wine or an exotic dish from one of his “business trips” that no one else at the table has ever heard of — because, let’s face it, only Red knows where to source these things. He’d entertain everyone with mysterious, globe-trotting tales, dropping just enough details to make you wonder what’s true and what’s embellished. And if any family tension flares up? Red would defuse it with a clever quip or a quick change of subject, keeping the mood light and intriguing. Thanksgiving with Reddington would be like dinner and a show, with a side of espionage charm — exactly the kind of guest who leaves everyone talking for weeks. Watch The Blacklist Online Thanksgiving with Alden Parker from NCIS would be as warm and easygoing as it gets. He’d show up with a thoughtful, maybe homemade dish and, of course, a couple of boxes of delicious pastries from his favorite bakery. Parker’s got that relaxed vibe that makes everyone feel comfortable, and he’d be genuinely interested in getting to know everyone around the table — no small talk, just real, engaging conversations. Plus, he’d share some great stories from his fieldwork, told with that dry humor that gets everyone chuckling. Parker would smoothly steer the conversation back on track if any awkward topics came up, keeping the mood light and enjoyable. With him there, Thanksgiving would feel like a true celebration, filled with good company, laughter, and a pastry or two to top it off. Watch NCIS Online Thanksgiving with Christopher Herrmann from Chicago Fire would feel like a big, cozy family gathering. He’d show up with a hearty side dish and maybe a bottle of whiskey from his favorite neighborhood spot, ready to make a toast or two. Herrmann has that down-to-earth charm that makes everyone feel at ease. He’d spend the evening telling hilarious stories from the firehouse that would have everyone in stitches. And if anyone needed help in the kitchen, he’d be right there, pitching in like it’s second nature. Plus, he’s the type to notice when someone’s feeling left out and draw them into the conversation, making sure everyone feels like part of the family. With Herrmann at the table, Thanksgiving would feel like home — good food, good laughs, and all-around good company. Watch Chicago Fire Online Thanksgiving with Gaby from Shrinking would be a total joy. She’d show up with a big smile, a dish full of comfort food, and a personality that lights up the room. Gaby has a way of making everyone feel seen, understood, and included — no one is left out of the conversation when she’s around. With her quick wit and funny stories about her life as a therapist, she’d have everyone laughing within minutes. And if any awkward family tension came up, Gaby would handle it like a pro, redirecting it with just the right mix of humor and empathy. By the end of the night, everyone would feel a little lighter, a little happier, and grateful for the genuine warmth she brought to the table. Thanksgiving with Gaby would feel like the kind of holiday you hope never ends. Watch Shrinking Online Who’s On Your Thanksgiving Guest List? Thanksgiving is all about celebrating with those who make life a little brighter — or at least a little more interesting! Whether it’s dream guests who bring warmth and laughter or nightmare guests who’d make you cringe, these TV characters would turn any holiday into an unforgettable experience. Now it’s your turn: Who would you invite, and who would you rather keep at a safe distance? Share your picks in the comments, and let the Thanksgiving guest list debate begin!
MILAN, Italy (AP) — Atalanta went to the top of Serie A when Ademola Lookman scored with three minutes remaining to beat AC Milan 2-1 on Friday. Atalanta’s ninth win in a row was a fitting gift to coach Gian Piero Gasperini, who was awarded the coach of the month award earlier in the day for guiding his team to a perfect record in November. Charles De Ketelaere put the home side ahead with a towering header after 11 minutes only for Milan to level 11 minutes later. Theo Hernández released Rafael Leão on the right wing and his inviting cross was converted by Álvaro Morata. Milan, which lost Christian Pulišić to a knock before halftime, looked set to end Atalanta’s impressive run but Lookman nipped in at the back post to nod home a corner in the dying moments. Atalanta has 34 points, two more than Napoli, which has a game in hand against Lazio on Sunday. Milan was in seventh place. Serie A champion Inter defeated Parma 3-1 and extended the Milan club’s unbeaten run to 13 games. Federico Dimarco put the home side ahead five minutes before halftime when he worked a neat one-two with Henrikh Mkhitaryan and fired a low shot past Zion Suzuki. Nicolò Barella made it two eight minutes into the second half when he finished a fast counterattack with aplomb. Marcos Thuram's 10th goal of the season made it 3-0 in the 66th. A Matteo Darmian own goal gave some late consolation for Parma. AP soccer: https://apnews.com/hub/soccerGEORGE TOWN, Cayman Islands (AP) — Kimani Hamilton led High Point with 18 points and Bobby Pettiford made a contested shot in the lane with 10.9 seconds remaining as the Panthers knocked off Hampton 76-73 on Tuesday. Hamilton also added eight rebounds for the Panthers (7-1). Trae Benham scored 17 points while shooting 4 for 5 (4 for 4 from 3-point range) and 5 of 5 from the free-throw line. Kezza Giffa shot 4 of 10 from the field and 2 of 3 from the free-throw line to finish with 11 points. George Beale led the way for the Pirates (3-5) with 17 points. Noah Farrakhan added 16 points for Hampton. High Point went into halftime ahead of Hampton 38-33. Giffa scored 11 points in the half. Hamilton scored a team-high 13 points in the second half. The Associated Press created this story using technology provided by Data Skrive and data from Sportradar .