Credit: Adobe Stock Deucravacitinib (Bristol Myers Squibb) was superior to placebo in achieving American College of Rheumatology 20 (ACR20) response in people with psoriatic arthritis (PsA) after 16 weeks of treatment, leading 2 pivotal phase 3 trials, POETYK PsA-1 (IM011-054) and POETYK PsA-2 (IM011-055), to achieve their primary endpoints. 1 "Psoriatic arthritis is a heterogenous disease that causes a range of different symptoms, including joint pain and swelling, as well as psoriatic skin lesions. Despite available therapies, rheumatologists continue to express a need for a safe and effective oral treatment," Roland Chen, MD, senior vice president and head, Immunology, Cardiovascular and Neuroscience development, Bristol Myers Squibb, said in a statement. 1 "These POETYK PsA-1 and POETYK PsA-2 findings demonstrate that oral Sotyktu has the potential to be the first TYK2 inhibitor for people living with psoriatic arthritis and reinforce the established efficacy and safety profile of Sotyktu. We are encouraged by the positive data across both Phase 3 trials and look forward to discussing the results with health authorities." Bristol Myers Squibb also announced that the 2 trials had met important secondary endpoints across PsA disease activity at Week 16, and the overall safety profile of deucravacitinib through 16 weeks of treatment was consistent with its established safety profile in a Phase 2 PsA clinical trial and Phase 3 trials in moderate-to-severe plaque psoriasis (PsO). Both trials were multicenter, randomized, double-blind, placebo-controlled trials that enrolled adults with active PsA. POETYK PsA-1 enrolled approximately 670 patients with biologic disease-modifying antirheumatic (bDMARD) drug-naïve active PsA. POETYK PsA-2 enrolled approximately 730 patients with active PsA who were bDMARD naïve or had previously received TNFα inhibitor treatment. Both trials were conducted over 52 weeks, with a placebo-controlled treatment period through Week 16, followed by a reallocation and continued active treatment period from Week 16 to Week 52. POETYK PsA-2 also included an apremilast safety reference arm. Patients that completed either study are potentially eligible to enroll in the open-label long-term extension (LTE) study. 1 Deucravacitinib is currently FDA approved under the name Sotyktu as an oral treatment for adults with moderate-to-severe plaque PsO. 2 Bristol Myers Squibb also recently announced data that demonstrate a consistent safety profile and durable clinical response with continuous deucravacitinib therapy through 3 years of use among people with PsO. 3 Among the 1519 individuals who were given at least a single administration of deucravacitinib, 513 maintained continuous treatment with the drug from the beginning of the parent trials and entered the LTE phase. Investigators found that exposure-adjusted incidence rates (EAIRs) per 100 person-years for adverse events (AEs), discontinuations due to treatment-related AEs, and deaths were all found to have either been lowered or remained consistent when comparing the 1-year and 3-year cumulative periods. 3 Specifically, from the 1-year point to the 3-year point, discontinuations were at 4.4 compared to 2.4, AEs had rates of 229.2 compared to 144.8, SAEs at 5.7 compared to 5.5, and deaths at 0.2 compared to 0.3. These adverse events (AEs) included COVID-19, nasopharyngitis, and upper respiratory tract infections, highlighting the varying rates of AE incidence across the cumulative periods. 3 Bristol Myers Squibb Announces Positive Topline Results from Two Pivotal Phase 3 Trials Evaluating Sotyktu (deucravacitinib) in Adults with Psoriatic Arthritis. News release. Bristol Myers Squibb. December 23, 2024. https://news.bms.com/news/details/2024/Bristol-Myers-Squibb-Announces-Positive-Topline-Results-from-Two-Pivotal-Phase-3-Trials-Evaluating-Sotyktu-deucravacitinib-in-Adults-with-Psoriatic-Arthritis/default.aspx U.S. Food and Drug Administration Approves SotyktuTM (deucravacitinib), Oral Treatment for Adults with Moderate-to-Severe Plaque Psoriasis. News release. Bristol Myers Squibb. September 9, 2022. https://news.bms.com/news/details/2022/U.S.-Food-and-Drug-Administration-Approves-Sotyktu-deucravacitinib-Oral-Treatment-for-Adults-with-Moderate-to-Severe-Plaque-Psoriasis/default.aspx Armstrong AW, Lebwohl M, Warren RB, et al. Safety and Efficacy of Deucravacitinib in Moderate to Severe Plaque Psoriasis For Up to 3 Years: An Open-Label Extension of Randomized Clinical Trials. JAMA Dermatol. Published online November 27, 2024. doi:10.1001/jamadermatol.2024.4688.FORT LAUDERDALE, Fla. (AP) — President-elect Donald Trump promised on Tuesday to “vigorously pursue” capital punishment after President Joe of most people on federal death row partly to stop Trump from pushing forward their executions. Trump criticized Biden’s decision on Monday to change the sentences of 37 of the 40 condemned people to life in prison without parole, arguing that it was senseless and insulted the families of their victims. Biden said converting their punishments to life imprisonment was consistent with the moratorium imposed on federal executions in cases other than terrorism and hate-motivated