GCC-4001 is under clinical development by Artiva Biotherapeutics and currently in Phase II for Angioimmunoblastic T-Cell Lymphoma (AITL)/Immunoblastic Lymphadenopathy. According to GlobalData, Phase II drugs for Angioimmunoblastic T-Cell Lymphoma (AITL)/Immunoblastic Lymphadenopathy does not have sufficient historical data to build an indication benchmark PTSR for Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. GCC-4001 overview GCC-4001 (AB-101) is under development for the treatment of rheumatoid arthritis, systemic lupus erythematosus, pemphigus vulgaris, granulomatosis with polyangiitis and microscopic polyangiitis, B-cell non-Hodgkin lymphoma, relapsed or refractory chronic lymphocytic leukemia, diffuse large B-cell lymphoma, primary mediastinal B-cell lymphoma, follicular lymphoma, Waldenstrom Macroglobulinemia, peripheral T-cell lymphomas (PTCL), angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma (ALCL), R/R classical Hodgkin lymphoma, lupus nephritis (LN) and autoimmune disorders. The therapeutic candidate is an allogeneic, non-engineered, cord blood-derived natural killer (NK) cell therapy. It is administered through intravenous route and is being developed based on AlloNK platform. Artiva Biotherapeutics overview Artiva Biotherapeutics is a biotechnology company developing allogeneic natural killer (NK) cell therapies to treat hematologic cancers or solid tumors. It is investigating AB-101, an allogeneic NK cell therapy used for the treatment of B-cell malignancies; AB-201, a CAR-NK (chimeric antigen receptor-modified natural killer) cell therapy targeting HER2 positive solid tumors; and AB-202 against CD19 positive B-cell malignancies. Artiva Biotherapeutics utilizes its proprietary CAR (chimeric antigen receptor) platform to improve NK cells’ therapeutic activity and tumor-targeting capability. Artiva Biotherapeutics is headquartered in San Diego, California, the US. For a complete picture of GCC-4001’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .MLB Winter Meetings Notebook: Juan Soto, Roki Sasaki drive Day 1 chatterMeet the team that keeps CVG running behind the scenes 24/7, 365 days a year
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Comrade Olusoji Oluwole, National President of Association of Senior Staff of Banks, Insurance and Financial Institutions (ASSBIFI), in this interview with SYLVESTER ENOGHASE, on the sideline of a capacity building organised by ASSBIFI for business editors in Lagos, speaks on the emergence of Artificial Intelligence in financial service sector and reporting, and the need to curb its excesses. He also advocated fair compensation package for the sector’s workforce. Excerpts: Looking at the intersection between finance, technology and innovation, how do you think this is going to impact the performance of financial journalists? The whole idea is to bring everything together, because there will be an intersection at some point in time. We are coming from a period where things were done manually, to when they became automated, and now, to an era where Artificial Inelligence does everything. So, what AI has come to do, is to do in minutes what several people would have done probably in weeks or days.. However, the challenge that we see is that, artificial intelligence is prone to manipulation. Hence, whatever results an artificial intelligence system brings out, with this kind of training, you will be able to dissect it, and pick out any issues that you may find, and bring them to question. Since AI is developed by human beings too, so, whatever its result on a task, it’s still human beings that will be able to decode and dissect it. So, the whole purpose of this training is to put journalists in a position to receive reports, and be able to analyse, and ask questions where questions need to be asked. So, by the time these things are being put into public space, you would have been the first point of contact to raise any questions. Just as AI currently influences journalistic work, so also in the banking sector where it could be deployed for both negative and positive tasks. So, as an association, how do you ensure that some of these banking staffs are well trained, just like you are training us here, to understand how to effectively deploy AI in customer service delivery? Well, artificial intelligence will always be used positively and negatively, but one thing I can tell you is that, banks generally have a huge focus on risk and IT security, so, when we’re talking about security, we’re talking about IT security, and other securities all around their systems. It is interesting to let you know that, banks upskill and update their staff regularly. So whatever it is that is being developed, the first thing that is at the back of