bet365 mobile

- Completed Initial Public Offering (IPO) of common stock, raising gross proceeds of $82.1M - Single Ascending Dose (SAD) portion of Phase 1 study of CMP-CPS-001 completed; safety data anticipated in Q1 2025 - Entered strategic research collaboration with BioMarin valued at over $370M CAMBRIDGE, Mass., Nov. 21, 2024 (GLOBE NEWSWIRE) -- CAMP4 Therapeutics Corporation (“CAMP4”) (Nasdaq: CAMP), a clinical-stage biotechnology company developing a pipeline of regRNA-targeting therapeutics designed to upregulate gene expression with the goal of restoring healthy protein levels across a range of genetic diseases, today reported financial results for the third quarter ended September 30, 2024, and provided a corporate update. “The third quarter of 2024 has been transformational for CAMP4, highlighted by our successful IPO and continued strong progress with our lead program, CMP-CPS-001, which received Orphan Drug Designation and Rare Pediatric Disease Designation from the FDA, underscoring its potential as a novel therapeutic candidate for the treatment of urea cycle disorders,” said Josh Mandel-Brehm, Chief Executive Officer of CAMP4. “We also partnered with BioMarin to identify novel therapeutics targeting regRNAs associated with genetic diseases, validating the potential of our RNA Actuating Platform and reinforcing our commitment to advance cutting-edge solutions for patients in need.” Mr. Mandel-Brehm continued, “We continue to advance our CMP-CPS-001 program through the Phase 1 trial, and we anticipate reporting SAD safety data in the first quarter of 2025 followed by multiple ascending dose (MAD) biomarker efficacy data in the second half of 2025, that may enable a registrational Phase 2/3 study. With the proceeds from our IPO, we are well positioned to support continued clinical and preclinical development of our ongoing programs.” Recent Corporate Highlights: Third Quarter 2024 Financial Results CAMP4 ended the third quarter with $2.5 million in cash and cash equivalents. On a pro forma basis, considering the $82.1M IPO proceeds, the company is well positioned to support continued growth and the development of its ongoing programs. Research and Development (R&D) expenses were $9.7 million for the third quarter of 2024 compared to $9.8 million for the third quarter of 2023. The decrease was mainly due to a modest reduction in workforce-related expense, offset in part by an increase in lab operation expense and preclinical and clinical consulting fees. General and administrative (G&A) expenses were $3.8 million for the quarter ended September 30, 2024, compared to $2.9 million for the quarter ended September 30, 2023. The increase in G&A expenses was primarily due to an increase in stock-based compensation expense and higher patent-related expenses vs. prior period. Net loss was $13.5 million for the third quarter 2024, compared to $11.7 million for the same period in 2023. About CAMP4 Therapeutics CAMP4 is developing disease-modifying treatments for a broad range of genetic diseases where amplifying healthy protein may offer therapeutic benefits. Our approach amplifies mRNA by harnessing a fundamental mechanism of how genes are controlled. To amplify mRNA, our therapeutic ASO drug candidates target regRNAs, which act locally on transcription factors and are the master regulators of gene expression. CAMP4’s proprietary RAP PlatformTM enables the mapping of regRNAs and generation of therapeutic candidates designed to target the regRNAs associated with genes underlying haploinsufficient and recessive partial loss-of-function disorders, of which there are more than 1,200, in which a modest increase in protein expression may have the potential to be clinically meaningful. Learn more about us at www.CAMP4tx.com and follow us on LinkedIn and X . Forward-Looking Statements This press release contains forward-looking statements which involve risks, uncertainties and contingencies, many of which are beyond the control of the Company, which may cause actual results, performance, or achievements to differ materially from anticipated results, performance, or achievements. All statements other than statements of historical facts contained in this press release are forward-looking statements. In some cases, you can identify forward-looking statements by terms such as “may,” “will,” “should,” “expect,” “plan,” “anticipate,” “could,” “intend,” “target,” “project,” “contemplate,” “believe,” “estimate,” “predict,” “potential” or “continue” or the negative of these terms or other similar expressions, although not all forward-looking statements contain these words. Forward-looking statements include, but are not limited to, statements concerning CAMP4’s plans, objectives, expectations and intentions; the timing and results of ongoing and future clinical trials, including expectations on the timing of reporting SAD and MAD data from and seeking regulatory approval for the CMP-CPS-001 trial; its growth strategy; and cash balance guidance. The