Unlike scores of people who scrambled for the blockbuster drugs Ozempic and Wegovy to lose weight in recent years, Danielle Griffin had no trouble getting them. The 38-year-old information technology worker from New Mexico had a prescription. Her pharmacy had the drugs in stock. And her health insurance covered all but $25 to $50 of the monthly cost. For Griffin, the hardest part of using the new drugs wasn’t access. It was finding out that the much-hyped medications didn’t really work for her. “I have been on Wegovy for a year and a half and have only lost 13 pounds,” said Griffin, who watches her diet, drinks plenty of water and exercises regularly. “I’ve done everything right with no success. It’s discouraging.” In clinical trials, most participants taking Wegovy or Mounjaro to treat obesity lost an average of 15% to 22% of their body weight — up to 50 pounds or more in many cases. But roughly 10% to 15% of patients in those trials were “nonresponders” who lost less than 5% of their body weight. Now that millions of people have used the drugs, several obesity experts told The Associated Press that perhaps 20% of patients — as many as 1 in 5 — may not respond well to the medications. It's a little-known consequence of the obesity drug boom, according to doctors who caution eager patients not to expect one-size-fits-all results. “It's all about explaining that different people have different responses,” said Dr. Fatima Cody Stanford, an obesity expert at Massachusetts General Hospital The drugs are known as GLP-1 receptor agonists because they mimic a hormone in the body known as glucagon-like peptide 1. Genetics, hormones and variability in how the brain regulates energy can all influence weight — and a person's response to the drugs, Stanford said. Medical conditions such as sleep apnea can prevent weight loss, as can certain common medications, such as antidepressants, steroids and contraceptives. “This is a disease that stems from the brain,” said Stanford. “The dysfunction may not be the same” from patient to patient. Despite such cautions, patients are often upset when they start getting the weekly injections but the numbers on the scale barely budge. “It can be devastating,” said Dr. Katherine Saunders, an obesity expert at Weill Cornell Medicine and co-founder of the obesity treatment company FlyteHealth. “With such high expectations, there’s so much room for disappointment.” That was the case for Griffin, who has battled obesity since childhood and hoped to shed 70 pounds using Wegovy. The drug helped reduce her appetite and lowered her risk of diabetes, but she saw little change in weight. “It’s an emotional roller coaster,” she said. “You want it to work like it does for everybody else.” The medications are typically prescribed along with eating behavior and lifestyle changes. It’s usually clear within weeks whether someone will respond to the drugs, said Dr. Jody Dushay, an endocrine specialist at Beth Israel Deaconess Medical Center. Weight loss typically begins right away and continues as the dosage increases. For some patients, that just doesn't happen. For others, side effects such as nausea, vomiting and diarrhea force them to halt the medications, Dushay said. In such situations, patients who were counting on the new drugs to pare pounds may think they’re out of options. “I tell them: It's not game over,” Dushay said. Trying a different version of the new class of drugs may help. Griffin, who didn't respond well to Wegovy, has started using Zepbound, which targets an additional hormone pathway in the body. After three months of using the drug, she has lost 7 pounds. “I'm hoping it's slow and steady,” she said. Other people respond well to older drugs, the experts said. Changing diet, exercise, sleep and stress habits can also have profound effects. Figuring out what works typically requires a doctor trained to treat obesity, Saunders noted. “Obesity is such a complex disease that really needs to be treated very comprehensively,” she said. “If what we’re prescribing doesn’t work, we always have a backup plan.”Guardiola hits back at claims of De Bruyne rift
Pep Guardiola has said his Manchester City side facing problems after giving up a 3-0 lead to draw 3-3 with Feyenoord in the Champions League on Tuesday. City went into the game with Feyenoord on the back of five consecutive games without a win. The Premier League champions looked set to halt the poor as they led 3-0 thanks to a goal from Ilkay Gundogan and a brace from Erling Haaland. But with 15 minutes left Feyenoord erased the 3-0 deficit to secure a 3-3 draw. ““We have problems, yes,” Guardiola said in his post match. “Three changes? The game is never over, but at 3-0, I could not see any danger.” Up next for City is a difficult trip to Anfield to face Premier League leaders Liverpool.