the mind of anybody is the security of it, and that is why if we look at it on the surface, for example, you will hear of two-factor authentication. The two-factor authentication is to further enhance securitisation of your account. In this regards, unless, you provided fraudsters some of your secret information, they will not be able to hack into your account and system. So, most time they hack customer’s account, we find out that there is usually a compromise on the part of the victim, but then, we will not blame the victim because there are times when things look normal, but are not actually what they seem to be. For example, some people who receive emails, or receive text messages purportedly from their financial institutions to click on something, and the moment they do that, their money is gone. Another scenario is, those who are asked to give their personal details, which they are not supposed to do; so, all those things combine to lead to loss of funds many times, because of that, banks have also gone on to do campaigns to their customers, telling them what is the things that they are not supposed to give to third parties, the things that are personal to them. There are occasions where systems may have been hacked, and where those happen, I know a lot of financial institutions will move swiftly, because there are regulations that guide all these things, so they move swiftly. There are people who check these things daily, they have teams that work 24 hours a day, they are sitting down looking at it. They are intelligent enough to tell you there is something amiss, so, all those things are in place in financial institutions. Financial fraud through artificial intelligence is not a Nigerian problem, it’s a global problem, and I recall a couple of weeks ago, I was in an engagement where we looked at a system that tracks cyber-attacks from various places. Cyber-attacks were more coming in from other countries into Nigeria than from Nigeria out. So, you find them from Europe, Asia, America, Latin America, South America, all coming in from different locations and there are millions. So, it is a global problem that needs to be addressed. As an institution that deals with workers’ welfare in the banking and financial industries sector, how have you been able to address casualisation of workers in the banking sector? For us, like we presented about two years ago, the then Minister of Labour, Dr Chris Ngige, released a document on casualisation, a guideline on how casualisation should be dealt with, the period of time that people can be in casual employment before they move into full employment, and we are aware that this was something that was given like a directive to financial institutions, and to the people who are providing those services. This is because casual workers are not actually staff of the banks, they are staff of outsourcing companies, so, we know that quite a number of organisations have complied, there are those who have still not done the same, so it’s become a case of not just us, but the government being able to monitor, regulate and ensure that the needful is done, because it’s almost like a law that has been passed and needs to be implemented. But, generally amongst our own institutions, it’s minimal, it’s quite minimal. Is there any advice for banks, especially, in terms of taking most of the responsibilities in what they do in this era of AI? Like we have always said, people should ensure that they increase their knowledge and skill in technology, it’s a dynamic environment, nothing remains the same, and everything keeps changing. AI is still going to be managed by humans, and the opportunities are very wide for people to exploit. So, our advice always is that, they should continue to improve on their skills, to continue to upskill and develop themselves very well. And while we are advising employees, we also advise employers, not to be too quick to discard people who, for some reason, have been unable to upskill, because one thing that you cannot just go out into the world to pick up is experience. This is because, there are times when artificial intelligence can malfunction, because it’s technology. If it decides to have a mind of its own, who is going to resolve it? It is the people with experience, because today, we are breeding a lot of people who are very versatile and conversant in technology, so, they can think it and they can write it, but they do not have that experience to be able to deal with it. Just like driving, today, everybody is driving an auto vehicle, put that same person who is fantastic in an auto vehicle, in a manual car, he’s going to have a problem, because he doesn’t understand the technology of clutch, changing up, changing down and all those