mass murder. “Joe Biden just commuted the Death Sentence on 37 of the worst killers in our Country,” he wrote on his social media site. “When you hear the acts of each, you won’t believe that he did this. Makes no sense. Relatives and friends are further devastated. They can’t believe this is happening!” Presidents historically have no involvement in dictating or recommending the punishments that federal prosecutors seek for defendants in criminal cases, though Trump has long sought more direct control over the Justice Department’s operations. The president-elect wrote that he would direct the department to pursue the death penalty “as soon as I am inaugurated,” but was vague on what specific actions he may take and said they would be in cases of “violent rapists, murderers, and monsters.” He highlighted the cases of two men who were on federal death row for slaying a woman and a girl, had admitted to killing more and had their sentences commuted by Biden. Is it a plan in motion or more rhetoric? On the campaign trail, Trump often called for expanding the federal death penalty — including for those who kill police officers, those convicted of drug and human trafficking, and migrants who kill U.S. citizens. “Trump has been fairly consistent in wanting to sort of say that he thinks the death penalty is an important tool and he wants to use it,” said Douglas Berman, an expert on sentencing at Ohio State University’s law school. “But whether practically any of that can happen, either under existing law or other laws, is a heavy lift.” Berman said Trump’s statement at this point seems to be just a response to Biden’s commutation. “I’m inclined to think it’s still in sort of more the rhetoric phase. Just, ‘don’t worry. The new sheriff is coming. I like the death penalty,’” he said. Most Americans have historically supported the death penalty for people convicted of murder, according to decades of annual polling by Gallup, but support has declined over the past few decades. About half of Americans were in favor in an October poll, while roughly 7 in 10 Americans backed capital punishment for murderers in 2007. Death row inmates are mostly sentenced by states Before Biden’s commutation, there were 40 federal death row inmates compared with more than 2,000 who have been sentenced to death by states. “The reality is all of these crimes are typically handled by the states,” Berman said. A question is whether the Trump administration would try to take over some state murder cases, such as those related to drug trafficking or smuggling. He could also attempt to take cases from states that have abolished the death penalty. Could rape now be punishable by death? Berman said Trump’s statement, along with some recent actions by states, may present an effort to get the Supreme Court to reconsider a precedent that considers the death penalty disproportionate punishment for rape. “That would literally take decades to unfold. It’s not something that is going to happen overnight,” Berman said. Before one of Trump’s rallies on Aug. 20, his prepared remarks released to the media said he would announce he would ask for the death penalty for child rapists and child traffickers. But Trump never delivered the line. What were the cases highlighted by Trump? One of the men Trump highlighted on Tuesday was ex-Marine Jorge Avila Torrez, who was sentenced to death for killing a sailor in Virginia and later pleaded guilty to the fatal stabbing of an 8-year-old and a 9-year-old girl in a suburban Chicago park several years before. The other man, Thomas Steven Sanders, was sentenced to death for the kidnapping and slaying of a 12-year-old girl in Louisiana, days after shooting the girl’s mother in a wildlife park in Arizona. Court records show he admitted to both killings. Some families of victims expressed anger with Biden’s decision, but the president had faced pressure from advocacy groups urging him to make it more difficult for Trump to increase the use of capital punishment for federal inmates. The ACLU and the U.S. Conference of Catholic Bishops were some of the groups that applauded the decision. Biden left three federal inmates to face execution. They are Dylann Roof, who carried out the in Charleston, South Carolina; 2013 Boston Marathon bomber ; and Robert Bowers, who fatally shot 11 congregants at Pittsburgh’s , the deadliest antisemitic attack in U.S history. _______ Associated Press writers Jill Colvin, Michelle L. Price and Eric Tucker contributed to this report. Adriana Gomez Licon, The Associated Press