forward-looking statements in this press release speak only as of the date of this press release and are subject to a number of known and unknown risks, uncertainties and assumptions that could cause the Company’s actual results to differ materially from those anticipated in the forward-looking statements, including, but not limited to: the Company’s limited operating history, incurrence of substantial losses since the Company’s inception and anticipation of incurring substantial and increasing losses for the foreseeable future; the Company’s need for substantial additional financing to achieve the Company’s goals; the uncertainty of clinical development, which is lengthy and expensive, and characterized by uncertain outcomes, and risks related to additional costs or delays in completing, or failing to complete, the development and commercialization of the Company’s current product candidates or any future product candidates; delays or difficulties in the enrollment and dosing of patients in clinical trials; the impact of any significant adverse events or undesirable side effects caused by the Company’s product candidates; potential competition, including from large and specialty pharmaceutical and biotechnology companies; the Company’s ability to realize the benefits of the Company’s current or future collaborations or licensing arrangements and ability to successfully consummate future partnerships; the Company’s ability to obtain regulatory approval to commercialize any product candidate in the United States or any other jurisdiction, and the risk that any such approval may be for a more narrow indication than the Company seeks; the Company’s dependence on the services of the Company’s senior management and other clinical and scientific personnel, and the Company’s ability to retain these individuals or recruit additional management or clinical and scientific personnel; the Company’s ability to grow the Company’s organization, and manage the Company’s growth and expansion of the Company’s operations; risks related to the manufacturing of the Company’s product candidates, which is complex, and the risk that the Company’s third-party manufacturers may encounter difficulties in production; the Company’s ability to obtain and maintain sufficient intellectual property protection for the Company’s product candidates or any future product candidates the Company may develop; the Company’s reliance on third parties to conduct the Company’s preclinical studies and clinical trials; the Company’s compliance with the Company’s obligations under the licenses granted to the Company by others, for the rights to develop and commercialize the Company’s product candidates; risks related to the operations of the Company’s suppliers; and other risks and uncertainties described in the section “Risk Factors” in the Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2024, as well as other information we file with the Securities and Exchange Commission. The forward-looking statements in this press release are inherently uncertain and are not guarantees of future events. Because forward-looking statements are inherently subject to risks and uncertainties, some of which cannot be predicted or quantified and some of which are beyond the Company’s control, you should not unduly rely on these forward-looking statements. The events and circumstances reflected in the forward-looking statements may not be achieved or occur and actual future results, levels of activity, performance and events and circumstances could differ materially from those projected in the forward-looking statements. Moreover, the Company operates in an evolving environment. New risks and uncertainties may emerge from time to time, and management cannot predict all risks and uncertainties. Investors, potential investors, and others should give careful consideration to these risks and uncertainties. Except as required by applicable law, the Company does not undertake to publicly update or revise any forward-looking statements contained herein, whether as a result of any new information, future events, changed circumstances or otherwise. Contacts Investor Relations: Sandya von der Weid LifeSci Advisors svonderweid@lifesciadvisors.com Media: Jason Braco, Ph.D. LifeSci Communications jbraco@lifescicomms.com (1) Working capital is defined as total current assets less total current liabilities. See our condensed consolidated financial statements and the related notes thereto included in our Quarterly Report on Form 10-Q for the period ended September 30, 2024 for further details regarding our current assets and current liabilities.DraftKings Sportsbook and Caesars Sportsbook are two of the best online sports betting sites in the country. DraftKings is a market leader in several states. Caesars is locked in a battle for third place with BetMGM Sportsbook in some states. DraftKings has a 30% to 45% market share in dozens of states. Caesars averages about 10% to 15%. However, there’s not much of a