things. It’s the same thing with technology, that, no matter how artificial intelligence malfunction , we must have that reserve in place in case, to deal with it. In this area of ongoing recapitalisation in the banking sector, are you putting measures in place to ensure that workers are not majorly affected? Yes, I’ve said this in different forums and interviews, that where we talk about it affecting our members, it’s situations where we have acquisitions and mergers happening. But again, when you look at the amount of money that is being required to raise, I do not expect any institution to remain the same size. So, it means that we expect business to grow, which means that we expect that there will be demand for staff in some of those areas. Nevertheless, we have simplified our interest in institutions that are likely to merge or are likely to be acquired. We’ve simplified our interest to them, to all parties involved and to the regulators as well, especially situations where one party is unionised and the other is not unionised. We let them know all that is happening. Of course we cannot discount the fact that there may be adjustments of some sort. So, what is important at the end of the day, is to find how some of these amendments can be appropriately placed, because there have been duplication of roles, whether we like it or not. If two organizations are coming together, let’s start from the top, we are going to have two chairmen, two folks, two MTs, two escorts, all down to the very last position. So, we understand that those things will happen. And where it happens, we are also campaigning to ensure that people are adequately compensated for the work that they have done, based on the kind of capitalisation that has been raised and based on the laws that govern such situations. As the anchor of this capacity building for Business Editors, what do you suggest as a take-home for business sectors? For me, my own desire, and a take-home for all of you, is that, at the end of this training, you will be able to give unbiased and objective reports without having to run to experts in the field, so to speak, because it’s not all the time that you are going to find professionals sitting in your position. There are times where they may just be people who studied journalism, not professionals who came into journalism, but you will be able to speak with authority. And where that comes to play is that, for professionals, there are times where they will have their own biases as well, because it’s difficult to have 100% objectivity. So, for people in your own field, in your own profession, you have the opportunity to be able to come out and say it the way it is, and be able to ask the right questions. So for us, the take-home that I want you to go with is that when you are reporting, you will be able to give to the public things that they will understand, they will be able to digest, and they will be able to use.11 Nordstrom Beauty Deals That Make Stunning Gifts3 fall into ocean after California wharf partially collapses due to heavy surf from major storm
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Here’s What’s in the $895 Billion Defense Authorization BillU.S. President-elect Donald Trump has vowed to repeal President Joe Biden's executive order on artificial intelligence security, setting the stage for deregulation for AI companies by nominating pro-business, pro-startups Silicon Valley leaders. The nomination of Jacob Helberg, an outspoken China critic, for a key State Department post indicates Trump’s intention to lead over China in AI, according to analysts. “We're likely to see quite a great focus on countering China when it comes to AI – beating China, when it comes to having the most advanced AI capabilities,” says Ruby Scanlon, a researcher on technology and national security at Center for a New America Security. Click here for the full story in Mandarin .
A Historic Index Continues to Shine The Dow Jones Industrial Average, a stalwart of American financial markets, showcases more than just numbers—it’s a pulse on economic sentiment. As this legendary index steadily climbed 15% this year, two standout companies, Nvidia and Walmart, have captured investors’ imaginations with stellar performances. Nvidia: Riding the AI Wave Leading the charge is Nvidia, an AI-driven powerhouse that has transformed the semiconductor landscape since its 1993 inception. The company specializes in cutting-edge GPUs and SoCs that are revolutionizing industries. With a breathtaking market capitalization of $3.4 trillion, Nvidia’s stock has soared 175% this year alone. Its latest quarterly results showcase enviable revenue figures of $35.1 billion, far surpassing market expectations. Nvidia’s relentless innovation