RLJ Lodging Trust ( NYSE:RLJ – Get Free Report ) declared a quarterly dividend on Friday, December 13th, RTT News reports. Investors of record on Tuesday, December 31st will be paid a dividend of 0.15 per share by the real estate investment trust on Wednesday, January 15th. This represents a $0.60 annualized dividend and a dividend yield of 5.91%. The ex-dividend date is Tuesday, December 31st. RLJ Lodging Trust has a dividend payout ratio of 315.8% meaning the company cannot currently cover its dividend with earnings alone and is relying on its balance sheet to cover its dividend payments. Equities research analysts expect RLJ Lodging Trust to earn $1.42 per share next year, which means the company should continue to be able to cover its $0.60 annual dividend with an expected future payout ratio of 42.3%. RLJ Lodging Trust Stock Performance Shares of RLJ opened at $10.15 on Friday. The company has a 50-day simple moving average of $9.85 and a two-hundred day simple moving average of $9.54. The company has a debt-to-equity ratio of 1.14, a current ratio of 2.74 and a quick ratio of 2.74. The firm has a market capitalization of $1.56 billion, a PE ratio of 35.00, a price-to-earnings-growth ratio of 2.31 and a beta of 1.72. RLJ Lodging Trust has a one year low of $8.74 and a one year high of $12.39. Analyst Ratings Changes A number of brokerages have recently commented on RLJ. Oppenheimer boosted their target price on shares of RLJ Lodging Trust from $11.00 to $12.00 and gave the company an “outperform” rating in a report on Tuesday, November 12th. StockNews.com raised shares of RLJ Lodging Trust from a “sell” rating to a “hold” rating in a research note on Friday, December 6th. Wolfe Research downgraded shares of RLJ Lodging Trust from an “outperform” rating to a “peer perform” rating in a research note on Thursday, September 26th. Wells Fargo & Company lifted their target price on shares of RLJ Lodging Trust from $10.00 to $10.50 and gave the company an “underweight” rating in a report on Monday, December 9th. Finally, Truist Financial cut their price target on RLJ Lodging Trust from $14.00 to $11.00 and set a “buy” rating on the stock in a research note on Monday, October 28th. Two equities research analysts have rated the stock with a sell rating, three have given a hold rating and three have issued a buy rating to the stock. Based on data from MarketBeat, the stock presently has an average rating of “Hold” and an average price target of $11.50. Get Our Latest Analysis on RLJ Lodging Trust RLJ Lodging Trust Company Profile ( Get Free Report ) RLJ Lodging Trust is a self-advised, publicly traded real estate investment trust that owns primarily premium-branded, high-margin, focused-service and compact full-service hotels. The Company's portfolio currently consists of 96 hotels with approximately 21,200 rooms, located in 23 states and the District of Columbia and an ownership interest in one unconsolidated hotel with 171 rooms. Further Reading Receive News & Ratings for RLJ Lodging Trust Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for RLJ Lodging Trust and related companies with MarketBeat.com's FREE daily email newsletter .
Everyone will love this Marry Me chicken budget mealExpanded CFP field draws more bets and on more teams
RLJ Lodging Trust ( NYSE:RLJ – Get Free Report ) declared a quarterly dividend on Friday, December 13th, RTT News reports. Investors of record on Tuesday, December 31st will be paid a dividend of 0.15 per share by the real estate investment trust on Wednesday, January 15th. This represents a $0.60 annualized dividend and a dividend yield of 5.91%. The ex-dividend date is Tuesday, December 31st. RLJ Lodging Trust has a dividend payout ratio of 315.8% meaning the company cannot currently cover its dividend with earnings alone and is relying on its balance sheet to cover its dividend payments. Equities research analysts expect RLJ Lodging Trust to earn $1.42 per share next year, which means the company should continue to be able to cover its $0.60 annual dividend with an expected future payout ratio of 42.3%. RLJ Lodging Trust Stock Performance Shares of RLJ opened at $10.15 on Friday. The company has a 50-day simple moving average of $9.85 and a two-hundred day simple moving average of $9.54. The company has a debt-to-equity ratio of 1.14, a current ratio of 2.74 and a quick ratio of 2.74. The firm has a market capitalization of $1.56 billion, a PE ratio of 35.00, a price-to-earnings-growth ratio of 2.31 and a beta of 1.72. RLJ Lodging Trust has a one year low of $8.74 and a one year high of $12.39. Analyst Ratings Changes A number of brokerages have recently commented on RLJ. Oppenheimer boosted their target price on shares of RLJ Lodging Trust from $11.00 to $12.00 and gave the company an “outperform” rating in a report on Tuesday, November 12th. StockNews.com raised shares of RLJ Lodging Trust from a “sell” rating to a “hold” rating in a research note on Friday, December 6th. Wolfe Research downgraded shares of RLJ Lodging Trust from an “outperform” rating to a “peer perform” rating in a research note on Thursday, September 26th. Wells Fargo & Company lifted their target price on shares of RLJ Lodging Trust from $10.00 to $10.50 and gave the company an “underweight” rating in a report on Monday, December 9th. Finally, Truist Financial cut their price target on RLJ Lodging Trust from $14.00 to $11.00 and set a “buy” rating on the stock in a research note on Monday, October 28th. Two equities research analysts have rated the stock with a sell rating, three have given a hold rating and three have issued a buy rating to the stock. Based on data from MarketBeat, the stock presently has an average rating of “Hold” and an average price target of $11.50. Get Our Latest Analysis on RLJ Lodging Trust RLJ Lodging Trust Company Profile ( Get Free Report ) RLJ Lodging Trust is a self-advised, publicly traded real estate investment trust that owns primarily premium-branded, high-margin, focused-service and compact full-service hotels. The Company's portfolio currently consists of 96 hotels with approximately 21,200 rooms, located in 23 states and the District of Columbia and an ownership interest in one unconsolidated hotel with 171 rooms. Further Reading Receive News & Ratings for RLJ Lodging Trust Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for RLJ Lodging Trust and related companies with MarketBeat.com's FREE daily email newsletter .Egypt’s Ambassador to Mali presents credentials, underscore bilateral ties