difference between the two online sportsbook products. Both have: Generous welcome bonuses for new bettors Ongoing promotions for existing bettors All kinds of odds boosts, contests, and other betting promos Competitive odds Easy-to-use software available via mobile apps and websites We've compared the two below in several important categories. If you’re asking whether you should place a bet with Caesars or DraftKings, this comparison might help you make that decision. Caesars Sportsbook Caesars is using a generous welcome bonus and the allure of its Caesars Rewards program to gain market share in several states. Caesars Sportsbook posts consistently better odds than its competition does, and it regularly runs odds boosts, parlay boosts, profit boosts, bonuses, and free-to-play contests. Pros of Caesars The most competitive odds Caesars Rewards Generous welcome bonus Cons of Caesars Mobile app features are limited Slow load times reported Lengthier wait times for withdrawals reported DraftKings DraftKings Sportsbook is a market leader in several states due to its massive welcome bonus and the broadest range of available betting markets online. That welcome bonus is worth up to $2,550. The value continues with various ongoing promos and DK’s always competitive odds. DraftKings also allows seamless movement between the sportsbook and DFS contests. Bettors earn Crowns and Tier Credits in DraftKings' Dynasty Rewards loyalty program with every bet and contest entry. Ongoing promos also include free-to-play contests, odds boosts, and bonus bets. Pros of DraftKings Easy-to-use software Single-account DFS and sportsbook access Generous welcome bonus Cons of DraftKings Customer support access is sometimes limited Slower withdrawal times reported Higher vig reported DraftKings vs. Caesars comparison From a product perspective, there isn’t much difference between DraftKings Sportsbook and Caesars Sportsbook. The big difference is how popular the DraftKings product seems to be with players. Both offer competitive odds, but the odds at Caesars are consistently better. Both have loyalty programs, but Caesars Rewards is widely considered the top loyalty program in US gaming. Both use generous welcome bonuses and ongoing promos to attract new players and keep existing ones on board. So, why is DraftKings beating Caesars in almost every market? The answer may be that the DraftKings brand has been around longer via daily fantasy sports. It has successfully leveraged its large DFS customer base and popular marketing and advertising campaigns. Caesars vs. DraftKings banking options Caesars and DraftKings have mostly the same banking options, although Caesars has a few more and faster options. As a result, Caesars wins the head-to-head comparison in this category. Here’s a look. Banking Methods DraftKings Deposits DraftKings Withdrawals Caesars Deposits Caesars Withdrawals Online Banking Instant w/ no maximum 2-4 business days (Trustly) Instant w/ no maximum 2-4 business days Instant Banking Instant w/ no maximum 2-4 business days N/A N/A Debit/Credit Card Visa, Mastercard Within 24 hours (Visa); 1-3 business days (Mastercard) Visa, Mastercard, Discover (Direct to Debit) Less than 1 hour after approval ACH/eCheck Instant w/ variable maximum 3-5 business days Instant w/ variable maximum At least 1 business days PayPal Instant w/ variable maximum Up to 48 hours Instant w/ variable maximum Same day Branded Prepaid Play+ Card Instant w/ $2,000 maximum Within 24 hours Instant w/ $2,000 maximum Less than 1 hour Cash at Sportsbooks Instant w/ no maximum Within 10-12 hours Instant w/ no maximum Instant Check N/A 7-21 business days N/A Up to 14 business days PayNearMe 15 minutes w/ $500 maximum N/A 15 minutes w/ $500 maximum N/A Venmo Instant w/ $5,000 maximum Within 24 hours Instant w/ $5,000 maximum At least 1 business day Caesars vs. DraftKings registration process The registration processes are practically identical for Caesars and DraftKings. Neither wins this category as a result. Caesars and DraftKings both offer website and app registration. Both ask for a username, password, and personal info that includes your name, email address, address, phone number, date of birth, and the last four digits of your SSN. While Caesars asks you to enter a promo code to get the best bonus available, you must sign up through the links here to get the same from DraftKings. Both will also ask you to accept specific terms and conditions and may require a copy of your driver’s license. Verification is almost always a same-day process with Caesars and DraftKings. DraftKings vs. Caesars betting apps DraftKings and Caesars have both designed fully functional sports betting apps for Apple and Android devices. The ratings on the App Store and Google Play are both high. Plus, both make account management and navigation easy. The DraftKings app may have more features, but Caesars’ is more stable. Ultimately, the choice is between additional features at DraftKings and the more stable