NoneLakers looking to get their offense back on trackNPSS Volleyball teams shine at B.C. Provincials, Girls finish 6th in best showing in 15 years
‘Don’t play with me’, threatens Shannon Sharpe in terrifying live First Take rant at ESPN colleague Kirk HerbstreitSaquon Barkley has become the Shohei Ohtani of the NFL. There's no better home run hitter playing football right now. Barkley had touchdown runs of 72 and 70 yards for the Philadelphia Eagles in a 37-20 victory over the Los Angeles Rams on Sunday night. He now has five runs of 50-plus yards this season and is on pace to break Eric Dickerson's single-season record of 2,105 yards set in 1984. Barkley's historic performance against the Rams — his 255 yards set a team record — captivated a national audience and turned him into a fan favorite for the AP NFL MVP award. He's not the betting favorite, however. Josh Allen has the best odds at plus-150, according to Bet MGM Sportsbook. Two-time MVP Lamar Jackson is next at plus-250 followed by Barkley at plus-400. People are also reading... Running backs have won the award 18 times, including three-time winner Jim Brown, who was the AP's first NFL MVP in 1957. Quarterbacks have dominated the award, winning it 45 times. Only three players who weren't QBs or RBs have been MVP. It takes a special season for a non-QB to win it mainly because the offense goes through the signal caller. Quarterbacks handle the ball every offensive snap, run the show and get the credit when things go well and the blame when it doesn't. Adrian Peterson was the most recent non-QB to win it when he ran for 2,097 yards and 12 touchdowns for the Minnesota Vikings in 2012. Playing for a winning team matters, too. Nine of the past 11 winners played for a No. 1 seed with the other two winners on a No. 2 seed. The Vikings earned the sixth seed when Pederson was MVP. Barkley is a major reason why the Eagles (9-2) are leading the NFC East and only trail Detroit (10-1) by one game for the top spot in the conference. Does he have a realistic chance to win the MVP award? Kicker Mark Moseley was the MVP in the strike-shortened 1982 season when he made 20 of 21 field goals and 16 of 19 extra points in nine games for Washington. If voters once selected a kicker, everyone has a chance, especially a game-changer such as Barkley. Defensive tackle Alan Page was the MVP in 1971 and linebacker Lawrence Taylor won it in 1986. Running back Christian McCaffrey finished third in voting last year and wide receiver Justin Jefferson placed fifth in 2022. The Offensive Player of the Year award and Defensive Player of the Year award recognize the best all-around players on both sides of the ball, allowing voters to recognize non-QBs if they choose. Wide receivers and running backs have won the AP OPOY award seven times over the past 11 seasons. McCaffrey was the 2023 winner. The AP's new voting format introduced in 2022 also gives non-QBs a better opportunity to get MVP recognition. Voter submit their top five picks for each award, with a weighted point system. Previously, voters made one choice for each award. A nationwide panel of 50 media members who regularly cover the league vote for MVP and seven other awards. The awards are based on regular-season performance. Clinching scenarios The Chiefs (10-1) and Bills (9-2) already are in position to lock up postseason berths right after Thanksgiving. Kansas City clinches a playoff berth with a win over Las Vegas on Black Friday and a loss by Miami on Thursday night, or a win plus a loss by Denver on Monday night. Buffalo can wrap up a fifth straight AFC East title with a victory over San Francisco on Sunday and a loss by the Dolphins. Status quo in Dallas? It's not a given that the Dallas Cowboys will be looking for a new head coach after this season. Owner Jerry Jones said Tuesday on local radio that Mike McCarthy could end up getting a contract extension. "I don't think that's crazy at all. This is a Super Bowl-winning coach. Mike McCarthy has been there and done that. He has great ideas. We got a lot of football left," Jones said. McCarthy led the Cowboys (4-7) to three straight 12-win seasons, but they went 1-3 in the playoffs and haven't reached the NFC championship game since winning the Super Bowl 29 years ago. Injuries have contributed to the team's struggles this season, but Dallas was just 3-5 before Dak Prescott was lost for the rest of the season. The Cowboys upset Washington last week and their next four games are against teams that currently have losing records. If they somehow end up 9-8 or even 8-9, Jones could make a case for keeping McCarthy. Be the first to know