drives its growth, highlighted by the introduction of the Blackwell platform. Expected to revolutionize AI model efficiency and energy use, Blackwell sets the stage for a formidable future. Looking ahead, Nvidia’s robust roadmap includes advances like Rubin and continued dominance in the GPU sphere, where it commands over 80% market share. Walmart: Retail’s Resilient Force Founded in 1962, Walmart’s global footprint stretches across over 10,500 stores worldwide. This retail giant has capitalized on both physical and digital avenues, with stock prices climbing a remarkable 74.8% year-to-date. The third quarter of fiscal 2025 was a testament to Walmart’s unmatched resilience, with revenues hitting $169.6 billion, invigorated by a burgeoning advertising business. Walmart’s pursuit of digital advancements and AI integration is redefining retail efficiency. The company anticipates strong financial growth, further solidifying its position as a market leader across various segments. Analysts overwhelmingly endorse Walmart with a “Strong Buy” recommendation, anticipating continued prosperity. The Future of Dow Jones: Innovations, Insights, and Market Trends The Dow Jones Industrial Average remains a crucial barometer of economic health and momentum. This year’s robust 15% ascent highlights burgeoning investor interest, particularly in standout performers like Nvidia and Walmart. These companies aren’t just riding the wave; they’re shaping the future of their respective industries. Nvidia: Pioneering AI Innovation Nvidia’s unparalleled success in the stock market, with a staggering 175% increase this year, is not just a coincidence. This is a testament to its strategic investments in AI and semiconductor technology. The introduction of their groundbreaking platform, Blackwell, aims to transform AI model efficiency, addressing long-standing energy consumption challenges in the tech industry. Nvidia’s dominance is shown through its remarkable market capitalization of $3.4 trillion, a figure that underscores its pivotal role in shaping future technological landscapes. Nvidia’s portfolio is expanding with future-oriented projects like Rubin, keeping the company at the forefront of the GPU market. Given its strong foothold, capturing over 80% of the market, Nvidia is poised for substantial growth and innovation in AI applications. Trends indicate continued advancement in high-performance computing, signaling new opportunities and competition dynamics within the tech industry. Walmart: The Digital Transformation of Retail Walmart’s impressive stock performance this year, with a rise of 74.8%, underscores its effective blend of digital innovation with traditional retail. The company’s efforts in digital transformation, particularly through artificial intelligence integration, are redefining retail processes, enhancing customer experiences, and optimizing operational efficiency. Walmart’s strong performance, propelled by their burgeoning advertising business, has generated revenues of $169.6 billion in the third quarter of fiscal 2025, showcasing the successful diversification of its revenue streams. Analysts remain confident in Walmart’s growth, reflecting in a consistent “Strong Buy” recommendation. As Walmart continues to innovate, it exemplifies how traditional retail can thrive in a digital era. Future Insights and Market Trends As Nvidia and Walmart exemplify transformative progress, broader market trends emerge. Sustainability, energy efficiency, and digital transformation are themes that investors are increasingly prioritizing. Companies like Nvidia are pioneering energy-efficient technologies, a critical innovation in the context of rising global energy concerns. Meanwhile, retailers like Walmart focus on digital synergies to maintain relevance and compete against pure e-commerce players. The intersection of technology with traditional sectors will likely redefine market dynamics, offering new use cases and growth opportunities. Innovations aimed at enhancing energy efficiency and retail experience are set to influence market strategies significantly. Predicting market movements, investors will look for companies that blend innovation with robust market fundamentals. For more on market dynamics and business strategies, visit the main pages of Nvidia and Walmart . These insights offer a glimpse into the evolving nature of how companies must adapt to achieve sustained growth in shifting economic landscapes.Rithm Capital Corp. ( NYSE:RITM – Get Free Report ) declared a quarterly dividend on Monday, December 16th, RTT News reports. Investors of record on Tuesday, December 31st will be given a dividend of 0.25 per share by the real estate investment trust on Friday, January 31st. This represents a $1.00 