software at Caesars. We prize the features, and since DraftKings doesn’t crash often, it’s tops in the mobile app category. See more: Best sports betting apps Caesars vs. DraftKings promotions and bonuses Sign up for a new account with Caesars Sportsbook using the promo code NEWS1000 and double your winnings on the 10 bets you make after you place a bet of $1 or more. Sign up for a new account with DraftKings Sportsbook through the links on this page, and you'll get a 20% deposit match bonus of up to $1,000, a $50 bonus bet with a $5 deposit, and $150 in bonus bets instantly after placing a $5 real-money bet. The sheer size of DraftKings’ welcome bonus gives it the edge here. The available promos and the size of the welcome bonus give DraftKings a clear win in this category. See more: Best sports betting bonuses & promo codes DraftKings vs. Caesars state accessibility Caesars Sportsbook is legal in: AZ, CO, DC (on-site only), IA, IL, IN, KS, KY, LA (varies by parish), MA, MD, ME, MI, NC, NJ, NV, NY, OH, PA, TN, VA, WV, WY. DraftKings Sportsbook is legal in: AZ, CO, CT, IA, IL, IN, KS, KY, LA (varies by parish), MA, MD, ME, MI, NC, NH, NJ, NY, OH, OR, PA, TN, VA, VT, WV, WY. Even though DraftKings' welcome offer isn't available in all states, it wins the accessibility and market share battle. North Carolina launched online sports betting on March 11, 2024, and both DraftKings and Caesars sportsbooks have their respective NC sportsbook promos for bettors in the Tar Heel State. Caesars vs. DraftKings odds DraftKings may offer a more extensive variety of betting options surrounding major US and international sports. However, Caesars consistently provides the best odds. In fact, Caesars is known for posting the best odds in the business, while DraftKings is the sportsbook with the highest vig. Consistently better odds give Caesars an edge over DraftKings (and others) in this category. Caesars vs. DraftKings payout speed Caesars and DraftKings offer similar withdrawal options along the same timelines. Payout speeds are mostly the same, but since Caesars has a slight edge in the number of fast payout options, it wins this payout speed category. See more: Top 7 fastest paying sports betting sites DraftKings vs. Caesars loyalty programs You can connect your Caesars Sportsbook account to the popular Caesars Rewards program, allowing you to earn and redeem in a top loyalty program in the country. Similarly, DraftKings offers membership in its Dynasty Rewards loyalty program, where you earn points with every bet redeemable for cashback and other bonuses. Caesars Rewards is the top loyalty program in the US, giving Caesars the win in this category. DraftKings vs. Caesars responsible gambling Caesars Sportsbook has a responsible gaming program to prevent problem gambling and underage gambling. It also lets you set personal limits on gambling and self-exclude if necessary. DraftKings is equally committed to responsible gaming. It encourages players to keep things fun, only bet what they can afford, and set reasonable limits. DraftKings also participates in problem gambling awareness and underage gambling prevention initiatives. This category is tied, as both are doing more than required on the responsible gambling front. Caesars vs. DraftKings customer service DraftKings’ customer support is available via online request on the DraftKings Help Center. Live chat is also available via the Help Center during standard business hours. The Caesars Sportsbook customer support team is available via phone, online, and email. They’re easier to get a hold of, so Caesars wins the customer service category. Conclusion: Is Caesars better than DraftKings? DraftKings is the second-biggest online sportsbook in the country in terms of market share, behind only FanDuel. Caesars is in a battle for the leftovers with BetMGM. DraftKings has a more feature-rich sports betting app; it’s in more states, has a bigger welcome bonus, and runs more ongoing promos at slower times. But Caesars wins in terms of its loyalty program and customer service. Plus, its odds are consistently better. However, in the end, DraftKings odds are competitive enough that it is the better online sportsbook when you add up the many things it does so well. Compare other sportsbooks DraftKings vs. FanDuel BetMGM vs. DraftKings FanDuel vs. BetMGM Caesars vs. FanDuel DraftKings vs. Caesars FAQ Which sportsbook is better: DraftKings or Caesars? A comparison between these two licensed online sportsbooks shows they’re close, but DraftKings has a slight edge. Better odds usually make for the better sportsbook, but Caesars and DraftKings are too close to call on that front. All the other things DraftKings does well make it the better online sportsbook. Can I use DraftKings and Caesars at the same time? You can have accounts with both DraftKings and Caesars, and why not? Having accounts at both means you can take advantage of all the promos and contests each one makes available. Which sportsbook is better for NFL betting? Caesars and DraftKings are both great for NFL betting odds . See more: Best football betting promos & bonuses Is Caesars or DraftKings better for bonuses and promotions? DraftKings has a bigger welcome bonus and runs more ongoing promotions in lean times for sports fans. This makes DraftKings the place for better bonuses and promos. If you purchase a product or register for an account through one of the links on our site, we may receive compensation. Learn more >bet365 mobile 。