Tiger Woods at the 2024 Hero World Challenge. Getty Images There were plenty of good vibes emanating from Tiger Woods’ Tuesday reappearance in the Bahamas, his annual State of the Tiger press conference ahead of this week’s Hero World Challenge . Woods isn’t playing this year but he seemed at peace with that, instead reprising his role as smiley tournament host. These days, Woods is largely congenial with the press and vice-versa, each owing a better understanding of what to expect from the other. As expected, the day’s back-and-forth failed to unearth any five-alarm breaking news. In some ways that was the biggest takeaway. But one line was hard to hear without wincing. Woods was asked about a prediction he’d made a year ago in this same chair, when he’d declared his intentions to play once per month in 2024. It seemed ambitious but exciting at the time, a dose of optimism from the greatest player of his generation. But it didn’t pan out that way. Woods’ 2024 began with a mysterious WD at the Genesis Invitational, it peaked with yet another made cut at the Masters and then came disappointing MCs at the PGA, U.S. Open and Open Championship. We didn’t hear much from him after that, just news of another successful back surgery — his sixth. So what happened? “Well, I didn’t think my back was going to go like it did this year,” Woods said. He described the pain that progressed throughout the season, the way it radiated down his leg, and how it stopped responding to treatment and recovery. He said he could commit to one tournament per month again, but he paused. “I truly don’t know.” Now comes the hard part. Prep mode for 2025, a year that promises the TGL and some unknown number of stroke-play golf tournaments. But 2024? “This year was kind of — I had to toss it away,” he said. “I wasn’t as sharp as I needed to be. I didn’t play as much as I needed to going into the major championships and I didn’t play well at them. Hopefully next year will be better, I’ll be physically stronger and better. I know the procedure helped and hopefully I can build upon that.” I had to toss it away. It’s painful to witness pain in another human being. It’s even harder to see what pain does to an athlete — how the body can betray the mind and the spirit. It’s painful to watch Woods in particular, who has pushed his body, mind and spirit past the limit for decades, and is now fighting Father Time for good measure. Woods’ words were painful too in the context of his other work as a central figure in the PGA Tour’s geopolitical negotiations — his lost year on the course felt emblematic of a lost year across the fragmented landscape of professional golf, which remains in frustrating limbo. This December marks the first anniversary of the original deal deadline between the PGA Tour, DP World Tour and Saudi Public Investment Fund. It seems like we’ll breeze past that unfortunate one-year mark without an agreement; Woods’ latest update on that front was a mix between some cautious optimism (“definitely moving”) and one giant shrug (“Even if we had gotten a deal done by now, it’s still in the DOJ’s hands, but we wish we would have had something more concrete”). Across the sport, it was hardly a lost year — think Scottie Scheffler’s stretch of dominance , Xander Schauffele’s validation , Bryson DeChambeau’s U.S. Open heroics . But within the sport, “high-level negotiations” between the interested parties are beginning to feel like intransigence. We’ve seen no progress on a satisfying top-tour resolution, inched no closer to peace or harmony, and we’ve reached December, again, staring down an offseason of LIV signing rumors and merger non-update eye-rolls. At this week’s Hero, we might not find comfort. But through Woods, we might at least find context. This year marks the 25th edition of the World Challenge, an event Woods first hosted in 1999 to benefit his foundation. Woods turns 49 later this month, which means he’s hosted this event for more than half his life. Mostly that seems surreal. Tiger turned 24 in his first year as tournament host, and it’s tough to imagine Ludvig Aberg (who turned 25 last month) or Akshay Bhatia (who turns 23 next month) hosting an invitational or getting the world’s best pros to turn up. But the 25th anniversary of this event is also a reminder that the issues facing pro golf in 2024 haven’t changed much from 1999. Woods was already the biggest player in golf then. He entered the 1999 World Challenge off four PGA Tour victories in a row, he’d kick off 2000 with two more and, later that year, he’d claim the first three legs of the Tiger Slam. But it wasn’t all sunshine and roses; Woods and agent Mark Steinberg had their issues with the operations of the PGA Tour. They didn’t appreciate the hefty rights fee the Tour charged their tournament, which quadrupled from 1999 to 2000. Nor did they approve of