dividend on an annualized basis and a yield of 9.16%. The ex-dividend date of this dividend is Tuesday, December 31st. Rithm Capital has increased its dividend payment by an average of 26.0% annually over the last three years. Rithm Capital has a dividend payout ratio of 51.8% meaning its dividend is sufficiently covered by earnings. Research analysts expect Rithm Capital to earn $1.92 per share next year, which means the company should continue to be able to cover its $1.00 annual dividend with an expected future payout ratio of 52.1%. Rithm Capital Trading Down 0.6 % NYSE RITM opened at $10.92 on Friday. The stock’s 50-day simple moving average is $10.87 and its two-hundred day simple moving average is $11.11. Rithm Capital has a twelve month low of $9.97 and a twelve month high of $12.02. The company has a quick ratio of 1.35, a current ratio of 1.35 and a debt-to-equity ratio of 1.63. The company has a market capitalization of $5.68 billion, a price-to-earnings ratio of 11.03 and a beta of 1.80. Wall Street Analyst Weigh In A number of equities research analysts have recently weighed in on RITM shares. Keefe, Bruyette & Woods boosted their price objective on shares of Rithm Capital from $13.00 to $13.50 and gave the stock an “outperform” rating in a report on Tuesday, December 3rd. Wedbush restated an “outperform” rating and set a $14.00 price target on shares of Rithm Capital in a research report on Thursday, November 7th. Finally, Royal Bank of Canada restated an “outperform” rating and issued a $13.00 target price on shares of Rithm Capital in a report on Thursday, November 21st. One equities research analyst has rated the stock with a hold rating and seven have given a buy rating to the company’s stock. According to MarketBeat.com, the company has a consensus rating of “Moderate Buy” and a consensus target price of $12.94. Get Our Latest Stock Analysis on Rithm Capital About Rithm Capital ( Get Free Report ) Rithm Capital Corp. operates as an asset manager focused on real estate, credit, and financial services. It operates through Origination and Servicing, Investment Portfolio, Mortgage Loans Receivable, and Asset Management segments. Its investment portfolio primarily comprises of mortgage servicing rights (MSR), and MSR financing receivables, title, appraisal and property preservation, excess MSRs, and services advance investments; real estate securities, call rights, SFR properties, and residential mortgage loans; consumer and business purpose loans; and asset management related investments. Recommended Stories Receive News & Ratings for Rithm Capital Daily - Enter your email address below to receive a concise daily summary of the latest news and analysts' ratings for Rithm Capital and related companies with MarketBeat.com's FREE daily email newsletter .
NonePresident Jimmy Carter, who died Sunday at 100, is leaving an enduring legacy in one of the causes he spent decades working on and cherished most, according to those who volunteered with him. Carter and his wife, Rosalynn Carter, had been "been champions and groundbreaking voices for affordable, decent housing for all" since 1984, according to Habitat for Humanity . The Carters donated their time and influence and worked with nearly 103,000 volunteers in 14 countries to build, renovate and repair 4,331 homes, the nonprofit stated. Rhode Island-based builder and designer Kenneth Young, 66, first began volunteering with Habitat for Humanity in the 1990s. After his first "Carter build" in 1995 in Watts, California, a neighborhood in southern Los Angeles, he "got the bug," he told ABC News. Since then, Young has carried out 20 builds, many alongside the 39th president of the United States -- including Carter's last build in Nashville in 2019, Young said. MORE: Biden lets it slip that Jimmy Carter wants him to deliver Carter's eulogy Young's favorite memory of Carter was during a build in Budapest, Hungary, in 1996, when the residents of a newly built home -- twin boy toddlers -- smacked him in the face with a balloon and Carter, a grandfather himself, "took in it stride" and with a smile. "It was classic," Young said. Don Shaw and Thomas Trumble -- lifelong friends who have been volunteering together for decades with the Habitat for Humanity chapter in Hartford, Connecticut, first worked with Carter in 2002 during a build in Durban, South Africa, they told ABC News. Much of the focus of the build was reconciliation from apartheid, and the project was part of Carter's aim to build 1,000 homes in Africa, Shaw said. Shaw and Trumble went on to join Carter on builds in Mexico, India, Thailand, Canada and twice in Haiti, they said. They were also with Carter during his last build in Nashville. The volunteers were often on a first-name basis