NoneA high-speed passenger train collided with a fire engine at a crossing on Saturday in Florida, injuring three firefighters and at least a dozen train passengers, authorities said. The crash happened at 10.45am in crowded downtown Delray Beach, multiple news outlets reported. The Brightline train was stopped on the tracks, its front destroyed, about a block away from the Delray Beach fire rescue truck, its ladder ripped off and strewn in the grass several yards away, The Sun-Sentinel newspaper reported. The Delray Beach Fire Rescue said in a social media post that three Delray Beach firefighters were in stable condition at a hospital. Palm Beach County Fire Rescue took 12 people from the train to the hospital with minor injuries. The front of the Brightline train was severely damaged in the accident (Mike Stocker/South Florida Sun-Sentinel via AP) He saw firefighters climbing out of the window of their damaged truck and pulling injured colleagues away from the tracks. One of their helmets came to rest several hundred feet away from the crash. “The front of that train is completely smashed, and there was even some of the parts to the fire truck stuck in the front of the train, but it split the car right in half. It split the fire truck right in half, and the debris was everywhere,” Mr Amaral said. Brightline officials did not immediately comment on the crash. A spokesperson for the National Transportation Safety Board said it was still gathering information about the crash and had not decided yet whether it will investigate. The NTSB is already investigating two crashes involving Brightline’s high-speed trains that killed three people early this year at the same crossing along the railroad’s route between Miami and Orlando. More than 100 people have died after being hit by trains since Brightline began operations in July 2017 – giving the railroad the worst death rate in the United States. But most of those deaths have been either suicides, pedestrians who tried to run across the tracks ahead of a train or drivers who went around crossing gates instead of waiting for a train to pass. Brightline has not been found to be at fault in those previous deaths.

Residents take to the water to escape massive Tondo fire

BOSTON (AP) — Donald Hand Jr. scored 15 of his career-high 29 points in the first half and grabbed 10 rebounds to help Boston College beat Fairleigh Dickinson 78-70 on Saturday. Chad Venning scored a season-high 18 points on 8-of-10 shooting for Boston College (8-5). Ahmed Barba-Bey was fouled on a 3-point shot and made all three free throws before Terrence Brown converted a three-point play to cut FDU's deficit to five points with 2 minutes left and Barba-Bey’s 3 with 39 seconds left made it 74-70. Hand answered with a layup 10 seconds later and followed with two free throws that capped the scoring with 18 seconds to play. Barba-Bey, a graduate transfer from Division-II Jefferson, hit eight 3-pointers and led Fairleigh Dickinson (4-11) with a career-high 31 points on 10-of-12 shooting. Brown added 20 points and Bismark Nsiah scored 10, all in the second half. Hand hit a 3-pointer that gave Boston College the lead for good with 17:17 left in the first half and scored 13 of the game's first 24, including a three-point play that gave the Eagles a 17-7 lead with 11:58 left before the intermission. Barba-Bey hit back-to-back 3-pointers to cut FDU's deficit to four just over a minute later but Boston College scored the next eight points and the Knights got no closer until the second half. Boston College won for just the second time since beating Boise State 63-61 on Joshua Beadle's late 3-pointer to win the Cayman Islands Classic on Nov. 26 and improve to 6-1. The Knights have lost four games in a row overall and are 0-10 away from home this season. Boston College won the lone previous meeting between the programs 72-54 on Dec. 10, 1992. ___ Get poll alerts and updates on the AP Top 25 throughout the season. Sign up here . AP college basketball: https://apnews.com/hub/ap-top-25-college-basketball-poll and https://apnews.com/hub/college-basketballFive facts about electric vehicles in 2024

‘World first’ Macca’s item lands in AustraliaITGR Stock Soars to All-Time High, Reaching $141.01

The Centers for Medicare and Medicaid Services shut down access to the Affordable Care Act marketplace to two health insurance agencies. Here's a look at what's happened.Anti-immigration and anti-fascism: Two opposing protests bring hundreds to the streets of Porto