Kalimuendo has hat trick in Rennes rout while PSG held at home
Spending Christmas alone this year? How to make the most of it
For former President Jimmy Carter who died on Sunday at his home in Plains, Georgia, at the age of 100, there will be two public observances—one in Atlanta and another in Washington, D.C., followed by a private interment, The Carter Center said in a statement. Why It Matters Carter was the longest living president in U.S. history. What to Know President Joe Biden said in a Sunday statement that he "will be ordering an official state funeral to be held in Washington D.C." Details of the state funeral, which is a formal ceremony with traditions of lying in state, processions, religious services, military honors, and national mourning, will be released by the Joint Task Force-National Capital Region. State funerals are typically a week to 10 days of events, with three stages, as outlined by the task force: "Stage I includes ceremonies within the state in which the president, former president, or president-elect was in residence. Stage II includes ceremonies within Washington, DC, and Stage III includes ceremonies in the state in which the authorized individual has chosen to be interred." Last year, Biden said at a fundraiser that Carter "asked me to do his eulogy" when the time came. Newsweek has reached out to the White House for comment via email on Sunday. The last presidential state funeral was held in 2018 for former President George H.W. Bush , who died from a form of Parkinson's disease at age 94. His funeral took place at the Washington National Cathedral, which has hosted four state funerals. The 39th president is survived by his children, Jack, Chip, Jeff, and Amy, 11 grandchildren , and 14 great-grandchildren. His wife, former first lady Rosalynn Carter, passed away last November. She was buried in Plains, Georgia, and Carter will rest in peace next to her. The couple was married for 77 years, the longest marriage in presidential history. In lieu of flowers, the Carter family requests contributions to The Carter Center, which can be completed online . Tributes will be collected in the Jimmy and Rosalynn Carter Enduring Hope Fund, according to the website. What People Are Saying Biden and first lady Jill Biden said in a statement on Sunday: "Today, America and the world lost an extraordinary leader, statesman and humanitarian. Over six decades, we had the honor of calling Jimmy Carter a dear friend. But, what's extraordinary about Jimmy Carter, though, is that millions of people throughout America and the world who never met him thought of him as a dear friend as well...We will miss them both [Rosalynn and Jimmy Carter] dearly, but take solace knowing they are reunited once again and remain forever in our hearts." Chip Carter, the former president's son, said in a statement released by The Carter Center on Sunday: "My father was a hero, not only to me but to everyone who believes in peace, human rights, and unselfish love. My brothers, sister, and I shared him with the rest of the world through these common beliefs. The world is our family because of the way he brought people together, and we thank you for honoring his memory by continuing to live these shared beliefs." President-elect Donald Trump wrote on Truth Social on Sunday : "The challenges Jimmy faced as President came at a pivotal time for our country and he did everything in his power to improve the lives of all Americans. For that, we all owe him a debt of gratitude. Melania and I are thinking warmly of the Carter Family and their loved ones during this difficult time. We urge everyone to keep them in their hearts and prayers." Former President Bill Clinton and former U.S. Secretary of State Hillary Clinton said in a joint statement on X, formerly Twitter, on Sunday: "Hillary and I mourn the passing of President Jimmy Carter and give thanks for his long, good life. Guided by his faith, President Carter lived to serve others—until the very end...I will always be proud to have presented the Medal of Freedom to him and Rosalynn in 1999, and to have worked with him in the years after he left the White House." What Happens Next Details of the public observances will be released in the coming days. "The final arrangements for President Carter's state funeral, including all public events and motorcade routes, are still pending," The Carter Center said in its statement. Updated 12/29/24, 6:06 p.m. ET: This article has been updated to include Biden's statement.