the ads used by tournament sponsors featuring Woods’ likeness. (Mercedes plastered Woods’ face on tournament advertising while Buick paid Woods directly for the same privilege.) Tiger and commissioner Tim Finchem had a frosty relationship, and there was even some concern Woods could look to play his golf elsewhere. “The players and the PGA Tour have been bucking heads on a lot of issues,” Woods said in 2000. “The public has no idea we do it, but we do it all the time.” Asked about speculation that he could leave the PGA Tour, the New York Times described his reaction this way : “Woods hummed, smiled and shrugged his shoulders.” His father Earl fueled the speculation. “He can take his game to Europe, Africa, Asia or wherever he wants,” Earl told the Associated Press, “and the world will follow.” Unlike today, when the tangible threat of departure can beam its advertising on the PGA Tour website, the conversation then was likely just chatter and leverage. Woods and the PGA Tour were better in shared company. But Woods’ displeasure was a reminder of the perennial push-pull between players and institutions — a push-pull echoed by LIV’s arrival, by Policy Board negotiations, by changing field sizes and Tour sizes and equity payments and media rights. And by the discourse around players being paid to play in the Ryder Cup, an issue that resurfaced again at Tiger’s presser on Tuesday. “Going back to my playing days, we had the same conversation back in ’99 and we didn’t want to get paid, we wanted to give more money to charity, and the media turned it around against us and said we want to get paid,” Woods recalled on Tuesday. “The Ryder Cup itself makes so much money, why can’t we allocate it to various charities? And what’s wrong with each player, 12 players getting a million dollars and the ability to divvy out to amazing charities that they’re involved in that they can help out?” A final reference to 1999 came in reference to Woods’ swing changes at the time, and here he made an effort to correct the record. As time has gone by Earl has gotten painted as Woods’ swing coach, but after his early golf days that was never really the case. “My father turned over all the keys to the golf swing, that wasn’t his thing,” Woods said. “My father understood more the mental side of it from his operational days in Special Forces and the mindset that it took to do what he had to do, but as far as golf mechanics, no.” In 1999, Woods underwent a controversial swing change under the watchful eye of Butch Harmon. First things got worse, and then they got much, much better. “We went to work on slowly integrating pieces of the golf swing and it took the better part of a year and a half or so to where it got to where I thought it was where I would like it to be. I had a good run in ’99, 2000, 2001,” Woods said in an understated, satisfied sort of way. The players battled the tour then, as now. They fought for more money, more control, a bigger piece of the pie. They threatened to look elsewhere. Largely they stayed. They battled tough fields and their own swings, and they tweaked both and tried to make ’em better. At the time, Woods did all of those things better than nearly all of his peers. They’ve nearly all gotten tougher with time. On Tuesday, Woods didn’t just look back, though. This is the 10th anniversary of Hero’s sponsorship of the World Challenge, and while Hero’s executive chairman Dr. Pawan Munjal admitted uncertainty — “There is confusion for the sponsors as well right now, what to do, where to go, how to look at the future,” — he also announced a sponsorship extension through 2030. Woods will turn 55 that December. It’s tough to predict the status of LIV Golf, the PGA Tour or their potential intersection. And it’s tough to know whether Woods will have stepped away from competitive golf altogether by that point — or if he’ll be teeing it up as a sponsor invite that week having made the cut at the Masters and dominated in a limited schedule on the PGA Tour Champions. Woods talked about the athlete’s journey and about the roles of recovery, patience, and frustration. His body doesn’t recover like it used to, he said. Still, he remembers and he hopes. Which brings us to his other line, uttered by athletes and sports fans as long as there have been seasons. Hopefully next year will be better. Latest In News Golf.com Editor Dylan Dethier is a senior writer for GOLF Magazine/GOLF.com. The Williamstown, Mass. native joined GOLF in 2017 after two years scuffling on the mini-tours. Dethier is a graduate of Williams College, where he majored in English, and he’s the author of 18 in America , which details the year he spent as an 18-year-old living from his car and playing a round of golf in every state.