with Carter, who made them feel like they were part of his "inner-circle," Shaw said. MORE: Jimmy Carter to receive hospice care following hospitalizations: Carter Center Although Carter's celebrity and political status often brought a media circus and extra funding, the former president also knew how to get his hands dirty, the volunteers said. On the job site, Carter was a natural leader, Young said. Carter's presence alone was enough inspire everyone to work hard and efficiently. The builds run by the Carters were "a logistical miracle," Shaw said, adding that it was often astonishing to see how many homes the group could build within a mere week. "President Carter, also being a Navy man, and having that military background., he wants it right. He wants it done properly. And he wants it on time," Young said. Shaw nicknamed Carter the "benevolent taskmaster," he said. "President Carter was all about getting the job done," Shaw said. "I can remember him going around the site saying, "No photos, no photos. We've got houses to build. Get back." MORE: A look back at Jimmy Carter's health journey and thoughts on aging After an eight-hour work day, the volunteers would come together under a huge camp and share a meal, Trumble said. One of Carter's favorite rituals was to walk into the completed homes to hand the new occupants the keys and a Bible, Young said. "He really cares about the people that we're building for," Young said. Carter will be sorely missed, the volunteers said. "God knows we're all going to miss President Carter when when he leaves us, but I'm hoping his legacy will continue quite a long way forward," Young said. Shaw said, "Being around the Carters was just magical."
Lesabelimab by Dragonboat Biopharmaceutical (Shanghai) for Endometrial Cancer: Likelihood of Approval
Lesabelimab is under clinical development by Dragonboat Biopharmaceutical (Shanghai) and currently in Phase I for Endometrial Cancer. According to GlobalData, Phase I drugs for Endometrial Cancer have an 81% phase transition success rate (PTSR) indication benchmark for progressing into Phase II. GlobalData tracks drug-specific phase transition and likelihood of approval scores, in addition to indication benchmarks based off 18 years of historical drug development data. Attributes of the drug, company and its clinical trials play a fundamental role in drug-specific PTSR and likelihood of approval. Lesabelimab overview lesabelimab is under development for the treatment of advanced malignant tumors including invasive bladder cancer, head and neck squamous cell carcinoma, esophageal squamous cell carcinoma and penile squamous cell carcinoma, endometrial cancer, cervical cancer, ovarian cancer, colorectal cancer, advanced non-clear cell renal cancer and advanced penile cancer, and unspecified indication. It acts by targeting PD L1. The drug candidate is administered as injection. lesabelimab is under development for the treatment of nasopharyngeal carcinoma and solid tumors. Dragonboat Biopharmaceutical (Shanghai) overview Dragonboat Biopharmaceutical (Shanghai) (Dragonboat Biopharmaceutical), a subsidiary of Guilin Sanjin Pharmaceutical Co Ltd, is a biopharmaceutical company that researches and develops biologics for cancers and autoimmune diseases. The company pipeline product includes BC003, BC001, BC005, BC006, BC007, BC008, BC010, BC011 and BCT2101. Dragonboat Biopharmaceutical drug candidate indications include solid tumors, tenosynovial giant cell tumors, asthma, gastric cancer and pancreatic cancer among others. It also utilizes an In-house systemic platform. The company operates a drug research and development center that covers early discovery, preclinical research, IND, clinical research, biologics license application and manufacturing. Dragonboat Biopharmaceutical is headquartered in Shanghai, China. For a complete picture of Lesabelimab’s drug-specific PTSR and LoA scores, This content was updated on 12 April 2024 From Blending expert knowledge with cutting-edge technology, GlobalData’s unrivalled proprietary data will enable you to decode what’s happening in your market. You can make better informed decisions and gain a future-proof advantage over your competitors. , the leading provider of industry intelligence, provided the underlying data, research, and analysis used to produce this article. GlobalData’s Likelihood of Approval analytics tool dynamically assesses and predicts how likely a drug will move to the next stage in clinical development (PTSR), as well as how likely the drug will be approved (LoA). This is based on a combination of machine learning and a proprietary algorithm to process data points from various databases found on GlobalData’s .
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