The Los Angeles Dodgers’ star player Shohei Ohtani is about to take on another, equally important role — that of a father! The 30-year-old baseball sensation and his wife, Mamiko Tanaka , 28, made the big announcement via Instagram on Saturday, December 28, 2024. “Can’t wait for the little rookie to join our family soon!” he proudly captioned the post, alongside a photo of their dog Dekopin, a set of pink ruffled baby pajamas, and an ultrasound photo covered by a baby-face emoji. Dekopin, otherwise known as “Decoy,” appeared to be taking the news in stride, laying back with his legs in the air for the sweet snapshot. Ahead of the arrival, here’s what you should about Shohei Ohtani’s wife Mamiko Tanaka and their life together as a married couple. Who is Shohei Ohtani’s Wife? According to PEOPLE , Mamiko Tanaka, 28, is a former pro Japanese basketball player. Per the outlet, early in her career, Tanaka played for Waseeda University. She went on to play professional basketball in 2019, joining the Fujitsu Red Wave of the Women’s Japan Basketball League. She stands tall and graceful at 5’11,” and her career as a pro basketball player spanned four years before she retired in 2023. Perhaps most importantly, she’s proven that Ohtani is not the only talented athlete in the family. How Long Has Shoehei Ohtani Been Married? Without naming the date or the bride, Ohtani announced his marriage in a February 29, 2024 Instagram post . “To all my friends and fans throughout, I have an announcement to make: Not only have I began a new chapter in my career with the Dodgers but I also have began a new life with someone from my Native country of Japan who is very special to me and I wanted everyone to know I am now married,” he wrote. “I am excited for what is to come and thank you for your support.” An adorable snap of Dekopin in the corner of the announcement punctuated the good news. A post shared by Shohei Ohtani | 大谷翔平 (@shoheiohtani) Two weeks later, Ohtani and Tanaka posed with his new wife as they prepared to board a plane to Seoul, South Korea. The Dodgers were on their way to play there, and the team ultimately made the big reveal with a shot on Twitter of Ohtani and Tanaka, as well as a separate photo of Mookie Betts and wife Brianna Hammonds. “Wheels up to Seoul,” the team captioned the post. Beyond his couple of big announcements, Ohtani has kept his personal life with Tanaka private — the baseball star has shared very little information about his daily life with Tanaka on social media. Does Shohei Ohtani Have Kids? As mentioned above, Ohtani has recently announced he’s about to become a father for the first time! His Instagram post, complete with a pink ruffled onesie, indicated that his first child will be a daughter. Fans were thrilled, and took to the comments thread to share their thoughts on the impending arrival. “I am so thrilled for you two! Congratulations, and best wishes for your baby girl! Decoy is going to be such a great sibling,” remarked a follower, while another quipped, “do you need a nanny?” According to The Los Angeles Times, Ohtani’s reveal comes amid a year of change, including switching teams from the Angels to the Los Angeles Dodgers. He signed a $700 million contract with the legendary team in December of 2023. He then led the team to its eighth world series title in November of 2024.LAHAINA, Hawaii (AP) — Andrej Jakimovski converted an off-balance layup with 8 seconds left, and Colorado handed No. 2 UConn its second loss in two days at the Maui Invitational, beating the two-time defending national champion 73-72 on Tuesday. A day after a 99-97 overtime loss to Memphis that left Huskies coach Dan Hurley livid about the officiating, UConn (4-2) couldn't shake the unranked Buffaloes (5-1), who shot 62.5% in the second half. With Colorado trailing 72-71 in the closing seconds, Jakimovski drove to his right and absorbed contact from UConn’s Liam McNeeley. He tossed the ball toward the glass and the shot was good as he fell to the floor. Hassan Diarra missed a 3-pointer just ahead of the buzzer for UConn. Elijah Malone and Julian Hammond III scored 16 points each for Colorado, and Jakimovski had 12 points and 10 rebounds. The Huskies led 40-32 at halftime and by nine points early in the second half, but Colorado quickly closed that gap. McNeeley led UConn with 20 points. Takeaways UConn: Hurley's squad is facing its first adversity in quite a while. The Huskies arrived on Maui with a 17-game winning streak that dated to February. Colorado: The Buffaloes were held to season lows in points (56) and field goal percentage (37%) in a 16-point loss to Michigan State on Monday but shot 51.1% overall and 56.3% (9 of 16) from 3-point range against the Huskies. Key moment Hurley called timeout to set up the Huskies' final possession, but the Buffs forced them to take a contested 3. Key stat Colorado had a 28-26 rebounding advantage after being out-rebounded 42-29 by Michigan State. Up next Colorado will play the Iowa-Dayton winner in the fifth-place game on Wednesday. UConn will play the loser of that matchup in the seventh-place game. Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college basketball: https://apnews.com/hub/ap-top-25-college-basketball-poll and https://apnews.com/hub/college-basketball .